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公开(公告)号：US10989721B2
公开(公告)日：2021-04-27
申请号：US15648162
申请日：2017-07-12
Applicant: Emulate Inc.
Inventor： Daniel Levner , Christopher David Hinojosa , Norman Wen , Jacob Fraser , Justin Nguyen , Riccardo Barrile , Geraldine Hamilton , Catherine Karalis , Hyoungshin Park , Antonio Varone , Andries Van der Meer , Monicah Otieno , David Conegliano
Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.
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Patent Agency Ranking
公开(公告)号：US10908171B2
公开(公告)日：2021-02-02
申请号：US15648000
申请日：2017-07-12
Applicant: Emulate Inc.
Inventor： Daniel Levner , Christopher David Hinojosa , Norman Wen , Jacob Fraser , Justin Nguyen , Riccardo Barrile , Geraldine Hamilton , Catherine Karalis , Hyoungshin Park , Antonio Varone , Andries Van der Meer , Monicah Otieno , David Conegliano
Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.
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公开(公告)号：US20230159899A1
公开(公告)日：2023-05-25
申请号：US17992168
申请日：2022-11-22
Applicant: EMULATE, INC.
Inventor： Geraldine Hamilton , Kyung Jin Jang , Suzzette Haney , Janey Ronxhi , Konstantia Kodella , Hyoungshin Park , Josiah Sliz , Debora Barreiros Petropolis , Daniel Levner , Monicah Otieno
CPC classification number: C12N5/067 , A61K35/407 , C12M23/16 , C12M25/02 , B01L3/5027 , C12M21/08 , C12N2502/28 , C12N2533/52 , C12N2533/90 , C12M25/14 , C12N5/0068
Abstract: Provided herein relates to devices for simulating a function of a tissue and methods of using the same. In some embodiments, the devices can be used to simulate a function of a human liver tissue. In some embodiments, the devices can be used to simulate a function of a dog liver tissue. Endothelial cell culture media for long-term culture of endothelial cells are also described herein.
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公开(公告)号：US11150255B2
公开(公告)日：2021-10-19
申请号：US15648182
申请日：2017-07-12
Applicant: Emulate Inc.
Inventor： Daniel Levner , Christopher David Hinojosa , Norman Wen , Jacob Fraser , Justin Nguyen , Riccardo Barrile , Geraldine Hamilton , Catherine Karalis , Hyoungshin Park , Antonio Varone , Andries Van der Meer , Monicah Otieno , David Conegliano
IPC: G01N33/00 , G01N33/86 , B01L3/00 , C12M3/06 , C12M1/00 , C12M1/42 , C12M1/34 , G01N33/543 , G01N33/80
Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.
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公开(公告)号：US10852311B2
公开(公告)日：2020-12-01
申请号：US15648029
申请日：2017-07-12
Applicant: Emulate Inc. , JANSSEN BIOTECH, Inc
Inventor： Daniel Levner , Christopher David Hinojosa , Norman Wen , Jacob Fraser , Justin Nguyen , Riccardo Barrile , Geraldine Hamilton , Catherine Karalis , Hyoungshin Park , Antonio Varone , Andries Van der Meer , Monicah Otieno , David Conegliano
Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.
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公开(公告)号：US10228381B2
公开(公告)日：2019-03-12
申请号：US15648085
申请日：2017-07-12
Applicant: Emulate Inc. , JANSSEN BIOTECH, Inc
Inventor： Daniel Levner , Christopher David Hinojosa , Norman Wen , Jacob Fraser , Justin Nguyen , Riccardo Barrile , Geraldine Hamilton , Catherine Karalis , Hyoungshin Park , Antonio Varone , Andries Van der Meer , Monicah Otieno , David Conegliano
IPC: B01L3/00 , G01N33/50 , G01N33/569 , C12M1/00 , C12M3/00 , G01N33/86 , C12M3/06 , C12M1/42 , C12M1/34 , G01N33/543 , G01N35/08
Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.
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