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公开(公告)号：US20240036033A1
公开(公告)日：2024-02-01
申请号：US18474875
申请日：2023-09-26
Applicant: EMULATE, INC.
Inventor： Kyung-Jin Jang , Jamey Ronxhi , Josiah Sliz , Sauveur Jeanty , Sushma Jadalannagari , Ananth Nookala , Hyoungshin Park
CPC classification number: G01N33/5088 , C12N5/0684 , C12N5/0691 , G01N33/5064 , G01N33/5014 , G01N33/5044 , C12N5/0697
Abstract: The present invention relates to microfluidic fluidic devices, methods and systems as microfluidic kidney on-chips, e.g. human Proximal Tubule-Kidney-Chip, Glomerulus (Kidney)-Chip, Collecting Duct (Kidney)-Chip. Devices, methods and systems are described for drug testing including drug transport and renal clearance. Further, such devices, methods and systems are used for determining drug-drug interactions and their effect upon renal transporter functions. Importantly, they may be used for pre-clinical and clinical drug development for treating kidney diseases and for personalized medicine.
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公开(公告)号：US11841361B2
公开(公告)日：2023-12-12
申请号：US17406732
申请日：2021-08-19
Applicant: EMULATE, INC.
Inventor： Kyung-Jin Jang , Janey Ronxhi , Josiah Sliz , Sauveur Jeanty , Sushma Jadalannagari , Ananth Nookala , Hyoungshin Park
CPC classification number: G01N33/5088 , C12N5/0684 , C12N5/0691 , C12N5/0697 , G01N33/5014 , G01N33/5044 , G01N33/5064
Abstract: The present invention relates to microfluidic fluidic devices, methods and systems as microfluidic kidney on-chips, e.g. human Proximal Tubule-Kidney-Chip, Glomerulus (Kidney)-Chip, Collecting Duct (Kidney)-Chip. Devices, methods and systems are described for drug testing including drug transport and renal clearance. Further, such devices, methods and systems are used for determining drug-drug interactions and their effect upon renal transporter functions. Importantly, they may be used for pre-clinical and clinical drug development for treating kidney diseases and for personalized medicine.
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公开(公告)号：US10908171B2
公开(公告)日：2021-02-02
申请号：US15648000
申请日：2017-07-12
Applicant: Emulate Inc.
Inventor： Daniel Levner , Christopher David Hinojosa , Norman Wen , Jacob Fraser , Justin Nguyen , Riccardo Barrile , Geraldine Hamilton , Catherine Karalis , Hyoungshin Park , Antonio Varone , Andries Van der Meer , Monicah Otieno , David Conegliano
Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.
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公开(公告)号：US20200270582A1
公开(公告)日：2020-08-27
申请号：US16454753
申请日：2019-06-27
Applicant: EMULATE, INC.
Inventor： Kyung-Jin Jang , Hyoungshin Park , Sauveur Jeanty , Janey Ronxhi , Sushma jadalannagari , Geraldine A. Hamilton , Catherine Karalis
Abstract: The present invention relates to microfluidic fluidic devices, methods and systems as microfluidic kidney on-chips, e.g. human Proximal Tubule-Kidney-Chip, Glomerulus (Kidney)-Chip, Collecting Duct (Kidney)-Chip. Devices, methods and systems are described for drug testing including drug transport and renal clearance. Further, such devices, methods and systems are used for determining drug-drug interactions and their effect upon renal transporter functions. Importantly, they may be used for pre-clinical and clinical drug development for treating kidney diseases and for personalized medicine.
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公开(公告)号：US11534753B2
公开(公告)日：2022-12-27
申请号：US16352234
申请日：2019-03-13
Applicant: EMULATE, Inc.
Inventor： Ville Kujala , Hyoungshin Park , Sonalee Barthakur , Sauveur Jeanty , Brian Zuckerman , Josiah Sliz , Tanvi Shroff , Geraldine A Hamilton , Kyung-Jin Jang , Ananth Nookala , Gang Luo , Donald Mckenzie
IPC: B01L3/00 , C12M3/06 , C12Q1/6809 , G01N33/50 , C12M1/12
Abstract: The present invention relates to microfluidic fluidic devices, methods and systems as microfluidic kidney on-chips, e.g. human Proximal Tubule-Chip.
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Patent Agency Ranking
公开(公告)号：US10989721B2
公开(公告)日：2021-04-27
申请号：US15648162
申请日：2017-07-12
Applicant: Emulate Inc.
Inventor： Daniel Levner , Christopher David Hinojosa , Norman Wen , Jacob Fraser , Justin Nguyen , Riccardo Barrile , Geraldine Hamilton , Catherine Karalis , Hyoungshin Park , Antonio Varone , Andries Van der Meer , Monicah Otieno , David Conegliano
Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.
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公开(公告)号：US20200269234A1
公开(公告)日：2020-08-27
申请号：US16352234
申请日：2019-03-13
Applicant: EMULATE, Inc.
Inventor： Ville Kujala , Hyoungshin Park , Sonalee Barthakur , Sauveur Jeanty , Brian Zuckerman , Josiah Sliz , Tanvi Shroff , Geraldine A. Hamilton , Kyung-Jin Jang , Ananth Nookala , Gang Luo , Donald Mckenzie
Abstract: The present invention relates to microfluidic fluidic devices, methods and systems as microfluidic kidney on-chips, e.g. human Proximal Tubule-Chip.
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公开(公告)号：US11725190B2
公开(公告)日：2023-08-15
申请号：US16454753
申请日：2019-06-27
Applicant: EMULATE, INC.
Inventor： Kyung-Jin Jang , Hyoungshin Park , Sauveur Jeanty , Janey Ronxhi , Sushma Jadalannagari , Geraldine A Hamilton , Catherine Karalis
CPC classification number: C12N5/0697 , B01L3/502715 , C12M23/16 , C12M25/02 , C12N5/0684 , C12N5/0691 , C12Q1/32 , G01N33/5005 , G01N33/5014 , G01N33/5082 , B01L2200/0652 , B01L2200/10
Abstract: The present invention relates to microfluidic fluidic devices, methods and systems as microfluidic kidney on-chips, e.g. human Proximal Tubule-Kidney-Chip, Glomerulus (Kidney)-Chip, Collecting Duct (Kidney)-Chip. Devices, methods and systems are described for drug testing including drug transport and renal clearance. Further, such devices, methods and systems are used for determining drug-drug interactions and their effect upon renal transporter functions. Importantly, they may be used for pre-clinical and clinical drug development for treating kidney diseases and for personalized medicine.
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公开(公告)号：US20230159899A1
公开(公告)日：2023-05-25
申请号：US17992168
申请日：2022-11-22
Applicant: EMULATE, INC.
Inventor： Geraldine Hamilton , Kyung Jin Jang , Suzzette Haney , Janey Ronxhi , Konstantia Kodella , Hyoungshin Park , Josiah Sliz , Debora Barreiros Petropolis , Daniel Levner , Monicah Otieno
CPC classification number: C12N5/067 , A61K35/407 , C12M23/16 , C12M25/02 , B01L3/5027 , C12M21/08 , C12N2502/28 , C12N2533/52 , C12N2533/90 , C12M25/14 , C12N5/0068
Abstract: Provided herein relates to devices for simulating a function of a tissue and methods of using the same. In some embodiments, the devices can be used to simulate a function of a human liver tissue. In some embodiments, the devices can be used to simulate a function of a dog liver tissue. Endothelial cell culture media for long-term culture of endothelial cells are also described herein.
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公开(公告)号：US11150255B2
公开(公告)日：2021-10-19
申请号：US15648182
申请日：2017-07-12
Applicant: Emulate Inc.
Inventor： Daniel Levner , Christopher David Hinojosa , Norman Wen , Jacob Fraser , Justin Nguyen , Riccardo Barrile , Geraldine Hamilton , Catherine Karalis , Hyoungshin Park , Antonio Varone , Andries Van der Meer , Monicah Otieno , David Conegliano
IPC: G01N33/00 , G01N33/86 , B01L3/00 , C12M3/06 , C12M1/00 , C12M1/42 , C12M1/34 , G01N33/543 , G01N33/80
Abstract: Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it “on-chip” before moving into the experimental region of the chip.
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