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公开(公告)号：US5322777A
公开(公告)日：1994-06-21
申请号：US961007
申请日：1992-10-14
CPC分类号： C07K5/06139 , C12R1/01 , A61K38/00
摘要： The present invention is directed to a new antibiotic substance denominated antibiotic GE 2270, the addition salts thereof, the pharmaceutical compositions thereof and their use as medicaments, particularly in the treatment of infectious diseases involving microorganisms susceptible to them.
摘要翻译： 本发明涉及一种新型抗生素物质GE2270，其加成盐，其药物组合物及其作为药物的用途，特别是用于治疗涉及对其敏感的微生物的感染性疾病。
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公开(公告)号：US5202241A
公开(公告)日：1993-04-13
申请号：US713567
申请日：1991-06-11
CPC分类号： C07K5/06139 , C12R1/01 , A61K38/00
摘要： The present invention is directed to a new antibiotic substance denominated antibiotic GE 2270, the addition salts thereof, the pharmaceutical compositions thereof and their use as medicaments, particularly in the treatment of infectious diseases involving microorganisms susceptible to them.
摘要翻译： 本发明涉及一种新型抗生素物质GE2270，其加成盐，其药物组合物及其作为药物的用途，特别是用于治疗涉及对其敏感的微生物的感染性疾病。
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公开(公告)号：US5610143A
公开(公告)日：1997-03-11
申请号：US493043
申请日：1995-06-21
申请人： Sergio Stella , Nicoletta Montanini , Francis J. LeMonnier , Luigi Colombo , Enrico Selva , Maurizio Denaro
发明人： Sergio Stella , Nicoletta Montanini , Francis J. LeMonnier , Luigi Colombo , Enrico Selva , Maurizio Denaro
CPC分类号： C07K5/0821 , A23K20/195 , C07K5/06139 , C12R1/465 , A61K38/00
摘要： The present invention is directed to new antibiotic substances denominated antibiotics GE 37468 A, B and C, their addition salts with bases, the pharmaceutical compositions thereof and their use as medicaments, particularly in the treatment of infectious diseases involving microorganisms susceptible to them.The compounds of the invention are also active as growth promotant agents in animals, such as poultry, swine, ruminants, etc.
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公开(公告)号：US5618724A
公开(公告)日：1997-04-08
申请号：US648646
申请日：1996-05-16
申请人： Sergio Stella , Nicoletta Montanini , Francis J. LeMonnier , Luigi Colombo , Enrico Selva , Maurizio Denaro
发明人： Sergio Stella , Nicoletta Montanini , Francis J. LeMonnier , Luigi Colombo , Enrico Selva , Maurizio Denaro
IPC分类号： A23K20/195 , A61K38/00 , C07K5/078 , C07K5/097 , C12M1/02
CPC分类号： C07K5/0821 , A23K20/195 , C07K5/06139 , C12R1/465 , A61K38/00
摘要： The present invention is directed to new antibiotic substances denominated antibiotics GE 37468 A, B and C, their addition salts with bases, the pharmaceutical compositions thereof and their use as medicaments, particularly in the treatment of infectious diseases involving microorganisms susceptible to them.The compounds of the invention are also active as growth promotant agents in animals, such as poultry, swine, ruminants, etc.
摘要翻译： 本发明涉及新的抗生素物质GE 37468A，B和C，它们与碱的加成盐，其药物组合物及其作为药物的用途，特别是用于治疗涉及对它们敏感的微生物的感染性疾病。 本发明的化合物在动物如动物，如家禽，猪，反刍动物等中也是有活性的。
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公开(公告)号：US5674490A
公开(公告)日：1997-10-07
申请号：US456010
申请日：1995-05-31
IPC分类号： A01N63/02 , A01N20060101 , A61K20060101 , A61K35/74 , A61P31/04 , C07G20060101 , C07G11/00 , C12N20060101 , C12P20060101 , C12P1/04 , C12P1/06 , C12P17/08 , C12R20060101 , C12P17/12
摘要： The present invention is directed to a new antibiotic denominated antibiotic GE1655 complex, its factors antibiotic GE1655 factor A, antibiotic GE1655 factor B, and antibiotic GE1655 factor C, the pharmaceutical acceptable salts thereof, the pharmaceutical compositions thereof, and their use as medicaments against bacteria and fungi, particularly for the treatment of fungal infections in animals and human beings.
摘要翻译： 本发明涉及一种新的抗生素抗生素GE1655复合物，其因子是抗生素GE1655因子A，抗生素GE1655因子B和抗生素GE1655因子C，其药学上可接受的盐，其药物组合物及其作为抗细菌药物的用途 和真菌，特别是用于治疗动物和人类的真菌感染。
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6.发明授权Central venous catheters loaded with antibiotics of the ramoplanin group preventing development of catheter related infections 失效中央静脉导管装载有拉莫瑞林组抗生素，预防导管相关感染的发展
公开(公告)号：US5752941A
公开(公告)日：1998-05-19
申请号：US687413
申请日：1996-08-02
CPC分类号： A61L29/16 , A61L29/06 , A61L29/085 , A61L2300/406 , A61L2300/606
摘要： The invention relates to central venous polyurethane catheters with a thin hydrophilic coating loaded with an antibiotic of the ramoplanin group or any mixture thereof and their use in preventing catheter related infections. These catheters are useful to prevent bacterial adherence and colonization and, therefore, to lower the risk of vascular infections in catheterized patients. The method of preparing the catheter of the invention consists in incubating polyurethane catheters coated with a hydrophilic film in an aqueous solution of the selected antibiotic.
摘要翻译： PCT No.PCT / EP95 / 00355 Sec。 371日期：1996年8月2日 102（e）日期1996年8月2日PCT提交1995年2月1日PCT公布。 出版物WO95 / 21636 日期1995年8月17日本发明涉及具有负载拉莫拉宁组抗生素或其任何混合物的薄亲水涂层的中心静脉聚氨酯导管及其在预防导管相关感染中的用途。 这些导管可用于防止细菌粘附和定植，并因此降低导管患者血管感染的风险。 制备本发明的导管的方法在于将包被亲水膜的聚氨酯导管在所选抗生素的水溶液中孵育。
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7.发明授权Method for selectively enhancing the production of factors A or B.sub.0 of antibiotic A 40926 complex 失效选择性增强抗生素A 40926复合物因子A或B0生成的方法
公开(公告)号：US5843679A
公开(公告)日：1998-12-01
申请号：US460024
申请日：1995-06-02
摘要： The present invention is directed to a method for selectively enhancing the production of factors A, and/or B.sub.0 of antibiotic A 40926 either to isolate these single components in better yields or to enrich the complex in one or both the above components, which comprises adding an appropriate precursor of the desired antibiotic factor to an A 40926 producing culture during fermentation.
摘要翻译： 本发明涉及一种用于选择性增强抗生素A 40926的因子A和/或B0的产生的方法，以便以更好的产率分离这些单一组分或富集上述组分的一种或两种中的复合物，其包括加入 在发酵期间产生A 40926的培养物的所需抗生素因子的合适前体。
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公开(公告)号：US5843890A
公开(公告)日：1998-12-01
申请号：US462997
申请日：1995-06-05
IPC分类号： A61K31/44 , A61K38/00 , A61P3/00 , A61P31/00 , C07D513/22 , C07K5/078 , C12P17/18 , C12P21/04 , C12R1/01 , A61K35/70
CPC分类号： C07K5/06139 , A61K38/00
摘要： The present invention is directed to new antibiotic substances denominated antibiotic GE 2270 factors B.sub.1, B.sub.2, C.sub.1, C.sub.2, D.sub.1, D.sub.2, E and T, the addition salts thereof, the pharmaceutical compositions thereof and their use as medicaments, particularly in the treatment of infectious diseases involving microorganisms susceptible to them and their use as animal growth promoters.
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公开(公告)号：US5567676A
公开(公告)日：1996-10-22
申请号：US457365
申请日：1995-06-01
申请人： Enrico Selva , Grazia Beretta , Angelo Borghi , Maurizio Denaro
发明人： Enrico Selva , Grazia Beretta , Angelo Borghi , Maurizio Denaro
IPC分类号： C12P21/02 , A61K38/00 , A61P31/04 , C07G11/00 , C07K20060101 , C07K9/00 , C07K14/195 , C07K14/41 , C12R1/045 , A61K38/14 , A61K38/12
CPC分类号： C07K9/008
摘要： The present invention concerns new antiobiotic substances demoninated de-acyl antibiotics A40926, de-acyl antibiotic A 40926P and antibiotic A 40926 amino glucronyl aglycon, and the use of these substances in the treatment of infectious diseases involving microorganisms susceptible to it.
摘要翻译： 本发明涉及脱酰基抗生素A40926，去酰基抗生素A40926P和抗生素A40926氨基葡糖苷酸苷的新抗生素物质，以及这些物质用于治疗涉及对其敏感的微生物的感染性疾病的用途。
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10.发明授权Antibiotic GE 2270 factors B.sub.1, B.sub.2, C.sub.1, C.sub.2, D.sub.1, D.sub.2, E and T 失效抗生素GE 2270因子B1，B2，C1，C2，D1，D2，E和T
公开(公告)号：US5747295A
公开(公告)日：1998-05-05
申请号：US460177
申请日：1995-06-02
IPC分类号： A61K31/44 , A61K38/00 , A61P3/00 , A61P31/00 , C07D513/22 , C07K5/078 , C12P17/18 , C12P21/04 , C12R1/01 , C12P1/00
CPC分类号： C07K5/06139 , A61K38/00
摘要： The present invention is directed to new antibiotic substances denominated antibiotic GE 2270 factors B.sub.1, B.sub.2, C.sub.1, C.sub.2, D.sub.1, D.sub.2, E and T, the addition salts thereof, the pharmaceutical compositions thereof and their use as medicaments, particularly in the treatment of infectious diseases involving microorganisms susceptible to them and their use as animal growth promoters.
摘要翻译： 本发明涉及新型抗生素物质GE 2270因子B1，B2，C1，C2，D1，D2，E和T，其加成盐，其药物组合物及其作为药物的用途，特别是用于治疗 涉及对它们敏感的微生物的感染性疾病及其作为动物生长促进剂的用途。
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