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公开(公告)号：US09668945B2
公开(公告)日：2017-06-06
申请号：US12162683
申请日：2007-02-09
摘要： The present invention relates to compositions and methods for mineralizing a dental surface or subsurface including providing a composition including stabilized ACP and a source of fluoride ions.
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公开(公告)号：US08871213B2
公开(公告)日：2014-10-28
申请号：US13060653
申请日：2009-08-28
IPC分类号： A61K38/00 , A61K39/00 , A61K39/38 , A61K39/02 , A61K39/385 , C07K14/195 , C07K16/12 , G01N33/569
CPC分类号： C07K14/195 , A61K39/0216 , A61K2039/505 , A61K2039/53 , A61K2039/55566 , C07K16/1203 , C07K16/1257 , C07K2317/34 , C07K2317/76 , C07K2319/00 , C12N9/14 , C12N9/52 , C12Y304/21 , C12Y304/21004 , C12Y306/05002 , G01N33/56955 , G01N2333/95
摘要： The invention relates to generation and use of cellular and humoral responses for the prevention and treatment of P. gingivalis related conditions and diseases.
摘要翻译： 本发明涉及细胞和体液应答的生成和使用，用于预防和治疗牙龈卟啉单胞菌相关病症和疾病。
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3.发明授权Antigenic complex for the diagnosis and treatment of Porphyromonas gingivalis infection 有权用于诊断和治疗牙龈卟啉单胞菌感染的抗原复合物公开(公告)号：US08765144B2
公开(公告)日：2014-07-01
申请号：US12944399
申请日：2010-11-11
IPC分类号： A61K39/02
CPC分类号： A61K39/0216 , A61K2039/505 , C07K14/195 , C07K16/1257
摘要： The present invention provides a purified multimeric complex from P. gingivalis. The complex comprises at least one domain from each of RgpA, Kgp and HagA, and has a molecular weight greater than about 300 kDa.
摘要翻译： 本发明提供了来自牙龈卟啉单胞菌的纯化多聚体复合物。 复合物包含来自RgpA，Kgp和HagA的至少一个结构域，并具有大于约300kDa的分子量。
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公开(公告)号：US20120283174A1
公开(公告)日：2012-11-08
申请号：US13509255
申请日：2010-11-11
CPC分类号： C07K14/4732 , A61K8/64 , A61K38/00 , A61Q11/00
摘要： The present invention relates to peptides and compositions that have antibiofilm properties. In particular, the peptides and compositions of the invention can be used for the treatment or prevention of various conditions including dental caries, gingivitis, periodontitis, oral mucositis, dry mouth and xerostomia.
摘要翻译： 本发明涉及具有抗菌膜性质的肽和组合物。 特别地，本发明的肽和组合物可用于治疗或预防各种病症，包括龋齿，牙龈炎，牙周炎，口腔粘膜炎，口干和口腔干燥症。
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公开(公告)号：US07419671B2
公开(公告)日：2008-09-02
申请号：US10174695
申请日：2002-06-18
IPC分类号： A61K39/02
CPC分类号： A61K8/64 , A61K39/00 , A61K2039/505 , A61K2800/86 , A61Q11/00 , C07K14/195 , C07K16/12 , C07K16/1257 , C07K2319/00
摘要： The present invention provides an antigenic composition, the composition comprising at least one recombinant protein. The recombinant protein comprises at least one epitope. The epitope is reactive with an antibody which is reactive with a polypeptide having the sequence set out in SEQ. ID. NO. 3 or SEQ. ID. NO. 5. The invention also provides methods and compositions for the production of the recombinant protein. Also provided are methods for the diagnosis, treatment and prevention of P. gingivalis infection.
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公开(公告)号：US08673363B2
公开(公告)日：2014-03-18
申请号：US11916831
申请日：2006-06-07
CPC分类号： A61K8/24 , A61K8/19 , A61K8/20 , A61K8/21 , A61K8/22 , A61K8/42 , A61K8/64 , A61K8/66 , A61K33/42 , A61K2800/70 , A61Q11/00
摘要： A method is provided for mineralizing a dental surface or subsurface including contacting the dental surface with a protein disrupting agent and stabilized amorphous calcium phosphate (ACP) or amorphous calcium fluoride phosphate (ACFP).
摘要翻译： 提供了一种使牙齿表面或地下矿化的方法，包括使牙齿表面与蛋白质破坏剂和稳定的无定形磷酸钙（ACP）或无定形磷酸氟化钙（ACFP）接触。
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7.发明申请PORPHYROMONAS GINGIVALIS POLYPEPTIDES USEFUL IN THE PREVENTION OF PERIODONTAL DISEASE 有权PORPHYROMONAS GINGIVALIS POLYPEPTIDES有用的预防周围疾病公开(公告)号：US20130236488A1
公开(公告)日：2013-09-12
申请号：US13547556
申请日：2012-07-12
IPC分类号： A61K39/02
CPC分类号： A61K39/0216 , A61K38/164 , A61K39/00 , C07K14/195 , G01N2333/195 , G01N2800/18
摘要： The invention is directed to vaccine compositions and methods based on P. gingivalis proteins identified to be regulated by haem availability that can be used in the prevention and treatment of periodontal disease. In particular, two specific internalin-like P. gingivalis proteins, namely PG0350 and PG1374 involved in the internalization of P. gingivalis by host cells, the hypothetical protein, PG1019 purported to be a cell surface lipoprotein and the alkyl hydroperoxide reductase protein, PG0618 have been identified as useful targets for the prevention and treatment of periodontal disease.
摘要翻译： 本发明涉及基于牙龈卟啉单胞菌蛋白的疫苗组合物和方法，该蛋白质被鉴定为可用于预防和治疗牙周病的血液可用性。 特别地，两种特异性内源蛋白样牙龈卟啉单胞菌蛋白，即PG0350和PG1374参与宿主细胞内分化牙龈卟啉单胞菌，假想蛋白质PG1019被认为是细胞表面脂蛋白和烷基过氧化氢还原酶蛋白质PG0618具有 被确定为预防和治疗牙周病的有用靶点。
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公开(公告)号：US20130129768A1
公开(公告)日：2013-05-23
申请号：US13580090
申请日：2011-02-25
CPC分类号： A61K39/0216 , A61K39/0208 , A61K45/06 , A61K2039/542
摘要： The invention relates to a method of reducing the incidence or severity of a disease or condition in a subject, said disease or condition being one associated with the presence of a microbial pathogen in an oral tissue of a subject, and including the use of a composition forming an anti-microbial and an immunogen against a microbial pathogen.
摘要翻译： 本发明涉及一种降低受试者的疾病或病症的发生率或严重程度的方法，所述疾病或病症是与受试者的口腔组织中存在微生物病原体有关的疾病或病症，并且包括使用组合物 形成针对微生物病原体的抗微生物剂和免疫原。
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公开(公告)号：US20100215593A1
公开(公告)日：2010-08-26
申请号：US11917395
申请日：2006-06-23
CPC分类号： A61K8/24 , A61K8/64 , A61K2800/52 , A61Q11/00
摘要： The present invention provides a phosphopeptide or phosphoprotein (PP) stabilised amorphous calcium phosphate or amorphous calcium fluoride phosphate complex having a calcium ion greater than about 30 moles of calcium per mole of PP
摘要翻译： 本发明提供磷酸肽或磷酸蛋白（PP）稳定化的无定形磷酸钙或无定形磷酸钙磷酸盐络合物，其钙离子大于约30摩尔钙/摩尔PP
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公开(公告)号：US20100209362A1
公开(公告)日：2010-08-19
申请号：US12668652
申请日：2008-07-11
CPC分类号： A61K31/4184 , A61K9/0056 , A61K9/0058 , A61K9/0063 , A61K31/155 , A61K31/381 , A61K31/427 , A61K31/505 , A61K31/506 , A61K2300/00
摘要： The invention provides a method of preventing, inhibiting or reducing a P. gingivalis biofilm in a subject comprising administering to the subject a pharmaceutical composition comprising an inhibiting agent of a polypeptide that reduces or inhibits biofilm formation and/or biofilm development. Also provided are compositions useful in the prevention, inhibition or treatment of periodontal disease or P. gingivalis infection.
摘要翻译： 本发明提供了预防，抑制或减少受试者牙龈卟啉单胞菌生物膜的方法，包括向受试者施用包含减少或抑制生物膜形成和/或生物膜发育的多肽抑制剂的药物组合物。 还提供了可用于预防，抑制或治疗牙周病或牙龈卟啉菌感染的组合物。
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