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1.发明授权Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation 有权用于椎间盘增大，恢复或替换的填充软化松质骨组织形式和植入方法公开(公告)号：US07959683B2
公开(公告)日：2011-06-14
申请号：US11878269
申请日：2007-07-23
IPC分类号： A61F2/28
CPC分类号： A61F2/442 , A61F2/28 , A61F2/441 , A61F2/4644 , A61F2002/30059 , A61F2002/3008 , A61F2002/30225 , A61F2002/30242 , A61F2002/30263 , A61F2002/30588 , A61F2002/30677 , A61F2002/444 , A61F2002/4495 , A61F2002/4649 , A61F2230/0069 , A61F2230/0071 , A61F2230/0084 , A61F2250/0098 , A61L27/3608 , A61L27/3654 , A61L27/3658 , A61L27/3683 , A61L27/56 , A61L2430/38
摘要： A composition for spinal disc repair comprising a plurality of uniformly shaped demineralized cancellous bone pieces ranging in size from about 2.0 mm to about 4.0 mm loaded into a porous mesh container with the cancellous bone pieces being treated so that they are not osteoinductive and are packed in the porous mesh container under compression forces.
摘要翻译： 一种用于脊椎椎间盘修复的组合物，其包含多个均匀形状的脱矿质松质骨片，其尺寸范围为约2.0mm至约4.0mm，装载到多孔网状容器中，其中松质骨片被处理，使得它们不是骨诱导性的并且被包装在 多孔网状容器受压力。
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2.发明申请Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation 有权用于椎间盘增大，恢复或替换的填充软化松质骨组织形式和植入方法公开(公告)号：US20080027546A1
公开(公告)日：2008-01-31
申请号：US11878269
申请日：2007-07-23
IPC分类号： A61F2/44
CPC分类号： A61F2/442 , A61F2/28 , A61F2/441 , A61F2/4644 , A61F2002/30059 , A61F2002/3008 , A61F2002/30225 , A61F2002/30242 , A61F2002/30263 , A61F2002/30588 , A61F2002/30677 , A61F2002/444 , A61F2002/4495 , A61F2002/4649 , A61F2230/0069 , A61F2230/0071 , A61F2230/0084 , A61F2250/0098 , A61L27/3608 , A61L27/3654 , A61L27/3658 , A61L27/3683 , A61L27/56 , A61L2430/38
摘要： A composition for spinal disc repair comprising a plurality of uniformly shaped demineralized cancellous bone pieces ranging in size from about 2.0 mm to about 4.0 mm loaded into a porous mesh container with the cancellous bone pieces being treated so that they are not osteoinductive and are packed in the porous mesh container under compression forces.
摘要翻译： 一种用于脊椎椎间盘修复的组合物，其包含多个均匀形状的脱矿质松质骨片，其尺寸范围为约2.0mm至约4.0mm，装载到多孔网状容器中，其中松质骨片被处理，使得它们不是骨诱导性的并且被包装在 多孔网状容器受压力。
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3.发明申请Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles 审中-公开松质骨构建体，软骨颗粒和松质骨构建体和软骨颗粒的组合公开(公告)号：US20090319045A1
公开(公告)日：2009-12-24
申请号：US12381072
申请日：2009-03-05
申请人： Katherine G. Truncale , Eric J. Semler , Arthur A. Gertzman , Moon Hae Sunwoo , William W. Tomford , Roman Shikhanovich , Alex B. Callahan , Judith I. Yannariello-Brown , Morris L. Jacobs , John C. Munson , Yen-Chen Huang
发明人： Katherine G. Truncale , Eric J. Semler , Arthur A. Gertzman , Moon Hae Sunwoo , William W. Tomford , Roman Shikhanovich , Alex B. Callahan , Judith I. Yannariello-Brown , Morris L. Jacobs , John C. Munson , Yen-Chen Huang
CPC分类号： A61F2/30756 , A61B17/00491 , A61F2/28 , A61F2/3094 , A61F2/3859 , A61F2/3872 , A61F2002/2817 , A61F2002/2839 , A61F2002/2842 , A61F2002/30057 , A61F2002/30059 , A61F2002/30062 , A61F2002/30224 , A61F2002/30225 , A61F2002/30227 , A61F2002/30233 , A61F2002/30235 , A61F2002/30327 , A61F2002/30331 , A61F2002/30354 , A61F2002/30387 , A61F2002/30448 , A61F2002/30459 , A61F2002/30461 , A61F2002/30492 , A61F2002/30604 , A61F2002/30759 , A61F2002/30762 , A61F2002/30764 , A61F2002/30772 , A61F2002/30785 , A61F2002/30789 , A61F2002/30795 , A61F2002/3085 , A61F2002/30932 , A61F2002/3096 , A61F2002/4635 , A61F2002/4646 , A61F2002/4649 , A61F2210/0004 , A61F2220/0025 , A61F2220/0033 , A61F2220/005 , A61F2220/0066 , A61F2220/0075 , A61F2230/0069 , A61F2250/0039 , A61F2310/00365 , A61L27/3608 , A61L27/3612 , A61L27/3654 , A61L27/48 , A61L27/54 , A61L2300/414 , A61L2300/43 , A61L2430/06 , C08L89/00
摘要： Constructs that are at least partially constructed of allograft cancellous bone are disclosed, along with cartilage particles that may be used with the constructs for repairing articular cartilage defects. A multi-piece construct includes a base member, a cap member and at least one pin that secures the cap member to the base member. The base member may be constructed of mineralized cancellous bone, and is used to replace the subchondral bone removed when a surgeon cuts a bore in the area of an adjacent cartilage defect. The base member includes a blind bore and first and second through-going transverse bores in opposite sides of a wall of the base member. The cap member includes an upper section that has a thickness that is similar to that of a patient's surrounding articular cartilage layer and a stem depending from the upper section that is dimensioned to be received in and by the blind bore of the base member. The stem includes a transverse through-going bore, which may be aligned with the transverse through-going bores of the base member to receive the pin therein when the construct has been assembled. The cap member is at least partially formed of demineralized allograft cancellous bone, into which a mixture containing lyophilized, freeze-milled allograft cartilage particles may be infused for the repair of articular cartilage defects. The cartilage particles have a size within a range of from about 10 microns to about 210 microns.
摘要翻译： 公开了至少部分由同种异体移植松质骨构成的构造物，以及可用于修复关节软骨缺损的构建体的软骨颗粒。 多件式构件包括底座构件，帽构件以及将盖构件固定到基座构件的至少一个销。 基部构件可以由矿化松质骨构成，并且当外科医生切割相邻软骨缺损区域中的孔时，用于替代被去除的软骨下骨。 基部构件包括盲孔以及在基部构件的壁的相对侧中的第一和第二穿过横向孔。 盖构件包括具有与患者周围的关节软骨层的厚度相似的厚度的上部部分和从上部部分延伸的杆部，该上部部分的尺寸设计成被接纳在基部构件的盲孔内和通过该盲孔。 所述杆包括横向通孔，所述横向通孔可以与所述基部构件的横向贯穿孔对齐，以在所述构造件已经组装时将其插入其中。 盖构件至少部分地由软化的同种异体移植松质骨形成，含有冻干的冷冻研磨的同种异体移植软骨颗粒的混合物可以被注入其中，用于修复关节软骨缺损。 软骨颗粒的尺寸在约10微米至约210微米的范围内。
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4.发明申请Cartilage particle tissue mixtures optionally combined with a cancellous construct 审中-公开软骨颗粒组织混合物任选地与松质骨构建体组合公开(公告)号：US20100274362A1
公开(公告)日：2010-10-28
申请号：US12657207
申请日：2010-01-14
申请人： Avner Yayon , Katherine G. Truncale , Hilla Barkay-Olami , Alex B. Callahan , Arthur A. Gertzman , Yen-Chen Huang , Morris L. Jacobs , John C. Munson , Eric J. Semler , Roman Shikhanovich , Baruch Stern , Moon Hae Sunwoo , William W. Tomford , Judith I. Yannariello-Brown
发明人： Avner Yayon , Katherine G. Truncale , Hilla Barkay-Olami , Alex B. Callahan , Arthur A. Gertzman , Yen-Chen Huang , Morris L. Jacobs , John C. Munson , Eric J. Semler , Roman Shikhanovich , Baruch Stern , Moon Hae Sunwoo , William W. Tomford , Judith I. Yannariello-Brown
CPC分类号： A61K9/19 , A61K35/32 , A61K38/1825 , A61L27/3612 , A61L27/3654 , A61L27/54 , A61L2300/414 , A61L2300/602
摘要： Mixtures, such as gels or pastes, comprising freeze-milled cartilage particles and exogenous growth factors are used for repairing chondral defects. Such mixtures may be applied to constructs comprising cancellous bone for implantation at the defect site. Suitable growth factors include variants of FGF-2, particularly variants that include a sole amino acid substitution for asparagine at amino acid 111 of the β8-β9 loop of the FGF-2 peptide. Such FGF-2 variants are released slowly and continuously at a constant rate from cartilage pastes. In other embodiments, the amino acid substituted for asparigine is glycine. Other variants that may be used include FGF-9 variants having truncated chains and a sole amino acid substitution in the β8-β9 loop of the FGF-9 peptide either for tryptophan at amino acid 144 or for asparagine at amino acid 143.
摘要翻译： 使用包含冷冻研磨的软骨颗粒和外源生长因子的混合物，例如凝胶或糊剂来修复软骨缺陷。 可以将这样的混合物施用于包含用于在缺损部位植入的松质骨的构建体。 合适的生长因子包括FGF-2的变体，特别是包括在FGF-2肽的8-＆amp; B9环的氨基酸111处的天冬酰胺的唯一氨基酸取代的变体。 这样的FGF-2变体以软骨糊剂的恒定速率缓慢且连续地释放。 在其它实施方案中，取代天冬酰胺的氨基酸是甘氨酸。 可以使用的其它变体包括FGF-9变体，其具有截短的链和唯一的氨基酸取代在FGF-9肽的8-＆Bgr9环中，对于在氨基酸144处的色氨酸或在氨基酸143处的天冬酰胺 。
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公开(公告)号：US20110004311A1
公开(公告)日：2011-01-06
申请号：US12814136
申请日：2010-06-11
IPC分类号： A61F2/44
CPC分类号： A61F2/442 , A61F2/28 , A61F2/3872 , A61F2002/2817 , A61F2002/30009 , A61F2002/30057 , A61F2002/30059 , A61F2002/30075 , A61F2002/30092 , A61F2002/30387 , A61F2002/30448 , A61F2002/30492 , A61F2002/30576 , A61F2002/30677 , A61F2002/4435 , A61F2002/4445 , A61F2210/0014 , A61F2210/0061 , A61F2220/0025 , A61F2220/005 , A61F2250/0028 , A61F2310/00359
摘要： Shaped constructs for repair of a defect in a body part or tissue of a subject are discussed herein. More specifically, implants suitable for delivery to a subject, such as a subject having a defect in a body part or body tissue, are discussed. Even more specifically, implants for intervertebral disc repair comprising corticocancellous bone, which can extend into the nucleus pulposus of an intervertebral disc and can be integrally attached to the annulus fibrosus of the disc to keep the implant in position, are described. Also, implants for meniscal repair comprising corticocancellous bone, which can extend from the outer edge of the meniscus to the inner region of the meniscus and can be integrally attached to the meniscal rim to keep the implant in position, are described. Implants for the repair of defects in bone, cartilage, and fibrocartilage are further described. Further described are methods for making such implants and for delivering the implants to a defect in a body part or body tissue of a subject.
摘要翻译： 本文讨论了用于修复受试者的身体部位或组织中的缺陷的形状构造。 更具体地，讨论了适合于递送到受试者的植入物，例如在身体部位或身体组织中具有缺陷的受试者。 甚至更具体地，描述了椎间盘修复的植入物，其包括可以延伸到椎间盘的髓核中并且可以一体地附接到椎间盘的纤维环以保持植入物就位的皮质静脉丛骨。 此外，描述了包括皮质根索骨的半月板修复植入物，其可以从弯月面的外边缘延伸到弯月面的内部区域并且可以整体地附接到半月板边缘以将植入物保持在适当位置。 进一步描述用于修复骨，软骨和纤维软骨缺损的植入物。 进一步描述了制造这种植入物并将植入物递送到受试者的身体部位或身体组织中的缺陷的方法。
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6.发明申请公开(公告)号：US20100015202A1
公开(公告)日：2010-01-21
申请号：US12508892
申请日：2009-07-24
申请人： Eric J. Semler , Roman Shikhanovich , Alex B. Callahan , Katherine Gomes Truncale , Judith I. Yannariello-Brown , Yen-Chen Huang
发明人： Eric J. Semler , Roman Shikhanovich , Alex B. Callahan , Katherine Gomes Truncale , Judith I. Yannariello-Brown , Yen-Chen Huang
CPC分类号： A61F2/28 , A61F2/30756 , A61F2/3859 , A61F2002/2817 , A61F2002/2839 , A61F2002/30057 , A61F2002/30059 , A61F2002/302 , A61F2002/30224 , A61F2002/30354 , A61F2002/30759 , A61F2002/30764 , A61F2002/30932 , A61F2220/0033 , A61F2230/0065 , A61F2230/0069 , A61K35/32 , A61K38/1825 , A61K38/1841 , A61K38/1875 , A61L27/3608 , A61L27/3654 , A61L27/446 , A61L27/48 , A61K2300/00
摘要： The invention is directed toward an osteochondral repair assembly comprising a shaped allograft construct comprising an unbalanced barbell-shaped cylindrical cancellous bone primary member formed with a mineralized cylindrical base section having a smaller diameter cylindrical stem leading to a second cylindrical section which is demineralized. A mineralized ring-shaped support member is forced over the compressed demineralized second demineralized the aperture of the ring-shaped member to fit around the stem with one ring surface being adjacent the bottom surface to the second cylindrical section and the opposite ring surface being adjacent the upper surface of the mineralized cylindrical base section.
摘要翻译： 本发明涉及一种软骨软骨修复组件，其包括成形的同种异体移植物构建体，其包括不平衡的杠铃形圆柱形松质骨主要构件，其形成有具有较小直径的圆柱形杆的矿化圆柱形基部，其通向软化的第二圆柱形部分。 矿化的环形支撑构件被迫超过压缩的软化的第二软化环形构件的孔以使其适配于杆的周围，一个环表面邻近底表面到第二圆柱形部分，并且相对的环表面邻近 矿化圆柱形基部的上表面。
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公开(公告)号：US07837740B2
公开(公告)日：2010-11-23
申请号：US11657042
申请日：2007-01-24
IPC分类号： A61F2/28
CPC分类号： A61F2/30756 , A61B17/00491 , A61F2/28 , A61F2/3859 , A61F2002/2817 , A61F2002/2839 , A61F2002/2842 , A61F2002/30057 , A61F2002/30059 , A61F2002/30225 , A61F2002/30227 , A61F2002/30233 , A61F2002/30235 , A61F2002/30327 , A61F2002/30354 , A61F2002/30448 , A61F2002/30459 , A61F2002/30461 , A61F2002/30492 , A61F2002/30604 , A61F2002/30759 , A61F2002/30762 , A61F2002/30764 , A61F2002/30772 , A61F2002/30785 , A61F2002/30789 , A61F2002/30795 , A61F2002/30932 , A61F2002/4635 , A61F2002/4646 , A61F2002/4649 , A61F2220/0025 , A61F2220/0033 , A61F2220/005 , A61F2220/0066 , A61F2220/0075 , A61F2230/0069 , A61F2250/0039 , A61F2310/00365 , A61L27/3608 , A61L27/3654 , A61L27/38 , A61L27/54 , A61L2300/414 , A61L2300/64 , A61L2430/06
摘要： The invention is directed toward a cartilage repair assembly comprising a shaped allograft two piece construct with a demineralized cancellous cap and a mineralized cylindrical base member defining a blind bore with a through going transverse bore intersecting the blind bore. The demineralized cancellous cap has a cylindrical top portion and a smaller diameter cylindrical stem extending away from the top portion which fits into the blind bore of the mineralized base member. The cap stem defines a transverse through going bore which is aligned with the through going bore of the base member to receive a cylindrical cortical pin holding the cap within the base member. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that the assembly engages the side wall of the drilled bore in an interference fit.
摘要翻译： 本发明涉及一种软骨修复组件，其包括具有软化松质骨的成形同种异体移植两片构件和定义具有与盲孔相交的穿过横向孔的盲孔的矿化圆柱形基底构件。 脱矿质松质骨盖具有圆柱形顶部和较小直径的圆柱形杆，其远离顶部部分延伸，该顶部配合到矿化基底的盲孔中。 盖杆限定横向通孔，其与基部构件的通孔对齐，以容纳将盖保持在基部构件内的圆柱形皮质销。 该成形结构的尺寸适于装配在软骨缺损区域中的钻孔中，使得组件以过盈配合接合钻孔的侧壁。
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公开(公告)号：US08906110B2
公开(公告)日：2014-12-09
申请号：US12881988
申请日：2010-09-14
CPC分类号： A61F2/30756 , A61B17/00491 , A61F2/28 , A61F2/3859 , A61F2002/2817 , A61F2002/2839 , A61F2002/2842 , A61F2002/30057 , A61F2002/30059 , A61F2002/30225 , A61F2002/30227 , A61F2002/30233 , A61F2002/30235 , A61F2002/30327 , A61F2002/30354 , A61F2002/30448 , A61F2002/30459 , A61F2002/30461 , A61F2002/30492 , A61F2002/30604 , A61F2002/30759 , A61F2002/30762 , A61F2002/30764 , A61F2002/30772 , A61F2002/30785 , A61F2002/30789 , A61F2002/30795 , A61F2002/30932 , A61F2002/4635 , A61F2002/4646 , A61F2002/4649 , A61F2220/0025 , A61F2220/0033 , A61F2220/005 , A61F2220/0066 , A61F2220/0075 , A61F2230/0069 , A61F2250/0039 , A61F2310/00365 , A61L27/3608 , A61L27/3654 , A61L27/38 , A61L27/54 , A61L2300/414 , A61L2300/64 , A61L2430/06
摘要： The invention is directed toward a cartilage repair assembly comprising a shaped allograft two piece construct with a demineralized cancellous cap and a mineralized cylindrical base member defining a blind bore with a through-going transverse bore intersecting the blind bore. The demineralized cancellous cap has a cylindrical top portion and a smaller diameter cylindrical stem extending away from the top portion which fits into the blind bore of the mineralized base member. The cap stem defines a transverse through-going bore which is aligned with the through-going bore of the base member to receive a cylindrical cortical pin holding the cap within the base member. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that the assembly engages the side wall of the drilled bore in an interference fit.
摘要翻译： 本发明涉及一种软骨修复组件，其包括具有软化松质骨的成形同种异体移植两片构件和定义具有与盲孔相交的贯穿横向孔的盲孔的矿化圆柱形基底构件。 脱矿质松质骨盖具有圆柱形顶部和较小直径的圆柱形杆，其远离顶部部分延伸，该顶部配合到矿化基底的盲孔中。 盖杆限定横向通孔，其与基部构件的通孔对准以接收将盖保持在基座构件内的圆柱形皮质销。 该成形结构的尺寸适于装配在软骨缺损区域中的钻孔中，使得组件以过盈配合接合钻孔的侧壁。
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9.发明授权公开(公告)号：US08435551B2
公开(公告)日：2013-05-07
申请号：US12508892
申请日：2009-07-24
申请人： Eric J. Semler , Roman Shikhanovich , Alex B. Callahan , Katherine Gomes Truncale , Judith I. Yannariello-Brown , Yen-Chen Huang
发明人： Eric J. Semler , Roman Shikhanovich , Alex B. Callahan , Katherine Gomes Truncale , Judith I. Yannariello-Brown , Yen-Chen Huang
IPC分类号： A61F2/28
CPC分类号： A61F2/28 , A61F2/30756 , A61F2/3859 , A61F2002/2817 , A61F2002/2839 , A61F2002/30057 , A61F2002/30059 , A61F2002/302 , A61F2002/30224 , A61F2002/30354 , A61F2002/30759 , A61F2002/30764 , A61F2002/30932 , A61F2220/0033 , A61F2230/0065 , A61F2230/0069 , A61K35/32 , A61K38/1825 , A61K38/1841 , A61K38/1875 , A61L27/3608 , A61L27/3654 , A61L27/446 , A61L27/48 , A61K2300/00
摘要： The invention is directed toward an osteochondral repair assembly comprising a shaped allograft construct comprising an unbalanced barbell-shaped cylindrical cancellous bone primary member formed with a mineralized cylindrical base section having a smaller diameter cylindrical stem leading to a second cylindrical section which is demineralized. A mineralized ring-shaped support member is forced over the compressed demineralized second demineralized the aperture of the ring-shaped member to fit around the stem with one ring surface being adjacent the bottom surface to the second cylindrical section and the opposite ring surface being adjacent the upper surface of the mineralized cylindrical base section.
摘要翻译： 本发明涉及一种软骨软骨修复组件，其包括成形的同种异体移植物构建体，其包括不平衡的杠铃形圆柱形松质骨主要构件，其形成有具有较小直径的圆柱形杆的矿化圆柱形基部，其通向软化的第二圆柱形部分。 矿化的环形支撑构件被迫超过压缩的软化的第二软化环形构件的孔以使其适配于杆的周围，一个环表面邻近底表面到第二圆柱形部分，并且相对的环表面邻近 矿化圆柱形基部的上表面。
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公开(公告)号：US20110224797A1
公开(公告)日：2011-09-15
申请号：US12881988
申请日：2010-09-14
IPC分类号： A61F2/30
CPC分类号： A61F2/30756 , A61B17/00491 , A61F2/28 , A61F2/3859 , A61F2002/2817 , A61F2002/2839 , A61F2002/2842 , A61F2002/30057 , A61F2002/30059 , A61F2002/30225 , A61F2002/30227 , A61F2002/30233 , A61F2002/30235 , A61F2002/30327 , A61F2002/30354 , A61F2002/30448 , A61F2002/30459 , A61F2002/30461 , A61F2002/30492 , A61F2002/30604 , A61F2002/30759 , A61F2002/30762 , A61F2002/30764 , A61F2002/30772 , A61F2002/30785 , A61F2002/30789 , A61F2002/30795 , A61F2002/30932 , A61F2002/4635 , A61F2002/4646 , A61F2002/4649 , A61F2220/0025 , A61F2220/0033 , A61F2220/005 , A61F2220/0066 , A61F2220/0075 , A61F2230/0069 , A61F2250/0039 , A61F2310/00365 , A61L27/3608 , A61L27/3654 , A61L27/38 , A61L27/54 , A61L2300/414 , A61L2300/64 , A61L2430/06
摘要： The invention is directed toward a cartilage repair assembly comprising a shaped allograft two piece construct with a demineralized cancellous cap and a mineralized cylindrical base member defining a blind bore with a through-going transverse bore intersecting the blind bore. The demineralized cancellous cap has a cylindrical top portion and a smaller diameter cylindrical stem extending away from the top portion which fits into the blind bore of the mineralized base member. The cap stem defines a transverse through-going bore which is aligned with the through-going bore of the base member to receive a cylindrical cortical pin holding the cap within the base member. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that the assembly engages the side wall of the drilled bore in an interference fit.
摘要翻译： 本发明涉及一种软骨修复组件，其包括具有软化松质骨的成形同种异体移植两片构件和定义具有与盲孔相交的贯穿横向孔的盲孔的矿化圆柱形基底构件。 脱矿质松质骨盖具有圆柱形顶部和较小直径的圆柱形杆，其远离顶部部分延伸，该顶部配合到矿化基底的盲孔中。 盖杆限定横向通孔，其与基部构件的通孔对准以接收将盖保持在基座构件内的圆柱形皮质销。 该成形结构的尺寸适于装配在软骨缺损区域中的钻孔中，使得组件以过盈配合接合钻孔的侧壁。
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