公开(公告)号：US20050038232A1

公开(公告)日：2005-02-17

申请号：US10686945

申请日：2003-10-16

申请人： Erik Karrer ,  Steven Bass ,  Robert Whalen ,  Phillip Patten

发明人： Erik Karrer ,  Steven Bass ,  Robert Whalen ,  Phillip Patten

IPC分类号： C07K16/00 ,  C07K16/12 ,  C12N1/21 ,  C12N15/13 ,  C12N15/49 ,  C07K16/46 ,  C07H21/04

CPC分类号： C07K16/1271 ,  C07K16/00 ,  C07K16/1275 ,  C07K2317/24

摘要： Methods for improving antibodies by a variety of DNA diversification and selection procedures are provided. Improvements include increases in affinity, alterations in specificity and effector function, as well as reduced antigenicity, e.g. humanization. Libraries of recombinant antibody sequences are provided, as are cells expressing members of such libraries. Novel phage display vectors are provided. Methods for the coevolution of an antibody and its cognate antigen are provided. Coevolution is used to evolve HIV envelope proteins with increased antigenicity and broadly neutralizing antibodies that interact therewith. Methods of improving antibodies for use in the detection of biological warfare agents are provided.

摘要翻译： 提供了通过多种DNA多样化和选择程序改进抗体的方法。 改善包括亲和力的增加，特异性和效应子功能的改变，以及降低的抗原性，例如。 人性化。 提供重组抗体序列的文库，以及表达这些文库成员的细胞。 提供了新的噬菌体展示载体。 提供了抗体及其同源抗原共转化方法。 共转化用于发展具有增加的抗原性的HIV包膜蛋白和与之相互作用的广泛中和抗体。 提供了改进用于检测生物战剂的抗体的方法。

公开(公告)号：US20080207459A1

公开(公告)日：2008-08-28

申请号：US12026412

申请日：2008-02-05

申请人： Erik Karrer ,  Steven H. Bass ,  Robert Whalen ,  Phillip A. Patten

发明人： Erik Karrer ,  Steven H. Bass ,  Robert Whalen ,  Phillip A. Patten

IPC分类号： C40B10/00 ,  C40B50/00 ,  C40B30/00 ,  C40B30/02 ,  C40B30/04 ,  C07K1/00 ,  C40B40/08 ,  C12N5/06 ,  C12N15/00

CPC分类号： C07K16/1271 ,  C07K16/00 ,  C07K16/1275 ,  C07K2317/24

摘要： Methods for improving antibodies by a variety of DNA diversification and selection procedures are provided. Improvements include increases in affinity, alterations in specificity and effector function, as well as reduced antigenicity, e.g. humanization. Libraries of recombinant antibody sequences are provided, as are cells expressing members of such libraries. Novel phage display vectors are provided. Methods for the coevolution of an antibody and its cognate antigen are provided. Coevolution is used to evolve HIV envelope proteins with increased antigenicity and broadly neutralizing antibodies that interact therewith. Methods of improving antibodies for use in the detection of biological warfare agents are provided.

摘要翻译： 提供了通过多种DNA多样化和选择程序改进抗体的方法。 改善包括亲和力的增加，特异性和效应子功能的改变，以及降低的抗原性，例如。 人性化。 提供重组抗体序列的文库，以及表达这些文库成员的细胞。 提供了新的噬菌体展示载体。 提供了抗体及其同源抗原共转化方法。 共转化用于发展具有增加的抗原性的HIV包膜蛋白和与之相互作用的广泛中和抗体。 提供了改进用于检测生物战剂的抗体的方法。

公开(公告)号：US08252727B2

公开(公告)日：2012-08-28

申请号：US12026412

申请日：2008-02-05

申请人： Erik Karrer ,  Steven H. Bass ,  Robert Whalen ,  Philip A. Patten

发明人： Erik Karrer ,  Steven H. Bass ,  Robert Whalen ,  Philip A. Patten

IPC分类号： C07K1/00 ,  C12N15/00 ,  C40B30/00 ,  C40B30/02 ,  C40B30/04 ,  C40B40/08 ,  C40B50/00

CPC分类号： C07K16/1271 ,  C07K16/00 ,  C07K16/1275 ,  C07K2317/24

摘要： Methods for improving antibodies by a variety of DNA diversification and selection procedures are provided. Improvements include increases in affinity, alterations in specificity and effector function, as well as reduced antigenicity, e.g. humanization. Libraries of recombinant antibody sequences are provided, as are cells expressing members of such libraries. Novel phage display vectors are provided. Methods for the coevolution of an antibody and its cognate antigen are provided. Coevolution is used to evolve HIV envelope proteins with increased antigenicity and broadly neutralizing antibodies that interact therewith. Methods of improving antibodies for use in the detection of biological warfare agents are provided.

摘要翻译： 提供了通过多种DNA多样化和选择程序改进抗体的方法。 改善包括亲和力的增加，特异性和效应子功能的改变，以及降低的抗原性，例如。 人性化。 提供重组抗体序列的文库，以及表达这些文库成员的细胞。 提供了新的噬菌体展示载体。 提供了抗体及其同源抗原共转化方法。 共转化用于发展具有增加的抗原性的HIV包膜蛋白和与之相互作用的广泛中和抗体。 提供了改进用于检测生物战剂的抗体的方法。

公开(公告)号：US20060045888A1

公开(公告)日：2006-03-02

申请号：US10980556

申请日：2004-11-03

申请人： Juha Punnonen ,  Steven Bass ,  Robert Whalen ,  Russell Howard ,  Willem Stemmer

发明人： Juha Punnonen ,  Steven Bass ,  Robert Whalen ,  Russell Howard ,  Willem Stemmer

IPC分类号： A61K39/295 ,  A61K39/116 ,  C07H21/04

CPC分类号： C40B40/02 ,  A61K39/00 ,  A61K39/0011 ,  A61K39/015 ,  A61K39/0225 ,  A61K39/0258 ,  A61K39/0291 ,  A61K39/085 ,  A61K39/105 ,  A61K39/107 ,  A61K39/12 ,  A61K39/35 ,  A61K2039/53 ,  A61K2039/70 ,  C07K14/005 ,  C07K14/24 ,  C07K2319/02 ,  C07K2319/40 ,  C07K2319/74 ,  C12N15/1027 ,  C12N15/1034 ,  C12N15/1037 ,  C12N15/62 ,  C12N2710/16634 ,  C12N2730/10134 ,  C12N2740/16134 ,  C12N2760/12134 ,  C12N2770/24134 ,  C12N2770/24234 ,  C12N2770/36134 ,  Y02A50/474

摘要： This invention is directed to antigen library immunization, which provides methods for obtaining antigens having improved properties for therapeutic and other uses. The methods are useful for obtaining improved antigens that can induce an immune response against pathogens, cancer, and other conditions, as well as antigens that are effective in modulating allergy, inflammatory and autoimmune diseases.

公开(公告)号：US3955933A

公开(公告)日：1976-05-11

申请号：US472577

申请日：1974-05-23

申请人： Oleg D. Sherby ,  Irvin C. Huseby ,  Robert Whalen ,  Steven L. Robinson

发明人： Oleg D. Sherby ,  Irvin C. Huseby ,  Robert Whalen ,  Steven L. Robinson

IPC分类号： B22F3/20 ,  C22C1/00 ,  C22C1/04 ,  C22C1/10 ,  C22C32/00 ,  B22F3/00 ,  B22F5/00 ,  C22C23/00

CPC分类号： C22C32/0073 ,  B22F3/20 ,  C22C1/00 ,  C22C1/0408 ,  C22C1/10

摘要： A magnesium-boron composite is made by mechanically mixing magnesium powders with boron powders. An alternative embodiment includes mixing a small amount of lithium powder with the magnesium boron composite to improve the ductility. The mixed powders are processed by cold pressing, hot pressing, sintering, extruding, rolling and re-extruding.

摘要翻译： 通过将镁粉与硼粉机械混合制成镁 - 硼复合材料。 一个替代实施例包括将少量的锂粉末与镁硼复合物混合以改善延展性。 混合粉末通过冷压，热压，烧结，挤出，轧制和再挤压加工。

公开(公告)号：US20070150709A1

公开(公告)日：2007-06-28

申请号：US11223733

申请日：2005-09-09

申请人： Janet Easton ,  Elke Nass ,  Kenneth Oakes ,  Andrew Piechowski ,  Martin Taubert ,  John Trotter ,  Ambrose Verdibello ,  Joachim Buttlar ,  Robert Whalen

发明人： Janet Easton ,  Elke Nass ,  Kenneth Oakes ,  Andrew Piechowski ,  Martin Taubert ,  John Trotter ,  Ambrose Verdibello ,  Joachim Buttlar ,  Robert Whalen

IPC分类号： G06F9/00 ,  G06F17/00

CPC分类号： G06F11/008 ,  G06F11/0715 ,  G06F11/0724 ,  G06F11/0766

摘要： Disclosed are a method and system of tracking real time use of I/O control blocks on a processing unit basis, in a multiprocessing system, such that in the case of a processing unit failure, a list accurately and concisely identifies the control blocks that need to be recovered. This eliminates the need to scan all the I/O control blocks, greatly reducing the overall system recovery time and minimizing impact to the rest of the running system. The preferred embodiment of the invention uses a task control block structure to record which I/O control blocks are in use by each Processing Unit. Also, the lock word structure defined in the I/O control blocks is provided with an index back into the task control block to facilitate managing the task control block entries.

摘要翻译： 公开了一种在多处理系统中基于处理单元跟踪I / O控制块的实时使用的方法和系统，使得在处理单元故障的情况下，列表精确和简洁地识别需要的控制块 要恢复 这样就不需要扫描所有的I / O控制块，大大降低了整个系统的恢复时间，并最大限度地减少了对其他运行系统的影响。 本发明的优选实施例使用任务控制块结构来记录每个处理单元使用哪个I / O控制块。 此外，在I / O控制块中定义的锁定字结构被提供回到任务控制块中的索引，以便于管理任务控制块条目。

公开(公告)号：US20050050451A1

公开(公告)日：2005-03-03

申请号：US10734358

申请日：2003-12-12

申请人： Mohsen Abdollahi ,  Kevin Giles ,  Charles Guffey ,  Jun Liu ,  Bernard Roche ,  Peter Sites ,  Robert Whalen

发明人： Mohsen Abdollahi ,  Kevin Giles ,  Charles Guffey ,  Jun Liu ,  Bernard Roche ,  Peter Sites ,  Robert Whalen

IPC分类号： G01N21/95 ,  G06F17/00

CPC分类号： G01N21/95

摘要： An apparatus in one example comprises a computer component that receives one or more images of one or more packaging materials from one or more imaging components. The computer component employs an analysis of the one or more images to make a determination of a package integrity of the one or more packaging materials.

摘要翻译： 一个示例中的装置包括从一个或多个成像部件接收一个或多个包装材料的一个或多个图像的计算机部件。 计算机组件采用对一个或多个图像的分析来确定一个或多个包装材料的包装完整性。

公开(公告)号：US4863607A

公开(公告)日：1989-09-05

申请号：US81933

申请日：1987-08-03

申请人： John E. Andrew ,  Howard R. Herrigel ,  George R. Jones ,  James C. Nowak ,  Mark K. Tose ,  Robert Whalen

发明人： John E. Andrew ,  Howard R. Herrigel ,  George R. Jones ,  James C. Nowak ,  Mark K. Tose ,  Robert Whalen

IPC分类号： B01D3/36 ,  B01D3/38 ,  B01D17/05 ,  C02F1/26

CPC分类号： B01D3/36 ,  B01D3/38

摘要： The present invention is a method for using water to remove amine from an oil-amine component. The oil-amine component is typically produced in prior art processes using an amine having an inverse critical solution temperature with water to break emulsions and sludges. The steps of the present invention include adding water to the oil-amine component in an amount sufficient to form a water-amine azeotrope with substantially all the amine in the oil-amine component followed by heating to remove the azeotrope. The method of the present invention may be used to remove amine from an oil-amine component even where the amine is present in an amount as low as 10% or less by weight.

公开(公告)号：US20070087374A1

公开(公告)日：2007-04-19

申请号：US11607038

申请日：2006-12-01

申请人： Juha Punnonen ,  Willem Stemmer ,  Robert Whalen ,  Russell Howard

发明人： Juha Punnonen ,  Willem Stemmer ,  Robert Whalen ,  Russell Howard

IPC分类号： C40B30/06 ,  C40B40/08

CPC分类号： C40B40/02 ,  A61K39/00 ,  A61K2039/53 ,  C07K14/005 ,  C07K14/24 ,  C07K2319/02 ,  C07K2319/40 ,  C07K2319/74 ,  C12N15/1027 ,  C12N15/1034 ,  C12N15/1037 ,  C12N15/1093 ,  C12N2730/10122 ,  C12N2740/16222

摘要： This invention provides methods for obtaining molecules that can modulate an immune response, and immunomodulatory molecules obtained using the methods. The molecules find use, for example, in the tailoring of an immune response induced by a genetic vaccine for a desired purpose.

公开(公告)号：US20050222069A1

公开(公告)日：2005-10-06

申请号：US10981535

申请日：2004-11-05

申请人： Juha Punnonen ,  Willem Stemmer ,  Robert Whalen ,  Russell Howard

发明人： Juha Punnonen ,  Willem Stemmer ,  Robert Whalen ,  Russell Howard

IPC分类号： A61K39/00 ,  C07K14/02 ,  C07K14/16 ,  C07K14/24 ,  C12N15/10 ,  C40B40/02 ,  A61K48/00 ,  C12Q1/68

CPC分类号： C40B40/02 ,  A61K39/00 ,  A61K2039/53 ,  C07K14/005 ,  C07K14/24 ,  C07K2319/02 ,  C07K2319/40 ,  C07K2319/74 ,  C12N15/1027 ,  C12N15/1034 ,  C12N15/1037 ,  C12N15/1093 ,  C12N2730/10122 ,  C12N2740/16222

摘要： This invention provides methods for obtaining molecules that can modulate an immune response, and immunomodulatory molecules obtained using the methods. The molecules find use, for example, in the tailoring of an immune response induced by a genetic vaccine for a desired purpose.