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公开(公告)号：US20130090326A1
公开(公告)日：2013-04-11
申请号：US13501834
申请日：2010-10-15
申请人： Erin M. Duffy , Ashoke Bhattacharjee , Hardwin O'Dowd , Marco DeVivo , Yanming Du , Sandra Sinishtaj , Yuanqing Tang , Brian T. Wimberly
发明人： Erin M. Duffy , Ashoke Bhattacharjee , Hardwin O'Dowd , Marco DeVivo , Yanming Du , Sandra Sinishtaj , Yuanqing Tang , Brian T. Wimberly
IPC分类号： C07D471/10 , C07D403/04 , C07D251/16 , C07D413/14 , C07D239/22 , C07D403/12
CPC分类号： C07D239/47 , A61K31/505 , A61K31/506 , A61L31/16 , A61L2300/404 , C07D239/10 , C07D239/22 , C07D239/36 , C07D251/16 , C07D251/42 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/10 , C07D487/04 , C07D491/048 , C07D519/00
摘要： The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and reducing the risk of microbial infections in humans and animals.
摘要翻译： 本发明一般涉及抗微生物化合物领域及其制备和使用方法。 这些化合物可用于治疗，预防和降低人类和动物中微生物感染的风险。
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公开(公告)号：US09216979B2
公开(公告)日：2015-12-22
申请号：US13501834
申请日：2010-10-15
申请人： Erin M. Duffy , Ashoke Bhattacharjee , Hardwin O'Dowd , Marco DeVivo , Yanming Du , Sandra Sinishtaj , Yuanqing Tang , Brian T. Wimberly
发明人： Erin M. Duffy , Ashoke Bhattacharjee , Hardwin O'Dowd , Marco DeVivo , Yanming Du , Sandra Sinishtaj , Yuanqing Tang , Brian T. Wimberly
IPC分类号： C07D239/36 , A61K31/505 , A61K31/506 , A61P31/04 , C07D471/10 , C07D487/04 , C07D491/048 , C07D519/00 , C07D239/22 , C07D251/16 , C07D403/04 , C07D403/12 , C07D413/14
CPC分类号： C07D239/47 , A61K31/505 , A61K31/506 , A61L31/16 , A61L2300/404 , C07D239/10 , C07D239/22 , C07D239/36 , C07D251/16 , C07D251/42 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/10 , C07D487/04 , C07D491/048 , C07D519/00
摘要： The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and reducing the risk of microbial infections in humans and animals.
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公开(公告)号：US08841263B2
公开(公告)日：2014-09-23
申请号：US13525900
申请日：2012-06-18
申请人： Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
发明人： Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
摘要： The present invention provides macrocyclic compounds useful as therapeutic agents of the formula: or a pharmaceutically acceptable salt, ester, N-oxide, or prodrug thereof, wherein T, R1, R2, R3, D, E, F, and G are as defined herein. More particularly, these compounds are useful as anti-infective, antiproliferative, anti-inflammatory and prokinetic agents.
摘要翻译： 本发明提供可用作下式的治疗剂的大环化合物：或其药学上可接受的盐，酯，N-氧化物或前药，其中T，R 1，R 2，R 3，D，E，F和G如上所定义 这里。 更具体地，这些化合物可用作抗感染，抗增殖，抗炎和促动力剂。
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公开(公告)号：US20120252747A1
公开(公告)日：2012-10-04
申请号：US13525900
申请日：2012-06-18
申请人： Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
发明人： Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
IPC分类号： A61K31/7056 , C07H17/08 , A61P1/14 , A61P31/00 , A61P29/00 , A61P35/00 , C07H17/00 , A61K31/706
摘要： The present invention provides macrocyclic compounds useful as therapeutic agents of the formula: or a pharmaceutically acceptable salt, ester, N-oxide, or prodrug thereof, wherein T, R1, R2, R3, D, E, F, and G are as defined herein. More particularly, these compounds are useful as anti-infective, antiproliferative, anti-inflammatory and prokinetic agents.
摘要翻译： 本发明提供可用作下式的治疗剂的大环化合物：或其药学上可接受的盐，酯，N-氧化物或前药，其中T，R 1，R 2，R 3，D，E，F和G如上所定义 这里。 更具体地，这些化合物可用作抗感染，抗增殖，抗炎和促动力剂。
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公开(公告)号：US08202843B2
公开(公告)日：2012-06-19
申请号：US10590782
申请日：2005-02-25
申请人： Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
发明人： Jay J. Farmer , Ashoke Bhattacharjee , Yi Chen , Joel A. Goldberg , Joseph A. Ippolito , Zoltan F. Kanyo , Rongliang Lou , Adegboyega K. Oyelere , Edward C. Sherer , Joyce A. Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
摘要： The present invention provides macrocyclic compounds useful as therapeutic agents of the formula: or a pharmaceutically acceptable salt, ester, N-oxide, or prodrug thereof, wherein T, R1, R2, R3, D, E, F, and G are as defined herein. More particularly, these compounds are useful as anti-infective, antiproliferative, anti-inflammatory and prokinetic agents.
摘要翻译： 本发明提供可用作下式的治疗剂的大环化合物：或其药学上可接受的盐，酯，N-氧化物或前药，其中T，R 1，R 2，R 3，D，E，F和G如上所定义 这里。 更具体地，这些化合物可用作抗感染，抗增殖，抗炎和促动力剂。
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公开(公告)号：US20080045585A1
公开(公告)日：2008-02-21
申请号：US10590782
申请日：2005-02-25
申请人： Jay Farmer , Ashoke Bhattacharjee , Yi Chen , Joel Goldberg , Joseph Ippolito , Zoltan Kanyo , Rongliang Lou , Adegboyega Oyelere , Edward Sherer , Joyce Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
发明人： Jay Farmer , Ashoke Bhattacharjee , Yi Chen , Joel Goldberg , Joseph Ippolito , Zoltan Kanyo , Rongliang Lou , Adegboyega Oyelere , Edward Sherer , Joyce Sutcliffe , Deping Wang , Yusheng Wu , Yanming Du
IPC分类号： A61K31/335 , A61P43/00 , C07D269/00
摘要： The present invention provides macrocyclic compounds useful as therapeutic agents. More particularly, these compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.
摘要翻译： 本发明提供可用作治疗剂的大环化合物。 更具体地，这些化合物可用作抗感染，抗增殖，抗炎和促动力剂。
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7.发明授权Hydroxylated sulfamides exhibiting neuroprotective action and their method of use 失效具有神经保护作用的羟基磺酰胺及其使用方法公开(公告)号：US08609849B1
公开(公告)日：2013-12-17
申请号：US13306103
申请日：2011-11-29
IPC分类号： C07D211/52 , C07C307/06 , A61K31/451 , A61K31/18
CPC分类号： C07C307/06 , C07D211/96 , C07D213/61 , C07D333/56
摘要： Pharmaceutical compositions of the invention include hydroxylated sulfamide derivatives having a disease-modifying action in the treatment of diseases associated with excitotoxicity and accompanying oxidative stress that include epilepsy, Alzheimer's disease, and any neurodegenerative disease involving glutamate toxicity.
摘要翻译： 本发明的药物组合物包括在治疗与兴奋性毒性相关的疾病和伴随的氧化应激（包括癫痫，阿尔茨海默病以及涉及谷氨酸毒性的任何神经变性疾病）中具有疾病改变作用的羟基化磺酰胺衍生物。
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8.发明申请NOVEL FLUORINATED SULFAMIDES EXHIBITING NEUROPROTECTIVE ACTION AND THEIR METHOD OF USE 审中-公开展示神经保护作用的新型氟化磺胺及其使用方法公开(公告)号：US20130253022A1
公开(公告)日：2013-09-26
申请号：US13990630
申请日：2011-11-18
IPC分类号： C07C307/06 , C07D261/20 , C07D333/58
CPC分类号： C07C307/06 , C07D261/20 , C07D263/56 , C07D333/58
摘要： Pharmaceutical compositions of the invention include fluorinated sulfamide derivatives having a disease-modifying action in the treatment of diseases associated with excitotoxicity and accompanying oxidative stress that include epilepsy, Alzheimer's disease, Parkinson's disease, Huntington's disease, heavy metal toxicity and any neurodegenerative disease involving glutamate toxicity.
摘要翻译： 本发明的药物组合物包括在治疗与兴奋性毒性相关的疾病和伴随的氧化应激中具有疾病改变作用的氟化磺酰胺衍生物，其包括癫痫，阿尔茨海默病，帕金森病，亨廷顿病，重金属毒性和任何涉及谷氨酸毒性的神经变性疾病 。
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9.发明申请NOVEL SULFAMIDES EXHIBITING NEUROPROTECTIVE ACTION AND METHODS FOR USE THEREOF 审中-公开展示神经保护作用的新型磺胺类及其使用方法公开(公告)号：US20120302546A1
公开(公告)日：2012-11-29
申请号：US13576556
申请日：2011-02-03
IPC分类号： C07C307/06 , A61P25/28 , A61K31/397 , C07D333/58 , A61K31/381 , C07D409/04 , A61K31/16 , A61P25/08
CPC分类号： C07C307/06 , C07D333/36 , C07D333/66 , C07D409/04
摘要： Pharmaceutical compositions of the invention include sulfamide derivatives having a disease-modifying action in the treatment of diseases associated with excitotoxicity and accompanying oxidative stress that include epilepsy, Alzheimer's disease, and any neurodegenerative disease involving glutamate toxicity.
摘要翻译： 本发明的药物组合物包括在治疗与兴奋性毒性相关的疾病和伴随的氧化应激（包括癫痫，阿尔茨海默氏病和涉及谷氨酸毒性的任何神经变性疾病）中具有疾病改变作用的磺酰胺衍生物。
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