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公开(公告)号：US20120202792A1
公开(公告)日：2012-08-09
申请号：US13501836
申请日：2010-10-15
申请人： Erin M. Duffy , Ashoke Bhattacharjee , Hardwin O'Dowd , Shili Chen , Marco DeVivo , Rongliang Lou , Brian T. Wimberly
发明人： Erin M. Duffy , Ashoke Bhattacharjee , Hardwin O'Dowd , Shili Chen , Marco DeVivo , Rongliang Lou , Brian T. Wimberly
IPC分类号： A61K31/5383 , A61P31/04 , C07D487/04 , A61K31/519 , C07D498/06 , A61K31/55
CPC分类号： C07D498/04 , A61L31/16 , C07D487/04 , C07D491/048 , C07D519/00
摘要： The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and/or reducing the risk of microbial infections in humans and animals.
摘要翻译： 本发明一般涉及抗微生物化合物领域及其制备和使用方法。 这些化合物可用于治疗，预防和/或降低人和动物中微生物感染的风险。
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公开(公告)号：US09023843B2
公开(公告)日：2015-05-05
申请号：US13501836
申请日：2010-10-15
申请人： Erin M. Duffy , Ashoke Bhattacharjee , Hardwin O'Dowd , Shili Chen , Marco DeVivo , Rongliang Lou , Brian T. Wimberly
发明人： Erin M. Duffy , Ashoke Bhattacharjee , Hardwin O'Dowd , Shili Chen , Marco DeVivo , Rongliang Lou , Brian T. Wimberly
IPC分类号： C07D487/04 , C07D491/048 , C07D519/00 , C07D498/04 , A61K31/5383 , A61K31/519
CPC分类号： C07D498/04 , A61L31/16 , C07D487/04 , C07D491/048 , C07D519/00
摘要： The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and/or reducing the risk of microbial infections in humans and animals.
摘要翻译： 本发明一般涉及抗微生物化合物领域及其制备和使用方法。 这些化合物可用于治疗，预防和/或降低人和动物中微生物感染的风险。
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公开(公告)号：US20130090326A1
公开(公告)日：2013-04-11
申请号：US13501834
申请日：2010-10-15
申请人： Erin M. Duffy , Ashoke Bhattacharjee , Hardwin O'Dowd , Marco DeVivo , Yanming Du , Sandra Sinishtaj , Yuanqing Tang , Brian T. Wimberly
发明人： Erin M. Duffy , Ashoke Bhattacharjee , Hardwin O'Dowd , Marco DeVivo , Yanming Du , Sandra Sinishtaj , Yuanqing Tang , Brian T. Wimberly
IPC分类号： C07D471/10 , C07D403/04 , C07D251/16 , C07D413/14 , C07D239/22 , C07D403/12
CPC分类号： C07D239/47 , A61K31/505 , A61K31/506 , A61L31/16 , A61L2300/404 , C07D239/10 , C07D239/22 , C07D239/36 , C07D251/16 , C07D251/42 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/10 , C07D487/04 , C07D491/048 , C07D519/00
摘要： The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and reducing the risk of microbial infections in humans and animals.
摘要翻译： 本发明一般涉及抗微生物化合物领域及其制备和使用方法。 这些化合物可用于治疗，预防和降低人类和动物中微生物感染的风险。
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公开(公告)号：US09216979B2
公开(公告)日：2015-12-22
申请号：US13501834
申请日：2010-10-15
申请人： Erin M. Duffy , Ashoke Bhattacharjee , Hardwin O'Dowd , Marco DeVivo , Yanming Du , Sandra Sinishtaj , Yuanqing Tang , Brian T. Wimberly
发明人： Erin M. Duffy , Ashoke Bhattacharjee , Hardwin O'Dowd , Marco DeVivo , Yanming Du , Sandra Sinishtaj , Yuanqing Tang , Brian T. Wimberly
IPC分类号： C07D239/36 , A61K31/505 , A61K31/506 , A61P31/04 , C07D471/10 , C07D487/04 , C07D491/048 , C07D519/00 , C07D239/22 , C07D251/16 , C07D403/04 , C07D403/12 , C07D413/14
CPC分类号： C07D239/47 , A61K31/505 , A61K31/506 , A61L31/16 , A61L2300/404 , C07D239/10 , C07D239/22 , C07D239/36 , C07D251/16 , C07D251/42 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/10 , C07D487/04 , C07D491/048 , C07D519/00
摘要： The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and reducing the risk of microbial infections in humans and animals.
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公开(公告)号：US09193731B2
公开(公告)日：2015-11-24
申请号：US13501825
申请日：2010-10-15
申请人： Erin M. Duffy , Ashoke Bhattacharjee , Hardwin O'Dowd , Marco DeVivo , Zoltan F. Kanyo , Jacek G. Martinow , Ik-Hyeon Paik , Matthew H. Scheideman , Sandra Sinishtaj , Brian T. Wimberly , Yusheng Wu
发明人： Erin M. Duffy , Ashoke Bhattacharjee , Hardwin O'Dowd , Marco DeVivo , Zoltan F. Kanyo , Jacek G. Martinow , Ik-Hyeon Paik , Matthew H. Scheideman , Sandra Sinishtaj , Brian T. Wimberly , Yusheng Wu
IPC分类号： C07D487/04 , A61P31/04 , C07D491/048 , C07D519/00
CPC分类号： C07D487/04 , A61F2/82 , A61F2250/0067 , C07D471/08 , C07D491/048 , C07D519/00
摘要： The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and reducing the risk of microbial infections in humans and animals.
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公开(公告)号：US20120220566A1
公开(公告)日：2012-08-30
申请号：US13501825
申请日：2010-10-15
申请人： Erin M. Duffy , Ashoke Bhattacharjee , Hardwin O'Dowd , Marco DeVivo , Zoltan F. Kanyo , Jacek G. Martinow , Ik-Hyeon Paik , Matthew H. Scheideman , Sandra Sinishtaj , Brian T. Wimberly , Yusheng Wu
发明人： Erin M. Duffy , Ashoke Bhattacharjee , Hardwin O'Dowd , Marco DeVivo , Zoltan F. Kanyo , Jacek G. Martinow , Ik-Hyeon Paik , Matthew H. Scheideman , Sandra Sinishtaj , Brian T. Wimberly , Yusheng Wu
IPC分类号： A61K31/551 , A61K31/522 , A61P31/04 , A61K31/541 , A61K31/496 , A61P31/00 , C07D487/04 , A61K31/5377
CPC分类号： C07D487/04 , A61F2/82 , A61F2250/0067 , C07D471/08 , C07D491/048 , C07D519/00
摘要： The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and reducing the risk of microbial infections in humans and animals.
摘要翻译： 本发明一般涉及抗微生物化合物领域及其制备和使用方法。 这些化合物可用于治疗，预防和降低人类和动物中微生物感染的风险。
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公开(公告)号：US08428884B1
公开(公告)日：2013-04-23
申请号：US12074200
申请日：2008-02-29
申请人： Brian T. Wimberly
发明人： Brian T. Wimberly
IPC分类号： G06F7/00
CPC分类号： G06F19/12 , G06F19/16 , G06F19/706
摘要： The invention provides a high resolution three-dimensional structure of a deacylated transfer RNA protein synthesis modulator in association with a large ribosomal subunit. The protein synthesis modulator binds at least a portion of the E-site of a large ribosomal subunit. The invention provides methods for designing and/or identifying analogs of candidate molecules, for example, analogs or derivatives of the protein synthesis modulator, that bind and/or modulate the protein biosynthetic activity of the ribosome.
摘要翻译： 本发明提供了与大核糖体亚基相关联的脱酰转移RNA蛋白合成调节剂的高分辨率三维结构。 蛋白质合成调节剂结合大核糖体亚基的E位点的至少一部分。 本发明提供了用于设计和/或鉴定候选分子的类似物的方法，例如蛋白质合成调节剂的类似物或衍生物，其结合和/或调节核糖体的蛋白质生物合成活性。
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公开(公告)号：US08374794B1
公开(公告)日：2013-02-12
申请号：US12072980
申请日：2008-02-29
申请人： Brian T. Wimberly
发明人： Brian T. Wimberly
IPC分类号： G06F7/00
CPC分类号： C12P21/02 , G06F19/12 , G06F19/16 , G06F19/706
摘要： The invention provides a high resolution three-dimensional structure of cycloheximide, either alone or in association with a large ribosomal subunit. The invention provides methods for designing and/or identifying cycloheximide analogs and derivatives that bind and/or modulate the protein biosynthetic activity of the ribosome.
摘要翻译： 本发明提供了单独或与大核糖体亚基相关联的放线菌酮的高分辨率三维结构。 本发明提供了设计和/或鉴定结合和/或调节核糖体的蛋白质生物合成活性的放线菌酮类似物和衍生物的方法。
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9.发明授权Screening methods using the crystal structure of ribosomal protein L11/GTPase activating region rRNA complex 失效筛选方法采用晶体结构的核糖体蛋白L11 / GTPase激活区域rRNA复合物公开(公告)号：US06845328B2
公开(公告)日：2005-01-18
申请号：US09998805
申请日：2001-11-01
IPC分类号： G01N33/50 , A61P31/04 , C07K14/47 , C12N9/22 , C12Q1/48 , C12Q1/66 , C12Q1/68 , G01N33/15 , G01N33/48 , G01N33/53 , G01N33/566 , G01N33/68 , G06F19/16 , G06F19/18 , G06F19/00
CPC分类号： C07K14/47 , C07K2299/00 , G01N33/6803 , G01N2500/04 , G01N2500/20 , G06F19/16 , G06F19/18
摘要： The present invention is broadly directed to methods of screening ribosomal protein L11/GTPase activating region (GAR) RNA-modulating compounds by using information from the high-resolution structure of the L11/GAR complex. The methods are useful in identifying compounds useful for anti-bacterial treatments.
摘要翻译： 本发明广泛地涉及通过使用来自L11 / GAR复合物的高分辨率结构的信息筛选核糖体蛋白L11 / GTPase活化区（GAR）RNA调节化合物的方法。 该方法可用于鉴定可用于抗细菌治疗的化合物。
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