-
公开(公告)号：US07419980B2
公开(公告)日：2008-09-02
申请号：US10963064
申请日：2004-10-12
申请人： Eugene John Trybulski , Paige Erin Mahaney , Lori Krim Gavrin , Joseph Peter Sabatucci , Gary Paul Stack
发明人： Eugene John Trybulski , Paige Erin Mahaney , Lori Krim Gavrin , Joseph Peter Sabatucci , Gary Paul Stack
IPC分类号： A61K31/497 , A61K31/4965 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00 , C07D241/04 , C07D295/00
CPC分类号： C07D295/092 , A61K31/496 , C07D207/14 , C07D207/22 , C07D209/14 , C07D211/48 , C07D211/56 , C07D211/58 , C07D213/38 , C07D215/12 , C07D307/34 , C07D307/52 , C07D307/81 , C07D309/10 , C07D317/58 , C07D333/28 , C07D333/58 , C07D409/06
摘要： The present invention is directed to fused-aryl and heteroaryl derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.
摘要翻译： 本发明涉及稠合芳基和杂芳基衍生物，含有这些衍生物的组合物及其用于预防和治疗由单胺再摄取改善的病症的方法，其中尤其包括血管舒缩症状（VMS），性功能障碍，胃肠道和 特别是选自重症抑郁障碍，血管舒缩症状，压力和急迫性尿失禁，纤维肌痛，疼痛，糖尿病性神经病变及其组合的那些病症，特别是选自下列的那些病症：泌尿生殖系统疾病，慢性疲劳综合征，纤维瘤病综合征，神经系统疾病及其组合 。
-
公开(公告)号：US07550456B2
公开(公告)日：2009-06-23
申请号：US12031187
申请日：2008-02-14
申请人： Eugene John Trybulski , Joseph Peter Sabatucci , An Thien Vu , Stephen Todd Cohn , Arthur Attilio Santilli , Lori Krim Gavrin , Fei Ye , Paige Erin Mahaney
发明人： Eugene John Trybulski , Joseph Peter Sabatucci , An Thien Vu , Stephen Todd Cohn , Arthur Attilio Santilli , Lori Krim Gavrin , Fei Ye , Paige Erin Mahaney
IPC分类号： A01N43/62 , C07D243/08
CPC分类号： C07D295/088 , C07D207/14 , C07D209/14 , C07D211/44 , C07D211/46 , C07D211/56 , C07D211/58 , C07D213/38 , C07D215/12 , C07D241/04 , C07D243/08 , C07D295/03 , C07D307/14 , C07D307/81 , C07D309/12 , C07D317/58 , C07D333/28 , C07D333/58
摘要： The present invention is directed to substituted aryl cycloalkanoyl derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromyalgia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.
摘要翻译： 本发明涉及取代的芳基环烷酰基衍生物，含有这些衍生物的组合物及其用于预防和治疗由单胺再摄取改善的病症的方法，所述方法尤其包括血管舒缩症状（VMS），性功能障碍，胃肠道和泌尿生殖系统疾病 特别是选自重度抑郁障碍，血管舒缩症状，压力和急迫性尿失禁，纤维肌痛，疼痛，糖尿病性神经病变及其组合的那些病症，慢性疲劳综合征，纤维肌痛综合征，神经系统疾病及其组合。
-
公开(公告)号：US07365076B2
公开(公告)日：2008-04-29
申请号：US10963111
申请日：2004-10-12
申请人： Eugene John Trybulski , Joseph Peter Sabatucci , An Thien Vu , Stephen Todd Cohn , Arthur Attilio Santilli , Lori Krim Gavrin , Fei Ye , Paige Erin Mahaney
发明人： Eugene John Trybulski , Joseph Peter Sabatucci , An Thien Vu , Stephen Todd Cohn , Arthur Attilio Santilli , Lori Krim Gavrin , Fei Ye , Paige Erin Mahaney
IPC分类号： A61K31/50 , A61K31/501 , C07D241/04 , C07D295/00
CPC分类号： C07D295/088 , C07D207/14 , C07D209/14 , C07D211/44 , C07D211/46 , C07D211/56 , C07D211/58 , C07D213/38 , C07D215/12 , C07D241/04 , C07D243/08 , C07D295/03 , C07D307/14 , C07D307/81 , C07D309/12 , C07D317/58 , C07D333/28 , C07D333/58
摘要： The present invention is directed to substituted aryl cycloalkanoyl derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.
摘要翻译： 本发明涉及取代的芳基环烷酰基衍生物，含有这些衍生物的组合物及其用于预防和治疗由单胺再摄取改善的病症的方法，所述方法尤其包括血管舒缩症状（VMS），性功能障碍，胃肠道和泌尿生殖系统疾病 特别是选自重度抑郁障碍，血管舒缩症状，压力和急迫性尿失禁，纤维肌痛，疼痛，糖尿病性神经病变及其组合的那些病症，慢性疲劳综合征，纤维瘤病综合征，神经系统疾病及其组合。
-
公开(公告)号：US20080153826A1
公开(公告)日：2008-06-26
申请号：US12031187
申请日：2008-02-14
申请人： Eugene John Trybulski , Joseph Peter Sabatucci , An Thien Vu , Stephen Todd Cohn , Arthur Attilio Santilli , Lori Krim Gavrin , Fei Ye , Paige Erin Mahaney
发明人： Eugene John Trybulski , Joseph Peter Sabatucci , An Thien Vu , Stephen Todd Cohn , Arthur Attilio Santilli , Lori Krim Gavrin , Fei Ye , Paige Erin Mahaney
IPC分类号： A61K31/5375 , C07D241/04 , C07D265/30 , A61P25/22 , A61P25/24 , A61P15/12 , A61K31/4965
CPC分类号： C07D295/088 , C07D207/14 , C07D209/14 , C07D211/44 , C07D211/46 , C07D211/56 , C07D211/58 , C07D213/38 , C07D215/12 , C07D241/04 , C07D243/08 , C07D295/03 , C07D307/14 , C07D307/81 , C07D309/12 , C07D317/58 , C07D333/28 , C07D333/58
摘要： The present invention is directed to substituted aryl cycloalkanoyl derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromyalgia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.
摘要翻译： 本发明涉及取代的芳基环烷酰基衍生物，含有这些衍生物的组合物及其用于预防和治疗由单胺再摄取改善的病症的方法，所述方法尤其包括血管舒缩症状（VMS），性功能障碍，胃肠道和泌尿生殖系统疾病 特别是选自重度抑郁障碍，血管舒缩症状，压力和急迫性尿失禁，纤维肌痛，疼痛，糖尿病性神经病变及其组合的那些病症，慢性疲劳综合征，纤维肌痛综合征，神经系统疾病及其组合。
-
公开(公告)号：US07491723B2
公开(公告)日：2009-02-17
申请号：US10962880
申请日：2004-10-12
申请人： Eugene John Trybulski , Paige Erin Mahaney , Lori Krim Gavrin , William Jay Moore , Joseph Peter Sabatucci
发明人： Eugene John Trybulski , Paige Erin Mahaney , Lori Krim Gavrin , William Jay Moore , Joseph Peter Sabatucci
IPC分类号： A61K31/497 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00 , C07D241/04 , C07D295/00
CPC分类号： C07D295/073 , C07D207/14 , C07D209/14 , C07D211/46 , C07D211/48 , C07D211/56 , C07D211/58 , C07D213/38 , C07D215/12 , C07D215/14 , C07D243/08 , C07D295/088 , C07D295/092 , C07D295/096 , C07D295/155 , C07D307/52 , C07D307/81 , C07D309/10 , C07D317/58 , C07D333/20 , C07D333/38 , C07D333/58 , C07D409/06 , C07D471/04
摘要： The present invention is directed to alkanoyl and cycloalkanoyl-amine derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.
摘要翻译： 本发明涉及烷酰基和环烷酰胺衍生物，含有这些衍生物的组合物及其用于预防和治疗由单胺再摄取改善的病症的方法，其中包括尤其是血管舒缩症状（VMS），性功能障碍，胃肠道和 特别是选自重症抑郁障碍，血管舒缩症状，压力和急迫性尿失禁，纤维肌痛，疼痛，糖尿病性神经病变及其组合的那些病症。 。
-
6.发明授权Secondary amino-and cycloamino-cycloalkanol derivatives and methods of their use 失效仲氨基和环氨基 - 环烷醇衍生物及其使用方法公开(公告)号：US07402698B2
公开(公告)日：2008-07-22
申请号：US10962899
申请日：2004-10-12
IPC分类号： C07C211/00 , A61K31/135
CPC分类号： C07C215/42 , C07C2601/04 , C07C2601/14 , C07D207/14 , C07D209/16 , C07D211/46 , C07D211/58 , C07D213/38 , C07D215/12 , C07D295/073 , C07D295/088 , C07D295/096 , C07D307/52 , C07D307/81 , C07D309/10 , C07D317/58 , C07D333/28 , C07D333/58 , C07D471/04
摘要： The present invention is directed to secondary amino- and cycloamino-cycloalkanol derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.
摘要翻译： 本发明涉及仲氨基和环氨基 - 环烷醇衍生物，含有这些衍生物的组合物及其用于预防和治疗由单胺再摄取改善的病症的方法，所述方法尤其包括血管舒缩症状（VMS），性功能障碍， 特别是选自重度抑郁障碍，血管舒缩症状，压力和急迫性尿失禁，纤维肌痛，疼痛，糖尿病性神经病变以及纤维肌痛症状 其组合。
-
公开(公告)号：US07531543B2
公开(公告)日：2009-05-12
申请号：US10963458
申请日：2004-10-12
IPC分类号： A61K31/4965 , C07D223/00 , C07D225/00 , C07D241/00 , C07D241/02 , C07D243/00 , C07D245/00
CPC分类号： C07D295/088
摘要： The present invention is directed to phenylpiperazine cycloalkanol derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.
摘要翻译： 本发明涉及苯基哌嗪环烷醇衍生物，含有这些衍生物的组合物及其用于预防和治疗由单胺再摄取改善的病症的方法，所述方法尤其包括血管舒缩症状（VMS），性功能障碍，胃肠道和泌尿生殖系统疾病， 特别是选自重度抑郁障碍，血管舒缩症状，压力和急迫性尿失禁，纤维肌痛，疼痛，糖尿病性神经病变及其组合的那些病症，慢性疲劳综合征，纤维肉瘤病综合征，神经系统疾病及其组合。
-
公开(公告)号：US20090093469A1
公开(公告)日：2009-04-09
申请号：US12335245
申请日：2008-12-15
申请人： Callain Younghee Kim , Paige Erin Mahaney , Eugene John Trybulski , Puwen Zhang , Eugene Anthony Terefenko , Casey Cameron McComas , Michael Anthony Marella , Richard Dale Coghlan , Gavin David Heffernan , Stephen Todd Cohn , An Thien Vu , Joseph Peter Sabatucci , Fei Ye
发明人： Callain Younghee Kim , Paige Erin Mahaney , Eugene John Trybulski , Puwen Zhang , Eugene Anthony Terefenko , Casey Cameron McComas , Michael Anthony Marella , Richard Dale Coghlan , Gavin David Heffernan , Stephen Todd Cohn , An Thien Vu , Joseph Peter Sabatucci , Fei Ye
IPC分类号： A61K31/5415 , C07D403/06 , A61K31/496 , C07D413/06 , A61K31/5377 , C07D209/04 , A61K31/404 , C07D401/06 , A61K31/4439 , A61K31/454 , C07D265/36 , A61K31/538 , C07D241/38 , A61K31/498 , C07D235/04 , A61K31/4184 , C07D471/04 , A61K31/437 , A61P29/00 , A61P25/00 , A61P25/24 , C07D409/06 , C07D209/96 , C07D279/16
CPC分类号： C07D209/08 , C07D209/30 , C07D209/42 , C07D235/06 , C07D241/42 , C07D265/36 , C07D471/04
摘要： The present invention is directed to phenylaminopropanol derivatives of formula I: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.
-
公开(公告)号：US20090099164A1
公开(公告)日：2009-04-16
申请号：US12335144
申请日：2008-12-15
申请人： Callain Younghee Kim , Paige Erin Mahaney , Eugene John Trybulski , Puwen Zhang , Eugene Anthony Terefenko , Casey Cameron McComas , Michael Anthony Marella , Richard Dale Coghlan , Gavin David Heffernan , Stephen Todd Cohn , An Thien Vu , Joseph Peter Sabatucci , Fei Ye
发明人： Callain Younghee Kim , Paige Erin Mahaney , Eugene John Trybulski , Puwen Zhang , Eugene Anthony Terefenko , Casey Cameron McComas , Michael Anthony Marella , Richard Dale Coghlan , Gavin David Heffernan , Stephen Todd Cohn , An Thien Vu , Joseph Peter Sabatucci , Fei Ye
IPC分类号： A61K31/538 , A61K31/496 , A61K31/5377 , A61K31/498 , A61K31/437 , A61P25/24 , A61P15/00 , A61P1/00 , A61P25/22 , A61P29/00 , A61K31/4184 , A61K31/404 , A61K31/4439
CPC分类号： C07D209/08 , C07D209/30 , C07D209/42 , C07D235/06 , C07D241/42 , C07D265/36 , C07D471/04
摘要： The present invention is directed to phenylaminopropanol derivatives of formula I: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.
摘要翻译： 本发明涉及式I的苯基氨基丙醇衍生物：或其药学上可接受的盐，含有这些衍生物的组合物及其用于预防和治疗由单胺再摄取改善的病症的方法，所述方法尤其包括血管舒缩症状（VMS） 特别是选自重度抑郁障碍，血管舒缩症状，压力和急迫性尿失禁，纤维肌痛，疼痛等的那些情况，特别是选自以下的那些病症：血管紧张素转换酶，抑制性功能障碍，性功能障碍，胃肠道和泌尿生殖系统疾病，慢性疲劳综合征，纤维瘤病综合征，神经系统疾病及其组合， 糖尿病性神经病变及其组合。
-
公开(公告)号：US07517899B2
公开(公告)日：2009-04-14
申请号：US11091885
申请日：2005-03-28
申请人： Callain Younghee Kim , Paige Erin Mahaney , Eugene John Trybulski , Puwen Zhang , Eugene Anthony Terefenko , Casey McComas , Michael Anthony Marella , Richard Dale Coghlan , Gavin David Heffernan , Stephen Todd Cohn , An Thien Vu , Joseph Peter Sabatucci , Fei Ye
发明人： Callain Younghee Kim , Paige Erin Mahaney , Eugene John Trybulski , Puwen Zhang , Eugene Anthony Terefenko , Casey McComas , Michael Anthony Marella , Richard Dale Coghlan , Gavin David Heffernan , Stephen Todd Cohn , An Thien Vu , Joseph Peter Sabatucci , Fei Ye
IPC分类号： A61K31/40 , A61K31/415 , C07D235/00 , C07D209/04
CPC分类号： C07D209/08 , C07D209/30 , C07D209/42 , C07D235/06 , C07D241/42 , C07D265/36 , C07D471/04
摘要： The present invention is directed to phenylaminopropanol derivatives of formula I: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.
摘要翻译： 本发明涉及式I的苯基氨基丙醇衍生物：或其药学上可接受的盐，含有这些衍生物的组合物及其用于预防和治疗由单胺再摄取改善的病症的方法，所述方法尤其包括血管舒缩症状（VMS） 特别是选自重度抑郁障碍，血管舒缩症状，压力和急迫性尿失禁，纤维肌痛，疼痛等的那些情况，特别是选自以下的那些病症：血管紧张素转换酶，抑制性功能障碍，性功能障碍，胃肠道和泌尿生殖系统疾病，慢性疲劳综合征，纤维瘤病综合征，神经系统疾病及其组合， 糖尿病性神经病变及其组合。
-
-
-
-
-
-
-
-
-
搜索结果
34 条记录 (耗时 0.048 秒)
