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    Intraocular, accommodating lens and methods of use
    3.
    发明授权
    Intraocular, accommodating lens and methods of use 有权
    眼内镜，适配镜片及使用方法

    公开(公告)号：US08715346B2

    公开(公告)日：2014-05-06

    申请号：US13858647

    申请日：2013-04-08

    申请人： Eugene de Juan, Jr. ,  Stephen Boyd ,  Hanson Gifford ,  Cary Reich

    发明人： Eugene de Juan, Jr. ,  Stephen Boyd ,  Hanson Gifford ,  Cary Reich

    IPC分类号： A61F2/16

    CPC分类号： A61F2/1694 ,  A61F2/1635 ,  A61F2/1648 ,  A61F2002/1682 ,  A61F2210/0019

    摘要： An intraocular lens is adapted for insertion into a capsular bag having a zonular contact region. The intraocular lens comprises a shape changing optical element and an accommodating element comprising at least one force transmitting element and a plurality of spaced apart contacting elements each adapted to contact a portion of the zonular contact region and transmit compressive displacement radially inward at an oblique angle to the optical element and configured to cooperate with at least one of the ciliary muscle of the mammalian eye, the zonules of the mammalian eye and the vitreous pressure in the eye to effect an accommodating shape and a disaccommodating shape change to the optical element.

    摘要翻译： 眼内透镜适于插入具有区域接触区域的囊袋中。 所述眼内透镜包括形状改变光学元件和容纳元件，所述容纳元件包括至少一个力传递元件和多个间隔开的接触元件，每个接触元件适于接触所述区域接触区域的一部分，并以 所述光学元件被配置为与哺乳动物眼睛的睫状肌，哺乳动物眼睛的小环和眼睛中的玻璃体压力中的至少一个配合，以实现对光学元件的适应形状和不适应的形状的变化。

    Method of correcting vision using corneal onlays
    7.
    发明授权
    Method of correcting vision using corneal onlays 有权
    使用角膜镶嵌矫正视力的方法

    公开(公告)号：US09125735B2

    公开(公告)日：2015-09-08

    申请号：US12897131

    申请日：2010-10-04

    申请人： Eugene de Juan, Jr. ,  Cary J. Reich ,  Stephen Boyd ,  David Sierra ,  Jose D. Alejandro

    发明人： Eugene de Juan, Jr. ,  Cary J. Reich ,  Stephen Boyd ,  David Sierra ,  Jose D. Alejandro

    IPC分类号： A61F2/14 ,  A61F9/00

    CPC分类号： A61F9/007 ,  A61F2/142 ,  A61F2/1451 ,  A61F2/1453 ,  A61F9/0017 ,  A61F2250/0019

    摘要： A corneal onlay is configured to adhere to the cornea so as to inhibit epithelial growth under the onlay. Structures can be provided on the onlay to adhere the onlay to the eye. At least one of an epithelial layer or the water inhibiting layer can be provided on or over the onlay, for example a natural epithelial layer or water inhibiting layer that inhibits, for example minimizes, water penetration into the onlay, so as to adhere the onlay to the eye with pumping of the endothelium. The water inhibiting layer may comprise a therapeutic covering positioned over the onlay to inhibit swelling of the cornea. The posterior surface of the onlay may be shaped so as to fit the anterior exposed surface of the cornea.

    摘要翻译： 角膜镶嵌被配置成粘附在角膜上，以便抑制覆盖物下的上皮生长。 可以在镶嵌上提供结构以将贴面粘附到眼睛上。 上皮层或水分抑制层中的至少一个可以设置在覆盖物上或上方，例如天然上皮层或水分抑制层，其抑制例如使水渗入到镶嵌物中的最小程度，以便粘附该覆盖层 通过泵送内皮到眼睛。 防水层可以包括定位在覆层上的治疗覆盖物，以抑制角膜的肿胀。 垫片的后表面可以被成形为适合角膜的前暴露表面。

    OCULAR INSERT APPARATUS AND METHODS
    9.
    发明申请
    OCULAR INSERT APPARATUS AND METHODS 有权
    OCULAR插入装置和方法

    公开(公告)号：US20130144128A1

    公开(公告)日：2013-06-06

    申请号：US13618052

    申请日：2012-09-14

    申请人： Eugene de Juan, Jr. ,  Yair Alster ,  Cary J. Reich ,  K. Angela MacFarlane ,  Janelle Chang ,  Stephen Boyd ,  David Sierra ,  Jose D. Alejandro ,  Douglas Sutton

    发明人： Eugene de Juan, Jr. ,  Yair Alster ,  Cary J. Reich ,  K. Angela MacFarlane ,  Janelle Chang ,  Stephen Boyd ,  David Sierra ,  Jose D. Alejandro ,  Douglas Sutton

    IPC分类号： A61B17/00

    CPC分类号： A61F9/0017 ,  A61B17/00234 ,  A61K9/0051 ,  A61K47/34 ,  A61L27/025 ,  A61L27/16

    摘要： A comfortable insert comprises a retention structure sized for placement under the eyelids and along at least a portion of conjunctival sac of the upper and lower lids of the eye. The retention structure resists deflection when placed in the conjunctival sac of the eye and to guide the insert along the sac when the eye moves. The retention structure can be configured in many ways to provide the resistance to deflection and may comprise a hoop strength so as to urge the retention structure outward and inhibit movement of the retention structure toward the cornea. The insert may move rotationally with deflection along the conjunctival sac, and may comprise a retention structure having a cross sectional dimension sized to fit within folds of the conjunctiva. The insert may comprise a release mechanism and therapeutic agent to release therapeutic amounts of the therapeutic agent for an extended time.

    摘要翻译： 舒适的插入物包括保持结构，其尺寸适于放置在眼睑下方并且沿着眼睛的上盖和下盖的结膜囊的至少一部分。 保留结构在放置在眼结膜囊中时抵抗偏转，并且当眼睛移动时沿着囊引导插入物。 保持结构可以以许多方式构造以提供对偏转的抵抗力，并且可以包括环箍强度，以便向外推动保持结构并阻止保持结构朝向角膜的移动。 插入件可以沿着结膜囊的偏转而旋转移动，并且可以包括保持结构，该保持结构具有尺寸适合于结膜折叠的横截面尺寸。 插入物可以包含释放机制和治疗剂以释放长期治疗剂的治疗剂量。

    Pre-filled package containing unit dose of medical gas and method of making the same
    10.
    发明授权
    Pre-filled package containing unit dose of medical gas and method of making the same 有权
    预装包装单位剂量的医用气体及其制造方法

    公开(公告)号：US06866142B2

    公开(公告)日：2005-03-15

    申请号：US10290093

    申请日：2002-11-07

    申请人： Andrew N. Lamborne ,  Eugene de Juan, Jr.

    发明人： Andrew N. Lamborne ,  Eugene de Juan, Jr.

    IPC分类号： A61M5/178 ,  A61J1/00 ,  A61J1/20 ,  A61M5/00 ,  A61M13/00 ,  A61M31/00 ,  B65D81/20

    CPC分类号： A61M5/002 ,  A61F9/0017 ,  A61J1/20 ,  A61J1/201 ,  A61J1/2082 ,  A61J1/2096 ,  A61M13/003 ,  A61M2209/06 ,  A61M2210/0612

    摘要： A unit dose, gas-filled syringe is provided which is filled with gas and packaged in a gas barrier material prior to use to increase shelf-life, that is, to minimize gas leakage and dilution of the contents of the syringe. The syringe is filled with a selected gas and sealed inside a container made from a high gas barrier material. The container is also filled with the selected gas. The container material is selected to have a gas transmission rate sufficient to prevent the selected gas from diffusing out of the container into the atmosphere. The volume of gas in the container is greater that atmospheric pressure to prevent atmospheric contaminants from entering the container and syringe.

    摘要翻译： 提供了单位剂量的充气注射器，其在使用之前填充有气体并封装在阻气材料中以增加保质期，即使气体泄漏和注射器内容物的稀释最小化。 注射器填充有选定的气体并密封在由高阻气材料制成的容器内。 容器还装有选定的气体。 容器材料被选择为具有足以防止选定气体从容器扩散进入大气中的气体透过率。 容器中的气体体积大于大气压，以防止大气污染物进入容器和注射器。