摘要:
Numerous embodiments of a system and method for treating cardiac tissue are described. In one embodiment, bone marrow cells are extracted from a patient. The cells are then processed to isolate mononuclear cells, which can then be delivered back near the cardiac tissue of the patient.
摘要:
Apparatus and method to perform therapeutic treatment and diagnosis of a patient's vasculature through the use of an intravascular device having an optical fiber disposed therein. In an embodiment of this invention, the apparatus includes a therapeutic guidewire and at least one optical fiber disposed through the therapeutic guidewire, the optical fiber capable of providing diagnostic information before, during, and after the therapeutic treatment. In an embodiment, diagnostic information includes vessel and blood characteristics such as hemodynamic characteristics, hematological parameters related to blood and blood components, and thermal parameters of the vasculature.
摘要:
A therapeutic intravascular device and method for performing thermal and laser Doppler velocimetry measurements. In one embodiment, the therapeutic intravascular device includes an elongated member having first and second optical fibers longitudinally disposed therethrough, the first optical fiber for performing a laser Doppler velocity measurement of a fluid within a body lumen, the second optical fiber for performing a temperature measurement within the body lumen.
摘要:
The present invention is directed to a gauging system and method for using the same for determining the size of a lesion within a patient's body prior to stenting the lesion. In one embodiment the gauging system includes a catheter having an elongated shaft with proximal and distal ends, and an outer sheath formed of a compliant material and disposed about at least a portion of the catheter elongated shaft and being slidable over the same. In another embodiment, the gauging system further includes a radially expandable member formed of the same or different compliant material mounted on a distal section of the shaft and has an interior chamber in fluid communication with an inflation lumen extending within at least a portion of a distal shaft section to a location spaced proximally from the shaft distal end.
摘要:
A balloon dilatation having a relatively stiff proximal catheter shaft which is formed at least in part of an engineering thermoplastic polymer material with a tensile strength of at least about 10,000 psi, an elongation of at least 50% and a tensile modulus of at least 300,000 psi. The polymer is preferably an aromatic polymer, and particularly polyetheretherketone.
摘要:
A guidewire with a sensor which can detect NO and/or superoxide levels is disclosed. This invention can be useful for in vivo analysis of vascular health.
摘要:
A method of treating vulnerable plaque comprising intentionally damaging or rupturing the vulnerable plaque using a wingless balloon which is inflated from a wingless unexpanded diameter to a limited expanded diameter. This process produces significant increase in ECM synthesis at the site of the damage or rupture. As a result, the method strengthens the vulnerable plaque while minimizing or avoiding damage to the surrounding wall of the body lumen or damaging a stable plaque mistakenly believed to be a vulnerable plaque. The method of the invention is particularly useful in treating a fibroatheroma type of vulnerable plaque. In one embodiment, the balloon is self-limiting such that it expands compliantly at initial inflation pressures, and above nominal pressure it expands noncompliantly. In an alternative embodiment, the balloon is inflated using a diameter-limiting device, such as a device which limits the inflation pressure or the volume of inflation fluid in the balloon.
摘要:
A method of treating vulnerable plaque comprising intentionally damaging or rupturing the vulnerable plaque using a wingless balloon which is inflated from a wingless unexpanded diameter to a limited expanded diameter. This process produces significant increase in ECM synthesis at the site of the damage or rupture. As a result, the method strengthens the vulnerable plaque while minimizing or avoiding damage to the surrounding wall of the body lumen or damaging a stable plaque mistakenly believed to be a vulnerable plaque. The method of the invention is particularly useful in treating a fibroatheroma type of vulnerable plaque. In one embodiment, the balloon is self-limiting such that it expands compliantly at initial inflation pressures, and above nominal pressure it expands noncompliantly. In an alternative embodiment, the balloon is inflated using a diameter-limiting device, such as a device which limits the inflation pressure or the volume of inflation fluid in the balloon.
摘要:
A composite tubular element for intravascular catheters, such as fixed-wire dilatation catheters and guiding and angiographic catheters, which is formed by braiding strands formed from an intimate mixture of polymeric matrix materials, such as fibers and powders, having a relatively low melting point and high strength reinforcing fibers having a relatively high melting point into a tubular element, heating the braided tubular element to melt the low melting point matrix materials and flow around the reinforcing fibers to form a matrix. A thermoplastic jacket or coating may then be extruded or otherwise applied to the exterior of the braided tubular element.
摘要:
In one embodiment, there is disclosed a device adapted to be used for percutaneous minimally invasive heart surgery including a catheter having a proximal end and a distal end adapted to be fed through a blood vessel, a pump associated with the distal end of the catheter, and a tool associated with the distal end of the catheter. The tool is adapted to be used for percutaneous minimally invasive heart surgery. Examples of the tools include a tool for excising natural tissue, a tool for excising a natural valve, and anthretomy device, a prosthetic valve delivery system, a balloon catheter, a knife, a stapler, and a screwdriver. The pump is used for maintaining blood flow around the site of the heart surgery while the surgery is taking place without the use of cardiopulmonary bypass.