Methods and compositions to treat myocardial conditions
    4.
    发明授权
    Methods and compositions to treat myocardial conditions 有权
    治疗心肌病症的方法和组合物

    公开(公告)号:US08821473B2

    公开(公告)日:2014-09-02

    申请号:US12632612

    申请日:2009-12-07

    摘要: Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.

    摘要翻译: 用于治疗心肌梗塞的方法,装置,试剂盒和组合物。 在一个实施例中,该方法包括防止脑室梗死区的重塑。 在其它实施方案中,该方法包括引入结构上增强剂。 在其它实施方案中,将药剂引入心室以增加心室的依从性。 在替代实施例中,预防重塑包括防止心室梗塞区变薄。 在另一个实施方案中,预防梗塞区的重塑和变薄包括胶原蛋白的交联和预防胶原蛋白滑脱。 在其它实施方案中,结构上增强剂可以伴随其它治疗剂。 这些药剂可以包括但不限于前成纤维细胞和血管生成剂。