公开(公告)号：US20240114801A1

公开(公告)日：2024-04-04

申请号：US18458127

申请日：2023-08-29

Applicant: FUJIFILM CORPORATION

Inventor： Seigo NAKAMURA ,  Hiroyuki KOBAYASHI ,  Shinya SUGIMOTO ,  Tsutomu SASAKI

IPC: H10N30/853 ,  H10N30/06 ,  H10N30/20 ,  H10N30/88

CPC classification number: H10N30/8554 ,  H10N30/06 ,  H10N30/2047 ,  H10N30/883

Abstract: A piezoelectric element includes a substrate; and a first electrode, a first piezoelectric film, a second electrode, a second piezoelectric film, and a third electrode which are provided on the substrate in this order, in which both the first piezoelectric film and the second piezoelectric film contain a perovskite-type oxide containing Pb at an A site and containing Zr, Ti, and M at a B site as a main component, an M composition ratio in the first piezoelectric film is different from an M composition ratio in the second piezoelectric film, and polarization-electric field hysteresis measured for the first piezoelectric film with the first electrode grounded and the second electrode as a drive electrode, and polarization-electric field hysteresis measured for the second piezoelectric film with the second electrode grounded and the third electrode as a drive electrode are shifted in the same electric field direction with respect to origins thereof.

公开(公告)号：US20180128844A1

公开(公告)日：2018-05-10

申请号：US15861753

申请日：2018-01-04

Applicant: FUJIFILM Corporation

Inventor： Tatsuya ISHIZAKA ,  Haruyasu NAKATSUGAWA ,  Susumu OSAWA ,  Shinya SUGIMOTO

IPC: G01N33/96 ,  G01N33/49

Abstract: An object of the present invention is to provide a blood analysis method in which a high level of repeatability and reproducibility is achieved with respect to measurement values in a blood sample, and a blood test kit which is used for the blood analysis method. According to the present invention, a blood analysis method including a step of diluting a collected blood sample with a diluent solution; a step of quantitatively determining sodium ions in the diluent solution of the blood sample by using a solution containing β-galactosidase and at least one substrate which is convertible by β-galactosidase so as to determine a dilution factor from a normal value of serum and blood plasm sodium ions which are homeostatically present in the blood and the quantitative value of sodium ions; and a step of analyzing a concentration of a target component to be measured in the blood sample from the determined dilution factor and a measurement value of a concentration of the target component to be measured in the blood sample, in which the diluent solution is a diluent solution which does not contain sodium ions, is provided.

公开(公告)号：US20240114797A1

公开(公告)日：2024-04-04

申请号：US18454073

申请日：2023-08-23

Applicant: FUJIFILM CORPORATION

Inventor： Hiroyuki KOBAYASHI ,  Seigo NAKAMURA ,  Shinya SUGIMOTO ,  Tsutomu SASAKI

IPC: H10N30/50 ,  H10N30/20 ,  H10N30/80 ,  H10N30/853

CPC classification number: H10N30/50 ,  H10N30/206 ,  H10N30/802 ,  H10N30/8554

Abstract: A piezoelectric element includes a substrate, a first electrode, a first piezoelectric film, a second electrode, a second piezoelectric film, and a third electrode, in which both the first piezoelectric film and the second piezoelectric film have spontaneous polarizations aligned in a film thickness direction and directions of the spontaneous polarizations are the same, and in a case where in a hysteresis curve of one piezoelectric film, a coercive voltage Vcf+, a coercive voltage Vcf−, |Vcf+−Vcf−|=ΔVcf, and the larger of an absolute value of Vcf+ and an absolute value of Vcf− is denoted by Vcf, and in a hysteresis curve of the other piezoelectric film, a coercive voltage Vcr+, a coercive voltage Vcr−, |Vcr+−Vcr−|=ΔVcr, and the larger of an absolute value of Vcr+ and an absolute value Vcr− is denoted by Vcr, ΔVcr

公开(公告)号：US20240114796A1

公开(公告)日：2024-04-04

申请号：US18454072

申请日：2023-08-23

Applicant: FUJIFILM CORPORATION

Inventor： Seigo NAKAMURA ,  Hiroyuki KOBAYASHI ,  Shinya SUGIMOTO ,  Tsutomu SASAKI

IPC: H10N30/50 ,  H10N30/20 ,  H10N30/80 ,  H10N30/853

CPC classification number: H10N30/50 ,  H10N30/206 ,  H10N30/802 ,  H10N30/8554

Abstract: A piezoelectric element includes a substrate; and a first electrode, a first piezoelectric film, a second electrode, a second piezoelectric film, and a third electrode which are provided on the substrate in this order, in which both the first piezoelectric film and the second piezoelectric film contain a perovskite-type oxide containing Pb Zr, Ti, and M, as a main component, Pb composition ratios in the perovskite-type oxides contained in the first piezoelectric film and the second piezoelectric film are different from each other, and polarization-electric field hysteresis measured for the first piezoelectric film with the first electrode grounded and the second electrode as a drive electrode, and polarization-electric field hysteresis measured for the second piezoelectric film with the second electrode grounded and the third electrode as a drive electrode are shifted in the same electric field direction with respect to origins thereof.

公开(公告)号：US20190313958A1

公开(公告)日：2019-10-17

申请号：US16454062

申请日：2019-06-27

Applicant: FUJIFILM Corporation

Inventor： Hikaru URANO ,  Shinya SUGIMOTO ,  Isao YONEKUBO

IPC: A61B5/15 ,  G01N1/10 ,  G01N1/38 ,  G01N33/49

Abstract: An object of the present invention is to provide a blood test kit and a blood analysis method, which are for performing quantitative analysis of components by precisely obtaining a dilution factor. According to the present invention, provided is a blood test kit for analyzing a concentration of a target component in a blood sample using a normal component which is homeostatically present in blood, the kit including a diluent solution for diluting the blood sample, a first storing instrument for storing the diluent solution, a separation instrument for separating and recovering blood plasma from the blood sample diluted with the diluent solution, a holding instrument for holding the separation instrument, a second storing instrument for storing the recovered blood plasma, and a sealing instrument for keeping the stored blood plasma within the second storing instrument, in which the separation instrument is composed of glass fiber coated with a resin.

公开(公告)号：US20190320961A1

公开(公告)日：2019-10-24

申请号：US16452555

申请日：2019-06-26

Applicant: FUJIFILM Corporation

Inventor： Hikaru URANO ,  Haruyasu NAKATSUGAWA ,  Shinya SUGIMOTO ,  Isao YONEKUBO

IPC: A61B5/15 ,  G01N33/96 ,  G01N1/38 ,  G01N33/49

Abstract: An object of the present invention is to provide a blood analysis method and a blood test kit, which are for performing quantitative analysis of components by precisely obtaining a dilution factor. According to the present invention, provided is a blood analysis method including: a step of diluting a collected blood sample with a diluent solution; a step of determining a dilution factor by using a normal value of a normal component which is homeostatically present in blood; and a step of analyzing a concentration of a target component in the blood sample, in which the blood analysis method uses a member selected from the group consisting of a first storing instrument for storing the diluent solution, a collection instrument for collecting the blood, a separation instrument for separating and recovering blood plasma from the blood sample diluted with the diluent solution, a holding instrument for holding the separation instrument, and a second storing instrument for storing the recovered blood plasma, and in which the dilution factor is corrected after calculating in advance an amount of the normal component derived from the diluent solution, and/or an amount of the normal component derived from at least one of the members which may be contained in the diluent solution.

公开(公告)号：US20190316175A1

公开(公告)日：2019-10-17

申请号：US16452553

申请日：2019-06-26

Applicant: FUJIFILM Corporation

Inventor： Hikaru URANO ,  Haruyasu NAKATSUGAWA ,  Tatsuya ISHIZAKA ,  Shinya SUGIMOTO ,  Isao YONEKUBO

IPC: C12Q1/52 ,  B01L3/00 ,  G01N1/38 ,  G01N33/49

Abstract: An object of the present invention is to provide a blood analysis method and a blood test kit, which are for performing quantitative analysis of components by precisely obtaining a dilution factor. According to the present invention, provided is a blood analysis method including a step of diluting a collected blood sample with a diluent solution; a step of determining a dilution factor by using a normal value of a normal component which is homeostatically present in blood; and a step of analyzing a concentration of a target component in the blood sample, in which the blood analysis method uses a member selected from the group consisting of a first storing instrument for storing a diluent solution, a separation instrument for separating and recovering blood plasma from the blood sample diluted with the diluent solution, a holding instrument for holding the separation instrument, a second storing instrument for storing the recovered blood plasma, and a sealing instrument for keeping the stored blood plasma within the second storing instrument, in which the diluent solution defines an amount of the normal component which is derived from the diluent solution and/or the members and may be contained in the diluent solution, and in which a volume of the blood sample is 50 μL or less, and a dilution factor of a blood plasma component in the blood sample is 14 times or more.

公开(公告)号：US20180143116A1

公开(公告)日：2018-05-24

申请号：US15861238

申请日：2018-01-03

Applicant: FUJIFILM Corporation

Inventor： Hikaru URANO ,  Tatsuya ISHIZAKA ,  Haruyasu NAKATSUGAWA ,  Susumu OSAWA ,  Shinya SUGIMOTO

IPC: G01N1/38 ,  G01N1/10 ,  G01N33/96 ,  B01L3/00 ,  G01N33/49

CPC classification number: G01N1/38 ,  A61B5/150022 ,  A61B5/150343 ,  A61B5/150351 ,  A61B5/150755 ,  B01L3/502 ,  B01L2300/0838 ,  B01L2300/12 ,  B01L2300/161 ,  B01L2400/0406 ,  G01N1/10 ,  G01N33/48 ,  G01N33/491 ,  G01N33/96

Abstract: An object is to provide a blood test kit and a blood analysis method capable of performing a blood test with a small amount of blood at high accuracy by visualizing a volume of blood collection and keeping the volume constant. Provided is a blood test kit for analyzing a concentration of a target component in a blood sample using a normal component homeostatically present in blood, the kit including: a blood collection instrument for collecting the blood sample; a diluent solution for diluting the collected blood sample; and a storing instrument for storing the diluted blood sample, in which the blood collection instrument is a capillary.

公开(公告)号：US20180128806A1

公开(公告)日：2018-05-10

申请号：US15861353

申请日：2018-01-03

Applicant: FUJIFILM Corporation

Inventor： Seiji YAMASHITA ,  Haruyasu NAKATSUGAWA ,  Susumu OSAWA ,  Shinya SUGIMOTO

IPC: G01N33/487 ,  G01N33/49 ,  G01N33/66 ,  G01N33/96

CPC classification number: G01N33/4875 ,  A61B5/150022 ,  A61B5/150206 ,  A61B5/150343 ,  A61B5/150351 ,  A61B5/150755 ,  G01N1/00 ,  G01N1/10 ,  G01N1/28 ,  G01N1/38 ,  G01N33/48 ,  G01N33/49 ,  G01N33/491 ,  G01N33/66 ,  G01N33/96

Abstract: An object of the present invention is to provide a blood test kit of which a component in a small volume of blood can be mailed in a safe state by controlling the influence of the outside temperature during the mailing, and a highly accurate blood analysis method in which coefficient of variation of a measurement value is reduced. According to the present invention, a blood test kit including a diluent solution for diluting a blood sample; a separating means for recovering blood plasma components from the diluted blood sample; a container for storing the blood plasma components recovered from the diluted blood sample; and a cold insulation means for cold-insulating the container, is provided.

公开(公告)号：US20240114793A1

公开(公告)日：2024-04-04

申请号：US18458124

申请日：2023-08-29

Applicant: FUJIFILM CORPORATION

Inventor： Hiroyuki KOBAYASHI ,  Seigo NAKAMURA ,  Shinya SUGIMOTO ,  Tsutomu SASAKI

IPC: H10N30/03 ,  H10N30/00 ,  H10N30/05 ,  H10N30/87

CPC classification number: H10N30/03 ,  H10N30/05 ,  H10N30/1071 ,  H10N30/87

Abstract: A piezoelectric element includes a substrate; and a first electrode, a first piezoelectric film, a second electrode, a second piezoelectric film, and a third electrode which are provided on the substrate in this order, in which both the first piezoelectric film and the second piezoelectric film contain PZT having a metal element M doped thereto, as a main component, one piezoelectric film of the first piezoelectric film and the second piezoelectric film has a spontaneous polarization aligned in a film thickness direction, and in a case where in a hysteresis curve showing polarization-voltage characteristics of the one piezoelectric film, a coercive voltage Vcf+ on a positive side and a coercive voltage Vcf− on a negative side, and in polarization-voltage characteristics of the other piezoelectric film, a coercive voltage Vcr+ on a positive side and a coercive voltage Vcr− on a negative sid, |Vcr++Vcr−|