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    Isolation, Characterization and Propagation of Germline Stem Cells
    1.
    发明申请
    Isolation, Characterization and Propagation of Germline Stem Cells 审中-公开
    种系干细胞的分离，表征和繁殖

    公开(公告)号：US20100285577A1

    公开(公告)日：2010-11-11

    申请号：US12672466

    申请日：2008-08-07

    申请人： Fariborz Izadyar ,  Jason Pachiarotti ,  Chad Maki ,  Thomas V. Ramos

    发明人： Fariborz Izadyar ,  Jason Pachiarotti ,  Chad Maki ,  Thomas V. Ramos

    IPC分类号： C12N5/07 ,  C12N5/074

    CPC分类号： C12N5/0611 ,  C12N5/0609 ,  C12N2501/13 ,  C12N2502/13

    摘要： Methods are provided for the isolation, characterization and propogation of germline cells stem cells from fetal and adult mammals. Additionally, isolated populations of germline cells having different phenotypes are disclosed wherein the subpopulations are capable of forming long-term cultures of multipotent or pluripotent cells or are capable of differentiating into mature germline cells and repopulating a sterile reproductive organ. The multipotent or pluripotent germline cells are also suitable for differentiation into tissue-specific somatic cells for therapeutic purposes.

    摘要翻译： 提供了用于从胎儿和成年哺乳动物分离，表征和传播种系细胞干细胞的方法。 此外，公开了具有不同表型的分离的种系细胞，其中亚群能够形成多能或多能细胞的长期培养物，或能够分化成成熟种系细胞并重新填充无菌生殖器官。 多潜能或多能种系细胞也适用于分化为组织特异性体细胞用于治疗目的。

    Laser treated platelet product
    3.
    发明授权
    Laser treated platelet product 有权

    公开(公告)号：US11965179B1

    公开(公告)日：2024-04-23

    申请号：US17353388

    申请日：2021-06-21

    申请人： Fariborz Izadyar

    发明人： Fariborz Izadyar

    IPC分类号： C12N5/078 ,  A61K9/00 ,  A61K35/19 ,  C12N11/04 ,  C12N13/00

    CPC分类号： C12N5/0644 ,  A61K9/0019 ,  A61K9/0095 ,  A61K35/19 ,  C12N11/04 ,  C12N13/00 ,  C12N2509/00 ,  C12N2529/00

    摘要： A method of creating a pooled platelet lysate product may include obtaining whole blood from a source; separating platelets from the whole blood using a pressurized rotating microfluidic filtration system; creating platelet rich plasma (PRP) by concentrating the platelets in plasma and removing red blood cells and white blood cells using centrifugation; centrifuging the PRP, removing the plasma, and re-suspending the PRP in the lactated ringers solution (LRS) to create concentrated PRP (C-PRP); laser activating the C-PRP to create an activated C-PRP product; freezing and thawing the activated C-PRP product at least 3 times, wherein vortexing and sonication are performed after each thaw; and reconstituting the activated C-PRP in a saline to create a platelet lysate product with a known potency.