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公开(公告)号：US09657267B2
公开(公告)日：2017-05-23
申请号：US12940894
申请日：2010-11-05
CPC分类号： C12N5/0609 , C12N5/061 , C12N2500/25 , C12N2500/30 , C12N2500/84 , C12N2500/90 , C12N2501/06 , C12N2501/10 , C12N2501/11 , C12N2501/119 , C12N2501/125 , C12N2501/13 , C12N2501/15 , C12N2501/235 , C12N2501/31 , C12N2501/385 , C12N2501/998 , C12N2509/00 , C12N2533/54 , C12N2533/90
摘要： Methods are provided for the ex host maturation of immature germline cells into haploid gametes for restoration of fertility in patients in need thereof.
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公开(公告)号：US20120009156A1
公开(公告)日：2012-01-12
申请号：US12940888
申请日：2010-11-05
申请人： Fariborz Izadyar , Joel Marh , Chad maki , Jason Pacchaiarotti , Thomas Ramos , Kyle Howerton , Jadelind Wong , Marnie Olmstead , Johnny Yung-Chiong Chow , Constance Yuen
发明人： Fariborz Izadyar , Joel Marh , Chad maki , Jason Pacchaiarotti , Thomas Ramos , Kyle Howerton , Jadelind Wong , Marnie Olmstead , Johnny Yung-Chiong Chow , Constance Yuen
CPC分类号： C12N5/0609 , C12N5/061 , C12N2500/25 , C12N2500/30 , C12N2500/84 , C12N2500/90 , C12N2501/06 , C12N2501/10 , C12N2501/11 , C12N2501/119 , C12N2501/125 , C12N2501/13 , C12N2501/15 , C12N2501/235 , C12N2501/31 , C12N2501/385 , C12N2501/998 , C12N2509/00 , C12N2533/54 , C12N2533/90
摘要： Methods and systems are provided for the isolation, characterization, cryopreservation and banking of human germline stem cells and gonadal tissue. Also disclosed are methods for the transplanting of the cryopreserved cells to repopulate a sterile reproductive organ.
摘要翻译： 提供了方法和系统用于人类种系干细胞和性腺组织的分离，表征，低温保存和储存。 还公开了用于移植冷冻保存细胞以重新填充无菌生殖器官的方法。
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公开(公告)号：US11965179B1
公开(公告)日：2024-04-23
申请号：US17353388
申请日：2021-06-21
申请人： Fariborz Izadyar
发明人： Fariborz Izadyar
CPC分类号： C12N5/0644 , A61K9/0019 , A61K9/0095 , A61K35/19 , C12N11/04 , C12N13/00 , C12N2509/00 , C12N2529/00
摘要： A method of creating a pooled platelet lysate product may include obtaining whole blood from a source; separating platelets from the whole blood using a pressurized rotating microfluidic filtration system; creating platelet rich plasma (PRP) by concentrating the platelets in plasma and removing red blood cells and white blood cells using centrifugation; centrifuging the PRP, removing the plasma, and re-suspending the PRP in the lactated ringers solution (LRS) to create concentrated PRP (C-PRP); laser activating the C-PRP to create an activated C-PRP product; freezing and thawing the activated C-PRP product at least 3 times, wherein vortexing and sonication are performed after each thaw; and reconstituting the activated C-PRP in a saline to create a platelet lysate product with a known potency.
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公开(公告)号：US20100285577A1
公开(公告)日：2010-11-11
申请号：US12672466
申请日：2008-08-07
CPC分类号： C12N5/0611 , C12N5/0609 , C12N2501/13 , C12N2502/13
摘要： Methods are provided for the isolation, characterization and propogation of germline cells stem cells from fetal and adult mammals. Additionally, isolated populations of germline cells having different phenotypes are disclosed wherein the subpopulations are capable of forming long-term cultures of multipotent or pluripotent cells or are capable of differentiating into mature germline cells and repopulating a sterile reproductive organ. The multipotent or pluripotent germline cells are also suitable for differentiation into tissue-specific somatic cells for therapeutic purposes.
摘要翻译： 提供了用于从胎儿和成年哺乳动物分离，表征和传播种系细胞干细胞的方法。 此外，公开了具有不同表型的分离的种系细胞，其中亚群能够形成多能或多能细胞的长期培养物，或能够分化成成熟种系细胞并重新填充无菌生殖器官。 多潜能或多能种系细胞也适用于分化为组织特异性体细胞用于治疗目的。
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