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公开(公告)号：US20100021892A1
公开(公告)日：2010-01-28
申请号：US12320170
申请日：2009-01-21
申请人： Fernand Labrie , Mohamed El-Alfy , Van Luu-The , Ezequiel L. Calvo , Jerome Aubert , Isabelle Carlavan , Sophie Deret , Johannes Voegel
发明人： Fernand Labrie , Mohamed El-Alfy , Van Luu-The , Ezequiel L. Calvo , Jerome Aubert , Isabelle Carlavan , Sophie Deret , Johannes Voegel
CPC分类号： G01N33/5008 , G01N2333/902 , G01N2500/00 , G01N2800/20
摘要： An in vitro method for screening candidate compounds for the preventive or curative treatment of acne, includes the determination of the capacity of a compound to modulate the expression or the activity of sterol-C4-methyl oxidase (SC4MOL), and the use of modulators of the expression or activity of this enzyme for the treatment of acne or skin disorders associated with a hyperseborrhea; methods for the in vitro diagnosis or prognosis of these pathologies are also described.
摘要翻译： 用于筛选候选化合物以预防或治疗痤疮的体外方法包括测定化合物调节甾醇-C4-甲基氧化酶（SC4MOL）的表达或活性的能力，以及使用调节剂 该酶用于治疗与高脂血症相关的痤疮或皮肤病症的表达或活性; 还描述了这些病理学的体外诊断或预后的方法。
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2.发明申请Modulators of the transporter ABCD3 for treating acne or hyperseborrhea 审中-公开转运蛋白ABCD3的调节剂用于治疗痤疮或高脂血症公开(公告)号：US20090258356A1
公开(公告)日：2009-10-15
申请号：US12320174
申请日：2009-01-21
申请人： Fernand Labrie , Mohamed El-Alfy , Ezequiel L. Calvo , Isabelle Carlavan , Pascal Collette , Sophie Deret , Michel Rivier
发明人： Fernand Labrie , Mohamed El-Alfy , Ezequiel L. Calvo , Isabelle Carlavan , Pascal Collette , Sophie Deret , Michel Rivier
CPC分类号： G01N33/5008 , G01N33/6872 , G01N2333/914 , G01N2500/00 , G01N2800/20
摘要： An in vitro method for screening candidate compounds for the preventive or curative treatment of acne, includes the determination of the capacity of a compound to modulate the expression or the activity of the peroxisome membrane transporter 1 comprising a type 3 ATP-binding site of the sub-family D (ABCD3), and the use of modulators of the expression or activity of this transporter for the treatment of acne or skin disorders associated with a hyperseborrhea; methods for the in vitro diagnosis or prognosis of these pathologies are also described.
摘要翻译： 用于筛选用于预防或治疗痤疮的候选化合物的体外方法包括测定化合物调节包含亚型的3型ATP结合位点的过氧化物酶体转运蛋白1的表达或活性的能力 - 家族D（ABCD3），以及使用该转运蛋白的表达或活性的调节剂来治疗与上呼吸道相关的痤疮或皮肤疾病; 还描述了这些病理学的体外诊断或预后的方法。
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公开(公告)号：US20090246776A1
公开(公告)日：2009-10-01
申请号：US12320166
申请日：2009-01-21
申请人： Fernand Labrie , Isabelle Carlavan , Pascal Collette , Ezequiel L. Calvo , Jerome Aubert , Johannes Voegel
发明人： Fernand Labrie , Isabelle Carlavan , Pascal Collette , Ezequiel L. Calvo , Jerome Aubert , Johannes Voegel
IPC分类号： C12Q1/68
CPC分类号： G01N33/6872 , C12Q1/6809 , C12Q1/6883 , C12Q1/6897 , C12Q2600/136 , C12Q2600/158 , G01N2500/00 , G01N2800/20
摘要： An in vitro method for screening candidate compounds for the preventive or curative treatment of acne, includes the determination of the capacity of a compound to modulate the expression or the activity of the SCARB-1 receptor, and the use of modulators of the expression or activity of this receptor for the treatment of acne or skin disorders associated with a hyperseborrhea; methods for the in vitro diagnosis or prognosis of these pathologies are also described.
摘要翻译： 用于筛选候选化合物用于预防或治疗痤疮的体外方法包括测定化合物调节SCARB-1受体的表达或活性的能力，以及使用表达或活性的调节剂 的这种受体用于治疗与高脂血症相关的痤疮或皮肤病症; 还描述了这些病理学的体外诊断或预后的方法。
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4.发明申请Modulators of UDP-glucose ceramide glucosyltransferase for treating acne or hyperkeratinization 审中-公开用于治疗痤疮或过度角化的UDP-葡萄糖神经酰胺葡糖基转移酶的调节剂公开(公告)号：US20100028878A1
公开(公告)日：2010-02-04
申请号：US12320168
申请日：2009-01-21
申请人： Fernand Labrie , Michel Rivier , Van Luu-The , Ezquiel L. Calvo , Irina Safonova , Isabelle Carlavan
发明人： Fernand Labrie , Michel Rivier , Van Luu-The , Ezquiel L. Calvo , Irina Safonova , Isabelle Carlavan
CPC分类号： G01N33/5008 , C12Q1/48 , G01N33/6893 , G01N2333/91102 , G01N2500/00 , G01N2800/20
摘要： An in vitro method for screening candidate compounds for the preventive or curative treatment of acne, includes the determination of the capacity of a compound to modulate the expression or the activity of UDP-glucose ceramide glucosyltransferase (UGCG), and the use of modulators of the expression or activity of this enzyme for the treatment of acne or skin disorders associated with a hyperkeratinization; methods for the in vitro diagnosis or prognosis of these pathologies are also described.
摘要翻译： 用于筛选候选化合物以预防或治疗痤疮的体外方法包括测定化合物调节UDP-葡萄糖神经酰胺葡糖基转移酶（UGCG）的表达或活性的能力，以及使用调节剂 该酶用于治疗与过度角化相关的痤疮或皮肤病症的表达或活性; 还描述了这些病理学的体外诊断或预后的方法。
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5.发明申请PCTP MODULATORS IN THE TREATMENT OF ACNE, OF SEBORRHOEIC DERMATITIS OR OF HYPERSEBORRHOEA 审中-公开治疗ACNE，SEBORRHOEIC DERMATITIS或者HYPERSEBORRHOEA的PCTP调节剂公开(公告)号：US20110268742A1
公开(公告)日：2011-11-03
申请号：US12991093
申请日：2009-05-07
申请人： Jérôme Aubert , Sophie Deret , Isabelle Carlavan , Michel Rivier
发明人： Jérôme Aubert , Sophie Deret , Isabelle Carlavan , Michel Rivier
IPC分类号： A61K39/395 , G01N33/566 , C12Q1/02 , A61P17/08 , C07H21/04 , C07K16/18 , A61P17/10 , C12Q1/68 , C07K14/47
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N2500/10 , G01N2800/20
摘要： An in vitro or in vivo method for screening for candidate compounds for the preventive or curative treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea, includes determining the ability of a compound to modulate the expression or the activity of the phosphatidylcholine transfer protein (PCTP), and also utilizes modulators of the expression or of the activity of this protein, for the treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea; methods for the in vitro diagnosis of or in vitro prognosis for these pathologies are also featured.
摘要翻译： 用于筛选候选化合物用于预防或治疗痤疮，脂溢性皮炎或与过度脂蛋白相关的皮肤病症的体外或体内方法包括测定化合物调节磷脂酰胆碱转运的表达或活性的能力 蛋白质（PCTP），并且还利用该蛋白质的表达或活性的调节剂，用于治疗痤疮，脂溢性皮炎或与过度脂蛋白相关的皮肤病症; 还提出了这些病理学的体外诊断或体外预后的方法。
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6.发明申请GOS2 MODULATORS IN THE TREATMENT OF ACNE, OF SEBORRHOEIC DERMATITIS OR OF HYPERSEBORRHOEA 审中-公开GOS2调节剂治疗ACNE，SEBORRHOEIC DERMATITIS或者HYPERSEBORRHOEA公开(公告)号：US20110263677A1
公开(公告)日：2011-10-27
申请号：US12990995
申请日：2009-05-07
IPC分类号： A61K31/713 , C12Q1/68 , A61P17/08 , C07H21/02 , C07H21/04 , G01N33/566 , C12Q1/02
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158
摘要： An in vitro or in vivo method for screening for candidate compounds for the preventive or curative treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea, includes determining the ability of a compound to modulate the expression or the activity of G0/G1 switch protein 2 (GOS2), and also utilizes modulators of the expression or of the activity of this protein, for the treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea; methods for the in vitro diagnosis of or in vitro prognosis for these pathologies are also featured.
摘要翻译： 用于筛选候选化合物用于预防或治疗痤疮，脂溢性皮炎或与过度脂蛋白相关的皮肤病症的体外或体内方法包括测定化合物调节G0 / G1的表达或活性的能力 开关蛋白2（GOS2），并且还利用这种蛋白质的表达或活性的调节剂，用于治疗痤疮，脂溢性皮炎或与超球囊相关的皮肤疾病; 还提出了这些病理学的体外诊断或体外预后的方法。
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7.发明申请Novel modulators of the PPAR-type receptors and cosmetic/pharmaceutical compositions comprised thereof 审中-公开PPAR型受体的新型调节剂及其组合的美容/药物组合物公开(公告)号：US20060035969A1
公开(公告)日：2006-02-16
申请号：US11202059
申请日：2005-08-12
IPC分类号： A61K31/24 , C07C311/45
CPC分类号： C07C323/62 , C07C2601/14
摘要： Novel compounds which modulate PPAR-type receptors have the following general formula (I): and are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology and in the fields of cardiovascular diseases, immune diseases and/or diseases linked to lipid metabolism), or are formulated into cosmetic compositions.
摘要翻译： 调节PPAR-型受体的新型化合物具有以下通式（I）：并配制成适用于人或兽医学药物（在皮肤病学和心血管疾病，免疫疾病和/或与 脂质代谢），或配制成化妆品组合物。
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8.发明授权Melanocortin receptor antagonist compounds, process for preparing them and use thereof in human medicine and cosmetics 有权黑皮质素受体拮抗剂化合物，其制备方法及其在人类药物和化妆品中的应用公开(公告)号：US08962846B2
公开(公告)日：2015-02-24
申请号：US13126221
申请日：2009-11-04
IPC分类号： C07D401/00 , A61K31/445 , C07D401/12 , C07D403/12
CPC分类号： C07D401/12 , C07D403/12
摘要： Melanocortin receptor antagonist compounds, processes for preparing them and uses thereof in human medicine and cosmetics are described.Melanocortin receptor antagonist compounds corresponding to the general formula (I): compositions containing them, and processes for their preparation and their use in pharmaceutical or cosmetic compositions are also described.
摘要翻译： 描述了黑皮质素受体拮抗剂化合物，其制备方法及其在人类药物和化妆品中的用途。 还描述了对应于通式（I）的黑皮质素受体拮抗剂化合物：含有它们的组合物及其制备方法及其在药物或化妆品组合物中的应用。
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9.发明申请MELANOCORTIN RECEPTOR ANTAGONIST COMPOUNDS, PROCESS FOR PREPARING THEM AND USE THEREOF IN HUMAN MEDICINE AND COSMETICS 有权梅兰康汀受体拮抗剂化合物，其制备方法及其在人体药物和化妆品中的应用公开(公告)号：US20110281913A1
公开(公告)日：2011-11-17
申请号：US13126221
申请日：2009-11-04
IPC分类号： A61K31/454 , A61P3/00 , A61P3/04 , A61P11/00 , A61P19/00 , A61P1/16 , A61P13/12 , A61P31/00 , A61P37/00 , C07D401/12 , A61P9/00
CPC分类号： C07D401/12 , C07D403/12
摘要： Melanocortin receptor antagonist compounds, processes for preparing them and uses thereof in human medicine and cosmetics are described.Melanocortin receptor antagonist compounds corresponding to the general formula (I): compositions containing them, and processes for their preparation and their use in pharmaceutical or cosmetic compositions are also described.
摘要翻译： 描述了黑皮质素受体拮抗剂化合物，其制备方法及其在人类药物和化妆品中的用途。 还描述了对应于通式（I）的黑皮质素受体拮抗剂化合物：含有它们的组合物及其制备方法及其在药物或化妆品组合物中的应用。
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10.发明申请Novel modulators of the PPAR-type receptors and cosmetic/pharmaceutical compositions comprised thereof 审中-公开PPAR型受体的新型调节剂及其组合的美容/药物组合物公开(公告)号：US20060052627A1
公开(公告)日：2006-03-09
申请号：US11202019
申请日：2005-08-12
IPC分类号： C07D241/02 , C07D239/02 , C07D237/02 , C07C229/40
CPC分类号： C07C323/62
摘要： Novel compounds which modulate PPAR-type receptors have the following general formula (I): and are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology and in the fields of cardiovascular diseases, immune diseases and/or diseases linked to lipid metabolism), or are formulated into cosmetic compositions.
摘要翻译： 调节PPAR-型受体的新型化合物具有以下通式（I）：
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