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公开(公告)号：US20100021892A1
公开(公告)日：2010-01-28
申请号：US12320170
申请日：2009-01-21
申请人： Fernand Labrie , Mohamed El-Alfy , Van Luu-The , Ezequiel L. Calvo , Jerome Aubert , Isabelle Carlavan , Sophie Deret , Johannes Voegel
发明人： Fernand Labrie , Mohamed El-Alfy , Van Luu-The , Ezequiel L. Calvo , Jerome Aubert , Isabelle Carlavan , Sophie Deret , Johannes Voegel
CPC分类号： G01N33/5008 , G01N2333/902 , G01N2500/00 , G01N2800/20
摘要： An in vitro method for screening candidate compounds for the preventive or curative treatment of acne, includes the determination of the capacity of a compound to modulate the expression or the activity of sterol-C4-methyl oxidase (SC4MOL), and the use of modulators of the expression or activity of this enzyme for the treatment of acne or skin disorders associated with a hyperseborrhea; methods for the in vitro diagnosis or prognosis of these pathologies are also described.
摘要翻译： 用于筛选候选化合物以预防或治疗痤疮的体外方法包括测定化合物调节甾醇-C4-甲基氧化酶（SC4MOL）的表达或活性的能力，以及使用调节剂 该酶用于治疗与高脂血症相关的痤疮或皮肤病症的表达或活性; 还描述了这些病理学的体外诊断或预后的方法。
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2.发明申请Modulators of lanosterol synthetase for treating acne or hyperseborrhea 审中-公开用于治疗痤疮或高血脂的羊毛甾醇合成酶的调节剂公开(公告)号：US20100021893A1
公开(公告)日：2010-01-28
申请号：US12320171
申请日：2009-01-21
申请人： Fernand Labrie , Mohamed El-Alfy , Van Luu-The , Ezequiel L. Calvo , Jerome Aubert , Pascal Collette , Johannes Voegel
发明人： Fernand Labrie , Mohamed El-Alfy , Van Luu-The , Ezequiel L. Calvo , Jerome Aubert , Pascal Collette , Johannes Voegel
CPC分类号： G01N33/573 , C12Q1/25 , G01N33/6893 , G01N2333/99 , G01N2800/20
摘要： An in vitro method for screening candidate compounds for the preventive or curative treatment of acne, includes the determination of the capacity of a compound to modulate the expression or the activity of lanosterol synthetase (LSS), and the use of modulators of the expression or activity of this enzyme for the treatment of acne or skin disorders associated with a hyperseborrhea; methods for the in vitro diagnosis or prognosis of these pathologies are also described.
摘要翻译： 用于筛选候选化合物以预防或治疗痤疮的体外方法包括测定化合物调节羊毛甾醇合成酶（LSS）的表达或活性的能力，以及使用表达或活性的调节剂 的这种酶用于治疗与过度脂肪相关的痤疮或皮肤病症; 还描述了这些病理学的体外诊断或预后的方法。
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公开(公告)号：US20100028879A1
公开(公告)日：2010-02-04
申请号：US12320169
申请日：2009-01-21
申请人： Fernand Labrie , Michel Rivier , Van Luu-The , Ezequiel L. Calvo , Jerome Aubert , Sophie Deret , Johannes Voegel
发明人： Fernand Labrie , Michel Rivier , Van Luu-The , Ezequiel L. Calvo , Jerome Aubert , Sophie Deret , Johannes Voegel
IPC分类号： C12Q1/68 , G01N33/573
CPC分类号： C12Q1/32 , G01N2333/904 , G01N2500/04 , G01N2800/20
摘要： An in vitro method for screening candidate compounds for the preventive or curative treatment of acne, includes the determination of the capacity of a compound to modulate the expression or the activity of hydroxysteroid (17-beta) dehydrogenase type 7, and the use of modulators of the expression or activity of this enzyme for the treatment of acne or skin disorders associated with a hyperseborrhea; methods for the in vitro diagnosis or in vitro prognosis of these pathologies are also described.
摘要翻译： 用于筛选候选化合物以预防或治疗痤疮的体外方法包括测定化合物调节7型羟基类固醇（17-β）脱氢酶的表达或活性的能力，以及使用调节剂 该酶用于治疗与高脂血症相关的痤疮或皮肤病症的表达或活性; 还描述了这些病理学的体外诊断或体外预后的方法。
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公开(公告)号：US20090246776A1
公开(公告)日：2009-10-01
申请号：US12320166
申请日：2009-01-21
申请人： Fernand Labrie , Isabelle Carlavan , Pascal Collette , Ezequiel L. Calvo , Jerome Aubert , Johannes Voegel
发明人： Fernand Labrie , Isabelle Carlavan , Pascal Collette , Ezequiel L. Calvo , Jerome Aubert , Johannes Voegel
IPC分类号： C12Q1/68
CPC分类号： G01N33/6872 , C12Q1/6809 , C12Q1/6883 , C12Q1/6897 , C12Q2600/136 , C12Q2600/158 , G01N2500/00 , G01N2800/20
摘要： An in vitro method for screening candidate compounds for the preventive or curative treatment of acne, includes the determination of the capacity of a compound to modulate the expression or the activity of the SCARB-1 receptor, and the use of modulators of the expression or activity of this receptor for the treatment of acne or skin disorders associated with a hyperseborrhea; methods for the in vitro diagnosis or prognosis of these pathologies are also described.
摘要翻译： 用于筛选候选化合物用于预防或治疗痤疮的体外方法包括测定化合物调节SCARB-1受体的表达或活性的能力，以及使用表达或活性的调节剂 的这种受体用于治疗与高脂血症相关的痤疮或皮肤病症; 还描述了这些病理学的体外诊断或预后的方法。
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5.发明申请GOS2 MODULATORS IN THE TREATMENT OF ACNE, OF SEBORRHOEIC DERMATITIS OR OF HYPERSEBORRHOEA 审中-公开GOS2调节剂治疗ACNE，SEBORRHOEIC DERMATITIS或者HYPERSEBORRHOEA公开(公告)号：US20110263677A1
公开(公告)日：2011-10-27
申请号：US12990995
申请日：2009-05-07
IPC分类号： A61K31/713 , C12Q1/68 , A61P17/08 , C07H21/02 , C07H21/04 , G01N33/566 , C12Q1/02
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158
摘要： An in vitro or in vivo method for screening for candidate compounds for the preventive or curative treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea, includes determining the ability of a compound to modulate the expression or the activity of G0/G1 switch protein 2 (GOS2), and also utilizes modulators of the expression or of the activity of this protein, for the treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea; methods for the in vitro diagnosis of or in vitro prognosis for these pathologies are also featured.
摘要翻译： 用于筛选候选化合物用于预防或治疗痤疮，脂溢性皮炎或与过度脂蛋白相关的皮肤病症的体外或体内方法包括测定化合物调节G0 / G1的表达或活性的能力 开关蛋白2（GOS2），并且还利用这种蛋白质的表达或活性的调节剂，用于治疗痤疮，脂溢性皮炎或与超球囊相关的皮肤疾病; 还提出了这些病理学的体外诊断或体外预后的方法。
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6.发明申请Novel modulators of the PPAR-type receptors and cosmetic/pharmaceutical compositions comprised thereof 审中-公开PPAR型受体的新型调节剂及其组合的美容/药物组合物公开(公告)号：US20060035969A1
公开(公告)日：2006-02-16
申请号：US11202059
申请日：2005-08-12
IPC分类号： A61K31/24 , C07C311/45
CPC分类号： C07C323/62 , C07C2601/14
摘要： Novel compounds which modulate PPAR-type receptors have the following general formula (I): and are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology and in the fields of cardiovascular diseases, immune diseases and/or diseases linked to lipid metabolism), or are formulated into cosmetic compositions.
摘要翻译： 调节PPAR-型受体的新型化合物具有以下通式（I）：并配制成适用于人或兽医学药物（在皮肤病学和心血管疾病，免疫疾病和/或与 脂质代谢），或配制成化妆品组合物。
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7.发明授权Melanocortin receptor antagonist compounds, process for preparing them and use thereof in human medicine and cosmetics 有权黑皮质素受体拮抗剂化合物，其制备方法及其在人类药物和化妆品中的应用公开(公告)号：US08962846B2
公开(公告)日：2015-02-24
申请号：US13126221
申请日：2009-11-04
IPC分类号： C07D401/00 , A61K31/445 , C07D401/12 , C07D403/12
CPC分类号： C07D401/12 , C07D403/12
摘要： Melanocortin receptor antagonist compounds, processes for preparing them and uses thereof in human medicine and cosmetics are described.Melanocortin receptor antagonist compounds corresponding to the general formula (I): compositions containing them, and processes for their preparation and their use in pharmaceutical or cosmetic compositions are also described.
摘要翻译： 描述了黑皮质素受体拮抗剂化合物，其制备方法及其在人类药物和化妆品中的用途。 还描述了对应于通式（I）的黑皮质素受体拮抗剂化合物：含有它们的组合物及其制备方法及其在药物或化妆品组合物中的应用。
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8.发明申请MELANOCORTIN RECEPTOR ANTAGONIST COMPOUNDS, PROCESS FOR PREPARING THEM AND USE THEREOF IN HUMAN MEDICINE AND COSMETICS 有权梅兰康汀受体拮抗剂化合物，其制备方法及其在人体药物和化妆品中的应用公开(公告)号：US20110281913A1
公开(公告)日：2011-11-17
申请号：US13126221
申请日：2009-11-04
IPC分类号： A61K31/454 , A61P3/00 , A61P3/04 , A61P11/00 , A61P19/00 , A61P1/16 , A61P13/12 , A61P31/00 , A61P37/00 , C07D401/12 , A61P9/00
CPC分类号： C07D401/12 , C07D403/12
摘要： Melanocortin receptor antagonist compounds, processes for preparing them and uses thereof in human medicine and cosmetics are described.Melanocortin receptor antagonist compounds corresponding to the general formula (I): compositions containing them, and processes for their preparation and their use in pharmaceutical or cosmetic compositions are also described.
摘要翻译： 描述了黑皮质素受体拮抗剂化合物，其制备方法及其在人类药物和化妆品中的用途。 还描述了对应于通式（I）的黑皮质素受体拮抗剂化合物：含有它们的组合物及其制备方法及其在药物或化妆品组合物中的应用。
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9.发明申请Novel modulators of the PPAR-type receptors and cosmetic/pharmaceutical compositions comprised thereof 审中-公开PPAR型受体的新型调节剂及其组合的美容/药物组合物公开(公告)号：US20060052627A1
公开(公告)日：2006-03-09
申请号：US11202019
申请日：2005-08-12
IPC分类号： C07D241/02 , C07D239/02 , C07D237/02 , C07C229/40
CPC分类号： C07C323/62
摘要： Novel compounds which modulate PPAR-type receptors have the following general formula (I): and are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology and in the fields of cardiovascular diseases, immune diseases and/or diseases linked to lipid metabolism), or are formulated into cosmetic compositions.
摘要翻译： 调节PPAR-型受体的新型化合物具有以下通式（I）：
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10.发明申请PACAP SIGNALING PATHWAY MODULATORS FOR TREATING INFLAMMATORY SKIN DISEASES HAVING A NEUROGENIC COMPONENT, NOTABLY ROSACEA, AND COMPOSITIONS COMPRISED THEREOF 审中-公开用于治疗具有神经细胞成分，非特异性ROSACEA及其组合物的炎症性皮肤疾病的PACAP信号途径调节剂公开(公告)号：US20110229423A1
公开(公告)日：2011-09-22
申请号：US13054769
申请日：2009-07-17
IPC分类号： A61K31/713 , G01N33/566 , C12Q1/68 , C07H21/02 , A61P29/00 , A61P17/10 , A61P17/02 , A61P17/00 , A61P31/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P31/10 , A61P23/00 , A61P37/08 , A61P39/06 , A61P37/06 , A61P17/08 , A61P17/12 , A61Q17/04 , A61P3/02
CPC分类号： G01N33/6881 , A61K9/0014 , A61K38/00 , G01N2500/04 , G01N2800/20 , G01N2800/202
摘要： Modulators of specific PACAP receptors are useful for treating inflammatory skin diseases having a neurogenic component, and more particularly rosacea and/or facial erythema, compositions containing these and screening methods are described for identifying PACAP signaling pathway modulators.
摘要翻译： 特异性PACAP受体的调节剂可用于治疗具有神经源成分的炎性皮肤疾病，更具体地，涉及红斑痤疮和/或面部红斑，含有这些和组合物的组合物和筛选方法用于鉴定PACAP信号通路调节剂。
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