公开(公告)号：US20110268742A1

公开(公告)日：2011-11-03

申请号：US12991093

申请日：2009-05-07

申请人： Jérôme Aubert ,  Sophie Deret ,  Isabelle Carlavan ,  Michel Rivier

发明人： Jérôme Aubert ,  Sophie Deret ,  Isabelle Carlavan ,  Michel Rivier

IPC分类号： A61K39/395 ,  G01N33/566 ,  C12Q1/02 ,  A61P17/08 ,  C07H21/04 ,  C07K16/18 ,  A61P17/10 ,  C12Q1/68 ,  C07K14/47

CPC分类号： G01N33/6893 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N2500/10 ,  G01N2800/20

摘要： An in vitro or in vivo method for screening for candidate compounds for the preventive or curative treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea, includes determining the ability of a compound to modulate the expression or the activity of the phosphatidylcholine transfer protein (PCTP), and also utilizes modulators of the expression or of the activity of this protein, for the treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea; methods for the in vitro diagnosis of or in vitro prognosis for these pathologies are also featured.

摘要翻译： 用于筛选候选化合物用于预防或治疗痤疮，脂溢性皮炎或与过度脂蛋白相关的皮肤病症的体外或体内方法包括测定化合物调节磷脂酰胆碱转运的表达或活性的能力 蛋白质（PCTP），并且还利用该蛋白质的表达或活性的调节剂，用于治疗痤疮，脂溢性皮炎或与过度脂蛋白相关的皮肤病症; 还提出了这些病理学的体外诊断或体外预后的方法。

公开(公告)号：US20090258356A1

公开(公告)日：2009-10-15

申请号：US12320174

申请日：2009-01-21

申请人： Fernand Labrie ,  Mohamed El-Alfy ,  Ezequiel L. Calvo ,  Isabelle Carlavan ,  Pascal Collette ,  Sophie Deret ,  Michel Rivier

发明人： Fernand Labrie ,  Mohamed El-Alfy ,  Ezequiel L. Calvo ,  Isabelle Carlavan ,  Pascal Collette ,  Sophie Deret ,  Michel Rivier

IPC分类号： C12Q1/68 ,  C12Q1/02

CPC分类号： G01N33/5008 ,  G01N33/6872 ,  G01N2333/914 ,  G01N2500/00 ,  G01N2800/20

摘要： An in vitro method for screening candidate compounds for the preventive or curative treatment of acne, includes the determination of the capacity of a compound to modulate the expression or the activity of the peroxisome membrane transporter 1 comprising a type 3 ATP-binding site of the sub-family D (ABCD3), and the use of modulators of the expression or activity of this transporter for the treatment of acne or skin disorders associated with a hyperseborrhea; methods for the in vitro diagnosis or prognosis of these pathologies are also described.

摘要翻译： 用于筛选用于预防或治疗痤疮的候选化合物的体外方法包括测定化合物调节包含亚型的3型ATP结合位点的过氧化物酶体转运蛋白1的表达或活性的能力 - 家族D（ABCD3），以及使用该转运蛋白的表达或活性的调节剂来治疗与上呼吸道相关的痤疮或皮肤疾病; 还描述了这些病理学的体外诊断或预后的方法。

公开(公告)号：US20100021892A1

公开(公告)日：2010-01-28

申请号：US12320170

申请日：2009-01-21

申请人： Fernand Labrie ,  Mohamed El-Alfy ,  Van Luu-The ,  Ezequiel L. Calvo ,  Jerome Aubert ,  Isabelle Carlavan ,  Sophie Deret ,  Johannes Voegel

发明人： Fernand Labrie ,  Mohamed El-Alfy ,  Van Luu-The ,  Ezequiel L. Calvo ,  Jerome Aubert ,  Isabelle Carlavan ,  Sophie Deret ,  Johannes Voegel

IPC分类号： C12Q1/68 ,  C12Q1/26

CPC分类号： G01N33/5008 ,  G01N2333/902 ,  G01N2500/00 ,  G01N2800/20

摘要： An in vitro method for screening candidate compounds for the preventive or curative treatment of acne, includes the determination of the capacity of a compound to modulate the expression or the activity of sterol-C4-methyl oxidase (SC4MOL), and the use of modulators of the expression or activity of this enzyme for the treatment of acne or skin disorders associated with a hyperseborrhea; methods for the in vitro diagnosis or prognosis of these pathologies are also described.

摘要翻译： 用于筛选候选化合物以预防或治疗痤疮的体外方法包括测定化合物调节甾醇-C4-甲基氧化酶（SC4MOL）的表达或活性的能力，以及使用调节剂 该酶用于治疗与高脂血症相关的痤疮或皮肤病症的表达或活性; 还描述了这些病理学的体外诊断或预后的方法。

公开(公告)号：US08086412B2

公开(公告)日：2011-12-27

申请号：US12457730

申请日：2009-06-19

申请人： Paul Fogel ,  Didier Zugaj ,  Jean-Marc Le Goff ,  Jérôme Aubert ,  Sophie Deret

发明人： Paul Fogel ,  Didier Zugaj ,  Jean-Marc Le Goff ,  Jérôme Aubert ,  Sophie Deret

IPC分类号： G01N33/48 ,  G06F19/00

CPC分类号： G06F19/20 ,  G06F19/24

摘要： A corrective method is described for processing results of transcriptome experiments obtained by differential analysis includes the following steps: obtaining the results of the level of expression of genes under a reference condition, and calculating the mean level of expression of each of such genes; obtaining the results of the level of expression of such genes under a treatment condition, and calculating the mean level of expression for each of such genes; calculating the modulation coefficient for the level of expression for each of such genes; calculating a p-value associated with each modulation coefficient; and calculating isobar curves of p-value as a function of the mean level of expression of each of such genes under the reference condition; calculating and associating a median modulation coefficient on the isobar curve of each p-value observed. The processing of results of experiments carried out on DNA chips is also described.

摘要翻译： 描述了通过差异分析获得的转录组实验处理结果的校正方法，包括以下步骤：获得参考条件下基因表达水平的结果，并计算每个这样的基因的平均表达水平; 在治疗条件下获得这些基因表达水平的结果，并计算每个这样的基因的平均表达水平; 计算每个这样的基因的表达水平的调节系数; 计算与每个调制系数相关联的p值; 并计算p值的等压曲线作为参考条件下每个这样的基因的平均表达水平的函数; 计算和关联每个p值的等压曲线上的中值调制系数。 还描述了对DNA芯片进行的实验结果的处理。

公开(公告)号：US20100057369A1

公开(公告)日：2010-03-04

申请号：US12457730

申请日：2009-06-19

申请人： Paul Fogel ,  Didier Zugaj ,  Jean-Marc Le Goff ,  Jérôme Aubert ,  Sophie Deret

发明人： Paul Fogel ,  Didier Zugaj ,  Jean-Marc Le Goff ,  Jérôme Aubert ,  Sophie Deret

IPC分类号： G06F19/00

CPC分类号： G06F19/20 ,  G06F19/24

摘要： A corrective method for processing results of transcriptome experiments obtained by differential analysis includes the following steps: obtaining the results of the level of expression of genes under a reference condition, and calculating the mean level of expression of each of such genes; obtaining the results of the level of expression of such genes under a treatment condition, and calculating the mean level of expression for each of such genes; calculating the modulation coefficient for the level of expression for each of such genes; calculating a p-value associated with each modulation coefficient; and calculating isobar curves of p-value as a function of the mean level of expression of each of such genes under the reference condition; calculating and associating a median modulation coefficient on the isobar curve of each p-value observed; this method applies in particular to the processing of results of experiments carried out on DNA chips.

摘要翻译： 通过差异分析获得的转录组实验处理结果的校正方法包括以下步骤：获得参考条件下基因表达水平的结果，并计算各基因的平均表达水平; 在治疗条件下获得这些基因表达水平的结果，并计算每个这样的基因的平均表达水平; 计算每个这样的基因的表达水平的调节系数; 计算与每个调制系数相关联的p值; 并计算p值的等压曲线作为参考条件下每个这样的基因的平均表达水平的函数; 计算和关联每个p值的等压曲线上的中值调制系数; 该方法特别适用于对DNA芯片进行的实验结果的处理。

公开(公告)号：US20100028879A1

公开(公告)日：2010-02-04

申请号：US12320169

申请日：2009-01-21

申请人： Fernand Labrie ,  Michel Rivier ,  Van Luu-The ,  Ezequiel L. Calvo ,  Jerome Aubert ,  Sophie Deret ,  Johannes Voegel

发明人： Fernand Labrie ,  Michel Rivier ,  Van Luu-The ,  Ezequiel L. Calvo ,  Jerome Aubert ,  Sophie Deret ,  Johannes Voegel

IPC分类号： C12Q1/68 ,  G01N33/573

CPC分类号： C12Q1/32 ,  G01N2333/904 ,  G01N2500/04 ,  G01N2800/20

摘要： An in vitro method for screening candidate compounds for the preventive or curative treatment of acne, includes the determination of the capacity of a compound to modulate the expression or the activity of hydroxysteroid (17-beta) dehydrogenase type 7, and the use of modulators of the expression or activity of this enzyme for the treatment of acne or skin disorders associated with a hyperseborrhea; methods for the in vitro diagnosis or in vitro prognosis of these pathologies are also described.

摘要翻译： 用于筛选候选化合物以预防或治疗痤疮的体外方法包括测定化合物调节7型羟基类固醇（17-β）脱氢酶的表达或活性的能力，以及使用调节剂 该酶用于治疗与高脂血症相关的痤疮或皮肤病症的表达或活性; 还描述了这些病理学的体外诊断或体外预后的方法。

公开(公告)号：US20110213009A1

公开(公告)日：2011-09-01

申请号：US12991329

申请日：2009-05-07

申请人： Jérôme Aubert ,  Sophie Deret ,  Valérie Trinquet

发明人： Jérôme Aubert ,  Sophie Deret ,  Valérie Trinquet

IPC分类号： A61K31/713 ,  C12Q1/68 ,  C07H21/04 ,  C40B30/04 ,  G01N33/53 ,  C07H21/02 ,  A61K31/56 ,  A61P17/00 ,  A61P17/10 ,  A61P17/08

CPC分类号： G01N33/566 ,  C12N15/1086 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/6881 ,  G01N2800/20 ,  G01N2800/202 ,  G01N2800/56

摘要： An in vitro or in vivo method for screening for candidate compounds for the preventive or curative treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea, includes determining the ability of a compound to modulate the expression or the activity of the adipose differentiation-related protein (ADFP), and also utilizes modulators of the expression or of the activity of this protein, for the treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea; methods for the in vitro diagnosis of or in vitro prognosis for these pathologies are also featured.

摘要翻译： 用于筛选候选化合物用于预防或治疗痤疮，脂溢性皮炎或与超星球症相关的皮肤病症的体外或体内方法包括测定化合物调节脂肪分化的表达或活性的能力 相关蛋白（ADFP），并且还利用该蛋白质的表达或活性的调节剂，用于治疗痤疮，脂溢性皮炎或与过度脂蛋白相关的皮肤疾病; 还提出了这些病理学的体外诊断或体外预后的方法。

公开(公告)号：US20090298074A1

公开(公告)日：2009-12-03

申请号：US12320167

申请日：2009-01-21

申请人： Fernand Labrie ,  Mohamed El-Alfy ,  Van Luu-The ,  Ezequiel L. Calvo ,  Pascal Collette ,  Sophie Deret ,  Michel Rivier

发明人： Fernand Labrie ,  Mohamed El-Alfy ,  Van Luu-The ,  Ezequiel L. Calvo ,  Pascal Collette ,  Sophie Deret ,  Michel Rivier

IPC分类号： C12Q1/68 ,  C12Q1/02

CPC分类号： G01N33/5023 ,  C12N9/1029 ,  G01N2333/91051 ,  G01N2500/00

摘要： An in vitro method for screening candidate compounds for the preventive or curative treatment of acne, includes the determination of the capacity of a compound to modulate the expression or the activity of ELOVL5 and the use of modulators of the expression or activity of this enzyme for the treatment of acne or skin disorders associated with a hyperseborrhea; methods for the in vitro diagnosis or prognosis of these pathologies are also described.

摘要翻译： 用于筛选用于预防或治疗痤疮的候选化合物的体外方法包括测定化合物调节ELOVL5的表达或活性的能力，以及使用该酶的表达或活性的调节剂用于 治疗与高脂血症相关的痤疮或皮肤疾病; 还描述了这些病理学的体外诊断或预后的方法。