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公开(公告)号：US11708572B2
公开(公告)日：2023-07-25
申请号：US16421459
申请日：2019-05-23
发明人： Bart Lipkens , Kedar C. Chitale , Krishna N. Kumar , Walter M. Presz, Jr. , Ruan Zhang , Benjamin Ross-Johnsrud , Rudolf Gilmanshin , Natalia Rodionova , Rui Tostoes
CPC分类号： C12N13/00 , A61M1/3678 , B01D21/283 , B01L3/502761 , C12M47/04 , G01N15/1484 , B01L2300/0864 , B01L2300/0867 , B01L2400/0436 , B01L2400/0439 , G01N2015/0053 , G01N2015/1006 , G01N2015/149
摘要： Beads with functionalized material applied to them are exposed to an acoustic field to trap, retain or pass the beads. The beads may include or be free of ferro magnetic material. The beads may be biocompatible or biodegradable for a host. The size of the beads may vary over a range, and/or be heterogenous or homogenous. The composition of the beads may include high, neutral or low acoustic contrast material. The chemistry of the functionalized material may be compatible with existing processes. The acoustic field may be generated, for example, in an acoustic angled wave device or in an acoustic fluidized bed.
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公开(公告)号：US11459540B2
公开(公告)日：2022-10-04
申请号：US15983823
申请日：2018-05-18
发明人： Rui Tostoes , Bart Lipkens , Kedar Chitale , Benjamin Ross-Johnsrud , Walter M. Presz, Jr. , Jack Saloio
摘要： Separation of materials is achieved using affinity binding and acoustophoretic techniques. A column provided with a fluid mixture of materials for separation and support structures may be used with acoustic waves to block flow of the support structures. The support structures can have an affinity for one or more materials in the fluid mixture. By blocking flow of the support structures, materials bound or adhered to the support structure are also blocked.
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公开(公告)号：US11324873B2
公开(公告)日：2022-05-10
申请号：US15257515
申请日：2016-09-06
发明人： Rudolf Gilmanshin , Bart Lipkens , Brian Dutra , Daniel Kennedy
摘要： Acoustophoretic devices are disclosed. The devices include a flow chamber, an ultrasonic transducer, a reflector, an inlet, a filtrate outlet, a concentrate outlet, and optionally a lipid collection trap. The ultrasonic transducer and reflector create a multi-dimensional acoustic standing wave in the flow chamber that traps and separates red blood cells and/or lipids from blood. Concentrated red blood cells can be recovered via the concentrate outlet, the lipids can be recovered via the lipid collection trap, and the remaining blood can be recovered via the filtrate outlet. Methods for separating blood components (e.g., red blood cells, lipids, platelets, white blood cells) from blood are also disclosed. The red blood cells can undergo washing with a solvent to remove undesired admixtures. Cryoprotectants can be added or removed from the blood.
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公开(公告)号：US11179747B2
公开(公告)日：2021-11-23
申请号：US15206244
申请日：2016-07-09
发明人： Bart Lipkens , Walter M Presz, Jr. , Kedar Chitale , Thomas J Kennedy, III , Rudolf Gilmanshin , Dane Mealey , Brian Dutra , David Sokolowski
摘要： An acoustophoretic device is disclosed. The acoustophoretic device includes an acoustic chamber, an ultrasonic transducer, and a reflector. The ultrasonic transducer includes a piezoelectric material driven by a voltage signal to create a multi-dimensional acoustic standing wave in the acoustic chamber emanating from a non-planar face of the piezoelectric material. A method for separating a second fluid or a particulate from a host fluid is also disclosed. The method includes flowing the mixture through an acoustophoretic device. A voltage signal is sent to drive the ultrasonic transducer to create the multi-dimensional acoustic standing wave in the acoustic chamber such that the second fluid or particulate is continuously trapped in the standing wave, and then agglomerates, aggregates, clumps, or coalesces together, and subsequently rises or settles out of the host fluid due to buoyancy or gravity forces, and exits the acoustic chamber.
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公开(公告)号：US20210277381A1
公开(公告)日：2021-09-09
申请号：US17323868
申请日：2021-05-18
摘要： Methods and systems for processing material in a host fluid use an acoustophoresis device. These methods and systems can deflect material (e.g., a second fluid, cells, beads or other particles, exosomes, viruses, oil droplets) in host fluid streams at high flow rates.
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公开(公告)号：US10967298B2
公开(公告)日：2021-04-06
申请号：US15872984
申请日：2018-01-16
发明人： Bart Lipkens , Ronald Musiak , Dane Mealey , John Artis , Ali Shajii
摘要： An acoustic standing wave is utilized to separate components from a multi-component fluid, such as oil from an oil-water mixture, or cells entrained in a fluid, in a fluid flow scheme with an acoustophoresis device. For example, the flow scheme and device allows for trapping of the oil as the oil coalesces, agglomerates, and becomes more buoyant than the water. A driver and controller for the acoustophoretic device accommodate variable loading as the components are separated, thereby improving separation efficiency.
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公开(公告)号：US20200308533A1
公开(公告)日：2020-10-01
申请号：US16880787
申请日：2020-05-21
发明人： Bart Lipkens , Erik Miller , Benjamin Ross-Johnsrud , Walter M. Presz, JR. , Kedar Chitale , Thomas J. Kennedy, III , Lauryn Winiarski
摘要： Acoustic perfusion devices for separating biological cells from other material in a fluid mixture are disclosed. The devices include an inlet port, an outlet port, and a collection port that are connected to an acoustic chamber. An ultrasonic transducer creates an acoustic standing wave in the acoustic chamber that permits a continuous flow of fluid to be recovered through the collection port while keeping the biological cells within the acoustic chamber to be returned to the bioreactor from which the fluid mixture is being drawn.
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公开(公告)号：US10785574B2
公开(公告)日：2020-09-22
申请号：US16221283
申请日：2018-12-14
发明人： Bart Lipkens , Ronald Musiak , John Artis
摘要： An acoustophoretic system is controlled and driven to attain a desired level of performance. An RF controller and a driver provide a frequency and power to an acoustic transducer, which can be implemented as a piezoelectric element, which presents a reactive load or a complex load. A controller implements a control technique for efficient transducer operation. The control technique can locate a frequency for operation that is at a reactance minimum or maximum for the system to produce a modal pattern and to provide efficient operation of the transducer. A method of detecting a minimum or maximum reactance in a acoustophoretic system used to trap, separate, deflect, cluster, fractionate or otherwise process particles or secondary fluids or tertiary fluids in a primary fluid and utilizing the frequency of the detected reactance to operate the acoustophoretic system.
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公开(公告)号：US10689609B2
公开(公告)日：2020-06-23
申请号：US15634955
申请日：2017-06-27
IPC分类号： C12N13/00 , B01D17/06 , C12M1/42 , C12M1/00 , B01D21/28 , B06B1/06 , B01D17/04 , C07K1/14 , G10K9/122 , H01L41/053 , H01L41/09
摘要： A series of multi-dimensional acoustic standing waves is set up inside a growth volume of a bioreactor. The acoustic standing waves are used to hold a cell culture in place as a nutrient fluid stream flows through the cell culture. The nutrient fluid stream dislodges some cells from the cell culture, which can then be recovered for cell therapy applications. The cell culture continues to expand and reproduce, permitting continuous recovery of cells from the bioreactor.
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10.发明申请公开(公告)号：US20200017376A1
公开(公告)日：2020-01-16
申请号：US16518941
申请日：2019-07-22
发明人： Jason Dionne , Bart Lipkens , Edward A. Rietman
摘要： Ultrasonic standing waves are generated to trap and separate oil droplets, cellular material and/or gases from a fluid. The methods and apparatuses operate at ultrasonic resonance and are low power, e.g., in the range of 1-5 W. One or more acoustic transducers operating in the 100 kHz to 5 MHz range may be used. The methods and apparatuses may be implemented using relatively large flow chamber and flow rates, e.g., in a range of from about 200 mL/min to greater than about 15 L/min.
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