公开(公告)号：US09506914B2

公开(公告)日：2016-11-29

申请号：US14535162

申请日：2014-11-06

Applicant: Fluidigm Corporation

Inventor： Ian D. Manger ,  Joseph W. Barco ,  Hany R. Nassef

IPC: B81B3/00 ,  G01N33/53 ,  F04B19/00 ,  F04B43/02 ,  F16K99/00 ,  G01N33/543 ,  B01L3/00

CPC classification number: B81B3/00 ,  B01L3/5025 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/088 ,  B01L2300/0887 ,  B01L2400/0415 ,  B01L2400/0481 ,  B01L2400/0655 ,  F04B19/006 ,  F04B43/02 ,  F16K99/0001 ,  F16K99/0003 ,  F16K99/0026 ,  F16K99/0036 ,  F16K99/0046 ,  F16K99/0051 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/0078 ,  F16K2099/008 ,  F16K2099/0084 ,  G01N33/5304 ,  G01N33/54366 ,  Y10T436/2575

Abstract: A microfluidic device includes a plurality of first flow channels and a plurality of second flow channels, each such second flow channel intersecting multiple of the first flow channels to define intersecting volumes and a plurality of looped flow channels that each include segments of the flow channels between the intersecting volumes to define a closed loop. The microfluidic device also includes a plurality of control valves each such control valve having a control channel and a deformable segment disposed to restrict flow through a respective one of the first and second flow channels in response to an actuation force applied to the control channel to deflect the deformable segment. The microfluidic device further includes a pump operatively disposed to regulate flow through one of the looped flow channels to regulate flow by the recirculating pump.

Abstract translation: 微流体装置包括多个第一流动通道和多个第二流动通道，每个这样的第二流动通道与第一流动通道的多个相交，以限定相交的体积，以及多个环形流动通道，每个流动通道包括在 相交的卷定义一个闭环。 微流体装置还包括多个控制阀，每个这样的控制阀具有控制通道和可变形部分，可变形部分设置成响应于施加到控制通道的致动力而限制流过第一和第二流动通道中的相应一个流动通道以偏转 可变形段。 微流体装置还包括一个可操作地设置成用于调节通过环形流动通道之一的流量以调节由再循环泵流动的泵。

公开(公告)号：US20150168385A1

公开(公告)日：2015-06-18

申请号：US14535162

申请日：2014-11-06

Applicant: Fluidigm Corporation

Inventor： Ian D. Manger ,  Joseph W. Barco ,  Hany R. Nassef

IPC: G01N33/53

CPC classification number: B81B3/00 ,  B01L3/5025 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/088 ,  B01L2300/0887 ,  B01L2400/0415 ,  B01L2400/0481 ,  B01L2400/0655 ,  F04B19/006 ,  F04B43/02 ,  F16K99/0001 ,  F16K99/0003 ,  F16K99/0026 ,  F16K99/0036 ,  F16K99/0046 ,  F16K99/0051 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/0078 ,  F16K2099/008 ,  F16K2099/0084 ,  G01N33/5304 ,  G01N33/54366 ,  Y10T436/2575

Abstract: A microfluidic device includes a plurality of first flow channels and a plurality of second flow channels, each such second flow channel intersecting multiple of the first flow channels to define intersecting volumes and a plurality of looped flow channels that each include segments of the flow channels between the intersecting volumes to define a closed loop. The microfluidic device also includes a plurality of control valves each such control valve having a control channel and a deformable segment disposed to restrict flow through a respective one of the first and second flow channels in response to an actuation force applied to the control channel to deflect the deformable segment. The microfluidic device further includes a pump operatively disposed to regulate flow through one of the looped flow channels to regulate flow by the recirculating pump.

Abstract translation: 微流体装置包括多个第一流动通道和多个第二流动通道，每个这样的第二流动通道与第一流动通道的多个相交，以限定相交的体积，以及多个环形流动通道，每个流动通道包括在 相交的卷定义一个闭环。 微流体装置还包括多个控制阀，每个这样的控制阀具有控制通道和可变形部分，可变形部分设置成响应于施加到控制通道的致动力而限制流过第一和第二流动通道中的相应一个流动通道以偏转 可变形段。 微流体装置还包括一个可操作地设置成用于调节通过环形流动通道之一的流量以调节由再循环泵流动的泵。