公开(公告)号：US20160354462A1

公开(公告)日：2016-12-08

申请号：US15172947

申请日：2016-06-03

Applicant: Forsyth Dental Infirmary for Children

Inventor： Antonio Campos-Neto ,  Mark Cayabyab ,  Margaret Duncan

IPC: A61K39/21 ,  C07K14/005 ,  C12N9/44 ,  C07K14/35 ,  A61K45/06 ,  C12N15/74 ,  C12N7/00 ,  A61K39/04

CPC classification number: A61K39/21 ,  A61K39/04 ,  A61K45/06 ,  A61K2039/523 ,  A61K2039/542 ,  A61K2039/572 ,  C07K14/00 ,  C07K14/005 ,  C07K14/155 ,  C07K14/162 ,  C07K14/315 ,  C07K14/35 ,  C07K2319/02 ,  C07K2319/40 ,  C12N7/00 ,  C12N9/2457 ,  C12N15/74 ,  C12N15/746 ,  C12N2740/15022 ,  C12N2740/15033 ,  C12N2740/16022 ,  C12N2740/16033 ,  C12N2740/16034 ,  C12N2740/16051 ,  C12N2740/16071 ,  C12N2740/16111 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16171 ,  C12Y302/01041

Abstract: The present invention relates to a new vaccine delivery system. In particular, the present invention includes compositions and methods of integrally transformed non-pathogenic, commensal bacteria that can express a nucleic acid molecule of a foreign polypeptide, wherein the nucleic acid molecule that encodes the foreign polypeptide is stably integrated into genomic DNA of the bacteria. The foreign polypeptide includes a vaccine antigen that elicits an immunogenic response, an inhibitor of a pathogen, or an immune booster or modulator.

公开(公告)号：US09884108B2

公开(公告)日：2018-02-06

申请号：US15172947

申请日：2016-06-03

Applicant: Forsyth Dental Infirmary for Children

Inventor： Antonio Campos-Neto ,  Mark Cayabyab ,  Margaret Duncan

IPC: A61K39/085 ,  A61K39/21 ,  A01N63/00 ,  C12P21/04 ,  C12N15/74 ,  C07K14/00 ,  C07K14/155 ,  C07K14/16 ,  C07K14/35 ,  C07K14/005 ,  C07K14/315 ,  A61K39/04 ,  A61K45/06 ,  C12N7/00 ,  C12N9/44 ,  A61K39/00

CPC classification number: A61K39/21 ,  A61K39/04 ,  A61K45/06 ,  A61K2039/523 ,  A61K2039/542 ,  A61K2039/572 ,  C07K14/00 ,  C07K14/005 ,  C07K14/155 ,  C07K14/162 ,  C07K14/315 ,  C07K14/35 ,  C07K2319/02 ,  C07K2319/40 ,  C12N7/00 ,  C12N9/2457 ,  C12N15/74 ,  C12N15/746 ,  C12N2740/15022 ,  C12N2740/15033 ,  C12N2740/16022 ,  C12N2740/16033 ,  C12N2740/16034 ,  C12N2740/16051 ,  C12N2740/16071 ,  C12N2740/16111 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16171 ,  C12Y302/01041

Abstract: The present invention relates to a new vaccine delivery system. In particular, the present invention includes compositions and methods of integrally transformed non-pathogenic, commensal bacteria that can express a nucleic acid molecule of a foreign polypeptide, wherein the nucleic acid molecule that encodes the foreign polypeptide is stably integrated into genomic DNA of the bacteria. The foreign polypeptide includes a vaccine antigen that elicits an immunogenic response, an inhibitor of a pathogen, or an immune booster or modulator.