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公开(公告)号：US06583120B1
公开(公告)日：2003-06-24
申请号：US09744245
申请日：2001-03-02
申请人： Franco Pellacini , Daniela Botta , Stefano Romagnano , Enrico Albini , Domenico Ungheri , Giovanna Schioppacassi
发明人： Franco Pellacini , Daniela Botta , Stefano Romagnano , Enrico Albini , Domenico Ungheri , Giovanna Schioppacassi
IPC分类号： A61K3170
CPC分类号： C07H17/08
摘要： The present invention discloses an erythromycin derivative with antibiotic activity and pharmaceutically acceptable salts thereof, a process for their preparation and pharmaceutical compositions containing them as active principle.
摘要翻译： 本发明公开了具有抗生素活性的红霉素衍生物及其药学上可接受的盐，其制备方法和含有它们作为活性成分的药物组合物。
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公开(公告)号：US06468979B1
公开(公告)日：2002-10-22
申请号：US09744244
申请日：2001-01-30
IPC分类号： A61K3170
CPC分类号： C07H17/08
摘要： Erythromycin derivatives with antibiotic activity and pharmaceutically acceptable salts thereof. A process for preparing such erythromycin derivatives and pharmaceutical compositions containing them as the active principle.
摘要翻译： 具有抗生素活性的红霉素衍生物及其药学上可接受的盐。 制备这种红霉素衍生物的方法和含有它们的药物组合物作为活性成分。
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3.发明授权公开(公告)号：US06214833B1
公开(公告)日：2001-04-10
申请号：US09381635
申请日：2000-01-31
申请人： Franco Pellacini , Domenico Ungheri , Giovanna Schioppacassi , Jean-Louis Kraus , Michel Camplo , Nicolas Mourier , Jean-Claude Chermann
发明人： Franco Pellacini , Domenico Ungheri , Giovanna Schioppacassi , Jean-Louis Kraus , Michel Camplo , Nicolas Mourier , Jean-Claude Chermann
IPC分类号： A61K31505
CPC分类号： C07D411/04 , A61K31/506
摘要： Compounds of formula (I) wherein Ra and Rb the same or different, are hydrogen atoms, acyl groups deriving from a lower carboxylic acid or chains of formula (a) useful as reverse transcriptase inhibitors antiviral activity are described.
摘要翻译： 描述了其中R a和R b相同或不同的式（I）化合物是氢原子，衍生自低级羧酸的酰基或用作逆转录酶抑制剂的抗病毒活性的式（a）的链。
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4.发明申请Fosfomycin and n-acetylcysteine for the treatment of biofilms caused by escheric ia coli and other pathogens of the urinary tract 审中-公开磷霉素和正乙酰半胱氨酸用于治疗由大肠杆菌和其他尿道病原体引起的生物膜公开(公告)号：US20060073156A1
公开(公告)日：2006-04-06
申请号：US10526404
申请日：2003-09-01
CPC分类号： A61K31/665 , A61K31/195 , Y02A50/473 , A61K2300/00
摘要： Pharmaceutical compositions for the treatment of infections by pathogens of the urinary tract and, more particularly, compositions containing fosfomycin optionally associated with N-acetylcysteine.
摘要翻译： 用于治疗尿道病原体感染的药物组合物，更具体地说，涉及任选与N-乙酰半胱氨酸相关的含有磷霉素的组合物。
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5.发明授权Synergistic composition comprising a fibroblast growth factor and a sulfated polysaccharide, for use as antiviral agent 失效包含成纤维细胞生长因子和硫酸化多糖的协同组合物，用作抗病毒剂
公开(公告)号：US5288704A
公开(公告)日：1994-02-22
申请号：US830330
申请日：1992-01-31
IPC分类号： A61K31/715 , A61K38/00 , A61K38/18 , A61P31/12 , A61P31/16 , A61P31/22 , A61P43/00 , A61K37/00
CPC分类号： A61K38/1825 , Y10S514/885 , Y10S514/886 , Y10S514/889
摘要： A pharmaceutcial composition is provided for use in the prevention or treatment of viral infections caused by enveloped viruses. The composition comprises a fibroblast growth factor, a sulfated polysaccharide with antiviral activity, and one or more pharmaceutically acceptable carriers. The fibroblast growth factor may be a basic fibroblast growth factor or an analogue thereof, and the polysaccharide may be a carrageenan, heparin, dextran sulfate, pentosan polysulfate or a sulfated polysaccharides produced by marine algae belonging to the class of Rhodophyceae.
摘要翻译： 提供了用于预防或治疗由包膜病毒引起的病毒感染的药物组合物。 组合物包含成纤维细胞生长因子，具有抗病毒活性的硫酸化多糖和一种或多种药学上可接受的载体。 成纤维细胞生长因子可以是碱性成纤维细胞生长因子或其类似物，并且多糖可以是角叉菜胶，肝素，硫酸葡聚糖，戊聚糖多硫酸盐或由属于红藻属类的海藻产生的硫酸化多糖。
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6.发明授权公开(公告)号：US06833389B2
公开(公告)日：2004-12-21
申请号：US09926738
申请日：2001-12-11
申请人： Giovanni Battista Colombo , Domenico Ungheri , Luciano Licciardello , Maria Rita Gismondo , Lorenzo Drago
发明人： Giovanni Battista Colombo , Domenico Ungheri , Luciano Licciardello , Maria Rita Gismondo , Lorenzo Drago
IPC分类号： A61K3116
CPC分类号： A61K31/165 , Y10S514/826
摘要： Use of thiamphenicol and derivatives thereof for the preparation of pharmaceutical compositions useful for the treatment Chlamydia pneumoniae infections is described.
摘要翻译： 描述了使用硫霉素及其衍生物制备可用于治疗肺炎衣原体感染的药物组合物。
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7.发明授权Treating vancomycin-intermediates and multiresistant staphylococci infection with thiamphenicol or a salt thereof 有权用硫霉素或其盐处理万古霉素中间体和多抗葡萄球菌感染公开(公告)号：US06589993B2
公开(公告)日：2003-07-08
申请号：US09958945
申请日：2001-10-16
IPC分类号： A61K3116
CPC分类号： A61K31/165
摘要： The present invention relates to methods of treating vancomycin-intermediates and multiresistant staphylococci infection using thiamphenicol or a salt thereof.
摘要翻译： 本发明涉及使用甲砜霉素或其盐治疗万古霉素中间体和多抗葡萄球菌感染的方法。
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8.发明申请Pharmaceutical compositions for the treatment of infections of the respiratory system by pathogenic agents 审中-公开用于通过致病剂治疗呼吸系统感染的药物组合物公开(公告)号：US20050107474A1
公开(公告)日：2005-05-19
申请号：US10486929
申请日：2003-06-19
IPC分类号： A61K31/165 , A61K31/198 , A61P11/00 , A61P11/12 , A61P31/04 , A61K31/16
CPC分类号： A61K31/198 , A61K31/165 , A61K2300/00
摘要： The present invention relates to pharmaceutical compositions for the treatment of infections by pathogen agents of the respiratory system, for example Staphylococcus aureus, and more particularly it relates to the aforesaid compositions containing N-acetyl-cysteine possibly combined with thiamphenicol.
摘要翻译： 本发明涉及用于治疗呼吸系统的病原体感染的药物组合物，例如金黄色葡萄球菌，更具体地说，涉及含有可能与甲砜霉素组合的N-乙酰半胱氨酸的上述组合物。
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9.发明授权Cyclic dinucleoside diphosphorothioates, related compounds and pharmaceutical compositions 失效环状二核苷二磷酸硫酸酯，相关化合物和药物组合物
公开(公告)号：US5547941A
公开(公告)日：1996-08-20
申请号：US354888
申请日：1994-12-09
IPC分类号： A61K31/70 , A61P31/12 , A61P31/18 , C07H19/10 , C07H19/20 , C07H21/00 , C07H21/04 , C07H19/213 , C07H21/02
摘要： There are provided compounds of formula (I) ##STR1## wherein each group B is, independently, a naturally occurring or modified heterocyclic base linked through a nitrogen or a carbon atom of the ring to the sugar moiety;each group X is a, independently, hydrogen, fluorine, hydroxy, or a C.sub.1 -C.sub.6 alkoxy group;each group Y is, independently, hydrogen, sulphidryl or hydroxy; and the pharmaceutically acceptable salts thereof.A process for their preparation and pharmaceutical compositions comprising them are also described. The compounds of this invention can be useful as antivirals, particularly as anti-HIV (Human Immunodeficiency Virus) agents, namely as drugs to be used against AIDS (Acquired Immunodeficiency Syndrome) therapeutically and/or prophylatically.
摘要翻译： 提供式（I）化合物（I）其中每个基团B独立地是通过环的氮或碳原子与糖部分连接的天然存在或修饰的杂环碱基; 每个基团X独立地是氢，氟，羟基或C 1 -C 6烷氧基; 每个基团Y独立地是氢，硫代或羟基; 及其药学上可接受的盐。 还描述了其制备方法和包含它们的药物组合物。 本发明的化合物可用作抗病毒剂，特别是作为抗HIV（人类免疫缺陷病毒）试剂，即用于治疗和/或预防用于抗艾滋病（获得性免疫缺陷综合征）的药物）。
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公开(公告)号：US5374626A
公开(公告)日：1994-12-20
申请号：US38331
申请日：1993-03-12
摘要： The present invention relates to the use as antivirals of compounds of formula: ##STR1## wherein B is a purinic or pyrimidinic heterocycle; X is oxygen or sulphur; R.sup.1 is a hydroxyl group or a hydrogen atom; R.sup.2 is a linear, branched or cyclic, alkyl group of up to twenty carbon atoms; R.sup.3 is as specified for R.sup.2 above or a hydrogen atom, a cation or a polyhydroxy group.
摘要翻译： 本发明涉及作为下式的化合物的抗病毒剂的用途：其中B是嘌呤或嘧啶杂环; X是氧或硫; R1是羟基或氢原子; R2是直链，支链或环状的，最多20个碳原子的烷基; R3如上述R2所定义或氢原子，阳离子或多羟基。
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