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1.发明申请VACCINES COMPRISING OUTER MEMBRANE VESICLES FROM GRAM NEGATIVE BACTERIA 审中-公开包含来自GRAM Negative BACTERIA的外膜的疫苗公开(公告)号：US20090117147A1
公开(公告)日：2009-05-07
申请号：US11949071
申请日：2007-12-03
申请人： Francois-Xavier Jacques BERTHET , Wilfried L J. Dalemans , Philippe Denoel , Guy Dequesne , Christiane Feron , Nathalie Garcon , Yves Lobet , Jan Poolman , Georges Thiry , Joelle Thonnard , Pierre Voet
发明人： Francois-Xavier Jacques BERTHET , Wilfried L J. Dalemans , Philippe Denoel , Guy Dequesne , Christiane Feron , Nathalie Garcon , Yves Lobet , Jan Poolman , Georges Thiry , Joelle Thonnard , Pierre Voet
IPC分类号： A61K39/02
CPC分类号： A61K39/02 , A61K39/092 , A61K39/102 , A61K39/39 , A61K2039/55555 , A61K2039/55572 , A61K2039/55594 , A61K2039/6068
摘要： The present invention relates to the field of vaccine formulation, particularly the field of novel adjuvant compositions comprising outer membrane vesicles (or blebs), and advantageous methods of detoxifying these compositions, and advantageous methods of use of such adjuvants.
摘要翻译： 本发明涉及疫苗制剂领域，特别涉及包含外膜囊泡（或泡沫）的新型佐剂组合物领域，以及使这些组合物解毒的有利方法以及使用这些佐剂的有利方法。
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公开(公告)号：US20080233154A1
公开(公告)日：2008-09-25
申请号：US11467396
申请日：2006-08-25
申请人： Francois-Xavier Jacques Berthet , Wilfried Dalemans , Philippe Denoel , Guy Dequesne , Christiane Feron , Yves Lobet , Jan Poolman , Georges Thiry , Joelle Thonnard , Pierre Voet
发明人： Francois-Xavier Jacques Berthet , Wilfried Dalemans , Philippe Denoel , Guy Dequesne , Christiane Feron , Yves Lobet , Jan Poolman , Georges Thiry , Joelle Thonnard , Pierre Voet
IPC分类号： A61K39/095 , A61P31/04
CPC分类号： A61K39/095 , A61K39/145 , A61K47/6911 , A61K2039/522 , A61K2039/55505 , A61K2039/55544 , A61K2039/70 , C07K14/22 , C12N15/102 , C12N15/74
摘要： The present invention relates to an immuno-protective and non-toxic Gram-negative bleb vaccine suitable for paediatric use. Examples of the Gram-negative strains from which the blebs are made are N. meningitidis, M. catarrhalis and H. influenzae. The blebs of the invention are improved by one or more genetic changes to the chromosome of the bacterium, including up-regulation of protective antigens, down-regulation of immunodominant non-protective antigens, and detoxification of the Lipid A moiety of LPS.
摘要翻译： 本发明涉及适用于儿科用途的免疫保护性和无毒革兰氏阴性泡状疫苗。 制作泡沫的革兰氏阴性菌株的实例是脑膜炎奈瑟菌，卡他莫拉菌和流感嗜血杆菌。 通过对细菌染色体的一个或多个遗传变化，包括保护性抗原的上调，免疫显性非保护性抗原的下调和LPS的脂质A部分的解毒来改善本发明的泡沫。
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公开(公告)号：US20060216307A1
公开(公告)日：2006-09-28
申请号：US11325116
申请日：2006-06-09
申请人： Francois-Xavier Berthet , Wilfried Dalemans , Philippe Denoel , Guy Dequesne , Christiane Feron , Yves Lobet , Jan Poolman , Georges Thiry , Joelle Thonnard , Pierre Voet
发明人： Francois-Xavier Berthet , Wilfried Dalemans , Philippe Denoel , Guy Dequesne , Christiane Feron , Yves Lobet , Jan Poolman , Georges Thiry , Joelle Thonnard , Pierre Voet
CPC分类号： A61K39/095 , A61K39/145 , A61K47/6911 , A61K2039/522 , A61K2039/55505 , A61K2039/55544 , A61K2039/70 , C07K14/22 , C12N15/102 , C12N15/74
摘要： The present invention relates to an immuno-protective and non-toxic Gram-negative bleb vaccine suitable for paediatric use. Examples of the Gram-negative strains from which the blebs are made are N. meningitidis, M. catarrhalis and H. influenzae. The blebs of the invention are improved by one or more genetic changes to the chromosome of the bacterium, including up-regulation of protective antigens, down-regulation of immunodominant non-protective antigens, and detoxification of the Lipid A moiety of LPS.
摘要翻译： 本发明涉及适用于儿科用途的免疫保护性和无毒革兰氏阴性泡状疫苗。 制作泡沫的革兰氏阴性菌株的实例是脑膜炎奈瑟菌，卡他莫拉菌和流感嗜血杆菌。 通过对细菌染色体的一个或多个遗传变化，包括保护性抗原的上调，免疫显性非保护性抗原的下调和LPS的脂质A部分的解毒来改善本发明的泡沫。
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公开(公告)号：US20060257418A1
公开(公告)日：2006-11-16
申请号：US11337733
申请日：2006-01-23
申请人： Lauren Bakaletz , Joseph Cohen , Guy Dequesne , Yves Lobet
发明人： Lauren Bakaletz , Joseph Cohen , Guy Dequesne , Yves Lobet
CPC分类号： C07K16/1242 , A61K39/00 , C07K14/285 , C07K2319/00 , G01N33/56911
摘要： This invention relates to three newly-identified, distinct groups of antigenic peptides [LB1(f) peptides] from the same region of the P5-like fimbrin protein discovered using sequence data from the fimbrin protein of many Haemophilus influenzae strains. The invention additionally provides chimeric polypeptides that carry one or more representatives of such peptides from different groups and which induce an immunogenic response in animals to Haemophilus influenzae. The peptides and polypeptides of the invention will be useful in vaccine compositions which provide protection against a wide range of H. influenzae strains.
摘要翻译： 本发明涉及使用来自许多流感嗜血杆菌菌株的fimbrin蛋白的序列数据发现的来自P5样fimbrin蛋白的相同区域的三种新鉴定的不同组的抗原肽[LB1（f）肽]。 本发明另外提供了携带来自不同群体的这种肽的一种或多种代表并且在动物中对流感嗜血杆菌诱导免疫原性应答的嵌合多肽。 本发明的肽和多肽可用于提供针对广泛的流感嗜血杆菌菌株的保护的疫苗组合物中。
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公开(公告)号：US20090191234A1
公开(公告)日：2009-07-30
申请号：US12343145
申请日：2008-12-23
申请人： Lauren Bakaletz , Joseph Cohen , Guy Dequesne , Yves Lobet
发明人： Lauren Bakaletz , Joseph Cohen , Guy Dequesne , Yves Lobet
IPC分类号： A61K39/145 , C07K14/11 , C07K7/08 , C07K19/00 , C07H21/04 , C07H21/02 , C12N15/63 , C12N1/21 , C12P21/02 , C07K16/08 , C12Q1/70
CPC分类号： C07K16/1242 , A61K39/00 , C07K14/285 , C07K2319/00 , G01N33/56911
摘要： This invention relates to three newly-identified, distinct groups of antigenic peptides [LB1(f) peptides] from the same region of the P5-like fimbrin protein discovered using sequence data from the fimbrin protein of many Haemophilus influenzae strains. The invention additionally provides chimeric polypeptides that carry one or more representatives of such peptides from different groups and which induce an immunogenic response in animals to Haemophilus influenzae. The peptides and polypeptides of the invention will be useful in vaccine compositions which provide protection against a wide range of H. influenzae strains.
摘要翻译： 本发明涉及使用来自许多流感嗜血杆菌菌株的fimbrin蛋白的序列数据发现的来自P5样fimbrin蛋白的相同区域的三种新鉴定的不同组的抗原肽[LB1（f）肽]。 本发明另外提供了携带来自不同群体的这种肽的一种或多种代表并且在动物中对流感嗜血杆菌诱导免疫原性应答的嵌合多肽。 本发明的肽和多肽可用于提供针对广泛的流感嗜血杆菌菌株的保护的疫苗组合物中。
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公开(公告)号：US20120244189A1
公开(公告)日：2012-09-27
申请号：US13384234
申请日：2010-07-16
申请人： Timothy Foster , Judy Higgins , Elisabet Josefsson , Joan Geoghegan , Guy Dequesne , Andrej Tarkowski , Carlake Andersson
发明人： Timothy Foster , Judy Higgins , Elisabet Josefsson , Joan Geoghegan , Guy Dequesne , Andrej Tarkowski , Carlake Andersson
IPC分类号： A61K39/085 , C12N15/31 , C07K19/00 , C07K16/12 , A61P31/00 , A61P9/00 , A61P29/00 , A61P37/04 , C12N15/63 , C12N1/21 , A61P31/04 , C07K14/31 , A61P19/02
摘要： The present invention is directed to improved microbial antigen vaccines, pharmaceutical compositions, immunogenic compositions and antibodies and their use in the treatment of microbial infections, particularly those of bacterial origin, including Staphylococcal origin. Ideally, the present invention is directed to a recombinant staphylococcal MSCRAMM or MSCRAMM-like proteins, or fragment thereof, with reduced binding to its host ligand, for use in therapy.
摘要翻译： 本发明涉及改进的微生物抗原疫苗，药物组合物，免疫原性组合物和抗体及其在治疗微生物感染，特别是包括葡萄球菌来源的细菌来源的微生物感染中的用途。 理想地，本发明涉及与其宿主配体结合降低的重组葡萄球菌MSCRAMM或MSCRAMM样蛋白或其片段，用于治疗。
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7.发明授权Method of prophlactically treating infection using a recombinant fibrinogen binding protein clumping factor A (ClfA) or fragment thereof 有权使用重组纤维蛋白原结合蛋白凝聚因子A（ClfA）或其片段前体治疗感染的方法公开(公告)号：US09353160B2
公开(公告)日：2016-05-31
申请号：US13384234
申请日：2010-07-16
申请人： Timothy Foster , Judy Higgins , Elisabet Josefsson , Joan Geoghegan , Guy Dequesne , Andrej Tarkowski , Carlake Andersson
发明人： Timothy Foster , Judy Higgins , Elisabet Josefsson , Joan Geoghegan , Guy Dequesne , Andrej Tarkowski
摘要： The present invention is directed to improved microbial antigen vaccines, pharmaceutical compositions, immunogenic compositions and antibodies and their use in the treatment of microbial infections, particularly those of bacterial origin, including Staphylococcal origin. Ideally, the present invention is directed to a recombinant staphylococcal MSCRAMM or MSCRAMM-like proteins, or fragment thereof, with reduced binding to its host ligand, for use in therapy.
摘要翻译： 本发明涉及改进的微生物抗原疫苗，药物组合物，免疫原性组合物和抗体及其在治疗微生物感染，特别是包括葡萄球菌来源的细菌来源的微生物感染中的用途。 理想地，本发明涉及与其宿主配体结合降低的重组葡萄球菌MSCRAMM或MSCRAMM样蛋白或其片段，用于治疗。
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8.发明授权Immunogenic composition comprising variants of Staphylococcal clumping factor A 有权包含葡萄球菌聚集因子A的变体的免疫原性组合物公开(公告)号：US08715687B2
公开(公告)日：2014-05-06
申请号：US13388715
申请日：2010-08-03
IPC分类号： A61K39/085 , C07K14/31 , C12N15/00
CPC分类号： C07K16/1271 , A61K39/00 , A61K39/085 , A61K2039/522 , A61K2039/55566 , C07K14/31 , C07K2317/76
摘要： The present invention relates to ClfA polypeptides wherein amino acid Y474 or an amino acid adjacent to Y474 is mutated such that fibrinogen binding activity is decreased compared to an equivalent ClfA polypeptide without mutation of Y474 or an amino acid adjacent to Y474 as well as immunogenic compositions, vaccines, processes and uses of such mutated ClfA polypeptides.
摘要翻译： 本发明涉及其中氨基酸Y474或与Y474相邻的氨基酸突变以使纤维蛋白原结合活性与不具有Y474突变或Y474相邻氨基酸的等价ClfA多肽以及免疫原性组合物相比降低的ClfA多肽， 这些突变的ClfA多肽的疫苗，方法和用途。
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9.发明申请IMMUNOGENIC COMPOSITION COMPRISING VARIANTS OF STAPHYLOCOCCAL CLUMPING FACTOR A 有权含有血小板沉淀因子A变异的免疫组合物公开(公告)号：US20120189650A1
公开(公告)日：2012-07-26
申请号：US13388715
申请日：2010-08-03
IPC分类号： A61K39/085 , A61P31/04 , A61P37/04 , C07K14/31 , C12N15/31
CPC分类号： C07K16/1271 , A61K39/00 , A61K39/085 , A61K2039/522 , A61K2039/55566 , C07K14/31 , C07K2317/76
摘要： The present invention relates to ClfA polypeptides wherein amino acid Y474 or an amino acid adjacent to Y474 is mutated such that fibrinogen binding activity is decreased compared to an equivalent ClfA polypeptide without mutation of Y474 or an amino acid adjacent to Y474 as well as immunogenic compositions, vaccines, processes and uses of such mutated ClfA polypeptides.
摘要翻译： 本发明涉及其中氨基酸Y474或与Y474相邻的氨基酸突变以使纤维蛋白原结合活性与不具有Y474突变或Y474相邻氨基酸的等价ClfA多肽以及免疫原性组合物相比降低的ClfA多肽， 这些突变的ClfA多肽的疫苗，方法和用途。
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