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1.发明授权N8- and C8-linked purine bases and structurally related heterocycles as universal nucleosides used for oligonucleotides hybridization 有权N8和C8连接的嘌呤碱基和结构相关杂环作为用于寡核苷酸杂交的通用核苷公开(公告)号：US07566775B2
公开(公告)日：2009-07-28
申请号：US11338149
申请日：2006-01-23
摘要： The present invention is directed to a nucleic acid binding compound comprising N8- or C8-linked purine bases or structurally related heterocycles, a compound useful for the preparation of such compound, a binding product of this nucleic acid binding compound with a nucleic acid, a method for the determination of a nucleic acid using said compound, and several uses of 8-linked purine bases and structurally related heterocycles. Compounds according to the present invention have advantageous properties when used in hybridization methods.
摘要翻译： 本发明涉及包含N8-或C8-连接的嘌呤碱基或结构相关杂环的核酸结合化合物，可用于制备该化合物的化合物，该核酸结合化合物与核酸的结合产物， 使用所述化合物测定核酸的方法以及8-连接的嘌呤碱基和结构相关杂环的几种用途。 当用于杂交方法时，根据本发明的化合物具有有利的性质。
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![Nucleic acid binding compounds containing pyrazolo[3,4-D]pyrimidine analogues of purin-2,6-diamine and their uses](/abs-image/US/2011/11/15/US08057997B2/abs.jpg.150x150.jpg)
2.发明授权Nucleic acid binding compounds containing pyrazolo[3,4-D]pyrimidine analogues of purin-2,6-diamine and their uses 有权含有嘌呤-2,6-二胺的吡唑并[3,4-D]嘧啶类似物的核酸结合化合物及其用途公开(公告)号：US08057997B2
公开(公告)日：2011-11-15
申请号：US11742416
申请日：2007-04-30
申请人： Frank Seela , Frank Bergmann , Herbert Von Der Eltz , Dieter Heindl , Christoph Seidel , Georg Becher
发明人： Frank Seela , Frank Bergmann , Herbert Von Der Eltz , Dieter Heindl , Christoph Seidel , Georg Becher
CPC分类号： C07H21/00 , C07H19/16 , Y10T436/143333
摘要： The present invention is in the field of nucleic acid binding compounds comprising 7-substituted 7-deaza-8aza-2,6-diamino-purine bases, compounds useful for the preparation of such compounds, various uses thereof and methods for the determination of nucleic acids using said compounds in the field of diagnostics.
摘要翻译： 本发明涉及包含7-取代的7-脱氮-8-氮杂-2,6-二氨基嘌呤碱基的核酸结合化合物领域，可用于制备这些化合物的化合物，其各种用途和用于测定核酸的方法 在诊断领域使用所述化合物的酸。
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![Nucleic Acid Binding Compounds Containing Pyrazolo[3,4-D]Pyrimidine Analogues of Purin-2,6-Diamine and Their Uses](/abs-image/US/2011/01/27/US20110021365A1/abs.jpg.150x150.jpg)
3.发明申请Nucleic Acid Binding Compounds Containing Pyrazolo[3,4-D]Pyrimidine Analogues of Purin-2,6-Diamine and Their Uses 有权含有嘌呤-2,6-二胺的吡唑并[3,4-D]嘧啶类似物的核酸结合化合物及其用途公开(公告)号：US20110021365A1
公开(公告)日：2011-01-27
申请号：US11742416
申请日：2007-04-30
申请人： Frank Seela , Frank Bergmann , Herbert Von Der Eltz , Dieter Heindl , Christoph Seidel , Georg Becher
发明人： Frank Seela , Frank Bergmann , Herbert Von Der Eltz , Dieter Heindl , Christoph Seidel , Georg Becher
CPC分类号： C07H21/00 , C07H19/16 , Y10T436/143333
摘要： The present invention is in the field of nucleic acid binding compounds comprising 7-substituted 7-deaza-8aza-2,6-diamino-purine bases, compounds useful for the preparation of such compounds, various uses thereof and methods for the determination of nucleic acids using said compounds in the field of diagnostics.
摘要翻译： 本发明涉及包含7-取代的7-脱氮-8-氮杂-2,6-二氨基嘌呤碱基的核酸结合化合物领域，可用于制备这些化合物的化合物，其各种用途和用于测定核酸的方法 在诊断领域使用所述化合物的酸。
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![Nucleic acid binding compounds containing pyrazolo[3,4-d]pyrimidine analogues of purin-2,6-diamine and their uses](/abs-image/US/2007/07/03/US07238795B2/abs.jpg.150x150.jpg)
4.发明授权Nucleic acid binding compounds containing pyrazolo[3,4-d]pyrimidine analogues of purin-2,6-diamine and their uses 有权含有嘌呤-2,6-二胺的吡唑并[3,4-d]嘧啶类似物的核酸结合化合物及其用途公开(公告)号：US07238795B2
公开(公告)日：2007-07-03
申请号：US10333518
申请日：2001-07-31
申请人： Frank Seela , Frank Bergmann , Herbert Von Der Eltz , Dieter Heindl , Christoph Seidel , Georg Becher
发明人： Frank Seela , Frank Bergmann , Herbert Von Der Eltz , Dieter Heindl , Christoph Seidel , Georg Becher
CPC分类号： C07H21/00 , C07H19/16 , Y10T436/143333
摘要： The present invention is in the field of nucleic acid binding compounds comprising 7-substituted 7-deaza-8aza-2,6-diamino-purine bases, compounds useful for the preparation of such compounds, various uses thereof and methods for the determination of nucleic acids using said compounds in the field of diagnostics.
摘要翻译： 本发明涉及包含7-取代的7-脱氮-8-氮杂-2,6-二氨基嘌呤碱基的核酸结合化合物领域，可用于制备这些化合物的化合物，其各种用途和用于测定核酸的方法 在诊断领域使用所述化合物的酸。
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5.发明申请N8- and C8-linked purine bases and structurally related heterocycles as universal nucleosides used for oligonucleotides hybridization 有权N8和C8连接的嘌呤碱基和结构相关杂环作为用于寡核苷酸杂交的通用核苷公开(公告)号：US20060135462A1
公开(公告)日：2006-06-22
申请号：US11338149
申请日：2006-01-23
IPC分类号： A61K48/00 , C07H21/02 , C07F9/6512
摘要： The present invention is directed to a nucleic acid binding compound comprising N8- or C8-linked purine bases or structurally related heterocycles, a compound useful for the preparation of such compound, a binding product of this nucleic acid binding compound with a nucleic acid, a method for the determination of a nucleic acid using said compound, and several uses of 8-linked purine bases and structurally related heterocycles. Compounds according to the present invention have advantageous properties when used in hybridization methods.
摘要翻译： 本发明涉及包含N 8 - 或C 8 - 连接的嘌呤碱基或结构相关杂环的核酸结合化合物，可用于制备该化合物的化合物 ，该核酸结合化合物与核酸的结合产物，使用所述化合物测定核酸的方法，以及8-连接的嘌呤碱基和结构相关杂环的若干用途。 当用于杂交方法时，根据本发明的化合物具有有利的性质。
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6.发明授权N8 -and c8 -linked purine based and structurally related heterocycles as universal nucleosides used oligonucleotides hybridization 有权N8-和c8连接的基于嘌呤和结构相关的杂环作为通用核苷使用寡核苷酸杂交公开(公告)号：US07063945B2
公开(公告)日：2006-06-20
申请号：US10221306
申请日：2001-03-27
摘要： The present invention is directed to a nucleic acid binding compound comprising N8- or C8-linked purine bases or structurally related heterocycles, a compound useful for the preparation of such compound, a binding product of this nucleic acid binding compound with a nucleic acid, a method for the determination of a nucleic acid using said compound, and several uses of 8-linked purine bases and structurally related heterocycles. Compounds according to the present invention have advantageous properties when used in hybridization methods.
摘要翻译： 本发明涉及包含N 8 - 或C 8 - 连接的嘌呤碱基或结构相关杂环的核酸结合化合物，可用于制备该化合物的化合物 ，该核酸结合化合物与核酸的结合产物，使用所述化合物测定核酸的方法，以及8-连接的嘌呤碱基和结构相关杂环的若干用途。 当用于杂交方法时，根据本发明的化合物具有有利的性质。
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公开(公告)号：US20080038745A1
公开(公告)日：2008-02-14
申请号：US11846555
申请日：2007-08-29
CPC分类号： A61K31/513 , A61K31/52 , A61K31/675 , C07D405/04 , C07D495/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H21/00 , C07H21/04 , C12P19/34 , C12P19/38 , C12Q1/68 , G01N33/53 , G01N33/566 , G01N33/58 , G01N37/00 , Y02P20/55
摘要： The present invention is related to compounds comprising six-membered rings capable of being incorporated into nucleic acids. Particularly, the six-membered ring is a derivative of cyclohexane, cyclohexene, tetrahydropyran, tetrahydrothiopyran or piperidine. These compounds may be used to build up oligomeric compounds. The invention is further related to uses of these oligomeric compounds for hybridization and as probes. In addition, methods for the detection of nucleic acids are provided wherein the oligomeric compounds are used.
摘要翻译： 本发明涉及能够并入核酸中的包含六元环的化合物。 特别地，六元环是环己烷，环己烯，四氢吡喃，四氢噻喃或哌啶的衍生物。 这些化合物可用于构建低聚化合物。 本发明还涉及这些寡聚化合物用于杂交和作为探针的用途。 此外，提供了检测核酸的方法，其中使用低聚化合物。
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公开(公告)号：US07276592B2
公开(公告)日：2007-10-02
申请号：US10816298
申请日：2004-04-01
CPC分类号： A61K31/513 , A61K31/52 , A61K31/675 , C07D405/04 , C07D495/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H21/00 , C07H21/04 , C12P19/34 , C12P19/38 , C12Q1/68 , G01N33/53 , G01N33/566 , G01N33/58 , G01N37/00 , Y02P20/55
摘要： The present invention is related to compounds comprising six-membered rings capable of being incorporated into nucleic acids. Particularly, the six-membered ring is a derivative of cyclohexane, cyclohexene, tetrahydropyran, tetrahydrothiopyran or piperidine. These compounds may be used to build up oligomeric compounds. The invention is further related to uses of these oligomeric compounds for hybridization and as probes. In addition, methods for the detection of nucleic acids are provided wherein the oligomeric compounds are used.
摘要翻译： 本发明涉及能够并入核酸中的包含六元环的化合物。 特别地，六元环是环己烷，环己烯，四氢吡喃，四氢噻喃或哌啶的衍生物。 这些化合物可用于构建低聚化合物。 本发明还涉及这些寡聚化合物用于杂交和作为探针的用途。 此外，提供了检测核酸的方法，其中使用低聚化合物。
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公开(公告)号：US20050004078A1
公开(公告)日：2005-01-06
申请号：US10816298
申请日：2004-04-01
IPC分类号： G01N33/53 , A61K31/513 , A61K31/52 , A61K31/675 , C07D405/04 , C07D495/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H21/00 , C07H21/04 , C12P19/34 , C12P19/38 , C12Q1/68 , G01N33/566 , G01N33/58 , G01N37/00
CPC分类号： A61K31/513 , A61K31/52 , A61K31/675 , C07D405/04 , C07D495/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H21/00 , C07H21/04 , C12P19/34 , C12P19/38 , C12Q1/68 , G01N33/53 , G01N33/566 , G01N33/58 , G01N37/00 , Y02P20/55
摘要： The present invention is related to compounds comprising six-membered rings capable of being incorporated into nucleic acids. Particularly, the six-membered ring is a derivative of cyclohexane, cyclohexene, tetrahydropyran, tetrahydrothiopyran or piperidine. These compounds may be used to build up oligomeric compounds. The invention is further related to uses of these oligomeric compounds for hybridization and as probes. In addition, methods for the detection of nucleic acids are provided wherein the oligomeric compounds are used.
摘要翻译： 本发明涉及能够并入核酸中的包含六元环的化合物。 特别地，六元环是环己烷，环己烯，四氢吡喃，四氢噻喃或哌啶的衍生物。 这些化合物可用于构建低聚化合物。 本发明还涉及这些寡聚化合物用于杂交和作为探针的用途。 此外，提供了检测核酸的方法，其中使用低聚化合物。
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公开(公告)号：US07169553B1
公开(公告)日：2007-01-30
申请号：US10070340
申请日：2000-08-28
CPC分类号： C12N15/113 , C07H19/04 , C07H19/10 , C07H19/20 , C07H21/00 , C12N2310/333 , C12Q1/6813
摘要： Within oligonucleotides 2-azapurine and especially 2-azaadenine bases form specifically base pairs with guanine. This base pair is of analogous stability as an adenine-thymine but less stable than a guanine-cytosine base pair. Therefore, the incorporation of 2-azaadenine residues into oligonucleotides instead of cytosine leads specifically to hybridization complexes with nucleic acids with homogenous stability. This is useful for the adaptation of the stabilities of different oligonucleotide sequences in all kinds of hybridization techniques, for example in oligomer chip technology.
摘要翻译： 寡核苷酸2-氮杂嘌呤，特别是2-氮杂腺嘌呤碱基与鸟嘌呤特异性碱基对形成。 该碱基对具有与腺嘌呤 - 胸腺嘧啶类似的稳定性，但不如鸟嘌呤 - 胞嘧啶碱基对稳定。 因此，将2-氮杂腺嘌呤残基并入寡核苷酸而不是胞嘧啶，特别导致与具有均匀稳定性的核酸的杂交复合物。 这对于在各种杂交技术中适应不同寡核苷酸序列的稳定性是有用的，例如在低聚物芯片技术中。
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