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    Temporary medical electrical lead having biodegradable electrode mounting pad
    1.
    发明授权
    Temporary medical electrical lead having biodegradable electrode mounting pad 有权
    临时医用电线，具有可生物降解的电极安装垫

    公开(公告)号：US06330481B1

    公开(公告)日：2001-12-11

    申请号：US09411846

    申请日：1999-10-04

    申请人： Frank Van Wijk ,  Berthold Kramm ,  Leo Kretzers ,  Marc Hendriks

    发明人： Frank Van Wijk ,  Berthold Kramm ,  Leo Kretzers ,  Marc Hendriks

    IPC分类号： A61N105

    CPC分类号： A61N1/0587

    摘要： A temporary cardiac electrical stimulating lead is disclosed where the lead body thereof may be removed from inside a patient through the application of a simple pulling force exerted on its proximal end. An electrode mounting pad is located at the distal end of the lead and has a stimulating electrode mounted thereon or therein. A distal end of the electrical conductor may serve as the stimulating electrode. The electrode mounting pad is preferably capable of biodegradably dissolving or otherwise dissociating over time in human body fluids. Thus, the lead body may be detached from the electrode mounting pad through the application of a simple pulling force and removed from the patient while the electrode mounting pad remains within the patient and dissolves or otherwise dissociates over time.

    摘要翻译： 公开了临时的心电刺激引线，其中可以通过施加在其近端上施加的简单的拉力将患者的引线体从患者体内移除。 电极安装垫位于引线的远端，并具有安装在其上或其中的刺激电极。 电导体的远端可以用作刺激电极。 电极安装垫优选能够在人体液中随时间生物降解地溶解或以其他方式解离。 因此，引线体可以通过施加简单的拉力从电极安装垫分离，并且当电极安装垫保持在患者体内并且随着时间的流逝而溶解或以其他方式解离时，从病人身上取出。

    Method of making a temporary medical lead having biodegradable electrode mounting pad loaded with therapeutic drug
    4.
    发明授权
    Method of making a temporary medical lead having biodegradable electrode mounting pad loaded with therapeutic drug 失效
    制造具有装有治疗药物的可生物降解电极安装垫的临时医用引线的方法

    公开(公告)号：US06748653B2

    公开(公告)日：2004-06-15

    申请号：US09947433

    申请日：2001-09-07

    申请人： Fredric W. Lindemans ,  Ursula Gebhardt ,  Marc Hendriks

    发明人： Fredric W. Lindemans ,  Ursula Gebhardt ,  Marc Hendriks

    IPC分类号： H05K1300

    CPC分类号： A61N1/0587 ,  Y10T29/49147 ,  Y10T29/49169 ,  Y10T29/49174 ,  Y10T29/49208

    摘要： A method of making a temporary medical electrical lead for pacing or defibrillating a heart of a patient. The method comprises providing at least one electrical conductor having proximal and distal ends; providing an insulating sheath formed of biocompatible material extending over and covering at least portions of the at least one electrical conductor, attaching an electrical connector assembly to the proximal end of the at least one electrical conductor for attachment to a device capable of providing pacing or defibrillation pulses; providing an electrode mounting pad in the form of a cast matrix structure made of a biodegradable, biocompatible material soluble in human body fluids and having an outer heart non-contacting surface and an inner heart contacting surface, the outer surface being less permeable to passage of body fluids than the inner surface and wherein the inner surface of the pad has larger interstices and is less dense than the outer surface; providing a drug for treating for treating a medical condition of the patient's heart; loading the drug into the matrix of the pad; and attaching at least portions of the distal end of the at least one electrical conductor or of the electrode member to the electrode mounting pad.

    摘要翻译： 制造用于起搏或除颤患者心脏的临时医用电线的方法。 该方法包括提供至少一个具有近端和远端的电导体; 提供由生物相容性材料形成的绝缘护套，所述绝缘护套由所述至少一个电导体的至少一部分延伸并覆盖所述至少一个电导体的至少一部分，将电连接器组件附接到所述至少一个电导体的近端以附接到能够提供起搏或除颤的装置 脉冲 提供由可溶于人体液体的可生物降解的生物相容性材料制成的铸造基质结构形式的电极安装垫，并且具有外部心脏非接触表面和内部心脏接触表面，所述外部表面对于通过 体液比内表面多，并且其中垫的内表面具有较大的间隙并且密度小于外表面; 提供用于治疗患者心脏的医疗状况的药物; 将药物加载到垫的基质中; 以及将所述至少一个电导体或所述电极构件的远端的至少一部分附接到所述电极安装垫。

    Method for improving the biocompatibility of solid surfaces
    5.
    发明授权
    Method for improving the biocompatibility of solid surfaces 失效
    提高固体表面生物相容性的方法

    公开(公告)号：US5350800A

    公开(公告)日：1994-09-27

    申请号：US5711

    申请日：1993-01-19

    申请人： Michel Verhoeven ,  Patrick Cahalan ,  Linda Cahalan ,  Marc Hendriks ,  Benedicte Foache

    发明人： Michel Verhoeven ,  Patrick Cahalan ,  Linda Cahalan ,  Marc Hendriks ,  Benedicte Foache

    IPC分类号： A61L27/00 ,  A61L29/00 ,  A61L33/00 ,  A61L33/10 ,  A61F2/54 ,  A61F2/02 ,  A61K9/22

    CPC分类号： A61L33/0029 ,  A61L33/0041 ,  A61L33/0047 ,  A61L33/0088

    摘要： A method for attaching a biomolecule having a plurality of carboxyl groups to an aminated solid surface by reacting the biomolecule with a carbodiimide to effect an activation of the carboxyl groups of the biomolecule, reacting the carbodiimide activated biomolecule with the solid surface to covalently bind the biomolecule to the aminated solid surface, and then selectively restoring carboxyl groups to the biomolecule. The selective restoration of carboxyl groups can be carried out by mild hydrolysis and restores the functionality of the biomolecule. The method is "selective" since the bonds between the biomolecule and the aminated solid surface remain intact.

    摘要翻译： 通过使生物分子与碳二亚胺反应以使生物分子的羧基活化，使碳二亚胺活化的生物分子与固体表面反应，使生物分子共价结合，将具有多个羧基的生物分子连接到胺化的固体表面上的方法 到胺化的固体表面，然后选择性地将羧基还原成生物分子。 羧基的选择性还原可以通过温和的水解进行，并恢复生物分子的功能。 该方法是“选择性的”，因为生物分子和胺化的固体表面之间的键保持完整。

    Temporary medical electrical lead having biodegradable electrode mounting pad loaded with therapeutic drug
    7.
    发明授权
    Temporary medical electrical lead having biodegradable electrode mounting pad loaded with therapeutic drug 失效
    临时医用电线，具有装有治疗药物的可生物降解的电极安装垫

    公开(公告)号：US06385491B1

    公开(公告)日：2002-05-07

    申请号：US09411837

    申请日：1999-10-04

    申请人： Fredric W. Lindemans ,  Ursula Gebhardt ,  Marc Hendriks

    发明人： Fredric W. Lindemans ,  Ursula Gebhardt ,  Marc Hendriks

    IPC分类号： A61N100

    CPC分类号： A61N1/0587 ,  Y10T29/49147 ,  Y10T29/49169 ,  Y10T29/49174 ,  Y10T29/49208

    摘要： A temporary cardiac electrical stimulating lead comprises a stimulating electrode mounted in or on a biodegradable electrode mounting pad disposed at a distal end of the lead. The electrode mounting pad is capable of biodegradably dissolving over time in human body fluids and is loaded with a drug for therapeutically treating a medical condition of a patient's heart. The electrode mounting pad may be loaded with any of a variety of different drugs, such anti-arrhythmia or anti-inflammatory drugs. When the lead body is pulled away from the electrode mounting pad and removed from the patient, any portion of the electrode mounting pad remaining within the patient dissolves over time and disappears.

    摘要翻译： 临时心电刺激引线包括安装在设置在引线的远端的可生物降解的电极安装垫中或上的刺激电极。 电极安装垫能够随着时间而生物降解地溶解在人体液中，并且装载有用于治疗性地治疗患者心脏的病症的药物。 电极安装垫可以装载各种不同药物中的任何一种，例如抗心律不齐或抗炎药。 当引线体被拉离电极安装垫并从患者身上取下时，残留在患者内的电极安装垫的任何部分随时间而溶解并消失。

    Biocompatible medical lead
    9.
    发明授权
    Biocompatible medical lead 失效
    生物相容性医用铅

    公开(公告)号：US5741319A

    公开(公告)日：1998-04-21

    申请号：US379423

    申请日：1995-01-27

    申请人： Jean Woloszko ,  Patrick T. Cahalan ,  Marc Hendriks ,  Michel Verhoeven

    发明人： Jean Woloszko ,  Patrick T. Cahalan ,  Marc Hendriks ,  Michel Verhoeven

    IPC分类号： A61N1/05 ,  A61N1/365

    CPC分类号： A61N1/0556

    摘要： A medical lead having a lead body and a biocompatible cuff and especially suitable for use as a nerve electrode. In the preferred bipolar embodiment the lead body has two conductors running therethrough. The distal end is coupled to a pulse generator, the proximal end is coupled to the biocompatible cuff. The biocompatible cuff is cylindrical and is constructed from collagen. Preferably the collagen is multi-layer, i.e. the first portion is cross-linked to an amount greater than the second portion. Through such a construction the collagen promotes tissue ingrowth in the region proximate a nerve and does not permit tissue ingrowth in the region away from the nerve, e.g. the exterior of the cuff.

    摘要翻译： 一种具有铅体和生物相容性袖带的医用铅，特别适用于神经电极。 在优选的双极实施例中，引线体具有穿过其中的两个导体。 远端连接到脉冲发生器，近端连接到生物相容的袖带。 生物相容的袖口是圆柱形的，由胶原构成。 优选地，胶原蛋白是多层的，即第一部分交联到大于第二部分的量。 通过这样的结构，胶原蛋白促进组织在靠近神经的区域向内生长，并且不允许组织向远离神经的区域向内生长，例如， 袖口的外观。

    Method for making heparinized biomaterials
    10.
    发明授权
    Method for making heparinized biomaterials 失效
    制备肝素化生物材料的方法

    公开(公告)号：US5679659A

    公开(公告)日：1997-10-21

    申请号：US518084

    申请日：1995-08-22

    申请人： Michel Verhoeven ,  Linda L. Cahalan ,  Marc Hendriks ,  Benedicte Fouache ,  Patrick T. Cahalan

    发明人： Michel Verhoeven ,  Linda L. Cahalan ,  Marc Hendriks ,  Benedicte Fouache ,  Patrick T. Cahalan

    IPC分类号： A61L33/10 ,  A61L33/00 ,  A61K31/725 ,  C08B37/10

    CPC分类号： A61L33/0011 ,  A61L33/0023 ,  A61L33/0029 ,  Y10S623/921

    摘要： An improved method of making a medical device having immobilized heparin on a blood-contacting surface in which heparin is admixed with sufficient periodate to react with not more than two sugar units per heparin molecule in a buffer solution having a pH in the range of about 4.5-8. This mixture is reacted for at least 3 hours while protected from light and is then applied to the immobilized amine groups. This is an improvement over the prior art methods which included using an excess of periodate and then stopping the reaction at a desired point by the addition of glycerol since the conversion of only a few of the natural functional groups to aldehydes better preserves the antithrombotic bioeffectiveness of the heparin molecules bound to the surface. The invention also avoids the prior art steps of drying and reconstituting the heparin by providing a reacted mixture of heparin and periodate that can be stored as a stable liquid and applied directly to the aminated surface several days later.

    摘要翻译： 在血液接触表面上制备具有固定化肝素的医疗装置的改进方法，其中将肝素与足够的高碘酸盐混合以在pH为约4.5的缓冲溶液中每个肝素分子与不超过两个糖单元反应 -8。 将该混合物反应至少3小时，同时保护光，然后将其施加到固定的胺基上。 这是相对于现有技术的方法的改进，其包括使用过量的高碘酸盐，然后通过加入甘油在期望点停止反应，因为仅将少数天然官能团转化为醛更好地保持抗血栓生物效力 肝素分子与表面结合。 本发明还避免了通过提供肝素和高碘酸盐的反应混合物来干燥和重构肝素的现有技术步骤，其可以作为稳定液体储存并在几天后直接施用于胺化表面。