3-D interconnected multi-layer microstructure of thermoplastic materials
    2.
    发明授权
    3-D interconnected multi-layer microstructure of thermoplastic materials 失效
    3-D互连多层微结构的热塑性材料

    公开(公告)号:US07557051B2

    公开(公告)日:2009-07-07

    申请号:US11078907

    申请日:2005-03-11

    IPC分类号: H01L21/00 B29C45/00

    摘要: Methods for compression molding through holes in polymer layers are provided, as are the resulting patterned polymer layers. Two key aspects of the invention are provision of a mold and substrate having different mechanical hardness, and provision of room for local flow of material. These aspects of the invention facilitate formation of through holes by compression molding that are not blocked or partially blocked by undesirable material. These polymer layers can be formed into three dimensional patterned structures by bonding patterned layers together. Since the layers include through holes, a three-dimensional polymer pattern can be formed. These patterned polymer layers and three dimensionally patterned polymer constructs have a wide variety of applications. For example, these constructs can be used for fabrication of micro-fluidic devices, and/or can be used for various medical and biological applications including drug delivery devices and tissue engineering devices.

    摘要翻译: 提供了聚合物层中的孔的压缩模塑方法,以及所形成的图案化聚合物层。 本发明的两个关键方面是提供具有不同机械硬度的模具和基材,并提供用于局部流动材料的空间。 本发明的这些方面有助于通过压缩成型形成未被不期望的材料阻挡或部分阻挡的通孔。 这些聚合物层可以通过将图案化层结合在一起而形成三维图案化结构。 由于层包括通孔,因此可以形成三维聚合物图案。 这些图案化的聚合物层和三维图案化的聚合物构造物具有广泛的应用。 例如,这些构建体可用于制造微流体装置,和/或可用于各种医疗和生物应用,包括药物递送装置和组织工程装置。

    Antibiotic bonding of vascular prostheses and other implants
    6.
    发明授权
    Antibiotic bonding of vascular prostheses and other implants 失效
    血管假体和其他植入物的抗生素结合

    公开(公告)号:US4442133A

    公开(公告)日:1984-04-10

    申请号:US351324

    申请日:1982-02-22

    摘要: A method of preparing a surgical vascular graft wherein a length of graft material carries an absorbed coating of tridodecyl methyl ammonium chloride (TDMAC) surfactant and an antibiotic bound thereto. A length of graft material such as polytetrafluoroethylene or Dacron is soaked in a 5% by weight solution of TDMAC for 30 minutes at room temperature, air dried and then washed in distilled water to remove excess TDMAC. The graft carrying the absorbed cationic TDMAC surfactant coating is incubated in a solution of negatively charged antibiotic for one hour, washed in sterile water to remove unbound antibiotic and stored for use in the operating room.

    摘要翻译: 一种制备手术血管移植物的方法,其中一段长度的移植材料携带十三烷基甲基氯化铵(TDMAC)表面活性剂和与之结合的抗生素的吸收涂层。 将诸如聚四氟乙烯或涤纶的接枝材料的长度在室温下浸泡在5%重量的TDMAC溶液中30分钟,空气干燥,然后在蒸馏水中洗涤以除去过量的TDMAC。 将携带吸收的阳离子TDMAC表面活性剂涂层的移植物在带负电荷的抗生素溶液中​​孵育1小时,在无菌水中洗涤以除去未结合的抗生素并储存以用于手术室。