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1.
公开(公告)号:US07444856B2
公开(公告)日:2008-11-04
申请号:US11233677
申请日:2005-09-22
申请人: Friedrich B. Prinz , Ye Tao , Rainer J. Fasching , Ralph S. Greco , Kyle Hammerick , Robert Lane Smith
发明人: Friedrich B. Prinz , Ye Tao , Rainer J. Fasching , Ralph S. Greco , Kyle Hammerick , Robert Lane Smith
CPC分类号: G01Q60/02 , G01Q60/38 , G01Q60/60 , Y10S977/86 , Y10S977/869 , Y10S977/875
摘要: Sensors and systems for electrical, electrochemical, or topographical analysis, as well as methods of fabricating these sensors are provided. The sensors include a cantilever and one or more probes, each of which has an electrode at its tip. The tips of the probes are sharp, with a radius of curvature of less than about 50 nm. In addition, the probes have a high aspect ratio of more than about 19:1. The sensors are suitable for both Atomic Force Microscopy and Scanning Electrochemical Microscopy.
摘要翻译: 提供了用于电气,电化学或地形分析的传感器和系统,以及制造这些传感器的方法。 传感器包括悬臂和一个或多个探针,每个探针在其尖端具有电极。 探针的尖端是锋利的,其曲率半径小于约50nm。 此外,探针的高纵横比大于约19:1。 传感器适用于原子力显微镜和扫描电化学显微镜。
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2.
公开(公告)号:US07557051B2
公开(公告)日:2009-07-07
申请号:US11078907
申请日:2005-03-11
申请人: WonHyoung Ryu , Seoung Jai Bai , Kyle Hammerick , Robert Lane Smith , Ralph S. Greco , Friedrich B. Prinz , Rainer J. Fasching
发明人: WonHyoung Ryu , Seoung Jai Bai , Kyle Hammerick , Robert Lane Smith , Ralph S. Greco , Friedrich B. Prinz , Rainer J. Fasching
CPC分类号: B29C43/021 , B01L3/5027 , B01L3/5085 , B29C33/0033 , B29C33/424 , B29C43/003 , B29C59/02 , B29C59/022 , B29C59/04 , B29C2043/025 , B29C2043/463 , B29C2043/5883 , B29C2059/023 , B29L2031/7532
摘要: Methods for compression molding through holes in polymer layers are provided, as are the resulting patterned polymer layers. Two key aspects of the invention are provision of a mold and substrate having different mechanical hardness, and provision of room for local flow of material. These aspects of the invention facilitate formation of through holes by compression molding that are not blocked or partially blocked by undesirable material. These polymer layers can be formed into three dimensional patterned structures by bonding patterned layers together. Since the layers include through holes, a three-dimensional polymer pattern can be formed. These patterned polymer layers and three dimensionally patterned polymer constructs have a wide variety of applications. For example, these constructs can be used for fabrication of micro-fluidic devices, and/or can be used for various medical and biological applications including drug delivery devices and tissue engineering devices.
摘要翻译: 提供了聚合物层中的孔的压缩模塑方法,以及所形成的图案化聚合物层。 本发明的两个关键方面是提供具有不同机械硬度的模具和基材,并提供用于局部流动材料的空间。 本发明的这些方面有助于通过压缩成型形成未被不期望的材料阻挡或部分阻挡的通孔。 这些聚合物层可以通过将图案化层结合在一起而形成三维图案化结构。 由于层包括通孔,因此可以形成三维聚合物图案。 这些图案化的聚合物层和三维图案化的聚合物构造物具有广泛的应用。 例如,这些构建体可用于制造微流体装置,和/或可用于各种医疗和生物应用,包括药物递送装置和组织工程装置。
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公开(公告)号:US4749585A
公开(公告)日:1988-06-07
申请号:US850848
申请日:1986-04-11
CPC分类号: A61L27/54 , A61K9/127 , A61L33/0017 , A61L33/0047 , A61L2300/406 , A61L2300/606 , A61L2300/626 , A61L2300/802 , Y10T428/31544 , Y10T428/31678
摘要: There is disclosed an improved prosthesis coated, respectively, with an ionic surfactant, an antibiotic and/or antithrombiotic agent and treated with an immobilizing ionic exchange compound, to remove un-antibiotic bound ionic surfactant. The drug may be encapsulated within phospholipid vesicles which are bound to the prosthesis.
摘要翻译: 公开了一种改进的假体,分别用离子表面活性剂,抗生素和/或抗血栓生物剂涂覆并用固定的离子交换化合物处理以去除未抗生素结合的离子表面活性剂。 药物可以包封在与假体结合的磷脂囊泡内。
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公开(公告)号:US4879135A
公开(公告)日:1989-11-07
申请号:US220503
申请日:1988-07-18
IPC分类号: A61L27/54
CPC分类号: A61L27/54 , A61L2300/254 , A61L2300/406 , A61L2300/42 , A61L2300/606 , A61L2300/802
摘要: There is disclosed an improved prosthesis coated, respectively, with an anionic surfactant, a drug such as an antibiotic and/or antithrombotic agent. Optionally, the coated prosthesis may be treated with an ion exchange compound, to remove un-drug bound anionic surfactant. The drug is bound directly to the surfactant coated prosthesis.
摘要翻译: 公开了分别用阴离子表面活性剂,药物如抗生素和/或抗血栓形成剂涂覆的改进的假体。 任选地,涂覆的假体可以用离子交换化合物处理,以去除未药物结合的阴离子表面活性剂。 药物直接与表面活性剂涂覆的假体结合。
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公开(公告)号:US4740382A
公开(公告)日:1988-04-26
申请号:US633615
申请日:1984-07-23
CPC分类号: A61L27/54 , A61L2300/406 , A61L2300/606 , A61L2300/802 , Y10S273/04 , Y10S273/09 , Y10T428/31544
摘要: There is disclosed an improved prosthesis coated, respectively, with a cationic surfactant, an antibiotic compound and treated with an cationic exchange compound, to remove un-antibiotic bound cationic surfactant.
摘要翻译: 公开了一种改进的假体,其分别用阳离子表面活性剂,抗生素化合物涂覆并用阳离子交换化合物处理,以去除未抗生素结合的阳离子表面活性剂。
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公开(公告)号:US4442133A
公开(公告)日:1984-04-10
申请号:US351324
申请日:1982-02-22
申请人: Ralph S. Greco , Richard A. Harvey
发明人: Ralph S. Greco , Richard A. Harvey
CPC分类号: A61L27/507 , A61L27/16 , A61L27/54 , A61L2300/406 , Y10S623/921
摘要: A method of preparing a surgical vascular graft wherein a length of graft material carries an absorbed coating of tridodecyl methyl ammonium chloride (TDMAC) surfactant and an antibiotic bound thereto. A length of graft material such as polytetrafluoroethylene or Dacron is soaked in a 5% by weight solution of TDMAC for 30 minutes at room temperature, air dried and then washed in distilled water to remove excess TDMAC. The graft carrying the absorbed cationic TDMAC surfactant coating is incubated in a solution of negatively charged antibiotic for one hour, washed in sterile water to remove unbound antibiotic and stored for use in the operating room.
摘要翻译: 一种制备手术血管移植物的方法,其中一段长度的移植材料携带十三烷基甲基氯化铵(TDMAC)表面活性剂和与之结合的抗生素的吸收涂层。 将诸如聚四氟乙烯或涤纶的接枝材料的长度在室温下浸泡在5%重量的TDMAC溶液中30分钟,空气干燥,然后在蒸馏水中洗涤以除去过量的TDMAC。 将携带吸收的阳离子TDMAC表面活性剂涂层的移植物在带负电荷的抗生素溶液中孵育1小时,在无菌水中洗涤以除去未结合的抗生素并储存以用于手术室。
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