公开(公告)号：US20140203189A1

公开(公告)日：2014-07-24

申请号：US14222160

申请日：2014-03-21

Applicant: GEN-PROBE INCORPORATED

Inventor： Robert E. HEINZ ,  Dennis NEWELL ,  David OPALSKY ,  Jason RHUBOTTOM

IPC: G01N21/64

CPC classification number: G01N21/6486 ,  G01N21/6428

Abstract: Systems and method for detecting optical signals, and for discriminating optical signals emitted by an emission moiety that is excited by an associated excitation signal from background signals and other optical noise, employing digital techniques for determining the portion of a detected optical signal having a modulation frequency corresponding to a modulation of the associated excitation signal.

Abstract translation: 用于检测光信号的系统和方法，以及用于鉴别由背景信号和其它光学噪声的相关联激励信号激发的发射部分发射的光信号，并采用数字技术确定检测到的具有调制频率的光信号的部分 对应于相关激励信号的调制。

公开(公告)号：US20170261431A1

公开(公告)日：2017-09-14

申请号：US15600245

申请日：2017-05-19

Applicant: GEN-PROBE INCORPORATED

Inventor： Gary D. LAIR ,  Thanh N. NGUYEN ,  Haitao LI ,  Florence LI ,  Byron J. KNIGHT ,  Robert E. HEINZ ,  Jerzy A. MACIOSZEK ,  Christopher B. DAVIS ,  Robert F. SCALESE

IPC: G01N21/64 ,  G01N35/02 ,  C12Q1/68 ,  G01N35/10 ,  G01N21/76 ,  G01N35/00 ,  G01N35/04

CPC classification number: G01N21/6428 ,  B01L7/52 ,  C12Q1/6813 ,  C12Q1/6851 ,  G01N21/6454 ,  G01N21/76 ,  G01N35/00693 ,  G01N35/0092 ,  G01N35/0098 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/026 ,  G01N35/028 ,  G01N35/04 ,  G01N35/1002 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2035/00346 ,  G01N2035/00356 ,  G01N2035/00524 ,  G01N2035/0097 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0455 ,  G01N2035/0491 ,  G01N2035/103 ,  G01N2201/0415 ,  Y10S435/808 ,  Y10S435/809 ,  Y10T436/113332 ,  Y10T436/25 ,  C12Q2537/165

Abstract: A continuous process for performing multiple nucleic acid amplification assays, where at least a portion of a second subset of reaction mixtures are transferred to a heater while a first subset of reaction mixtures are being subjected to conditions for performing a nucleic acid amplification assay. During the process, a plurality of reaction mixtures from the first and second subsets of reaction mixtures are simultaneously subjected to conditions sufficient to perform multiple nucleic acid amplification assays in the reaction mixtures. The presence or absence of a target nucleic acid in the first subset of reaction mixtures is determined while the reaction mixtures are in the heater.

公开(公告)号：US20140203192A1

公开(公告)日：2014-07-24

申请号：US14222180

申请日：2014-03-21

Applicant: Gen-Probe Incorporated

Inventor： Robert E. HEINZ ,  Dennis NEWELL ,  David OPALSKY ,  Jason RHUBOTTOM

IPC: G01N21/64

CPC classification number: G01N21/6486 ,  G01N21/6428

Abstract: Systems and method for detecting optical signals, and for discriminating optical signals emitted by an emission moiety that is excited by an associated excitation signal from background signals and other optical noise, employing digital techniques for determining the portion of a detected optical signal having a modulation frequency corresponding to a modulation of the associated excitation signal.

公开(公告)号：US20190049378A1

公开(公告)日：2019-02-14

申请号：US16014139

申请日：2018-06-21

Applicant: GEN-PROBE INCORPORATED

Inventor： Gary D. LAIR ,  Thanh N. NGUYEN ,  Haitao LI ,  Florence LI ,  Byron J. KNIGHT ,  Robert E. HEINZ ,  Jerzy A. MACIOSZEK ,  Christopher B. DAVIS ,  Robert F. SCALESE

IPC: G01N21/64 ,  G01N35/04 ,  G01N35/10 ,  C12Q1/6813 ,  C12Q1/6851 ,  G01N21/76 ,  G01N35/02 ,  G01N35/00 ,  B01L7/00

Abstract: A method of determining the presence or amount of a target nucleic acid in each of a plurality of reaction mixtures. In the method, a first plurality of reaction mixtures are provided to a heater and subjected to conditions for performing a first amplification reaction. The presence or amount of a first target nucleic acid in each of the first plurality of reaction mixtures is determined during the first amplification reaction. During the first amplification reaction, a second plurality of reaction mixtures are provided to the heater and subjected to conditions for performing a second amplification reaction. The presence or amount of a second target nucleic acid in each of the second plurality of reaction mixtures is determined during the second amplification reaction. At least a portion of the second plurality of reaction mixtures are removed from the heater during the second amplification reaction.