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公开(公告)号：US20180195050A1
公开(公告)日：2018-07-12
申请号：US15910525
申请日：2018-03-02
申请人： Genelux Corporation
发明人： Aladar A. SZALAY , Alexa Frentzen , Yong A. Yu , Nanhai Chen , Qian Zhang
IPC分类号： C12N7/00 , G01N33/58 , A61K9/00 , C12Q1/04 , G01N33/574 , A61K31/282 , A61K31/4745 , A61K31/7068 , A61K33/24 , A61K35/76 , A61K38/17 , A61K38/20 , A61K38/36 , A61K38/48 , A61K39/12 , A61K39/285 , A61K39/395 , A61K45/06 , A61K48/00 , A61K49/00 , C12N15/86 , C07K16/22 , C07K14/715 , C07K14/54 , C07K14/47 , C07K14/005 , A61K49/18 , A61K49/14 , A61K39/00
摘要： Modified viruses and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including cancer, and as anti-tumor and/or antiangiogenic agents. The viruses also can be used in diagnostic methods.
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公开(公告)号：US09492534B2
公开(公告)日：2016-11-15
申请号：US14301813
申请日：2014-06-11
申请人： GENELUX CORPORATION
发明人： Aladar A. Szalay , Tatyana Timiryasova , Yong A. Yu , Qian Zhang
IPC分类号： A61K39/285 , A61K35/768 , C12P19/34 , A61K35/744 , C12P21/02 , C12N7/00 , C07K16/40 , A61K35/74 , C07K16/30 , C12N15/86 , A61K39/00 , A61K48/00
CPC分类号： A61K39/285 , A61K9/0019 , A61K35/74 , A61K35/744 , A61K35/768 , A61K39/00 , A61K45/06 , A61K48/00 , A61K2039/5254 , A61K2039/5256 , C07K16/30 , C07K16/40 , C12N7/00 , C12N15/86 , C12N2710/24132 , C12N2710/24134 , C12N2710/24143 , C12N2710/24161 , C12P19/34 , C12P21/02 , Y02A50/472
摘要： Therapeutic methods and vaccinia virus therefor are provided. The viruses are designed so that they accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. Combinations of the viruses and anti-cancer agents and uses thereof for treating cancer also are provided.
摘要翻译： 提供了治疗方法和痘苗病毒。 这些病毒被设计成与其他组织，细胞和器官相比，它们在免疫缺陷组织和细胞中积累，例如在肿瘤和其他增殖组织和发炎组织中，使得它们对宿主生物体具有较低的毒性。 还提供了病毒和抗癌剂的组合及其用于治疗癌症的用途。
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公开(公告)号：US20230008052A1
公开(公告)日：2023-01-12
申请号：US17466381
申请日：2021-09-03
申请人： GENELUX CORPORATION
发明人： Aladar A. SZALAY , Nanhai G. Chen , Yong A. Yu , Qian Zhang
IPC分类号： C12N7/00 , A61K35/768 , C07K16/22
摘要： Clonal strains of vaccinia viruses are provided. Also provided are methods of identifying and isolating attenuated and oncolytic clonal strains from virus preparations. Modified recombinant forms of the clonal strains also are provided. The clonal strains and virus preparations can be used for diagnostic and therapeutic methods, in particular for therapy and diagnosis or monitoring treatment of proliferative disorders, including neoplastic diseases, such as, but are not limited to, solid tumors and blood cancers.
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公开(公告)号：US10463730B2
公开(公告)日：2019-11-05
申请号：US15331742
申请日：2016-10-21
申请人： GENELUX CORPORATION
发明人： Aladar A. Szalay , Tatyana Timiryasova , Yong A. Yu , Qian Zhang
IPC分类号： A61K39/285 , A61K35/74 , C07K16/30 , C07K16/40 , C12N7/00 , A61K35/744 , C12N15/86 , C12P19/34 , C12P21/02 , A61K35/768 , A61K9/00 , A61K45/06 , A61K39/00 , A61K48/00
摘要： Therapeutic methods and vaccinia virus therefor are provided. The viruses are designed so that they accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. Combinations of the viruses and anti-cancer agents and uses thereof for treating cancer also are provided.
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公开(公告)号：US10584317B2
公开(公告)日：2020-03-10
申请号：US15910525
申请日：2018-03-02
申请人： Genelux Corporation
发明人： Aladar A. Szalay , Alexa Frentzen , Yong A. Yu , Nanhai Chen , Qian Zhang
IPC分类号： C12N7/00 , A61K39/12 , A61K38/48 , A61K9/00 , A61K31/282 , A61K31/4745 , A61K31/7068 , A61K33/24 , A61K38/17 , A61K38/20 , A61K39/285 , A61K45/06 , A61K48/00 , A61K49/00 , A61K49/14 , A61K49/18 , C07K14/005 , C07K14/54 , C07K16/22 , C12N15/86 , C12Q1/04 , G01N33/574 , G01N33/58 , A61K38/36 , A61K35/76 , A61K39/395 , C07K14/47 , C07K14/715 , A61K39/00
摘要： Modified viruses and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including cancer, and as anti-tumor and/or antiangiogenic agents. The viruses also can be used in diagnostic methods.
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公开(公告)号：US09944903B2
公开(公告)日：2018-04-17
申请号：US14638604
申请日：2015-03-04
申请人： Genelux Corporation
发明人： Aladar A. Szalay , Alexa Frentzen , Yong A. Yu , Nanhai Chen , Qian Zhang
IPC分类号： C12N7/00 , A61K9/00 , A61K31/282 , A61K31/4745 , A61K31/7068 , A61K33/24 , A61K38/17 , A61K38/20 , A61K39/285 , A61K45/06 , A61K48/00 , A61K49/00 , A61K49/14 , A61K49/18 , C07K14/005 , C07K14/54 , C07K16/22 , C12N15/86 , C12Q1/04 , G01N33/574 , G01N33/58 , A61K38/48 , A61K38/36 , A61K35/76 , A61K39/12 , A61K39/395 , C07K14/47 , C07K14/715 , A61K39/00
CPC分类号： C12N7/00 , A61K9/0019 , A61K31/282 , A61K31/4745 , A61K31/7068 , A61K33/24 , A61K35/76 , A61K38/1709 , A61K38/1793 , A61K38/20 , A61K38/204 , A61K38/36 , A61K38/484 , A61K39/12 , A61K39/285 , A61K39/3955 , A61K45/06 , A61K48/00 , A61K48/0058 , A61K49/0008 , A61K49/0045 , A61K49/0047 , A61K49/0097 , A61K49/14 , A61K49/1896 , A61K2039/523 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C07K14/47 , C07K14/54 , C07K14/5412 , C07K14/7155 , C07K16/22 , C07K2317/622 , C07K2317/73 , C07K2319/00 , C07K2319/20 , C07K2319/60 , C07K2319/61 , C07K2319/74 , C12N15/86 , C12N2710/14171 , C12N2710/24121 , C12N2710/24122 , C12N2710/24132 , C12N2710/24141 , C12N2710/24143 , C12N2710/24162 , C12Q1/04 , G01N33/574 , G01N33/585
摘要： Modified viruses and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including cancer, and as anti-tumor and/or antiangiogenic agents. The viruses also can be used in diagnostic methods.
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公开(公告)号：US20170095552A1
公开(公告)日：2017-04-06
申请号：US15331742
申请日：2016-10-21
申请人： GENELUX CORPORATION
发明人： Aladar A. SZALAY , Tatyana Timiryasova , Yong A. Yu , Qian Zhang
IPC分类号： A61K39/285 , A61K45/06 , A61K9/00
CPC分类号： A61K39/285 , A61K9/0019 , A61K35/74 , A61K35/744 , A61K35/768 , A61K39/00 , A61K45/06 , A61K48/00 , A61K2039/5254 , A61K2039/5256 , C07K16/30 , C07K16/40 , C12N7/00 , C12N15/86 , C12N2710/24132 , C12N2710/24134 , C12N2710/24143 , C12N2710/24161 , C12P19/34 , C12P21/02
摘要： Therapeutic methods and vaccinia virus therefor are provided. The viruses are designed so that they accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. Combinations of the viruses and anti-cancer agents and uses thereof for treating cancer also are provided.
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8.发明申请公开(公告)号：US20150175976A1
公开(公告)日：2015-06-25
申请号：US14638604
申请日：2015-03-04
申请人： Genelux Corporation
发明人： Aladar A. Szalay , Alexa Frentzen , Yong A. Yu , Nanhai Chen , Qian Zhang
IPC分类号： C12N7/00 , C07K14/54 , C07K14/47 , A61K35/76 , A61K38/20 , A61K38/17 , A61K39/395 , A61K45/06 , C07K14/715 , C07K16/22
CPC分类号： C12N7/00 , A61K9/0019 , A61K31/282 , A61K31/4745 , A61K31/7068 , A61K33/24 , A61K35/76 , A61K38/1709 , A61K38/1793 , A61K38/20 , A61K38/204 , A61K38/36 , A61K38/484 , A61K39/12 , A61K39/285 , A61K39/3955 , A61K45/06 , A61K48/00 , A61K48/0058 , A61K49/0008 , A61K49/0045 , A61K49/0047 , A61K49/0097 , A61K49/14 , A61K49/1896 , A61K2039/523 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C07K14/47 , C07K14/54 , C07K14/5412 , C07K14/7155 , C07K16/22 , C07K2317/622 , C07K2317/73 , C07K2319/00 , C07K2319/20 , C07K2319/60 , C07K2319/61 , C07K2319/74 , C12N15/86 , C12N2710/14171 , C12N2710/24121 , C12N2710/24122 , C12N2710/24132 , C12N2710/24141 , C12N2710/24143 , C12N2710/24162 , C12Q1/04 , G01N33/574 , G01N33/585
摘要： Modified viruses and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including cancer, and as anti-tumor and/or antiangiogenic agents. The viruses also can be used in diagnostic methods.
摘要翻译： 提供了修饰的病毒和用于制备修饰病毒的方法。 提供含有病毒的疫苗。 病毒可以用于治疗诸如增殖性和炎性疾病（包括癌症）的疾病的方法，以及作为抗肿瘤和/或抗血管生成剂。 病毒也可用于诊断方法。
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