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公开(公告)号：US20160147056A1
公开(公告)日：2016-05-26
申请号：US14550187
申请日：2014-11-21
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Alex David Corwin , Kevin Bernard Kenny , Christine Lynne Pitner
IPC: G02B21/34
CPC classification number: G02B21/34 , B01L9/52 , B01L2200/025 , B01L2300/0822 , G02B27/32
Abstract: The invention provides a slide holder that utilizes edge detection algorithms to determine the location of various edges of a slide. From these edges, and integrating characteristic slide dimension, both linear offset of the edge of the slide in the holder and any rotation of the slide relative to the microscope stage axis are determined. The process of using the slide holder of the invention ensures precise and accurate placement of a slide during a first round of imaging and for reload in subsequent rounds.
Abstract translation: 本发明提供了一种利用边缘检测算法来确定幻灯片的各种边缘的位置的滑块架。 从这些边缘，并整合特征滑动尺寸，确定支架中滑块边缘的线性偏移和滑块相对于显微镜载物台轴线的任何旋转。 使用本发明的滑块保持器的过程确保在第一轮成像期间精确和准确地放置滑块，并在随后的回合中重新加载。
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公开(公告)号：US20160061654A1
公开(公告)日：2016-03-03
申请号：US14469362
申请日：2014-08-26
Applicant: GENERAL ELECTRIC COMPANY
CPC classification number: G01J1/0228 , G01N21/274 , G01N21/64 , G01N21/6458 , G02B21/365
Abstract: Approaches are disclosed for calibrating a plurality of imaging devices, such as microscopes. In certain implementations, a calibration plate is employed that include a variety of calibration features. Imaging devices calibrated in accordance with the present approaches may be used to generate images having consistent attributes, such as brightness, regardless of which imaging device is employed.
Abstract translation: 公开了用于校准诸如显微镜的多个成像装置的方法。 在某些实施方案中，采用包括各种校准特征的校准板。 根据本方法校准的成像装置可用于生成具有一致属性（例如亮度）的图像，而不管采用何种成像装置。
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公开(公告)号：US09581800B2
公开(公告)日：2017-02-28
申请号：US14550187
申请日：2014-11-21
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Alex David Corwin , Kevin Bernard Kenny , Christine Lynne Pitner
CPC classification number: G02B21/34 , B01L9/52 , B01L2200/025 , B01L2300/0822 , G02B27/32
Abstract: The invention provides a slide holder that utilizes edge detection algorithms to determine the location of various edges of a slide. From these edges, and integrating characteristic slide dimension, both linear offset of the edge of the slide in the holder and any rotation of the slide relative to the microscope stage axis are determined. The process of using the slide holder of the invention ensures precise and accurate placement of a slide during a first round of imaging and for reload in subsequent rounds.
Abstract translation: 本发明提供了一种利用边缘检测算法来确定幻灯片的各种边缘的位置的滑块架。 从这些边缘，并整合特征滑动尺寸，确定支架中滑块边缘的线性偏移和滑块相对于显微镜载物台轴线的任何旋转。 使用本发明的滑块保持器的过程确保在第一轮成像期间精确和准确地放置滑块，并在随后的回合中重新加载。
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公开(公告)号：US09176032B2
公开(公告)日：2015-11-03
申请号：US13786747
申请日：2013-03-06
Applicant: General Electric Company
Inventor： Anup Sood , Kevin Bernard Kenny , Arunkumar Natarajan , Lakshmi Sireesha Kaanumalle
IPC: G01N33/53 , G01N33/532 , G01N33/533 , G01N21/76 , G01N1/30 , G01N33/58 , G01N21/64
CPC classification number: G01N1/30 , G01N21/64 , G01N21/6428 , G01N33/582
Abstract: Methods comprising the use probing multiple targets in a H&E stained biological sample are provided. The methods include the steps of providing a hematoxylin and eosin stained biological sample containing multiple targets, observing the sample, removing the hematoxylin and partially removing the eosin by washing the sample, contacting the sample with a borate salt, and irradiating the sample to remove the residual eosin fluorescence. The method further includes the optionally performing the additional steps of binding at least one probe to one or more targets to the sample, observing a signal from the probe and contacting the sample with a bleaching agent. The process of binding, observing and bleaching may be iteratively repeated.
Abstract translation: 提供了包括在H＆E染色的生物样品中使用探测多个靶标的方法。 所述方法包括以下步骤：提供含有多个靶标的苏木精和伊红染色的生物样品，观察样品，除去苏木精并通过洗涤样品部分除去曙红，使样品与硼酸盐接触，并照射样品以除去 残余曙红荧光。 该方法还包括任选地执行将至少一个探针结合至样品的一个或多个靶的附加步骤，观察来自探针的信号并使样品与漂白剂接触。 结合，观察和漂白的过程可以迭代地重复。
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公开(公告)号：US20140267671A1
公开(公告)日：2014-09-18
申请号：US13846490
申请日：2013-03-18
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Kevin Bernard Kenny , Alex David Corwin
CPC classification number: G02B21/26 , G06K9/3208 , G06T3/0075 , G06T3/40 , G06T3/60 , G06T7/0012
Abstract: Referencing of image acquired in multiple rounds of imaging is disclosed. In certain implementations, a baseline round of images are acquired and registered to one another to establish a global transformation matrix. In a subsequent round of image acquisition, a limited number of field of view images are initially acquired and registered to the corresponding baseline images to solve for translation, rotation, and scale. The full set of baseline images is then acquired for the subsequent round and each image is pre-rotated and pre-scaled based on the transform determined for the subset of images. The pre-rotated, pre-scaled images are then registered using a translation-only transform.
Abstract translation: 公开了在多轮成像中获取的图像的参考。 在某些实施方式中，获取基线一轮图像并将其相互注册以建立全局变换矩阵。 在随后的一轮图像采集中，初始获取有限数量的视野图像，并将其注册到相应的基线图像，以解决平移，旋转和缩放。 然后针对后续轮次获取完整的基线图像集合，并且基于为图像子集确定的变换来预先旋转和预缩放每个图像。 然后使用仅翻译变换来注册预旋转的预缩放图像。
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Patent Agency Ranking
公开(公告)号：US20130178392A1
公开(公告)日：2013-07-11
申请号：US13786747
申请日：2013-03-06
Applicant: General Electric Company
Inventor： Anup Sood , Kevin Bernard Kenny , Arunkumar Natarajan , Lakshmi Sireesha Kaanumalle
IPC: G01N1/30
CPC classification number: G01N1/30 , G01N21/64 , G01N21/6428 , G01N33/582
Abstract: Methods comprising the use probing multiple targets in a H&E stained biological sample are provided. The methods include the steps of providing a hematoxylin and eosin stained biological sample containing multiple targets, observing the sample, removing the hematoxylin and partially removing the eosin by washing the sample, contacting the sample with a borate salt, and irradiating the sample to remove the residual eosin fluorescence. The method further includes the optionally performing the additional steps of binding at least one probe to one or more targets to the sample ,observing a signal from the probe and contacting the sample with a bleaching agent. The process of binding, observing and bleaching may be iteratively repeated.
Abstract translation: 提供了包括在H＆E染色的生物样品中使用探测多个靶标的方法。 所述方法包括以下步骤：提供含有多个靶标的苏木精和伊红染色的生物样品，观察样品，除去苏木精并通过洗涤样品部分除去曙红，使样品与硼酸盐接触，并照射样品以除去 残余曙红荧光。 该方法还包括任选地执行将至少一个探针结合至样品的一个或多个靶的附加步骤，观察来自探针的信号并使样品与漂白剂接触。 结合，观察和漂白的过程可以迭代地重复。
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公开(公告)号：US09797767B2
公开(公告)日：2017-10-24
申请号：US14469362
申请日：2014-08-26
Applicant: GENERAL ELECTRIC COMPANY
CPC classification number: G01J1/0228 , G01N21/274 , G01N21/64 , G01N21/6458 , G02B21/365
Abstract: Approaches are disclosed for calibrating a plurality of imaging devices, such as microscopes. In certain implementations, a calibration plate is employed that include a variety of calibration features. Imaging devices calibrated in accordance with the present approaches may be used to generate images having consistent attributes, such as brightness, regardless of which imaging device is employed.
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公开(公告)号：US20160069782A1
公开(公告)日：2016-03-10
申请号：US14772305
申请日：2014-03-05
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Anup Sood , Kevin Bernard Kenny , Arunkumar Natarajan , Lakshmi Sireesha Kaanumalle , Elizabeth Mary McDonough
CPC classification number: G01N1/30 , G01N33/5005 , G01N33/582
Abstract: Methods comprising probing multiple targets in an H&E stained biological sample are provided. The methods include the steps of providing a hematoxylin and eosin stained biological sample containing multiple targets, optionally detecting H&E staining of the sample, removing the hematoxylin and eosin signals, and detecting additional features or targets in the biological sample. The detecting step may include performing the steps of binding at least one probe to one or more targets to the sample, detecting a signal from the probe and contacting the sample with a bleaching agent. The process of binding, detecting and bleaching may be iteratively repeated.
Abstract translation: 提供了包括在H＆E染色的生物样品中探测多个靶标的方法。 所述方法包括提供一个苏木精和曙红含有多个目标染色生物样本，任选检测所述样品的H＆E染色，除去苏木精和曙红信号，并且检测生物样品中另外的特征或对象的步骤。 检测步骤可以包括执行中的至少一个探针结合到一个或多个目标的样品中，检测来自探针的信号，并且与漂白剂接触所述样品的步骤。 结合，检测和漂白的过程可以迭代重复。
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公开(公告)号：US10088658B2
公开(公告)日：2018-10-02
申请号：US13846490
申请日：2013-03-18
Applicant: General Electric Company
Inventor： Kevin Bernard Kenny , Alex David Corwin
Abstract: Referencing of image acquired in multiple rounds of imaging is disclosed. In certain implementations, a baseline round of images are acquired and registered to one another to establish a global transformation matrix. In a subsequent round of image acquisition, a limited number of field of view images are initially acquired and registered to the corresponding baseline images to solve for translation, rotation, and scale. The full set of baseline images is then acquired for the subsequent round and each image is pre-rotated and pre-scaled based on the transform determined for the subset of images. The pre-rotated, pre-scaled images are then registered using a translation-only transform.
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公开(公告)号：US09064304B2
公开(公告)日：2015-06-23
申请号：US13846447
申请日：2013-03-18
Applicant: General Electric Company
Inventor： Kevin Bernard Kenny , Megan Pearl Rothney
IPC: G06T7/00
CPC classification number: G06T7/0012 , G06K9/00134 , G06K9/036 , G06T7/0002 , G06T7/37 , G06T2200/32 , G06T2207/30024 , G06T2207/30072
Abstract: Automated assessment of registration quality, focus, and area defects in sequentially acquired images, such as images acquired by a digital microscope, is disclosed. In one embodiment, acquired images are registered and whole-image defects are automatically detected based on a figure of merit generated by the registration process. In related implementations, area defects may be automatically detected by calculating correlations in localized image regions for images acquired in different imaging rounds.
Abstract translation: 公开了对由数字显微镜获取的图像等顺序获取的图像进行注册质量，焦点和区域缺陷的自动评估。 在一个实施例中，记录获取的图像，并且基于由注册过程生成的品质因数来自动检测全图像缺陷。 在相关实现中，可以通过计算在不同成像轮中获取的图像的局部化图像区域中的相关性来自动检测区域缺陷。
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