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公开(公告)号：US11590502B2
公开(公告)日：2023-02-28
申请号：US16459363
申请日：2019-07-01
Applicant: General Electric Company
Inventor： Alex David Corwin , Erik Leeming Kvam , Christine Lynne Surrette , Brian Joseph Scherer , Pei-Hsin Kuo , Ralf Lenigk , Tyler John Hammond
Abstract: The present disclosure relates to a consumable sample partition device and it assembly and use. The sample partition device can be used to test a sample for absence of microorganisms (sterility) and/or for concentration of said organisms (bio-burden). The sample partition device partitions the sample input volume into multiple discrete measurement zones with little or no loss of sample (e.g., zero-loss) and with little operator involvement, thereby reducing operator- and environment-based false positives.
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公开(公告)号：US20170175105A1
公开(公告)日：2017-06-22
申请号：US15453719
申请日：2017-03-08
Applicant: General Electric Company
Inventor： John Richard Nelson , Wei Gao , Christopher Michael Puleo , Todd Frederick Miller , Christine Lynne Pitner , David Andrew Shoudy , Alex David Corwin
CPC classification number: C12N15/1013 , B01L3/502 , B01L2200/025 , B01L2200/0689 , B01L2300/06 , B01L2300/0654 , B01L2300/0861 , C12Q1/6806 , G01N1/02 , G01N1/10 , G01N1/40 , G01N2001/028 , G01N2001/4038
Abstract: A system for extracting material from a region of interest includes a fluid delivery base comprising an inlet channel and an outlet channel formed within the fluid delivery base, a gasket affixed to the fluid delivery base, wherein the gasket comprises at least one opening exposing an open end of the inlet channel and an open end of the outlet channel; a support comprising a sample-supporting surface facing the gasket and an opposing surface; and an alignment member coupled to the opposing surface in a fixed position and such that the support is positioned between the fluid delivery base and the alignment member, wherein one or both of the alignment member or the fluid delivery base are biased towards one another by a force (e.g., a magnet or spring force) and wherein the fluid delivery base is separable from the support and configured to move along a plane of the sample-supporting surface to align with the alignment member.
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公开(公告)号：US09581800B2
公开(公告)日：2017-02-28
申请号：US14550187
申请日：2014-11-21
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Alex David Corwin , Kevin Bernard Kenny , Christine Lynne Pitner
CPC classification number: G02B21/34 , B01L9/52 , B01L2200/025 , B01L2300/0822 , G02B27/32
Abstract: The invention provides a slide holder that utilizes edge detection algorithms to determine the location of various edges of a slide. From these edges, and integrating characteristic slide dimension, both linear offset of the edge of the slide in the holder and any rotation of the slide relative to the microscope stage axis are determined. The process of using the slide holder of the invention ensures precise and accurate placement of a slide during a first round of imaging and for reload in subsequent rounds.
Abstract translation: 本发明提供了一种利用边缘检测算法来确定幻灯片的各种边缘的位置的滑块架。 从这些边缘，并整合特征滑动尺寸，确定支架中滑块边缘的线性偏移和滑块相对于显微镜载物台轴线的任何旋转。 使用本发明的滑块保持器的过程确保在第一轮成像期间精确和准确地放置滑块，并在随后的回合中重新加载。
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公开(公告)号：US20140267671A1
公开(公告)日：2014-09-18
申请号：US13846490
申请日：2013-03-18
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Kevin Bernard Kenny , Alex David Corwin
CPC classification number: G02B21/26 , G06K9/3208 , G06T3/0075 , G06T3/40 , G06T3/60 , G06T7/0012
Abstract: Referencing of image acquired in multiple rounds of imaging is disclosed. In certain implementations, a baseline round of images are acquired and registered to one another to establish a global transformation matrix. In a subsequent round of image acquisition, a limited number of field of view images are initially acquired and registered to the corresponding baseline images to solve for translation, rotation, and scale. The full set of baseline images is then acquired for the subsequent round and each image is pre-rotated and pre-scaled based on the transform determined for the subset of images. The pre-rotated, pre-scaled images are then registered using a translation-only transform.
Abstract translation: 公开了在多轮成像中获取的图像的参考。 在某些实施方式中，获取基线一轮图像并将其相互注册以建立全局变换矩阵。 在随后的一轮图像采集中，初始获取有限数量的视野图像，并将其注册到相应的基线图像，以解决平移，旋转和缩放。 然后针对后续轮次获取完整的基线图像集合，并且基于为图像子集确定的变换来预先旋转和预缩放每个图像。 然后使用仅翻译变换来注册预旋转的预缩放图像。
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公开(公告)号：US09625355B2
公开(公告)日：2017-04-18
申请号：US14557169
申请日：2014-12-01
Applicant: GENERAL ELECTRIC COMPANY
Inventor： John Richard Nelson , Wei Gao , Christopher Michael Puleo , Todd Frederick Miller , Christine Lynne Pitner , David Andrew Shoudy , Alex David Corwin
CPC classification number: C12N15/1013 , B01L3/502 , B01L2200/025 , B01L2200/0689 , B01L2300/06 , B01L2300/0654 , B01L2300/0861 , C12Q1/6806 , G01N1/02 , G01N1/10 , G01N1/40 , G01N2001/028 , G01N2001/4038
Abstract: A system for extracting material from a region of interest includes a fluid delivery base comprising an inlet channel and an outlet channel formed within the fluid delivery base; a gasket affixed to the fluid delivery base, wherein the gasket comprises at least one opening exposing an open end of the inlet channel and an open end of the outlet channel; a support comprising a sample-supporting surface facing the gasket and an opposing surface; and an alignment member coupled to the opposing surface in a fixed position and such that the support is positioned between the fluid delivery base and the alignment member, wherein one or both of the alignment member or the fluid delivery base are biased towards one another by a force (e.g., a magnet or spring force) and wherein the fluid delivery base is separable from the support and configured to move along a plane of the sample-supporting surface to align with the alignment member.
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Patent Agency Ranking
公开(公告)号：US20160153868A1
公开(公告)日：2016-06-02
申请号：US14557169
申请日：2014-12-01
Applicant: GENERAL ELECTRIC COMPANY
Inventor： John Richard Nelson , Wei Gao , Christopher Michael Puleo , Todd Frederick Miller , Christine Lynne Pitner , David Andrew Shoudy , Alex David Corwin
IPC: G01N1/10
CPC classification number: C12N15/1013 , B01L3/502 , B01L2200/025 , B01L2200/0689 , B01L2300/06 , B01L2300/0654 , B01L2300/0861 , C12Q1/6806 , G01N1/02 , G01N1/10 , G01N1/40 , G01N2001/028 , G01N2001/4038
Abstract: A system for extracting material from a region of interest includes a fluid delivery base comprising an inlet channel and an outlet channel formed within the fluid delivery base; a gasket affixed to the fluid delivery base, wherein the gasket comprises at least one opening exposing an open end of the inlet channel and an open end of the outlet channel; a support comprising a sample-supporting surface facing the gasket and an opposing surface; and an alignment member coupled to the opposing surface in a fixed position and such that the support is positioned between the fluid delivery base and the alignment member, wherein one or both of the alignment member or the fluid delivery base are biased towards one another by a force (e.g., a magnet or spring force) and wherein the fluid delivery base is separable from the support and configured to move along a plane of the sample-supporting surface to align with the alignment member.
Abstract translation: 用于从感兴趣区域提取材料的系统包括流体输送基底，其包括形成在流体输送基底内的入口通道和出口通道; 固定到流体输送基座上的垫圈，其中垫圈包括暴露入口通道的开口端和出口通道的开口端的至少一个开口; 支撑件，其包括面向所述垫圈的样品支撑表面和相对表面; 以及对准构件，其在固定位置联接到所述相对表面，并且使得所述支撑件定位在所述流体输送基座和所述对准构件之间，其中所述对准构件或所述流体输送基座中的一个或两个被朝向彼此偏置 力（例如，磁体或弹簧力），并且其中流体输送基座可与支撑件分离并且构造成沿着样品支撑表面的平面移动以与对准构件对准。
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公开(公告)号：US20160147056A1
公开(公告)日：2016-05-26
申请号：US14550187
申请日：2014-11-21
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Alex David Corwin , Kevin Bernard Kenny , Christine Lynne Pitner
IPC: G02B21/34
CPC classification number: G02B21/34 , B01L9/52 , B01L2200/025 , B01L2300/0822 , G02B27/32
Abstract: The invention provides a slide holder that utilizes edge detection algorithms to determine the location of various edges of a slide. From these edges, and integrating characteristic slide dimension, both linear offset of the edge of the slide in the holder and any rotation of the slide relative to the microscope stage axis are determined. The process of using the slide holder of the invention ensures precise and accurate placement of a slide during a first round of imaging and for reload in subsequent rounds.
Abstract translation: 本发明提供了一种利用边缘检测算法来确定幻灯片的各种边缘的位置的滑块架。 从这些边缘，并整合特征滑动尺寸，确定支架中滑块边缘的线性偏移和滑块相对于显微镜载物台轴线的任何旋转。 使用本发明的滑块保持器的过程确保在第一轮成像期间精确和准确地放置滑块，并在随后的回合中重新加载。
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公开(公告)号：US20160061654A1
公开(公告)日：2016-03-03
申请号：US14469362
申请日：2014-08-26
Applicant: GENERAL ELECTRIC COMPANY
CPC classification number: G01J1/0228 , G01N21/274 , G01N21/64 , G01N21/6458 , G02B21/365
Abstract: Approaches are disclosed for calibrating a plurality of imaging devices, such as microscopes. In certain implementations, a calibration plate is employed that include a variety of calibration features. Imaging devices calibrated in accordance with the present approaches may be used to generate images having consistent attributes, such as brightness, regardless of which imaging device is employed.
Abstract translation: 公开了用于校准诸如显微镜的多个成像装置的方法。 在某些实施方案中，采用包括各种校准特征的校准板。 根据本方法校准的成像装置可用于生成具有一致属性（例如亮度）的图像，而不管采用何种成像装置。
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公开(公告)号：US20210002688A1
公开(公告)日：2021-01-07
申请号：US16459336
申请日：2019-07-01
Applicant: General Electric Company
Inventor： Alex David Corwin , Erik Leeming Kvam , Christine Lynne Surrette , Brian Joseph Scherer , Pei-Hsin Kuo , Ralf Lenigk
Abstract: The present disclosure relates to approaches for assessing a sample or the presence of microorganisms. The sample, in certain implementations may be assessed for one or both of absence of microorganisms (sterility) and/or for concentration of said organisms (bio-burden). sample partition device may be employed that partitions the sample input volume into multiple discrete measurement zones with little or no loss of sample (e.g., zero-loss) and with little operator involvement, thereby reducing operator- and environment-based false positives.
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公开(公告)号：US09817221B2
公开(公告)日：2017-11-14
申请号：US14410890
申请日：2013-06-26
Applicant: General Electric Company
Inventor： Alex David Corwin , Robert John Filkins , Jun Xie , Nannan Chen , Kashan Ali Shaikh
CPC classification number: G02B21/008 , G01N1/30 , G01N1/312 , G01N35/00029 , G01N35/0092 , G01N35/0099
Abstract: A method for processing and imaging a first and second plurality of samples, comprising processing at least one sample from the first plurality of samples, imaging the at least one sample from the first plurality of samples, while being capable of simultaneously processing at least one sample from the second plurality of samples; and imaging the at least one processed sample from the second plurality of samples.
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