摘要:
The present invention discloses the compounds of formula I or their pharmaceutically acceptable salts, which are useful as CCR5 antagonists. The preparation and use of the compounds of formula I, pharmaceutical composition containing the same are also disclosed. Furthermore, the present invention discloses an intermediate for the preparation of the compounds of formula I.
摘要:
A method for reconstructing an image using an imaging apparatus that includes a radiation source, a detector array, and a computer. The method includes performing a helical scan of an object at a selected helical pitch using the radiation source and detector array to obtain image data, and reconstructing an image of the object utilizing the computer programmed to perform a hybrid cone beam image reconstruction having ray-wise 3D weighting, wherein the weighting is dependent upon both helical pitch and z-distance.
摘要:
The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acid sequences and sequence changes. The methods of the present invention permit the detection and/or identification of genetic polymorphism such as those associated with human disease and permit the identification of pathogens (e.g., viral and bacterial strain identification).
摘要:
One embodiment provides a system and method for synchronously buffering real-time streaming content in a peer-to-peer overlay network to improve inter-peer-node synchronization. A requesting peer node identifies a partner peer node that transiently stages content segments. The requesting peer node determines the status of its local buffer and sends a request that indicates such status to a partner peer node. After receiving the most recent segment not present in the buffer from the partner peer node, the requesting peer node transiently stages the received segments in the buffer.
摘要:
A method for reconstructing an image using an imaging apparatus that includes a radiation source, a detector array, and a computer. The method includes performing a helical scan of an object at a selected helical pitch using the radiation source and detector array to obtain image data, and reconstructing an image of the object utilizing the computer programmed to perform a hybrid cone beam image reconstruction having ray-wise 3D weighting, wherein the weighting is dependent upon both helical pitch and z-distance.
摘要:
A method and an apparatus for registering frames of imaging data using Fourier phase matching. Successive image frames of pixel data are processed using an image registration algorithm. Either image frames or the frames after edge detection are transformed into polar-logarithmic coordinates in the frequency domain and the phases of the Fourier transform of the resulting image representations, after inverse Fast Fourier transformation, are matched. The coordinates at the maximum phase difference are used to determine the scaling and rotation parameters needed for image frame registration. The frequency domain representation of one of the image frames is then scaled and rotated using an anti-aliasing algorithm in accordance with those parameters. The phase of the result is matched with the phase of the frequency domain representation of the other image frame to determine the translation parameters needed for image frame registration.
摘要:
A CT system includes a generator configured to energize an x-ray source to a first kilovoltage (kVp) and to a second kVp, and a computer that is programmed to acquire a first view dataset with the x-ray source energized to the first kVp and a second view dataset with the x-ray source energized to the second kVp, generate a base correction image using the first view dataset and the second view dataset, and reconstruct a pair of base material images from the first view dataset and from the second view dataset. The computer is also programmed to estimate artifact correlation in the pair of base material images using the base correction image, generate a pair of final base material images and a final monochromatic image, and correct one of the pair of final base material images and the final monochromatic image at a keV value using the estimated artifact correlation.
摘要:
The present invention relates to methods and compositions for analyzing nucleic acids, and in particular, methods and compositions for detection and characterization of nucleic acid sequences and sequence changes using mass spectrometry. The present invention also provides methods and compositions for identifying oligonucleotides with desired hybridization properties to nucleic acid targets containing secondary structure using mass spectrometry.
摘要:
Method and apparatus for locally enhancing image data represented as pixels having CT numbers is provided. The image data includes bony structures, and the method comprises segmenting pixels within the image data into areas based on the pixel's CT number. A first area represents a combination of soft tissue and lower density bones and a second area represents higher density bones. A subset of pixels is identified within the first area representative of the lower density bones. An enhancement is applied to the subset of pixels within the first area and to the second area to create an enhanced dataset, and a locally enhanced image is generated based on the image data and the enhanced dataset.
摘要:
The present invention relates to methods and compositions for analyzing nucleic acids, and in particular, methods and compositions for detection and characterization of nucleic acid sequences and sequence changes. The present invention also provides methods and compositions for identifying oligonucleotides with desired hybridization properties to nucleic acid targets containing secondary structure.