公开(公告)号：US06893859B2

公开(公告)日：2005-05-17

申请号：US10115198

申请日：2002-04-02

申请人： Gary Ashley ,  Robert L. Arslanian ,  John Carney ,  Brian Metcalf ,  Li Tang

发明人： Gary Ashley ,  Robert L. Arslanian ,  John Carney ,  Brian Metcalf ,  Li Tang

IPC分类号： C07D313/00 ,  C07D405/06 ,  C07D413/06 ,  C07D417/06 ,  C07D491/04 ,  C12N1/20 ,  C12N9/00 ,  C12N15/52 ,  C12N15/74 ,  C12P17/16 ,  C12P17/18 ,  C12N1/21

CPC分类号： C07D405/06 ,  C07D313/00 ,  C07D413/06 ,  C07D417/06 ,  C07D491/04 ,  C12N1/20 ,  C12N9/00 ,  C12N15/52 ,  C12N15/74 ,  C12P17/16 ,  C12P17/181 ,  C12R1/01

摘要： This invention relates to compounds of formula (I) and to pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, R5, W, X, Y, and Ar are as defined herein. Compounds of formula (I) are useful in the treatment of diseases or conditions characterized by cellular hyperproliferation. This invention also relates to means for the preparation of compounds of formula (I); formulations containing compounds of formula (I); and methods for the use of said compounds and formulations in the treatment of a disease or condition characterized by cellular hyperproliferation, including cancer.

摘要翻译： 本发明涉及式（I）化合物及其药用盐和溶剂合物，其中R 1，R 2，R 3， R 4，R 5，W，X，Y和Ar如本文所定义。 式（I）化合物可用于治疗以细胞过度增殖为特征的疾病或病症。 本发明还涉及制备式（I）化合物的方法; 含有式（I）化合物的制剂; 以及在治疗以细胞过度增殖为特征的疾病或病症（包括癌症）中使用所述化合物和制剂的方法。

公开(公告)号：US20050038086A1

公开(公告)日：2005-02-17

申请号：US10845467

申请日：2004-05-12

申请人： Gary Ashley ,  Robert Arslanian ,  John Carney ,  Brian Metcalf ,  Li Tang

发明人： Gary Ashley ,  Robert Arslanian ,  John Carney ,  Brian Metcalf ,  Li Tang

IPC分类号： C07D313/00 ,  C07D405/06 ,  C07D413/06 ,  C07D417/06 ,  C07D491/04 ,  C12N1/20 ,  C12N9/00 ,  C12N15/52 ,  C12N15/74 ,  C12P17/16 ,  C12P17/18 ,  C07D417/02 ,  A61K31/427

CPC分类号： C07D405/06 ,  C07D313/00 ,  C07D413/06 ,  C07D417/06 ,  C07D491/04 ,  C12N1/20 ,  C12N9/00 ,  C12N15/52 ,  C12N15/74 ,  C12P17/16 ,  C12P17/181 ,  C12R1/01

摘要： This invention relates to compounds of formula (I) and to pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, R5, W, X, Y, and Ar are as defined herein. Compounds of formula (I) are useful in the treatment of diseases or conditions characterized by cellular hyperproliferation. This invention also relates to means for the preparation of compounds of formula (I); formulations containing compounds of formula (I); and methods for the use of said compounds and formulations in the treatment of a disease or condition characterized by cellular hyperproliferation, including cancer.

摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐和溶剂化物，其中R 1，R 2，R 3，R 4，R 5，W，X，Y ，Ar如本文所定义。 式（I）化合物可用于治疗以细胞过度增殖为特征的疾病或病症。 本发明还涉及制备式（I）化合物的方法; 含有式（I）化合物的制剂; 以及在治疗以细胞过度增殖为特征的疾病或病症（包括癌症）中使用所述化合物和制剂的方法。

公开(公告)号：US08578411B1

公开(公告)日：2013-11-05

申请号：US10672983

申请日：2003-09-25

申请人： John Carney ,  David deAndrade

发明人： John Carney ,  David deAndrade

IPC分类号： G06F3/00 ,  G06F13/00 ,  H04N5/445

CPC分类号： H04N21/47 ,  G06Q30/02 ,  H04N21/241 ,  H04N21/25808 ,  H04N21/26291 ,  H04N21/4424 ,  H04N21/6582 ,  H04N21/8166 ,  H04N21/8545

摘要： Controlling the admission of interactive television iTV applications to an iTV application distribution system is accomplished through the use of iTV application profiles that enumerate sets of allowed functions and behaviors for the iTV applications within the distribution system. In general, the profiles comprise filters that enable various functions within the distribution system, and may be applied to the iTV applications according to any of a number of bases. The distribution system includes an interface or console adapted to permit a system operator to create the application profiles and establish rules for attaching the profiles to the iTV applications, and an application profile engine configured to automatically validate the iTV applications against the profiles according to those rules.

摘要翻译： 通过使用iTV应用程序配置文件来实现将交互式电视iTV应用程序接纳到iTV应用程序分发系统，该配置文件列举了分发系统中iTV应用程序的允许功能和行为的集合。 通常，配置文件包括能够在分配系统内实现各种功能的滤波器，并且可以根据多个基础中的任何一个应用于iTV应用。 分发系统包括适于允许系统操作者创建应用程序简档并建立用于将简档附加到iTV应用程序的规则的接口或控制台，以及配置为根据这些规则自动验证针对配置文件的iTV应用程序的应用程序配置文件引擎 。

公开(公告)号：US20130191863A1

公开(公告)日：2013-07-25

申请号：US13795792

申请日：2013-03-12

申请人： Samuel Moreau ,  Don Ahrens ,  Georgia Gibbs ,  John Carney ,  David de Andrade

发明人： Samuel Moreau ,  Don Ahrens ,  Georgia Gibbs ,  John Carney ,  David de Andrade

IPC分类号： H04N21/482

摘要： An interface for an interactive television application includes a graphical representation of a channel changing apparatus and is configured such that in response to a channel change request a channel change event limited to a channel change within a designated family of television channels is initiated. The graphical element may be labeled so as to indicate the presently viewed family of television channels. In various embodiment, the channel content may be scaled to fit within a window or may be full screen, in which latter case the interface may be overlaid on top of the full screen video. In one example, the graphical representation of the channel changing apparatus resembles a pair of channel up/down buttons.

摘要翻译： 用于交互式电视应用的接口包括频道改变设备的图形表示，并且被配置为使得响应于频道改变请求，启动限制在指定的电视频道系列内的频道改变的频道改变事件。 图形元素可以被标记以指示当前观看的电视频道的系列。 在各种实施例中，频道内容可以被缩放以适合窗口或者可以是全屏幕，其中后一种情况下，该界面可以覆盖在全屏幕视频的顶部。 在一个示例中，频道改变设备的图形表示类似于一对频道上/下按钮。

公开(公告)号：US07930631B2

公开(公告)日：2011-04-19

申请号：US11023178

申请日：2004-12-22

申请人： Ranjit Sahota ,  John Carney ,  David de Andrade ,  Mark Knowles

发明人： Ranjit Sahota ,  John Carney ,  David de Andrade ,  Mark Knowles

IPC分类号： G06F17/00 ,  H04N5/445

CPC分类号： H04L67/325 ,  G06F17/211 ,  G06F17/2247 ,  G06F17/30873 ,  G06F17/3089 ,  G06F17/30905 ,  H04L67/16 ,  H04N7/16 ,  H04N21/25883 ,  H04N21/2668 ,  H04N21/434 ,  H04N21/44222 ,  H04N21/4532 ,  H04N21/4622 ,  H04N21/4782 ,  H04N21/812 ,  H04N21/858 ,  H04N21/8586

摘要： A method and system are disclosed for acquiring and transforming existing content (e.g., Hyper Text Markup Language HTML content) for display and execution on multiple platforms and architectures. In one embodiment, capture templates are created to harvest content from disparate content sources on multiple platforms. Data is extracted from the content from the disparate content sources using the created capture templates that drives extracting process. A standardized data stream is generated from the extracted data. The standardized data stream is provided for display on one or more different type of platforms.

摘要翻译： 公开了用于获取和转换现有内容（例如，超文本标记语言HTML内容）以在多个平台和架构上显示和执行的方法和系统。 在一个实施例中，创建捕获模板以从多个平台上的不同内容源收集内容。 使用创建的捕获模板从不同的内容源的内容中提取数据，该捕获模板驱动提取过程。 从提取的数据生成标准化数据流。 标准化数据流被提供用于在一个或多个不同类型的平台上显示。

公开(公告)号：USD632953S1

公开(公告)日：2011-02-22

申请号：US29369151

申请日：2010-09-02

申请人： John Carney

设计人： John Carney

公开(公告)号：US07703116B1

公开(公告)日：2010-04-20

申请号：US10664275

申请日：2003-09-16

申请人： Samuel Moreau ,  Donald Ahrens ,  Georgia Gibbs ,  John Carney ,  David de Andrade

发明人： Samuel Moreau ,  Donald Ahrens ,  Georgia Gibbs ,  John Carney ,  David de Andrade

IPC分类号： G06F13/00 ,  G06F3/00 ,  H04N5/445

CPC分类号： H04N21/4438 ,  G06F3/0482 ,  H04N5/44543 ,  H04N5/44591 ,  H04N5/45 ,  H04N21/4312 ,  H04N21/472 ,  H04N21/47202 ,  H04N21/478 ,  H04N21/482 ,  H04N21/4821 ,  H04N21/854 ,  H04N21/8545

摘要： A user interface allows for blending of television program choices from which a viewer may select, the blending representing options for linear and non-linear programming presented together within a single hierarchy of a designated category. The blending may further include managed content relevant to the designated category, where desired. Such designated categories may include television programming categories and/or content categories. The options for linear and non-linear programming may be presented together within a single screen of the user interface.

摘要翻译： 用户界面允许混合观众可以从其中选择的电视节目选择，混合表示在指定类别的单个层级中一起呈现的用于线性和非线性节目的选项。 如果需要，混合可以进一步包括与指定类别相关的被管理内容。 这样的指定类别可以包括电视节目类别和/或内容类别。 线性和非线性编程的选项可以一起显示在用户界面的单个屏幕内。

公开(公告)号：USD569528S1

公开(公告)日：2008-05-20

申请号：US29250118

申请日：2006-11-02

申请人： John Carney

设计人： John Carney

公开(公告)号：US20050272724A1

公开(公告)日：2005-12-08

申请号：US11053747

申请日：2005-02-08

申请人： John Carney ,  Robert Floyd

发明人： John Carney ,  Robert Floyd

IPC分类号： A61K31/13 ,  A61K31/135 ,  A61K31/15 ,  A61K31/165 ,  A61K31/167 ,  A61K31/195 ,  A61K31/40 ,  A61K31/4172 ,  A61K31/44 ,  A61K31/445 ,  A61K31/5415 ,  C07C291/02

CPC分类号： C07C291/02 ,  A61K31/13 ,  A61K31/135 ,  A61K31/15 ,  A61K31/165 ,  A61K31/167 ,  A61K31/195 ,  A61K31/40 ,  A61K31/4172 ,  A61K31/44 ,  A61K31/445 ,  A61K31/5415

摘要： Spin trapping compositions in general have now been discovered to be effective in treating a variety of disorders, including disorders such as those arising from ischemia, infection, inflammation, exposure to radiation or cytotoxic compounds, not just of the central and peripheral nervous systems but of peripheral organ disease having a wide variety of etiologies. In the preferred embodiment, the compositions for treating tissue damage from ischemia contain PBN, or active derivatives thereof, in a suitable pharmaceutical carrier for intravenous oral, topical, or nasal/pulmonary administration. Other preferred spin-trapping agents include 5,5-dimethyl pyrrolidine N-oxide (DMPO), α-(4-pyridyl-1-oxide)-N-tert-butylnitrone (POBN), and (TEMPO) and spin-trapping derivatives, conjugates with drugs or targeting molecules, dimmers and cyclodextran polymers of PBN. Many different disorders can be treated using these compounds, including diseases or disorders of the central and peripheral nervous systems, and disorders arising from ischemia, infection, inflammation, oxidation from exposure to radiation or cytotoxic compounds, as well as due to naturally occurring processes such as aging.

公开(公告)号：US20050108634A1

公开(公告)日：2005-05-19

申请号：US11023143

申请日：2004-12-22

申请人： Ranjit Sahota ,  John Carney ,  David Andrade ,  Mark Knowles

发明人： Ranjit Sahota ,  John Carney ,  David Andrade ,  Mark Knowles

IPC分类号： G06F17/30 ,  H04N21/258 ,  H04N21/2668 ,  H04N21/434 ,  H04N21/442 ,  H04N21/45 ,  H04N21/462 ,  H04N21/4782 ,  H04N21/81 ,  H04N21/858 ,  G06F17/00

CPC分类号： H04L67/325 ,  G06F17/211 ,  G06F17/2247 ,  G06F17/30873 ,  G06F17/3089 ,  G06F17/30905 ,  H04L67/16 ,  H04N7/16 ,  H04N21/25883 ,  H04N21/2668 ,  H04N21/434 ,  H04N21/44222 ,  H04N21/4532 ,  H04N21/4622 ,  H04N21/4782 ,  H04N21/812 ,  H04N21/858 ,  H04N21/8586

摘要： A method and system are disclosed for acquiring and transforming existing content (e.g., Hyper Text Markup Language HTML content) for display and execution on multiple platforms and architectures. In one embodiment, capture templates are created to harvest content from disparate content sources on multiple platforms. Data is extracted from the content from the disparate content sources using the created capture templates that drives extracting process. A standardized data stream is generated from the extracted data. The standardized data stream is provided for display on one or more different type of platforms.