Process for preparing 2-amino-5-cyanobenzoic acid derivatives
    5.
    发明授权
    Process for preparing 2-amino-5-cyanobenzoic acid derivatives 有权
    制备2-氨基-5-氰基苯甲酸衍生物的方法

    公开(公告)号:US08049029B2

    公开(公告)日:2011-11-01

    申请号:US12516807

    申请日:2007-12-18

    IPC分类号: C07C253/00

    摘要: Disclosed is a method for preparing a compound of Formula 1 comprising contacting a compound of Formula 2 with a metal cyanide reagent, a copper(I) salt reagent, an iodide salt reagent and at least one compound of Formula 3 wherein R1 is NHR3 or OR4; R2 is CH3 or Cl; R3 is H, C1-C4 alkyl, cyclopropyl, cyclopropylcyclopropyl, cyclopropylmethyl or methylcyclopropyl; R4 is H or C1-C4 alkyl; Y is Br or Cl; X is NR13 or O; n is 0 or 1; and R5, R6, R7, R8, R9, R10, R11, R12 and R13 are as defined in the disclosure. Also disclosed is a method for preparing a compound of Formula 2 wherein Y is Br and R1 is NHR3 comprising introducing a gas containing bromine into a liquid containing a compound of Formula 4, and further disclosed is a method for preparing a compound of Formula 5 wherein R14, R15, R16 and Z are as defined in the disclosure using a compound of Formula 1 characterized by preparing the compound of Formula 1 by the method disclosed above.

    摘要翻译: 公开了一种制备式1化合物的方法,包括使式2化合物与金属氰化物试剂,铜(I)盐试剂,碘化物盐试剂和至少一种式3化合物(其中R1是NHR3或OR4)接触 ; R2是CH3或Cl; R3是H,C1-C4烷基,环丙基,环丙基环丙基,环丙基甲基或甲基环丙基; R4是H或C1-C4烷基; Y为Br或Cl; X为NR 13或O; n为0或1; 并且R5,R6,R7,R8,R9,R10,R11,R12和R13如本公开所定义。 还公开了制备式2化合物的方法,其中Y是Br,R 1是NHR 3,包括将含溴的气体引入含有式4化合物的液体中,并且还公开了制备式5化合物的方法,其中 R14,R15,R16和Z如本公开中所定义,使用式1的化合物,其特征在于通过上述方法制备式1的化合物。

    PROCESS FOR PREPARING 2-AMINO-5-CYANOBENZOIC ACID DERIVATIVES
    10.
    发明申请
    PROCESS FOR PREPARING 2-AMINO-5-CYANOBENZOIC ACID DERIVATIVES 有权
    制备2-氨基-5-氰基苯甲酸衍生物的方法

    公开(公告)号:US20100063287A1

    公开(公告)日:2010-03-11

    申请号:US12596556

    申请日:2008-06-23

    申请人: Gary David Annis

    发明人: Gary David Annis

    摘要: Disclosed is a method for preparing a compound of Formula 1 comprising (1) contacting a compound of Formula 2, with (2) at least one alkali metal cyanide and (3) at least one compound of Formula 4 wherein R1 is NHR3 or OR4; R2 is CH3 or Cl; R3 is H, C1-C4 alkyl, cyclopropyl, cyclopropylcyclopropyl, cyclopropylmethyl or methylcyclopropyl; R4 is H or C1-C4 alkyl; and X is Br, Cl or I.Also disclosed is a method for preparing a compound of Formula 4 comprising contacting a mixture of (i) at least one compound of Formula 9 and (ii) at least one metal reducing agent with (iii) dichlorobis(triphenylphosphine)nickel, and further disclosed is a method for removing nickel impurities from a mixture thereof with compounds of Formula 1 comprising contacting the mixture with oxygen in the presence of an aqueous cyanide solution, and additionally disclosed is a method for preparing a compound of Formula 5 wherein R5, R6, R7 and Z are as defined in the disclosure, using a compound of Formula 1, characterized by preparing the compound of Formula 1 by the method disclosed above.

    摘要翻译: 公开了制备式1化合物的方法,其包括(1)使式2的化合物与(2)至少一种碱金属氰化物和(3)至少一种式4的化合物(其中R 1是NHR 3或OR 4)接触; R2是CH3或Cl; R3是H,C1-C4烷基,环丙基,环丙基环丙基,环丙基甲基或甲基环丙基; R4是H或C1-C4烷基; 还公开了制备式4化合物的方法,包括使(i)至少一种式9化合物和(ii)至少一种金属还原剂与(iii)的混合物的混合物接触, 二氯双(三苯基膦)镍,并且还公开了一种从其与式I化合物的混合物中除去镍杂质的方法,包括在氰化水溶液存在下使该混合物与氧接触,另外公开了一种制备化合物的方法 其中R 5,R 6,R 7和Z如本公开所定义,使用式1的化合物,其特征在于通过上述方法制备式1的化合物。