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    PROCESS FOR PREPARING 2-AMINO-5-CYANOBENZOIC ACID DERIVATIVES
    5.
    发明申请
    PROCESS FOR PREPARING 2-AMINO-5-CYANOBENZOIC ACID DERIVATIVES 有权
    制备2-氨基-5-氰基苯甲酸衍生物的方法

    公开(公告)号：US20100280251A1

    公开(公告)日：2010-11-04

    申请号：US12516807

    申请日：2007-12-18

    申请人： Joerg Bruening ,  Gary David Annis ,  Martin James Currie ,  Donald J. Dumas ,  Rafael Shapiro

    发明人： Joerg Bruening ,  Gary David Annis ,  Martin James Currie ,  Donald J. Dumas ,  Rafael Shapiro

    IPC分类号： C07D401/04 ,  C07C253/32 ,  C07C231/22 ,  C07D231/22 ,  C07D231/12

    CPC分类号： C07C253/14 ,  C07C231/12 ,  C07C233/65 ,  C07C255/58

    摘要： Disclosed is a method for preparing a compound of Formula 1 comprising contacting a compound of Formula 2 with a metal cyanide reagent, a copper(I) salt reagent, an iodide salt reagent and at least one compound of Formula 3 wherein R1 is NHR3 or OR4; R2 is CH3 or Cl; R3 is H, C1-C4 alkyl, cyclopropyl, cyclopropylcyclopropyl, cyclopropylmethyl or methylcyclopropyl; R4 is H or C1-C4 alkyl; Y is Br or Cl; X is NR13 or O; n is 0 or 1; and R5, R6, R7, R8, R9, R10, R11, R12 and R13 are as defined in the disclosure.Also disclosed is a method for preparing a compound of Formula 2 wherein Y is Br and R1 is NHR3 comprising introducing a gas containing bromine into a liquid containing a compound of Formula 4, and further disclosed is a method for preparing a compound of Formula 5 wherein R14, R15, R16 and Z are as defined in the disclosure using a compound of Formula 1 characterized by preparing the compound of Formula 1 by the method disclosed above.

    摘要翻译： 公开了一种制备式1化合物的方法，包括使式2化合物与金属氰化物试剂，铜（I）盐试剂，碘化物盐试剂和至少一种式3化合物（其中R1是NHR3或OR4）接触 ; R2是CH3或Cl; R3是H，C1-C4烷基，环丙基，环丙基环丙基，环丙基甲基或甲基环丙基; R4是H或C1-C4烷基; Y为Br或Cl; X为NR 13或O; n为0或1; 并且R5，R6，R7，R8，R9，R10，R11，R12和R13如本公开所定义。 还公开了制备式2化合物的方法，其中Y是Br，R 1是NHR 3，包括将含溴的气体引入含有式4化合物的液体中，并且还公开了制备式5化合物的方法，其中 R14，R15，R16和Z如本公开中所定义，使用式1的化合物，其特征在于通过上述方法制备式1的化合物。

    Process for preparing 2-amino-5-cyanobenzoic acid derivatives
    6.
    发明授权
    Process for preparing 2-amino-5-cyanobenzoic acid derivatives 有权
    制备2-氨基-5-氰基苯甲酸衍生物的方法

    公开(公告)号：US08049029B2

    公开(公告)日：2011-11-01

    申请号：US12516807

    申请日：2007-12-18

    申请人： Joerg Bruening ,  Gary David Annis ,  Donald J Dumas ,  Rafael Shapiro

    发明人： Joerg Bruening ,  Gary David Annis ,  Donald J Dumas ,  Rafael Shapiro

    IPC分类号： C07C253/00

    CPC分类号： C07C253/14 ,  C07C231/12 ,  C07C233/65 ,  C07C255/58

    摘要： Disclosed is a method for preparing a compound of Formula 1 comprising contacting a compound of Formula 2 with a metal cyanide reagent, a copper(I) salt reagent, an iodide salt reagent and at least one compound of Formula 3 wherein R1 is NHR3 or OR4; R2 is CH3 or Cl; R3 is H, C1-C4 alkyl, cyclopropyl, cyclopropylcyclopropyl, cyclopropylmethyl or methylcyclopropyl; R4 is H or C1-C4 alkyl; Y is Br or Cl; X is NR13 or O; n is 0 or 1; and R5, R6, R7, R8, R9, R10, R11, R12 and R13 are as defined in the disclosure. Also disclosed is a method for preparing a compound of Formula 2 wherein Y is Br and R1 is NHR3 comprising introducing a gas containing bromine into a liquid containing a compound of Formula 4, and further disclosed is a method for preparing a compound of Formula 5 wherein R14, R15, R16 and Z are as defined in the disclosure using a compound of Formula 1 characterized by preparing the compound of Formula 1 by the method disclosed above.

    摘要翻译： 公开了一种制备式1化合物的方法，包括使式2化合物与金属氰化物试剂，铜（I）盐试剂，碘化物盐试剂和至少一种式3化合物（其中R1是NHR3或OR4）接触 ; R2是CH3或Cl; R3是H，C1-C4烷基，环丙基，环丙基环丙基，环丙基甲基或甲基环丙基; R4是H或C1-C4烷基; Y为Br或Cl; X为NR 13或O; n为0或1; 并且R5，R6，R7，R8，R9，R10，R11，R12和R13如本公开所定义。 还公开了制备式2化合物的方法，其中Y是Br，R 1是NHR 3，包括将含溴的气体引入含有式4化合物的液体中，并且还公开了制备式5化合物的方法，其中 R14，R15，R16和Z如本公开中所定义，使用式1的化合物，其特征在于通过上述方法制备式1的化合物。

    Method for preparing 2-aminobenzamide derivatives
    8.
    发明授权
    Method for preparing 2-aminobenzamide derivatives 有权
    2-氨基苯甲酰胺衍生物的制备方法

    公开(公告)号：US08871939B2

    公开(公告)日：2014-10-28

    申请号：US13981919

    申请日：2012-01-27

    申请人： Sigridur Soley Kristjansdottir ,  Rafael Shapiro ,  Matthew Richard Oberholzer

    发明人： Sigridur Soley Kristjansdottir ,  Rafael Shapiro ,  Matthew Richard Oberholzer

    IPC分类号： C07C231/10 ,  C07D231/14 ,  C07D401/04

    CPC分类号： C07C231/02 ,  C07C231/10 ,  C07D231/14 ,  C07D401/04 ,  C07C237/30

    摘要： A method for preparing a compound of Formula 1 comprising contacting a compound of Formulae 2 and 3 in the presence of a palladium source, a ligand, a base and carbon monoxide wherein R1, R2, X and R3 are as defined in the disclosure. A method for preparing a compound of Formula 5 wherein R1, R2, R3, R4, R5, R6 and Z are as defined in the disclosure, using a compound of Formula 1 characterized by preparing a compound of Formula 1 by the method disclosed above or using a compound of Formula 1 prepared by the method above.

    摘要翻译： 制备式1化合物的方法，包括在钯源，配体，碱和一氧化碳的存在下使式2和3的化合物接触，其中R 1，R 2，X和R 3如本公开所定义。 制备式5化合物的方法，其中R 1，R 2，R 3，R 4，R 5，R 6和Z如本公开所定义，使用式1化合物，其特征在于通过上述方法制备式1化合物或式 使用通过上述方法制备的式1的化合物。