公开(公告)号：US20070082007A1

公开(公告)日：2007-04-12

申请号：US11638520

申请日：2006-12-14

申请人： Gary Zlotnick ,  Leah Fletcher ,  John Farley ,  Liesel Bernfield ,  Robert Zagursky ,  Benjamin Metcalf

发明人： Gary Zlotnick ,  Leah Fletcher ,  John Farley ,  Liesel Bernfield ,  Robert Zagursky ,  Benjamin Metcalf

IPC分类号： A61K39/095 ,  A61K39/02 ,  C07K14/22

CPC分类号： C07K14/22 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/53

摘要： The present invention relates to Neisseria ORF2086 proteins, crossreactive immunogenic proteins which can be isolated from nesserial strains or prepared recombinantly, including immunogenic portions thereof, biological equivalents thereof, antibodies that immunospecifically bind to the foregoing and nucleic acid sequences encoding each of the foregoing, as well as the use of same in immunogenic compositions that are effective against infection by Neisseria meningitidis serogroup B.

公开(公告)号：US20070253964A1

公开(公告)日：2007-11-01

申请号：US10553670

申请日：2004-04-16

申请人： Gary Zlotnick ,  Leah Fletcher ,  John Farley ,  Liesel Bernfield ,  Robert Zagursky ,  Benjamin Metcalf

发明人： Gary Zlotnick ,  Leah Fletcher ,  John Farley ,  Liesel Bernfield ,  Robert Zagursky ,  Benjamin Metcalf

IPC分类号： A61K39/095 ,  A61K38/16 ,  A61K39/40 ,  C07H21/04 ,  C07K14/22 ,  C07K14/67 ,  C07K16/12 ,  C12N1/08 ,  C12N15/63 ,  C12N5/12 ,  C12P21/02 ,  C12P21/08

CPC分类号： C07K14/22 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/53

摘要： The present invention relates to Neisseria ORF2086 proteins, crossreactive immunogenic proteins which can be isolated from neisserial strains or prepared recombinantly, including immunogenic portions thereof, biological equivalents thereof, antibodies that immunospecifically bind to the foregoing and nucleic acid sequences encoding each of the foregoing, as well as the use of same in immunogenic compositions that are effective against infection by Neisseria meningitidis serogroup B.

摘要翻译： 本发明涉及奈瑟氏菌ORF2086蛋白质，其可从奈瑟氏菌菌株分离或重组制备，包括其免疫原性部分，其生物等同物，免疫特异性结合前述的抗体和编码上述每一种的核酸序列的交叉反应性免疫原性蛋白，如 以及在针对脑膜炎奈瑟氏球菌血清群B感染有效的免疫原性组合物中的用途。

公开(公告)号：US20070082866A1

公开(公告)日：2007-04-12

申请号：US11638401

申请日：2006-12-14

申请人： Gary Zlotnick ,  Leah Fletcher ,  John Farley ,  Liesel Bernfield ,  Robert Zagursky ,  Benjamin Metcalf

发明人： Gary Zlotnick ,  Leah Fletcher ,  John Farley ,  Liesel Bernfield ,  Robert Zagursky ,  Benjamin Metcalf

IPC分类号： A61K48/00

CPC分类号： C07K14/22 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/53

摘要： The present invention relates to Neisseria ORF2086 proteins, crossreactive immunogenic proteins which can be isolated from nesserial strains or prepared recombinantly, including immunogenic portions thereof, biological equivalents thereof, antibodies that immunospecifically bind to the foregoing and nucleic acid sequences encoding each of the foregoing, as well as the use of same in immunogenic compositions that are effective against infection by Neisseria meningitidis serogroup B.

公开(公告)号：US20070082006A1

公开(公告)日：2007-04-12

申请号：US11638443

申请日：2006-12-14

申请人： Gary Zlotnick ,  Leah Fletcher ,  John Farley ,  Liesel Bernfield ,  Robert Zagursky ,  Benjamin Metcalf

发明人： Gary Zlotnick ,  Leah Fletcher ,  John Farley ,  Liesel Bernfield ,  Robert Zagursky ,  Benjamin Metcalf

IPC分类号： A61K39/02 ,  A61K39/095

CPC分类号： C07K14/22 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/53

摘要： The present invention relates to Neisseria ORF2086 proteins, crossreactive immunogenic proteins which can be isolated from nesserial strains or prepared recombinantly, including immunogenic portions thereof, biological equivalents thereof, antibodies that immunospecifically bind to the foregoing and nucleic acid sequences encoding each of the foregoing, as well as the use of same in immunogenic compositions that are effective against infection by Neisseria meningitidis serogroup B.

摘要翻译： 本发明涉及奈瑟氏菌ORF2086蛋白质，其可以从胎儿菌株分离或重组制备的交联反应性免疫原性蛋白质，包括其免疫原性部分，其生物等同物，免疫特异性结合前述的抗体和编码上述每一种的核酸序列，作为 以及在针对脑膜炎奈瑟氏球菌血清群B感染有效的免疫原性组合物中的用途。

公开(公告)号：US20060257413A1

公开(公告)日：2006-11-16

申请号：US10492427

申请日：2002-10-11

申请人： Gary Zlotnick ,  Leah Fletcher ,  John Farley ,  Liesel Bernfield ,  Robert Zagursky ,  Benjamin Metcalf

发明人： Gary Zlotnick ,  Leah Fletcher ,  John Farley ,  Liesel Bernfield ,  Robert Zagursky ,  Benjamin Metcalf

IPC分类号： A61K39/00 ,  A61K39/38

CPC分类号： A61K39/095 ,  A61K39/00 ,  A61K39/39 ,  A61K47/543 ,  A61K47/646 ,  A61K2039/505 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/55505 ,  A61K2039/55572 ,  A61K2039/55577 ,  A61K2039/58 ,  A61K2039/6087 ,  C07K14/22 ,  C07K16/1217 ,  C12N9/2417 ,  C12N9/2465 ,  C12N9/2471 ,  G01N33/56911 ,  G01N2333/22 ,  Y10S530/825

摘要： The present invention relates to Neisseria ORF2086 proteins, crossreactive immunogenic proteins which can be isolated from nesserial strains or prepared recombinantly, including immunogenic portions thereof, biological equivalents thereof, antibodies that immunospecifically bind to the foregoing and nucleic acid sequences encoding each of the foregoing, as well as the use of same in immunogenic compositions that are effective against infection by Neisseria meningitidis serogroup B.

公开(公告)号：US20060234260A1

公开(公告)日：2006-10-19

申请号：US11366965

申请日：2006-03-02

申请人： Remy Griffais ,  Susan Hoiseth ,  Robert Zagursky ,  Benjamin Metcalf ,  Joel Peek ,  Banumathi Sankaran ,  Leah Fletcher

发明人： Remy Griffais ,  Susan Hoiseth ,  Robert Zagursky ,  Benjamin Metcalf ,  Joel Peek ,  Banumathi Sankaran ,  Leah Fletcher

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C12N1/21 ,  C07K14/195 ,  C07K16/12

CPC分类号： C07K14/295

摘要： The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia trachomatis, such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism, in the replication process or in virulence, polypeptides encoded by such sequences, as well as vectors including the said sequences and cells or animals transformed with these vectors. The invention also relates to transcriptional gene products of the Chlamydia trachomatis genome, such as, for example, antisense and ribozyme molecules, which can be used to control growth of the microorganism. The invention also relates to methods of detecting these nucleic acids or polypeptides and kits for diagnosing Chlamydia trachomatis infection. The invention also relates to a method of selecting compounds capable of modulating bacterial infection and a method for the biosynthesis or biodegradation of molecules of interest using the said nucleotide sequences or the said polypeptides. The invention finally comprises, pharmaceutical, in particular vaccine, compositions for the prevention and/or treatment of bacterial, in particular Chlamydia trachomatis, infections.

公开(公告)号：US20070053927A1

公开(公告)日：2007-03-08

申请号：US11366942

申请日：2006-03-02

申请人： Remy Griffais ,  Susan Hoiseth ,  Robert Zagursky ,  Benjamin Metcalf ,  Joel Peek ,  Banumathi Sankaran ,  Leah Fletcher

发明人： Remy Griffais ,  Susan Hoiseth ,  Robert Zagursky ,  Benjamin Metcalf ,  Joel Peek ,  Banumathi Sankaran ,  Leah Fletcher

IPC分类号： A61K39/02 ,  C07H21/04 ,  C12P21/06 ,  C12N1/21 ,  C12N15/74 ,  C07K14/295 ,  C07K16/12

CPC分类号： C07K14/295 ,  A01K2217/05 ,  A61K39/00

摘要： The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia pneumoniae, such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism, in the replication process or in virulence, polypeptides encoded by such sequences, as well as vectors including the said sequences and cells or animals transformed with these vectors. The invention also relates to transcriptional gene products of the Chlamydia pneumoniae genome, such as, for example, antisense and ribozyme molecules, which can be used to control growth of the microorganism. The invention also relates to methods of detecting these nucleic acids or polypeptides and kits for diagnosing Chlamydia pneumoniae infection. The invention also relates to a method of selecting compounds capable of modulating bacterial infection and a method for the biosynthesis or biodegradation of molecules of interest using the said nucleotide sequences or the said polypeptides. The invention finally comprises, pharmaceutical, in particular vaccine, compositions for the prevention and/or treatment of bacterial, in particular Chlamydia pneumoniae, infections.

摘要翻译： 本发明的主题是编码肺炎衣原体多肽的基因组序列和核苷酸序列，例如细胞包膜多肽，其在分泌或特异性中或在复制过程中或在毒力中参与代谢，由此编码的多肽 序列，以及包含所述序列的载体和用这些载体转化的细胞或动物。 本发明还涉及可用于控制微生物生长的肺炎衣原体基因组的转录基因产物，例如反义和核酶分子。 本发明还涉及检测这些核酸或多肽的方法以及用于诊断肺炎衣原体感染的试剂盒。 本发明还涉及使用所述核苷酸序列或所述多肽选择能够调节细菌感染的化合物的方法和用于生物合成或生物降解感兴趣分子的方法。 本发明最终包括用于预防和/或治疗细菌，特别是肺炎衣原体感染的药物，特别是疫苗组合物。

公开(公告)号：US20050249746A1

公开(公告)日：2005-11-10

申请号：US10507786

申请日：2003-03-13

申请人： Bruce Green ,  Gary Zlotnick ,  Leah Fletcher ,  Arnold Smith ,  Thomas Reilly

发明人： Bruce Green ,  Gary Zlotnick ,  Leah Fletcher ,  Arnold Smith ,  Thomas Reilly

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K39/00 ,  A61K39/02 ,  A61K39/102 ,  A61P27/16 ,  A61P31/04 ,  C07K14/285 ,  C07K16/12 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/16 ,  C12N9/48

CPC分类号： A61K39/102 ,  A61K38/00 ,  A61K39/00 ,  C07K14/285 ,  C07K16/1242

摘要： A P4 variant protein that has reduced enzymatic activity and that induces antibody to wild-type P4 protein and/or has good bactericidal activity against non-typable H. influenzae (NTHi) is useful as an active component in an immunogenic composition for humans. Methods of using these proteins, and compositions containing them in combination with additional antigens, are also provided.

摘要翻译： 具有降低的酶活性并诱导野生型P4蛋白的抗体和/或对非特异性流感嗜血杆菌（NTHi）具有良好杀菌活性的P4变体蛋白质可用作人类免疫原性组合物中的活性成分。 还提供了使用这些蛋白质的方法，以及含有它们与其它抗原组合的组合物。

公开(公告)号：US20050203280A1

公开(公告)日：2005-09-15

申请号：US10501282

申请日：2002-11-25

申请人： John McMichael ,  Robert Zagursky ,  Leah Fletcher

发明人： John McMichael ,  Robert Zagursky ,  Leah Fletcher

IPC分类号： A61K39/00 ,  C07H21/04 ,  C07K14/195 ,  C12Q1/68

CPC分类号： C07K14/195 ,  A61K39/00 ,  A61K2039/53

摘要： The present invention relates to the complete genomic sequence of Gram-positive bacterium, Alloiococcus otitidis. The present invention also relates to polynucleotide sequences encoding polypeptides of Alloiococcus otitidis. In particular, the invention relates to antigenic polypeptides encoded by the Alloiococcus otitidis open reading frames (ORFs), and to their use in immunogenic compositions, therapeutics, diagnostics and the like.

摘要翻译： 本发明涉及革兰氏阳性细菌，变形球菌（Alloiococcus otitidis）的完整基因组序列。 本发明还涉及编码变形链球菌多肽的多核苷酸序列。 特别地，本发明涉及由变形链球菌开放阅读框（ORFs）编码的抗原多肽，以及它们在免疫原性组合物，治疗学，诊断学等中的用途。

公开(公告)号：US20060147470A1

公开(公告)日：2006-07-06

申请号：US10544048

申请日：2004-01-27

申请人： Dai-Fang Liu ,  John McMichael ,  Steven Baker ,  Leah Fletcher

发明人： Dai-Fang Liu ,  John McMichael ,  Steven Baker ,  Leah Fletcher

IPC分类号： A61K39/02

CPC分类号： A61K39/1045 ,  A01K2217/05 ,  A61K2039/55505 ,  A61K2039/55572 ,  A61K2039/6037 ,  C07K14/47 ,  C07K14/4727 ,  C07K2319/00

摘要： The present invention broadly relates to immunogenic compositions for administering to a host susceptible to Moraxella catarrhalis infection. More particularly, the invention is directed to the identification of cross-reactive epitope sequences of the CopB protein of Moraxella catarrhalis.

摘要翻译： 本发明广泛地涉及用于施用对卡他莫拉菌感染易感的宿主的免疫原性组合物。 更具体地，本发明涉及鉴定卡他莫拉菌的CopB蛋白的交叉反应性表位序列。