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1.发明申请METHODS AND COMPOSITIONS FOR PRODUCING HYDROGEL CAPSULES COATED FOR LOW PERMEABILITY AND PHYSICAL INTEGRITY 有权生产用于低渗透性和物理完整性的水凝胶囊剂的方法和组合物公开(公告)号：US20110104218A1
公开(公告)日：2011-05-05
申请号：US12612881
申请日：2009-11-05
申请人： Georgios D. Karles , Daqing Wu , Shuzhong Zhuang
发明人： Georgios D. Karles , Daqing Wu , Shuzhong Zhuang
CPC分类号： A24B15/186 , A23L27/72 , A23P10/30 , A23V2002/00 , A24B13/00 , A24B15/283 , A24D3/061 , A61K8/11 , A61K8/31 , A61K8/731 , A61K8/733 , A61K8/8152 , A61K9/5026 , A61K9/5036 , A61K9/5073 , A61Q19/00 , B01J13/22 , C09B67/0097 , A23V2200/224 , A23V2250/5026 , A23V2250/5036 , A23V2250/5072
摘要： Methods and compositions for producing hydrogel capsules enveloped with at least one coating layer is disclosed. The coating formulations deposited on the surface of the capsules can improve the physical integrity and the water-retention properties of the alginate beads. The coating formulations can be sequentially applied in various combinations to obtain desirable properties, such as improved physical integrity, mechanical strength, and low permeability, that can extend the shelf-life of the capsules when incorporated into various consumer products.
摘要翻译： 公开了用至少一个涂层包裹的生产水凝胶胶囊的方法和组合物。 沉积在胶囊表面上的涂料制剂可以改善藻酸盐珠的物理完整性和保水性。 涂层制剂可以以各种组合顺序施用以获得所需的性能，例如改善的物理完整性，机械强度和低渗透性，当将其并入各种消费品时可延长胶囊的保存期限。
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2.发明授权Methods and compositions for producing hydrogel capsules coated for low permeability and physical integrity 有权生产水凝胶胶囊用于低渗透性和物理完整性的方法和组合物公开(公告)号：US08663671B2
公开(公告)日：2014-03-04
申请号：US12612881
申请日：2009-11-05
申请人： Georgios D. Karles , Daqing Wu , Shuzhong Zhuang
发明人： Georgios D. Karles , Daqing Wu , Shuzhong Zhuang
CPC分类号： A24B15/186 , A23L27/72 , A23P10/30 , A23V2002/00 , A24B13/00 , A24B15/283 , A24D3/061 , A61K8/11 , A61K8/31 , A61K8/731 , A61K8/733 , A61K8/8152 , A61K9/5026 , A61K9/5036 , A61K9/5073 , A61Q19/00 , B01J13/22 , C09B67/0097 , A23V2200/224 , A23V2250/5026 , A23V2250/5036 , A23V2250/5072
摘要： Methods and compositions for producing hydrogel capsules enveloped with at least one coating layer is disclosed. The coating formulations deposited on the surface of the capsules can improve the physical integrity and the water-retention properties of the alginate beads. The coating formulations can be sequentially applied in various combinations to obtain desirable properties, such as improved physical integrity, mechanical strength, and low permeability, that can extend the shelf-life of the capsules when incorporated into various consumer products.
摘要翻译： 公开了用至少一个涂层包裹的生产水凝胶胶囊的方法和组合物。 沉积在胶囊表面上的涂料制剂可以改善藻酸盐珠的物理完整性和保水性。 涂层制剂可以以各种组合顺序施用以获得所需的性能，例如改善的物理完整性，机械强度和低渗透性，当将其并入各种消费品时可延长胶囊的保存期限。
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公开(公告)号：US08402978B2
公开(公告)日：2013-03-26
申请号：US12577008
申请日：2009-10-09
申请人： Georgios Karles , Shuzhong Zhuang , Yi Zeng , Hongwei Liu , Daqing Wu
发明人： Georgios Karles , Shuzhong Zhuang , Yi Zeng , Hongwei Liu , Daqing Wu
IPC分类号： A24D3/06
摘要： A process for producing a coated filter plug for a smoking article including: (a) incorporating an additive to a porous filter plug, thereby obtaining an impregnated filter plug; (b) coating a surface of the impregnated filter plug with a cross-linkable polymer material; and (c) cross-linking the cross-linkable polymer material, to form a cross-linked, breakable coating substantially enclosing the impregnated filter plug. The process may further include at least partially coating the impregnated filter plug with a cross-linking agent prior to, or subsequent to, coating with the cross-linkable polymer material.
摘要翻译： 一种用于制造用于吸烟制品的涂覆过滤嘴的方法，包括：（a）将添加剂并入多孔过滤塞中，从而获得浸渍过滤嘴塞; （b）用可交联的聚合物材料涂覆浸渍的过滤嘴的表面; 和（c）交联可交联的聚合物材料，以形成基本上封闭浸渍的过滤塞的交联的可破坏的涂层。 该方法可以进一步包括在用可交联聚合物材料涂覆之前或之后用交联剂至少部分地涂覆浸渍的过滤嘴塞。
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公开(公告)号：US20110083676A1
公开(公告)日：2011-04-14
申请号：US12577008
申请日：2009-10-09
申请人： Georgios Karles , Shuzhong Zhuang , Yi Zeng , Hongwei Liu , Daqing Wu
发明人： Georgios Karles , Shuzhong Zhuang , Yi Zeng , Hongwei Liu , Daqing Wu
摘要： A process for producing a coated filter plug for a smoking article including: (a) incorporating an additive to a porous filter plug, thereby obtaining an impregnated filter plug; (b) coating a surface of the impregnated filter plug with a cross-linkable polymer material; and (c) cross-linking the cross-linkable polymer material, to form a cross-linked, breakable coating substantially enclosing the impregnated filter plug. The process may further include at least partially coating the impregnated filter plug with a cross-linking agent prior to, or subsequent to, coating with the cross-linkable polymer material.
摘要翻译： 一种用于制造用于吸烟制品的涂覆过滤嘴的方法，包括：（a）将添加剂并入多孔过滤塞中，从而获得浸渍过滤嘴塞; （b）用可交联的聚合物材料涂覆浸渍的过滤嘴的表面; 和（c）交联可交联的聚合物材料，以形成基本上封闭浸渍的过滤塞的交联的可破坏的涂层。 该方法可以进一步包括在用可交联聚合物材料涂覆之前或之后用交联剂至少部分地涂覆浸渍的过滤嘴塞。
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公开(公告)号：US09187601B2
公开(公告)日：2015-11-17
申请号：US13253186
申请日：2011-10-05
申请人： Jinyu Huang , Frank Chang , Robert Scott , Arturo Norberto Medina , Manivakkam J. Shankernarayanan , Selma Kuyu , Dawn Alison Smith , Daqing Wu
发明人： Jinyu Huang , Frank Chang , Robert Scott , Arturo Norberto Medina , Manivakkam J. Shankernarayanan , Selma Kuyu , Dawn Alison Smith , Daqing Wu
IPC分类号： C08F230/08 , C08G77/42 , C08G77/442 , C08L83/10 , G02B1/04 , C08G77/20
CPC分类号： G02B1/043 , C08G77/20 , C08G77/42 , C08G77/442 , C08J3/075 , C08J2343/04 , C08J2383/08 , C08L83/10 , C08L101/14 , C08L83/04
摘要： The invention provide a class of water-processable polymerizable prepolymers which comprises (1) siloxane-containing monomeric units derived at least one siloxane containing monomer having one hydrophilic group or chain and/or polysiloxane-containing crosslinking units derived from at least one hydrophilized polysiloxane or chain-extended polysiloxane crosslinker; (2) hydrophilic monomeric units derived from one or more hydrophilic vinylic monomers; and (3) from about 0.05% to about 5% by weight of polymerizable units each having a pendant or terminal, ethylenically-unsaturated group and free of any polysiloxane segment. The prepolymer comprises from about 20% to about 50% by weight of silicone relative to the total weight of the prepolymer and has a high water solubility or dispersibility of at least about 5% by weight in water and suitable for making silicone hydrogel contact lenses.
摘要翻译： 本发明提供了一类可水加工的可聚合预聚物，其包含（1）衍生自至少一种含有一个含硅氧烷的单体的含硅氧烷的单体单元，所述单体具有一个亲水基团或至少一种亲水化聚硅氧烷的链和/或含聚硅氧烷的交联单元，或 链延长聚硅氧烷交联剂; （2）衍生自一种或多种亲水乙烯基单体的亲水单体单元; 和（3）约0.05％至约5％重量的各自具有侧基或末端的可聚合单元，烯属不饱和基团并且不含任何聚硅氧烷链段。 预聚物相对于预聚物的总重量包含约20重量％至约50重量％的硅氧烷，并且在水中具有至少约5重量％的高水溶性或分散性，并且适于制备硅酮水凝胶隐形眼镜。
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公开(公告)号：US09052439B2
公开(公告)日：2015-06-09
申请号：US13186616
申请日：2011-07-20
申请人： Newton T. Samuel , John Dallas Pruitt , Daqing Wu , Selma Kuyu
发明人： Newton T. Samuel , John Dallas Pruitt , Daqing Wu , Selma Kuyu
CPC分类号： G02B1/043 , B29D11/00038 , B29D11/00048 , G02C7/04 , G02C7/049 , C08L101/14
摘要： Described herein is a cost-effective and time-efficient method for making UV-absorbing contact lenses. In contrast to the conventional method for making UV-absorbing contact lenses which involves copolymerizing a lens forming composition including a UV-absorbing vinylic monomer, a method of the invention involves covalent attachment of a UV-absorbing compound having a second reactive functional group to a preformed contact lens having a first reactive functional group therein and/or thereon.
摘要翻译： 本文描述了制造紫外线吸收隐形眼镜的成本效益和时间有效的方法。 与使紫外线吸收性隐形眼镜相关的常规方法与包含紫外线吸收性乙烯基单体的透镜形成组合物共聚，本发明的方法涉及将具有第二反应性官能团的紫外线吸收性化合物与 其中和/或其上具有第一反应性官能团的预成型隐形眼镜。
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公开(公告)号：US08557334B2
公开(公告)日：2013-10-15
申请号：US12960617
申请日：2010-12-06
申请人： Newton T. Samuel , Daqing Wu
发明人： Newton T. Samuel , Daqing Wu
CPC分类号： G02B1/043 , C08L101/14 , C08L51/085
摘要： The invention provides a cost-effective method for making a silicone hydrogel contact lens having a hydrophilic coating thereon that is covalently attached to the lens and has a good hydrophilicity, intactness and durability. The invention also provides a silicone hydrogel contact lenses having a hydrophilic coating consisting of a prime coating covalently attached to the contact lens and a top coating covalently attached to the prime coating.
摘要翻译： 本发明提供了一种制备其上具有共价连接到透镜上并具有良好的亲水性，完整性和耐久性的亲水涂层的硅酮水凝胶隐形眼镜的成本有效的方法。 本发明还提供一种具有亲水性涂层的硅酮水凝胶隐形眼镜，该亲水性涂层由共价连接到隐形眼镜的主涂层和共价连接到主涂层的顶涂层组成。
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公开(公告)号：US08246994B2
公开(公告)日：2012-08-21
申请号：US12130001
申请日：2008-05-30
申请人： Daqing Wu , Chih-Chang Chu , Joseph Carozza
发明人： Daqing Wu , Chih-Chang Chu , Joseph Carozza
IPC分类号： A61K9/14
CPC分类号： A61K39/385 , A61K47/34 , A61K2039/55516 , A61K2039/6081
摘要： New hydrogel, including a hydrogel containing cationic BSA is included in a vaccine to stimulate the immune system to increase the potency of the vaccine.
摘要翻译： 包含含有阳离子BSA的水凝胶的新水凝胶包括在疫苗中以刺激免疫系统以增加疫苗的效力。
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公开(公告)号：US08246993B2
公开(公告)日：2012-08-21
申请号：US11148641
申请日：2005-06-09
申请人： Daqing Wu , Chih-Chang Chu , Joseph Carozza
发明人： Daqing Wu , Chih-Chang Chu , Joseph Carozza
IPC分类号： A61K9/14
CPC分类号： A61K39/385 , A61K47/34 , A61K2039/55516 , A61K2039/6081
摘要： New hydrogel, including a hydrogel containing cationic BSA is included in a vaccine to stimulate the immune system to increase the potency of the vaccine.
摘要翻译： 包含含有阳离子BSA的水凝胶的新水凝胶包括在疫苗中以刺激免疫系统以增加疫苗的效力。
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公开(公告)号：US20100144678A1
公开(公告)日：2010-06-10
申请号：US12595296
申请日：2008-04-09
申请人： Lajos Gera , John M. Stewart , Leland W.K. Chung , Daqing Wu
发明人： Lajos Gera , John M. Stewart , Leland W.K. Chung , Daqing Wu
IPC分类号： A61K31/675 , C12Q1/68 , C12N5/02 , A61K31/662 , C07F9/28 , A61P35/04
摘要： Small molecule bradykinin inhibitor bisphosphonate amide derivatives useful for inhibiting cancer growth and treating cancer residing in and around bone are disclosed. These compounds and pharmaceutical compositions containing these compounds are particularly useful for the treatment of prostate cancer bone metastases.
摘要翻译： 公开了用于抑制癌症生长和治疗存在于骨骼内和周围的癌症的小分子缓激肽抑制剂双膦酸酯衍生物。 这些化合物和含有这些化合物的药物组合物特别可用于治疗前列腺癌骨转移。
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