摘要:
In the purification of impure titanium tetrachloride comprising adding an agent to said titanium tetrachloride and thereafter distilling off purified titanium tetrachloride while leaving the impurity in the distillation residue, the improvement which comprises employing as said agent at least one amine of the formula ##EQU1## in which R.sub.1 and R.sub.2 each independently is hydrogen, alkyl or alkenyl of up to 6 carbon atoms, cycloalkyl of 5 to 7 carbon atoms, or aryl, andR.sub.3 is cycloalkyl of 5 to 7 ring carbon atoms, or aryl, orR.sub.2 together with R.sub.3 is butylene, pentylene or hexylene, in which eventR.sub.1 is hydrogen, alkyl of up to 6 carbon atoms or aryl.The preferred agents are aniline, cyclohexylamine, N,N-dimethyl-aniline, diphenylamine, 2,3-dimethyl-aniline and 2,6-dimethyl-aniline. The process serves to remove vanadium impurities.
摘要:
A plastic composition degradable under the influence of weather or light, comprising a plastic material and finely divided titanium dioxide with a specific surface of more than about 20 m.sup.2 /g. Preferably the titanium dioxide is obtained by hydrolyzing titanium sulfate in aqueous solution, has a predominantly anatase structure, a lightening power of less than about 400, a specific surface of about 60 to 400 m.sup.2 /g and is present in about 0.5 to 5% by weight of the composition, and the plastic material is selected from the group consisting of polyethylene, ethylene-vinyl acetate copolymer, polystyrene, polyvinyl chloride, polyamides and ABS-polymers.
摘要:
Titanates of zinc and/or alkaline earth metals are produced by simultaneously adding to a suspension of finely divided TiO.sub.2, maintained at a substantially constant pH above about 8, a solution of a salt of zinc and/or alkaline earth metal and alkali to form a hydroxide precipitate. Filtration produces a filter cake mixture of TiO.sub.2 and hydroxide and calcination at above 500.degree. C. produces the desired titanate of narrow particle size distribution and desirable optical properties. Non-simultaneous addition results in a non-filterable material. Zinc, magnesium and/or calcium are preferred and doping elements such as aluminum, phosphorus, boron and/or silicon may also be present.
摘要:
The invention concerns lyophilized pharmaceutical preparations of monoclonal or polyclonal antibodies which contain a sugar or an amino sugar, an amino acid and a surfactant as stabilizers. In addition the invention concerns a process for the production of this stable lyophilizate as well as the use of a sugar or amino sugar, an amino acid and a surfactant as stabilizers for therapeutic or diagnostic agents containing antibodies.
摘要:
The present invention relates to a batch crystallization method for crystallizing anti-human TNFalpha (hTNFalpha) antibody and antibody fragments which allows the production of said antibody on an industrial scale; a method of controlling the size of antibody crystals, for example, crystals of anti-hTNFalpha antibody fragments, compositions containing said crystals as well as methods of use of said crystals and compositions.
摘要:
The present invention relates to a pharmaceutical composition for sustained release of a pharmaceutically active compound, the composition comprising a vesicular phospholipid gel. More particularly, the invention relates to a pharmaceutical composition comprising at least one proteinaceous substance as the pharmaceutically active compound in encapsulated form, the at least one proteinaceous substance being a biologically active protein, peptide or polypeptide. Furthermore, the present invention relates to a method for the production of said pharmaceutical composition comprising dual asymmetric centrifugation and to the use of said pharmaceutical composition for immunotherapy and/or for stimulating selective tissue regeneration in the treatment of surgical defects in the course of surgical interventions.
摘要:
The present invention concerns processes for the production of dry, partially amorphous products containing biologically active and in particular therapeutically active material which are macroscopically homogeneous substance mixtures, the substance mixtures being selected from at least one substance of each of the groups (i) carbohydrate or zwitterion with a polar residue and derivatives thereof, and (ii) zwitterion with an apolar residue and derivatives thereof, wherein a solution is prepared of the biologically or therapeutically active material and of substances (i) and (ii) and the solution is dried at a product temperature above the freezing point of the solution. In addition the invention concerns new substance mixtures which are obtained by the said process as well as the use thereof in diagnostic or therapeutic methods.
摘要:
Aqueous pharmaceutical preparations of G-CSF are disclosed that are stable on storage and a buffer selected from the group consisting of a salt of citrate, maleate, a combination of phosphate and citrate, and arginine; and at least one surfactant.
摘要:
A thermal fuse includes a leaf spring formed of a narrow sheet metal strip. The leaf spring has ends and at least two contact points at the ends. At least one of the contact points is a soldering point for connection with corresponding circuit contacts of a circuit substrate. The leaf spring has at least one spring arm interconnecting the contact points. The spring arm has a roof-shaped deformation in the vicinity of one contact point. The spring arm has a flat and elongated spring segment with a transition adjoining the deformation and a transition extending to the other contact point. The spring segment is bending resistant in the vicinities of the transitions, for transforming a compressive deformation applied to the roof-shaped deformation into a lateral movement and into an arching of the spring segment, with both ends of the leaf spring attached to the circuit substrate without pretensioning. A method for activation of the thermal fuse includes placing the contact points of the leaf springs free of tension on the circuit contacts, soldering the contact points to the circuit contacts, and compressively deforming the roof-shaped deformation after the soldering for creating an arching of the spring segment and a desired pretensioning.
摘要:
A method for the production of a radiographic screen comprising the following steps:1) dispersing phosphor particles in an organic liquid in the presence of a charge controlling agent that charges said phosphor particles with a positive or negative net charge,2) arranging said dispersion between a pair of electrodes, wherein one of said electrodes is or carries a conductive support of said radiographic screen,3) applying and maintaining between said electrodes a sufficiently high direct current voltage to deposit charged phosphor particles onto said conductive support, and4) separating said support carrying electrophoretically deposited phosphor particles from said organic liquid,wherein the dispersing of said phosphor particles proceeds by means of an organic surface active compound acting as dispersing agent for said phosphor particles, and said phosphor particles are electrostatically charged through adsorption thereon of ionic components of said organic surface active compound and/or through adsorption of cations or anions stemming from an ionic inorganic compound incorporated in said liquid.