Poly(amino acid) adhesive tissue grafts
    2.
    发明授权
    Poly(amino acid) adhesive tissue grafts 失效
    聚(氨基酸)粘合剂组织移植

    公开(公告)号:US5733868A

    公开(公告)日:1998-03-31

    申请号:US633118

    申请日:1996-04-16

    摘要: A composition and method for repairing damaged connective tissue is provided. The composition comprises pseudo-poly(amino acids) and/or classic poly(amino acids) that exhibit adhesiveness for connective tissues. The composition is formed into an adhesive tissue repair implant and pressed against the damaged tissue to adhere the adhesive composition to the tissue.

    摘要翻译: 提供了修复损伤的结缔组织的组合物和方法。 该组合物包含对结缔组织显示粘附性的假聚(氨基酸)和/或经典聚(氨基酸)。 将组合物形成为粘合剂组织修复植入物并压靠损伤的组织以将粘合剂组合物粘附到组织上。

    Peptide-based scaffolds for cartilage regeneration and methods for their use
    7.
    发明授权
    Peptide-based scaffolds for cartilage regeneration and methods for their use 有权
    用于软骨再生的基于肽的支架及其使用方法

    公开(公告)号:US08450271B2

    公开(公告)日:2013-05-28

    申请号:US12759683

    申请日:2010-04-13

    摘要: Disclosed herein are novel peptide amphiphile molecules and compositions composed of a peptide sequence that non-covalently binds the growth factor TGF-β1. Also disclosed are methods of using these peptide amphiphiles to create a gel scaffold in situ that enhances articular cartilage regeneration when used in combination with microfracture. Significant improvement in tissue quality and overall O'Driscoll histological scores were observed in rabbits with full thickness articular cartilage defects treated with the TGF-binding peptide amphiphile. The gel can further serve as a delivery vehicle for recombinant TGF-β1 protein growth factor. Scaffolds that localize and retain chondrogenic growth factors may synergistically enhance cartilage repair when combined with microfracture, by inducing bone marrow mesenchymal stem cells into chondrogenic differentiation. This invention represents a promising new biomimetic approach to enhance current techniques of articular cartilage regeneration in the clinical setting.

    摘要翻译: 本文公开了新型肽两亲物分子和由非共价结合生长因子TGF-β1的肽序列组成的组合物。 还公开了使用这些肽两亲物来制备原位凝胶支架的方法,当与微裂缝组合使用时,其可增强关节软骨再生。 在用TGF-结合肽两亲物处理的全层关节软骨缺损的兔子中观察到组织质量和总体O'Driscoll组织学评分的显着改善。 该凝胶可进一步用作重组TGF-β1蛋白生长因子的递送载体。 定位和保留软骨形成生长因子的支架可以通过将骨髓间充质干细胞诱导成软骨形成分化来协同增强软骨修复与微裂缝结合。 本发明代表了在临床环境中增强关节软骨再生的当前技术的有希望的新的仿生方法。

    MODULAR SUPRAMOLECULAR APPROACH FOR CO-CRYSTALLIZATION OF DONORS AND ACCEPTORS INTO ORDERED NETWORKS
    8.
    发明申请
    MODULAR SUPRAMOLECULAR APPROACH FOR CO-CRYSTALLIZATION OF DONORS AND ACCEPTORS INTO ORDERED NETWORKS 有权
    捐赠者和接受者共同结构化到有序网络的模块化SUPRAMONAL分析方法

    公开(公告)号:US20130069010A1

    公开(公告)日:2013-03-21

    申请号:US13476974

    申请日:2012-05-21

    IPC分类号: H01B1/12 C07D487/14

    CPC分类号: H01B1/121 C07D487/14

    摘要: Organic charge-transfer (CT) co-crystals in a mixed stack system are disclosed, wherein a donor molecule (D) and an acceptor molecule (A) occupy alternating positions (DADADA) along the CT axis. A platform is provided which amplifies the molecular recognition of donors and acceptors and produces co-crystals at ambient conditions, wherein the platform comprises (i) a molecular design of the first constituent (α-complement), (ii) a molecular design of the second compound (β-complement), and (iii) a solvent system that promotes co-crystallization.

    摘要翻译: 公开了混合堆叠系统中的有机电荷转移(CT)共晶体,其中供体分子(D)和受体分子(A)沿CT轴占据交替位置(DADADA)。 提供了一种平台,其放大了供体和受体的分子识别,并在环境条件下产生共晶体,其中平台包括(i)第一组分(α-互补体)的分子设计,(ii) 第二化合物(&bgr; - 补体),和(iii)促进共结晶的溶剂体系。

    Encapsulated peptide amphiphile nanostructures
    10.
    发明授权
    Encapsulated peptide amphiphile nanostructures 有权
    封装肽两亲物纳米结构

    公开(公告)号:US08080262B2

    公开(公告)日:2011-12-20

    申请号:US11923428

    申请日:2007-10-24

    IPC分类号: A61K9/127 A61K38/00 A61K38/08

    CPC分类号: A61K38/10 A61K9/1278

    摘要: The present invention provides compositions and methods for creating encapsulated peptide amphiphilic nanostructures useful in treating diseases. In particular, the present invention provides compositions and methods for preparing peptide amphiphile nanostructures that are encapsulated in liposomes by the application of light, and using such compositions in treating diseases, such as cancer.

    摘要翻译: 本发明提供用于产生用于治疗疾病的包封的肽两亲性纳米结构的组合物和方法。 特别地,本发明提供了通过应用光来制备封装在脂质体中的肽两亲物纳米结构的组合物和方法,并且使用这些组合物治疗诸如癌症的疾病。