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1.发明申请METHODS OF MAKING A MOLECULAR DETECTION CHIP HAVING A METAL OXIDE SILICON FIELD EFFECT TRANSISTOR ON SIDEWALLS OF A MICRO-FLUID CHANNEL 有权在微流体通道上形成金属氧化物半导体场效应晶体管的分子检测芯片的方法公开(公告)号：US20070218610A1
公开(公告)日：2007-09-20
申请号：US11755952
申请日：2007-05-31
申请人： Geun-Bae Lim , Chin-Sung Park , Yoon-Kyoung Cho , Sun-Hee Kim
发明人： Geun-Bae Lim , Chin-Sung Park , Yoon-Kyoung Cho , Sun-Hee Kim
IPC分类号： H01L21/22
CPC分类号： G01N33/5438 , B01J2219/00497 , B01J2219/00511 , B01J2219/00585 , B01J2219/00596 , B01J2219/00653 , B01J2219/00657 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , B01J2219/00743 , B01L3/5027 , B82Y15/00 , B82Y30/00 , C12Q1/6837 , G01N27/4145 , G01N33/54373 , C12Q2565/607
摘要： A molecular detection chip including a metal oxide silicon-field effect transistor (MOSFET) on sidewalls of a micro-fluid channel and a molecular detection device including the molecular detection chip are provided. A molecular detection method, particularly, qualification methods for the immobilization of molecular probes and the binding of a target sample to the molecular probes, using the molecular detection device, and a nucleic acid mutation assay device and method are also provided. The formation of the MOSFET on the sidewalls of the micro-fluid channel makes easier to highly integrate a molecular detection chip. In addition, immobilization of probes directly on the surface of a gate electrode ensures the molecular detection chip to check for the immobilization of probes and coupling of a target molecule to the probes in situ.
摘要翻译： 提供了包括在微流体通道的侧壁上的金属氧化物硅场效应晶体管（MOSFET）和包括分子检测芯片的分子检测装置的分子检测芯片。 还提供了使用分子检测装置的分子检测方法，特别是用于固定分子探针的鉴定方法和靶样品与分子探针的结合，以及核酸突变测定装置和方法。 在微流体通道的侧壁上形成MOSFET更容易高度集成分子检测芯片。 此外，探针直接固定在栅电极的表面上确保了分子检测芯片，以检查探针的固定和目标分子与探针原位偶联。
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公开(公告)号：US07235389B2
公开(公告)日：2007-06-26
申请号：US10239736
申请日：2002-04-23
申请人： Geun-Bae Lim , Chin-Sung Park , Yoon-Kyoung Cho , Sun-Hee Kim
发明人： Geun-Bae Lim , Chin-Sung Park , Yoon-Kyoung Cho , Sun-Hee Kim
CPC分类号： G01N33/5438 , B01J2219/00497 , B01J2219/00511 , B01J2219/00585 , B01J2219/00596 , B01J2219/00653 , B01J2219/00657 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , B01J2219/00743 , B01L3/5027 , B82Y15/00 , B82Y30/00 , C12Q1/6837 , G01N27/4145 , G01N33/54373 , C12Q2565/607
摘要： A molecular detection chip including a metal oxide silicon-field effect transistor (MOSFET) on sidewalls of a micro-fluid channel and a molecular detection device including the molecular detection chip are provided. A molecular detection method, particularly, qualification methods for the immobilization of molecular probes and the binding of a target sample to the molecular probes, using the molecular detection device, and a nucleic acid mutation assay device and method are also provided. The formation of the MOSFET on the sidewalls of the micro-fluid channel makes easier to highly integrate a molecular detection chip. In addition, immobilization of probes directly on the surface of a gate electrode ensures the molecular detection chip to check for the immobilization of probes and coupling of a target molecule to the probes in situ.
摘要翻译： 提供了包括在微流体通道的侧壁上的金属氧化物硅场效应晶体管（MOSFET）和包括分子检测芯片的分子检测装置的分子检测芯片。 还提供了使用分子检测装置的分子检测方法，特别是用于固定分子探针的鉴定方法和靶样品与分子探针的结合，以及核酸突变测定装置和方法。 在微流体通道的侧壁上形成MOSFET更容易高度集成分子检测芯片。 此外，探针直接固定在栅电极的表面上确保了分子检测芯片，以检查探针的固定和目标分子与探针原位偶联。
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3.发明授权Molecular detection methods using molecular detection chips including a metal oxide semiconductor field effect transistor 有权使用包括金属氧化物半导体场效应晶体管的分子检测芯片的分子检测方法公开(公告)号：US07781167B2
公开(公告)日：2010-08-24
申请号：US11756083
申请日：2007-05-31
申请人： Geun-Bae Lim , Chin-Sung Park , Yoon-Kyoung Cho , Sun-Hee Kim
发明人： Geun-Bae Lim , Chin-Sung Park , Yoon-Kyoung Cho , Sun-Hee Kim
CPC分类号： G01N33/5438 , B01J2219/00497 , B01J2219/00511 , B01J2219/00585 , B01J2219/00596 , B01J2219/00653 , B01J2219/00657 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , B01J2219/00743 , B01L3/5027 , B82Y15/00 , B82Y30/00 , C12Q1/6837 , G01N27/4145 , G01N33/54373 , C12Q2565/607
摘要： A molecular detection chip including a metal oxide silicon-field effect transistor (MOSFET) on sidewalls of a micro-fluid channel and a molecular detection device including the molecular detection chip are provided. A molecular detection method, particularly, qualification methods for the immobilization of molecular probes and the binding of a target sample to the molecular probes, using the molecular detection device, and a nucleic acid mutation assay device and method are also provided. The formation of the MOSFET on the sidewalls of the micro-fluid channel makes easier to highly integrate a molecular detection chip. In addition, immobilization of probes directly on the surface of a gate electrode ensures the molecular detection chip to check for the immobilization of probes and coupling of a target molecule to the probes in situ.
摘要翻译： 提供了包括在微流体通道的侧壁上的金属氧化物硅场效应晶体管（MOSFET）和包括分子检测芯片的分子检测装置的分子检测芯片。 还提供了使用分子检测装置的分子检测方法，特别是用于固定分子探针的鉴定方法和靶样品与分子探针的结合，以及核酸突变测定装置和方法。 在微流体通道的侧壁上形成MOSFET更容易高度集成分子检测芯片。 此外，探针直接固定在栅电极的表面上确保了分子检测芯片，以检查探针的固定和目标分子与探针原位偶联。
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4.发明授权Methods of making a molecular detection chip having a metal oxide silicon field effect transistor on sidewalls of a micro-fluid channel 有权制造在微流体通道的侧壁上具有金属氧化物硅场效应晶体管的分子检测芯片的方法公开(公告)号：US07863140B2
公开(公告)日：2011-01-04
申请号：US11755952
申请日：2007-05-31
申请人： Geun-Bae Lim , Chin-Sung Park , Yoon-Kyoung Cho , Sun-Hee Kim
发明人： Geun-Bae Lim , Chin-Sung Park , Yoon-Kyoung Cho , Sun-Hee Kim
IPC分类号： H01L21/336 , G01N27/02 , C12M1/34
CPC分类号： G01N33/5438 , B01J2219/00497 , B01J2219/00511 , B01J2219/00585 , B01J2219/00596 , B01J2219/00653 , B01J2219/00657 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , B01J2219/00743 , B01L3/5027 , B82Y15/00 , B82Y30/00 , C12Q1/6837 , G01N27/4145 , G01N33/54373 , C12Q2565/607
摘要： A molecular detection chip including a metal oxide silicon-field effect transistor (MOSFET) on sidewalls of a micro-fluid channel and a molecular detection device including the molecular detection chip are provided. A molecular detection method, particularly, qualification methods for the immobilization of molecular probes and the binding of a target sample to the molecular probes, using the molecular detection device, and a nucleic acid mutation assay device and method are also provided. The formation of the MOSFET on the sidewalls of the micro-fluid channel makes easier to highly integrate a molecular detection chip. In addition, immobilization of probes directly on the surface of a gate electrode ensures the molecular detection chip to check for the immobilization of probes and coupling of a target molecule to the probes in situ.
摘要翻译： 提供了包括在微流体通道的侧壁上的金属氧化物硅场效应晶体管（MOSFET）和包括分子检测芯片的分子检测装置的分子检测芯片。 还提供了使用分子检测装置的分子检测方法，特别是用于固定分子探针的鉴定方法和靶样品与分子探针的结合，以及核酸突变测定装置和方法。 在微流体通道的侧壁上形成MOSFET更容易高度集成分子检测芯片。 此外，探针直接固定在栅电极的表面上确保了分子检测芯片，以检查探针的固定和目标分子与探针原位偶联。
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5.发明申请MOLECULAR DETECTION METHODS USING MOLECULAR DETECTION CHIPS INCLUDING A METAL OXIDE SEMICONDUCTOR FIELD EFFECT TRANSISTOR 有权使用分子检测包括金属氧化物半导体场效应晶体管的分子检测方法公开(公告)号：US20080093229A1
公开(公告)日：2008-04-24
申请号：US11756083
申请日：2007-05-31
申请人： Geun-Bae Lim , Chin-Sung Park , Yoon-Kyoung Cho , Sun-Hee Kim
发明人： Geun-Bae Lim , Chin-Sung Park , Yoon-Kyoung Cho , Sun-Hee Kim
IPC分类号： G01N27/26
CPC分类号： G01N33/5438 , B01J2219/00497 , B01J2219/00511 , B01J2219/00585 , B01J2219/00596 , B01J2219/00653 , B01J2219/00657 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , B01J2219/00743 , B01L3/5027 , B82Y15/00 , B82Y30/00 , C12Q1/6837 , G01N27/4145 , G01N33/54373 , C12Q2565/607
摘要： A molecular detection chip including a metal oxide silicon-field effect transistor (MOSFET) on sidewalls of a micro-fluid channel and a molecular detection device including the molecular detection chip are provided. A molecular detection method, particularly, qualification methods for the immobilization of molecular probes and the binding of a target sample to the molecular probes, using the molecular detection device, and a nucleic acid mutation assay device and method are also provided. The formation of the MOSFET on the sidewalls of the micro-fluid channel makes easier to highly integrate a molecular detection chip. In addition, immobilization of probes directly on the surface of a gate electrode ensures the molecular detection chip to check for the immobilization of probes and coupling of a target molecule to the probes in situ.
摘要翻译： 提供了包括在微流体通道的侧壁上的金属氧化物硅场效应晶体管（MOSFET）和包括分子检测芯片的分子检测装置的分子检测芯片。 还提供了使用分子检测装置的分子检测方法，特别是用于固定分子探针的鉴定方法和靶样品与分子探针的结合，以及核酸突变测定装置和方法。 在微流体通道的侧壁上形成MOSFET更容易高度集成分子检测芯片。 此外，探针直接固定在栅电极的表面上确保了分子检测芯片，以检查探针的固定和目标分子与探针原位偶联。
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