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公开(公告)号：US09763952B2
公开(公告)日：2017-09-19
申请号：US14976998
申请日：2015-12-21
申请人： Giorgio Caravatti , Sylvie Chamoin , Pascal Furet , Klemens Hogenauer , Konstanze Hurth , Karen Kammertoens , Ian Lewis , Henrik Moebitz , Alexander Baxter Smith , Nicolas Soldermann , Romain Wolf , Frederic Zecri
发明人： Giorgio Caravatti , Sylvie Chamoin , Pascal Furet , Klemens Hogenauer , Konstanze Hurth , Karen Kammertoens , Ian Lewis , Henrik Moebitz , Alexander Baxter Smith , Nicolas Soldermann , Romain Wolf , Frederic Zecri
IPC分类号： A61K31/538 , A61K31/5383 , C07D498/04 , C07D413/14 , C12Q1/25 , C12N9/12
CPC分类号： A61K31/5383 , A61K31/538 , C07D413/14 , C07D498/04 , C12N9/12 , C12Q1/25 , C12Q1/686 , Y02A50/409 , Y02A50/411
摘要： The invention relates to dihydro-benzo-oxazine and dihydro-pyrido-oxazine compounds of the formula (I) and/or pharmaceutically acceptable salts and/or solvates thereof, wherein Y, V, W, U, Q, R1, R5, R7 and R30 are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.
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公开(公告)号：US20130237519A1
公开(公告)日：2013-09-12
申请号：US13599267
申请日：2012-08-30
申请人： Ian Bruce , Sylvie Chamoin , Stephen Paul Collingwood , Pascal Furet , Vikki Furminger , Diana Janus , Sarah Lewis , Jon Christopher Loren , Valentina Molteni , Alex Michael Saunders , Duncan Shaw , Lilya Sviridenko , Christopher Thomson , Ryan West , Vince Yeh
发明人： Ian Bruce , Sylvie Chamoin , Stephen Paul Collingwood , Pascal Furet , Vikki Furminger , Diana Janus , Sarah Lewis , Jon Christopher Loren , Valentina Molteni , Alex Michael Saunders , Duncan Shaw , Lilya Sviridenko , Christopher Thomson , Ryan West , Vince Yeh
IPC分类号： C07D471/04 , A61K31/4545 , A61K31/444 , A61K45/06 , A61K31/5377 , A61K31/496
CPC分类号： C07D471/04 , A61K31/444 , A61K31/4545 , A61K31/4745 , A61K31/496 , A61K31/5377 , A61K45/06
摘要： Bicyclic heterocyclic derivatives of formula I useful in inhibiting PDGF receptor mediated biological activity. wherein A is and R1, R1a, R2, R3, R4, R5, R6 and X are as defined herein.
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公开(公告)号：US09073921B2
公开(公告)日：2015-07-07
申请号：US14187214
申请日：2014-02-21
申请人： Ian Bruce , Sylvie Chamoin , Stephen Paul Collingwood , Pascal Furet , Vikki Furminger , Sarah Lewis , Jon Christopher Loren , Lin Lv , Valentina Molten , Alex Michael Saunders , Duncan Shaw , Roy Maxwell Turner , Vince Yeh
发明人： Ian Bruce , Sylvie Chamoin , Stephen Paul Collingwood , Pascal Furet , Vikki Furminger , Sarah Lewis , Jon Christopher Loren , Lin Lv , Valentina Molten , Alex Michael Saunders , Duncan Shaw , Roy Maxwell Turner , Vince Yeh
IPC分类号： C07D401/00 , A61K31/44 , C07D471/04 , A61K45/06
CPC分类号： C07D471/04 , A61K45/06
摘要： The present invention provides novel solid forms of pharmaceutically active agents and therapeutic uses thereof. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译： 本发明提供药物活性剂的新型固体形式及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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4.发明申请BICYCLIC HETEROCYCLE DERIVATIVES FOR THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSION 有权用于治疗肺动脉高压的双相异构体衍生物公开(公告)号：US20150025059A1
公开(公告)日：2015-01-22
申请号：US14511044
申请日：2014-10-09
申请人： Ian Bruce , Sylvie Chamoin , Stephen Paul Collingswood , Pascal Furet , Vikki Furminger , Diana Janus , Sarah Lewis , Jon Christopher Loren , Valentina Molteni , Alex Michael Saunders , Duncan Shaw , Lilya Sviridenko , Christopher Thomson , Ryan West , Vince Yeh
发明人： Ian Bruce , Sylvie Chamoin , Stephen Paul Collingswood , Pascal Furet , Vikki Furminger , Diana Janus , Sarah Lewis , Jon Christopher Loren , Valentina Molteni , Alex Michael Saunders , Duncan Shaw , Lilya Sviridenko , Christopher Thomson , Ryan West , Vince Yeh
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , A61K31/444 , A61K31/4545 , A61K31/4745 , A61K31/496 , A61K31/5377 , A61K45/06
摘要： Bicyclic heterocyclic derivatives of formula I useful in inhibiting PDGF receptor mediated biological activity. wherein A is and R1, R1a, R2, R3, R4, R5, R6 and X are as defined herein.
摘要翻译： 式I的双环杂环衍生物可用于抑制PDGF受体介导的生物活性。 其中A是且R 1，R 1a，R 2，R 3，R 4，R 5，R 6和X如本文所定义。
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5.发明授权公开(公告)号：US08883819B2
公开(公告)日：2014-11-11
申请号：US13599267
申请日：2012-08-30
申请人： Ian Bruce , Sylvie Chamoin , Stephen Paul Collingwood , Pascal Furet , Vikki Furminger , Diana Janus , Sarah Lewis , Jon Christopher Loren , Valentia Molteni , Alex Michael Saunders , Duncan Shaw , Lilya Sviridenko , Christopher Thomson , Ryan West , Vince Yeh
发明人： Ian Bruce , Sylvie Chamoin , Stephen Paul Collingwood , Pascal Furet , Vikki Furminger , Diana Janus , Sarah Lewis , Jon Christopher Loren , Valentia Molteni , Alex Michael Saunders , Duncan Shaw , Lilya Sviridenko , Christopher Thomson , Ryan West , Vince Yeh
IPC分类号： A01N43/42 , A61K31/44 , C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , C07D515/02 , A61K31/5377 , A61K45/06 , A61K31/444 , A61K31/496 , C07D471/04
CPC分类号： C07D471/04 , A61K31/444 , A61K31/4545 , A61K31/4745 , A61K31/496 , A61K31/5377 , A61K45/06
摘要： Bicyclic heterocyclic derivatives of formula I useful in inhibiting PDGF receptor mediated biological activity. wherein A is and R1, R1a, R2, R3, R4, R5, R6 and X are as defined herein.
摘要翻译： 式I的双环杂环衍生物可用于抑制PDGF受体介导的生物活性。 其中A是且R 1，R 1a，R 2，R 3，R 4，R 5，R 6和X如本文所定义。
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公开(公告)号：US08519134B2
公开(公告)日：2013-08-27
申请号：US13509646
申请日：2010-11-16
申请人： Martin Allan , Sylvie Chamoin , Qi-Ying Hu , Hidetomo Imase , Julien Papillon
发明人： Martin Allan , Sylvie Chamoin , Qi-Ying Hu , Hidetomo Imase , Julien Papillon
IPC分类号： C07D221/02 , A61K31/44
CPC分类号： C07D213/57 , C07D213/30 , C07D213/61 , C07D401/04 , C07D405/04 , C07D409/04
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5 and n are defined herein. The invention also relates to a method for manufacturing compounds of the invention, and their therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译： 本发明提供式（I）化合物或其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5和n如本文所定义。 本发明还涉及一种制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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公开(公告)号：US09498540B2
公开(公告)日：2016-11-22
申请号：US14208493
申请日：2014-03-13
申请人： Paul A. Barsanti , Sylvie Chamoin , Lionel Doumampouom-Metoul , Stephanie Guerro-Lagasse , Robert Martin Grotzfeld , Alexei Karpov , Marc Lafrance , Cristina Montserrat Nieto-Oberhuber , Grazia Piizzi
发明人： Paul A. Barsanti , Sylvie Chamoin , Lionel Doumampouom-Metoul , Stephanie Guerro-Lagasse , Robert Martin Grotzfeld , Alexei Karpov , Marc Lafrance , Cristina Montserrat Nieto-Oberhuber , Grazia Piizzi
IPC分类号： A61K31/437 , A61K31/4725 , C07D413/14 , A61K47/48 , C07D233/64 , A61K31/4174 , A61K45/06 , C07D413/12 , A61K31/5377 , C07D249/08 , A61K31/4196 , C07D403/12 , A61K31/4178 , C07D405/14 , C07D409/06 , A61K31/7028
CPC分类号： A61K47/6851 , A61K31/4174 , A61K31/4178 , A61K31/4196 , A61K31/5377 , A61K31/7028 , A61K45/06 , A61K47/6803 , A61K47/6855 , C07D233/64 , C07D249/08 , C07D403/12 , C07D405/14 , C07D409/06 , C07D413/12 , C07D413/14
摘要： Disclosed herein are immunoconjugates comprising an inhibitor of Eg5 linked to an antigen binding moiety such as an antibody, that are useful for treating cell proliferative disorders. Also disclosed are novel inhibitors of Eg5 that can be used either alone or as part of an immunoconjugate to treat cell proliferation disorders. The Eg5 inhibitors include compounds of this formula as described herein: The invention further provides pharmaceutical compositions comprising these compounds and immunoconjugates, and compositions comprising the immunoconjugates or compounds with a therapeutic co-agent, and methods to use these compounds, conjugates and compositions for treating cell proliferation disorders.
摘要翻译： 本发明还提供包含这些化合物和免疫缀合物的药物组合物，以及包含免疫缀合物或化合物与治疗性助剂的组合物，以及使用这些化合物，缀合物和组合物用于治疗细胞增殖障碍的方法。
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公开(公告)号：US08809545B2
公开(公告)日：2014-08-19
申请号：US13939232
申请日：2013-07-11
申请人： Sylvie Chamoin , Qi-Ying Hu , Julien Papillon
发明人： Sylvie Chamoin , Qi-Ying Hu , Julien Papillon
IPC分类号： C07D405/04 , C07D401/04 , C07D417/04
CPC分类号： C07D513/04 , A61K31/437 , A61K31/44 , A61K31/443 , A61K31/4439 , A61K31/4709 , A61K31/542 , A61K45/06 , C07D213/46 , C07D213/76 , C07D401/02 , C07D401/04 , C07D405/04 , C07D417/04 , C07D471/04
摘要： The present invention provides a compound of formula I; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译： 本发明提供式I化合物; 制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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公开(公告)号：US20130296309A1
公开(公告)日：2013-11-07
申请号：US13939232
申请日：2013-07-11
申请人： Sylvie Chamoin , Qi-Ying Hu , Julien Papillon
发明人： Sylvie Chamoin , Qi-Ying Hu , Julien Papillon
IPC分类号： C07D513/04 , A61K31/437 , A61K31/4709 , A61K31/443 , A61K31/4439 , A61K45/06 , C07D471/04 , C07D401/02 , C07D417/04 , C07D401/04 , C07D405/04 , C07D213/46 , A61K31/542 , A61K31/44
CPC分类号： C07D513/04 , A61K31/437 , A61K31/44 , A61K31/443 , A61K31/4439 , A61K31/4709 , A61K31/542 , A61K45/06 , C07D213/46 , C07D213/76 , C07D401/02 , C07D401/04 , C07D405/04 , C07D417/04 , C07D471/04
摘要： The present invention provides a compound of formula I; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译： 本发明提供式I化合物; 制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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公开(公告)号：US20140275175A1
公开(公告)日：2014-09-18
申请号：US14291053
申请日：2014-05-30
IPC分类号： C07D417/04 , C07D413/04 , A61K31/4439 , A61K45/06 , C07D401/04
CPC分类号： C07D417/04 , A61K31/4439 , A61K45/06 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14
摘要： The present invention provides a compound of formula I; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译： 本发明提供式I化合物; 制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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