公开(公告)号：US20160067161A1

公开(公告)日：2016-03-10

申请号：US14783714

申请日：2014-04-09

申请人： GIULIANI S.P.A.

发明人： Giammaria GIULIANI ,  Anna BENEDUSI ,  Barbara MARZANI ,  Sergio BARONI ,  Ralf PAUS

IPC分类号： A61K8/41 ,  A61Q19/08

CPC分类号： A61K8/41 ,  A61K31/132 ,  A61P17/00 ,  A61Q19/08

摘要： The invention relates to the use of compounds of formula (I) R—N1-spermidine, i.e. 1.4-butanediamine,N-(3-aminopropyl)-N1—R, (I) H2N —(CH2)3—N1(R)—(CH2)4—NH2, as such or in the form of pharmaceutically acceptable derivatives, as active principle in a cosmetic or pharmaceutical composition for resisting the effects of skin ageing through an anti-inflammatory action, by topical administration. Such compounds also have an antioxidant activity against oxygen free radicals (ROS) comparable with that of α-tocopherol.

摘要翻译： 本发明涉及式（I）化合物R-N1-亚精胺，即1,4-丁二胺，N-（3-氨基丙基）-N1-R，（I）H 2 N - （CH 2）3 -N 1（R） - （CH 2）4 -NH 2，以药学上可接受的衍生物的形式作为通过局部给药抵抗抗炎作用的皮肤老化作用的化妆品或药物组合物中的活性成分。 这些化合物还具有与α-生育酚相当的抗氧自由基（ROS）的抗氧化活性。

公开(公告)号：US20220071921A1

公开(公告)日：2022-03-10

申请号：US17057814

申请日：2019-05-21

申请人： GIULIANI S.P.A.

发明人： Giammaria GIULIANI ,  Ralf PAUS ,  Jeremy CHERET ,  Barbara MARZANI ,  Sergio BARONI

IPC分类号： A61K31/045 ,  A61K8/34 ,  A61P29/00 ,  A61Q19/00 ,  A61Q15/00 ,  A61P17/00

摘要： The present invention concerns the use of selected compounds in a cosmetic skincare treatment or in the treatment of certain skin, scalp or mucosal diseases. The invention also provides a composition for topical use incorporating a pharmaceutically or cosmetically effective amount of a compound for preventing or treating skin or mucosal diseases having an inflammatory component or for reducing the redness or irritation of skin or mucosae.

公开(公告)号：US20210177925A1

公开(公告)日：2021-06-17

申请号：US16636291

申请日：2018-08-02

申请人： GIULIANI S.P.A.

发明人： Giammaria GIULIANI ,  Ralf PAUS ,  Benedetto GRIMALDI ,  Barbara MARZANI ,  Sergio BARONI

IPC分类号： A61K36/53 ,  A61K31/132 ,  A61K47/36 ,  A61K47/02 ,  A61K9/00 ,  A61K31/4188

摘要： The invention relates to a synergistic composition comprising a dry extract of plant of genus Galeopsis and a compound promoting autophagy selected from biotin and R-N1-spermidine or a salt thereof, wherein R is hydrogen or methyl and mixtures thereof. The synergistic compositions according to the invention may be in the form of a topical formulation or oral formulation and is useful as a promoter of autophagy especially in cells of human scalp hair follicles and in promoting hair growth and/or in the treatment of hair thinning or hair loss.

公开(公告)号：US20210000801A1

公开(公告)日：2021-01-07

申请号：US16969246

申请日：2019-02-13

申请人： GIULIANI S.P.A.

发明人： Giammaria GIULIANI ,  Barbara MARZANI ,  Daniela PINTO ,  Sergio BARONI ,  Ralf PAUS ,  Nathan HAWKSHAW

IPC分类号： A61K31/427 ,  A61K8/49 ,  A61P17/14 ,  A61Q7/00

摘要： The present invention relates to the use of iminooxothiazolidine derivatives for preventing or treating hair growth disorders. The iminooxothiazolidine derivatives may be formulated as compositions suitable for either the systemic administration or the local application to the scalp.

公开(公告)号：US20160030500A1

公开(公告)日：2016-02-04

申请号：US14777181

申请日：2014-03-14

申请人： GIULIANI S.P.A.

发明人： Giammaria GIULIANI ,  Anna BENEDUSI ,  Barbara MARZANI ,  Antonio MASCOLO ,  Antonio LIMITONE ,  Sergio BARONI

IPC分类号： A61K36/87 ,  A61K36/63 ,  A61K31/047 ,  A61K33/04 ,  A61K36/06 ,  A61Q19/00 ,  A61Q5/00 ,  A61K8/97 ,  A61K8/49 ,  A61K8/34 ,  A61K9/00 ,  A61K8/23 ,  A61K31/7048 ,  A61K31/375 ,  A61K31/355 ,  A61K33/30 ,  A61K8/19 ,  A61K8/60 ,  A61K8/27 ,  A61K33/34 ,  A23L1/30 ,  A61K31/353

CPC分类号： A61K36/87 ,  A23L33/105 ,  A23V2002/00 ,  A61K8/19 ,  A61K8/23 ,  A61K8/27 ,  A61K8/345 ,  A61K8/4973 ,  A61K8/498 ,  A61K8/602 ,  A61K8/97 ,  A61K9/0012 ,  A61K9/0014 ,  A61K31/047 ,  A61K31/05 ,  A61K31/353 ,  A61K31/355 ,  A61K31/375 ,  A61K31/7048 ,  A61K33/04 ,  A61K33/30 ,  A61K33/34 ,  A61K36/06 ,  A61K36/63 ,  A61K45/06 ,  A61K2800/522 ,  A61K2800/5922 ,  A61K2800/92 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q7/00 ,  A61Q19/00 ,  A61Q19/08 ,  A61K2300/00 ,  A23V2200/30 ,  A23V2200/318 ,  A23V2250/21 ,  A23V2250/2116 ,  A23V2250/21168

摘要： The invention relates to a composition for pharmaceutical or nutritional or cosmetic use, formulated for oral or topical use and possessing antioxidant activity against free radicals, comprising: a) a Vitis vinifera seed, or seed and leaf, extract containing a combination of the flavonoids catechin and quercetin in a molar ratio in a range from 6:1 to 3:1, respectively, or a′) a Vitis vinifera seed, or seed and leaf, extract containing a combination of the flavonoids catechin and quercetin in a molar ratio in a range from 7:1 to 4:1, respectively, or a″) a mixture of Vitis vinifera extracts a) and a′), or a′″) a mixture of catechin and quercetin in a molar ratio in a range from 7:1 to 3:1, respectively, together with b) an olive, Olea europaea L, leaf extract having a hydroxytyrosol content in a range from 1% to 30% by weight of the extract, or b′) hydroxytyrosol in an amount equal to that contained in the b) extract.

摘要翻译： 本发明涉及一种用于药物或营养或化妆品用途的组合物，其配制用于口服或局部使用并具有抗自由基的抗氧化活性，其包含：a）葡萄葡萄种子或种子和叶子，含有类黄酮儿茶素 和槲皮素，其摩尔比分别为6:1至3:1，或一种葡萄酒种子或种子和叶子提取物，其含有类黄酮儿茶素和槲皮素的组合，摩尔比为 范围为7：1至4：1，或者“）葡萄酒提取物a）和a'）的混合物，或a'），儿茶素和槲皮素的混合物，摩尔比为7： 1至3：1，分别与b）橄榄油橄榄叶L，提取物的羟基酪醇含量为提取物重量的1％至30％，或b'）羟基酪醇的量等于 包含在b）提取物。

公开(公告)号：US20180072698A1

公开(公告)日：2018-03-15

申请号：US15561611

申请日：2016-03-23

申请人： GIULIANI S.P.A.

发明人： Giammaria GIULIANI ,  Anna BENEDUSI ,  Barbara MARZANI ,  Sergio BARONI

IPC分类号： C07D319/06 ,  C07D407/04 ,  A61K8/49 ,  A61Q17/00

CPC分类号： C07D319/06 ,  A61K8/498 ,  A61Q17/00 ,  C07D407/04

摘要： The invention relates to compounds having general formula (I): where R═H, CH2—OH, CH2—O—CO—CH3, CH2—O—CO—Ph (Ph=phenyl) R′═H, CH2—O—CO—CH3, CH2—O—CO-Ph (Ph=phenyl) Ar=phenyl, 3-methoxy-4-hydroxy phenyl, 2-furyl. These are compounds having antioxidant activity against free radicals together with anti-inflammatory activity, the compounds being useful as active ingredients for the preparation of pharmaceutical dermatological or cosmetic compositions for skin care.

公开(公告)号：US20150366770A1

公开(公告)日：2015-12-24

申请号：US14764914

申请日：2014-02-17

申请人： GIULIANI S.P.A.

发明人： Giammaria GIULIANI ,  Ralf PAUS ,  Anna BENEDUSI ,  Barbara MARZANI ,  Sergio BARONI

IPC分类号： A61K8/41 ,  A61Q5/10

CPC分类号： A61K8/41 ,  A61K8/411 ,  A61K8/69 ,  A61K2800/42 ,  A61K2800/74 ,  A61K2800/78 ,  A61Q5/00 ,  A61Q5/10

摘要： The invention concerns the use of compounds with formula (I) R—N1-spermidine, or 1,4-butandiamin,N-(3-amino propyl)-N1-R, (I) H2N—(CH2)3—N1(R)—(CH2)4—NH2 either as such or in the form of a pharmaceutically acceptable derivative, such as an active ingredient in a cosmetic composition designed to promote hair pigmentation, particularly the pigmentation of the shaft, and a composition suitable to achieve said pigmentation effect and containing said active ingredient, either as such or in the form of a pharmaceutically acceptable derivative such as a salt, for topical administration.

摘要翻译： 本发明涉及式（I）R-N1-亚精胺或1,4-丁二胺，N-（3-氨基丙基）-N1-R，（I）H2N-（CH2）3-N1（ R） - （CH 2）4 -NH 2，或者以药学上可接受的衍生物的形式，例如设计用于促进头发色素沉着的化妆品组合物中的活性成分，特别是轴的色素沉着，以及适于实现 所述色素沉着效应并含有所述活性成分，或者以药学上可接受的衍生物例如盐的形式，用于局部给药。

公开(公告)号：US20190216696A1

公开(公告)日：2019-07-18

申请号：US16302472

申请日：2016-05-19

申请人： GIULIANI S.P.A.

发明人： Ralf PAUS ,  Jeremy CHERET ,  Hanns HATT ,  Sergio BARONI

IPC分类号： A61K8/34 ,  A61Q7/00 ,  A61K31/045

CPC分类号： A61K8/34 ,  A61K31/045 ,  A61Q5/02 ,  A61Q7/00

摘要： The invention concerns the use of compounds of general formula (I): (I) wherein: R1 and R2 form together a double bond, or R1 and R2 form together a cyclopropyl group; R3, R4 are the same or different and independently chosen from hydrogen, methyl, or R3 and R4 form together a double bond; R5, R6 are the same or different and independently chosen from hydrogen, methyl; or R5 and R6 form together a double bond, or R5 and R6 form together a cyclopropyl group; R7=methyl, or ethyl; R8=hydrogen, or methyl, for promoting hair growth and/or inhibiting or delaying hair loss in the human scalp, and cosmetic and pharmaceutical compositions suitable for such use.

公开(公告)号：US20170240502A1

公开(公告)日：2017-08-24

申请号：US15501997

申请日：2015-08-04

申请人： GIULIANI S.P.A.

发明人： Giammaria GIULIANI ,  Anna BENEDUSI ,  Barbara MARZANI ,  Sergio BARONI ,  Elena PINI

IPC分类号： C07C233/49 ,  A61Q19/00 ,  A61K8/44

CPC分类号： C07C233/49 ,  A61K8/42 ,  A61K8/44 ,  A61K31/197 ,  A61K31/42 ,  A61K2800/522 ,  A61K2800/74 ,  A61Q17/04 ,  A61Q19/007 ,  A61Q19/08

摘要： The invention relates to the 4-((2E,4E,6E)-octa-2,6,4-trienamid)butanoic acid; its use in the therapeutic and cosmetic field for topical application to the skin to achieve a combined antioxidant activity against ROS together with an anti-inflammatory effect and an effect of promoting the production of hyaluronic acid, so as to oppose at the same time the oxidizing action of free radicals and inflammatory effects, in order to preserve the physiological conditions of human epidermis and skin homeostasis and prevent skin aging (anti-aging); the compositions for therapeutic and cosmetic use which comprise 4-((2E,4E,6E)-octa-2,6,4-trienamid)butanoic acid as active ingredient, formulated with excipients for topical use suitable for local administration on the skin.

公开(公告)号：US20170224598A1

公开(公告)日：2017-08-10

申请号：US15316003

申请日：2016-12-02

申请人： Giuliani S.P.A.

发明人： Giammaria GIULIANI ,  Ralf PAUS ,  Anna BENEDUSI ,  Barbara MARZANI ,  Sergio BARONI

IPC分类号： A61K8/41 ,  A61Q5/10

CPC分类号： A61K8/41 ,  A61K8/411 ,  A61K8/69 ,  A61K2800/42 ,  A61K2800/74 ,  A61K2800/78 ,  A61Q5/00 ,  A61Q5/10

摘要： The invention concerns the use of compounds with formula (I) R—N1-spermidine, or 1,4-butandiamin,N-(3-amino propyl)-N1-R, (I) H2N—(CH2)3—N1(R)—(CH2)4—NH2 either as such or in the form of a pharmaceutically acceptable derivative, such as an active ingredient in a cosmetic composition designed to promote hair pigmentation, particularly the pigmentation of the shaft, and a composition suitable to achieve said pigmentation effect and containing said active ingredient, either as such or in the form of a pharmaceutically acceptable derivative such as a salt, for topical administration.