公开(公告)号：US20160030500A1

公开(公告)日：2016-02-04

申请号：US14777181

申请日：2014-03-14

申请人： GIULIANI S.P.A.

发明人： Giammaria GIULIANI ,  Anna BENEDUSI ,  Barbara MARZANI ,  Antonio MASCOLO ,  Antonio LIMITONE ,  Sergio BARONI

IPC分类号： A61K36/87 ,  A61K36/63 ,  A61K31/047 ,  A61K33/04 ,  A61K36/06 ,  A61Q19/00 ,  A61Q5/00 ,  A61K8/97 ,  A61K8/49 ,  A61K8/34 ,  A61K9/00 ,  A61K8/23 ,  A61K31/7048 ,  A61K31/375 ,  A61K31/355 ,  A61K33/30 ,  A61K8/19 ,  A61K8/60 ,  A61K8/27 ,  A61K33/34 ,  A23L1/30 ,  A61K31/353

CPC分类号： A61K36/87 ,  A23L33/105 ,  A23V2002/00 ,  A61K8/19 ,  A61K8/23 ,  A61K8/27 ,  A61K8/345 ,  A61K8/4973 ,  A61K8/498 ,  A61K8/602 ,  A61K8/97 ,  A61K9/0012 ,  A61K9/0014 ,  A61K31/047 ,  A61K31/05 ,  A61K31/353 ,  A61K31/355 ,  A61K31/375 ,  A61K31/7048 ,  A61K33/04 ,  A61K33/30 ,  A61K33/34 ,  A61K36/06 ,  A61K36/63 ,  A61K45/06 ,  A61K2800/522 ,  A61K2800/5922 ,  A61K2800/92 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q7/00 ,  A61Q19/00 ,  A61Q19/08 ,  A61K2300/00 ,  A23V2200/30 ,  A23V2200/318 ,  A23V2250/21 ,  A23V2250/2116 ,  A23V2250/21168

摘要： The invention relates to a composition for pharmaceutical or nutritional or cosmetic use, formulated for oral or topical use and possessing antioxidant activity against free radicals, comprising: a) a Vitis vinifera seed, or seed and leaf, extract containing a combination of the flavonoids catechin and quercetin in a molar ratio in a range from 6:1 to 3:1, respectively, or a′) a Vitis vinifera seed, or seed and leaf, extract containing a combination of the flavonoids catechin and quercetin in a molar ratio in a range from 7:1 to 4:1, respectively, or a″) a mixture of Vitis vinifera extracts a) and a′), or a′″) a mixture of catechin and quercetin in a molar ratio in a range from 7:1 to 3:1, respectively, together with b) an olive, Olea europaea L, leaf extract having a hydroxytyrosol content in a range from 1% to 30% by weight of the extract, or b′) hydroxytyrosol in an amount equal to that contained in the b) extract.

摘要翻译： 本发明涉及一种用于药物或营养或化妆品用途的组合物，其配制用于口服或局部使用并具有抗自由基的抗氧化活性，其包含：a）葡萄葡萄种子或种子和叶子，含有类黄酮儿茶素 和槲皮素，其摩尔比分别为6:1至3:1，或一种葡萄酒种子或种子和叶子提取物，其含有类黄酮儿茶素和槲皮素的组合，摩尔比为 范围为7：1至4：1，或者“）葡萄酒提取物a）和a'）的混合物，或a'），儿茶素和槲皮素的混合物，摩尔比为7： 1至3：1，分别与b）橄榄油橄榄叶L，提取物的羟基酪醇含量为提取物重量的1％至30％，或b'）羟基酪醇的量等于 包含在b）提取物。

公开(公告)号：US20160081935A1

公开(公告)日：2016-03-24

申请号：US14786496

申请日：2014-04-22

申请人： GIULIANI S.P.A.

发明人： Giammaria GIULIANI ,  Anna BENEDUSI ,  Antonio MASCOLO ,  Antonio LIMITONE

IPC分类号： A61K9/20 ,  A61K31/122 ,  A61K9/28 ,  A61K31/525

摘要： In one aspect, the present invention relates to a system for the modified release of one or more active ingredients, comprising a polymeric matrix based on hyaluronic acid with molecular weight ranging from 100 to 100,000 Daltons and a non-ionic polymer which jellifies in contact with water, in which one or more active ingredients are dispersed, optionally in form of microgranules or microcapsules.

摘要翻译： 一方面，本发明涉及一种用于一种或多种活性成分的改性释放的体系，其包含基于分子量范围为100至100,000道尔顿的透明质酸的聚合物基质和与所述聚合物基质接触的非离子聚合物 水，其中一种或多种活性成分被分散，任选呈微粒或微胶囊形式。

公开(公告)号：US20160067161A1

公开(公告)日：2016-03-10

申请号：US14783714

申请日：2014-04-09

申请人： GIULIANI S.P.A.

发明人： Giammaria GIULIANI ,  Anna BENEDUSI ,  Barbara MARZANI ,  Sergio BARONI ,  Ralf PAUS

IPC分类号： A61K8/41 ,  A61Q19/08

CPC分类号： A61K8/41 ,  A61K31/132 ,  A61P17/00 ,  A61Q19/08

摘要： The invention relates to the use of compounds of formula (I) R—N1-spermidine, i.e. 1.4-butanediamine,N-(3-aminopropyl)-N1—R, (I) H2N —(CH2)3—N1(R)—(CH2)4—NH2, as such or in the form of pharmaceutically acceptable derivatives, as active principle in a cosmetic or pharmaceutical composition for resisting the effects of skin ageing through an anti-inflammatory action, by topical administration. Such compounds also have an antioxidant activity against oxygen free radicals (ROS) comparable with that of α-tocopherol.

摘要翻译： 本发明涉及式（I）化合物R-N1-亚精胺，即1,4-丁二胺，N-（3-氨基丙基）-N1-R，（I）H 2 N - （CH 2）3 -N 1（R） - （CH 2）4 -NH 2，以药学上可接受的衍生物的形式作为通过局部给药抵抗抗炎作用的皮肤老化作用的化妆品或药物组合物中的活性成分。 这些化合物还具有与α-生育酚相当的抗氧自由基（ROS）的抗氧化活性。

公开(公告)号：US20170240502A1

公开(公告)日：2017-08-24

申请号：US15501997

申请日：2015-08-04

申请人： GIULIANI S.P.A.

发明人： Giammaria GIULIANI ,  Anna BENEDUSI ,  Barbara MARZANI ,  Sergio BARONI ,  Elena PINI

IPC分类号： C07C233/49 ,  A61Q19/00 ,  A61K8/44

CPC分类号： C07C233/49 ,  A61K8/42 ,  A61K8/44 ,  A61K31/197 ,  A61K31/42 ,  A61K2800/522 ,  A61K2800/74 ,  A61Q17/04 ,  A61Q19/007 ,  A61Q19/08

摘要： The invention relates to the 4-((2E,4E,6E)-octa-2,6,4-trienamid)butanoic acid; its use in the therapeutic and cosmetic field for topical application to the skin to achieve a combined antioxidant activity against ROS together with an anti-inflammatory effect and an effect of promoting the production of hyaluronic acid, so as to oppose at the same time the oxidizing action of free radicals and inflammatory effects, in order to preserve the physiological conditions of human epidermis and skin homeostasis and prevent skin aging (anti-aging); the compositions for therapeutic and cosmetic use which comprise 4-((2E,4E,6E)-octa-2,6,4-trienamid)butanoic acid as active ingredient, formulated with excipients for topical use suitable for local administration on the skin.

公开(公告)号：US20170224598A1

公开(公告)日：2017-08-10

申请号：US15316003

申请日：2016-12-02

申请人： Giuliani S.P.A.

发明人： Giammaria GIULIANI ,  Ralf PAUS ,  Anna BENEDUSI ,  Barbara MARZANI ,  Sergio BARONI

IPC分类号： A61K8/41 ,  A61Q5/10

CPC分类号： A61K8/41 ,  A61K8/411 ,  A61K8/69 ,  A61K2800/42 ,  A61K2800/74 ,  A61K2800/78 ,  A61Q5/00 ,  A61Q5/10

摘要： The invention concerns the use of compounds with formula (I) R—N1-spermidine, or 1,4-butandiamin,N-(3-amino propyl)-N1-R, (I) H2N—(CH2)3—N1(R)—(CH2)4—NH2 either as such or in the form of a pharmaceutically acceptable derivative, such as an active ingredient in a cosmetic composition designed to promote hair pigmentation, particularly the pigmentation of the shaft, and a composition suitable to achieve said pigmentation effect and containing said active ingredient, either as such or in the form of a pharmaceutically acceptable derivative such as a salt, for topical administration.

公开(公告)号：US20170015700A1

公开(公告)日：2017-01-19

申请号：US15124273

申请日：2015-03-10

申请人： GIULIANI S.P.A.

发明人： Giammaria GIULIANI ,  Anna BENEDUSI ,  Barbara MARZANI ,  Sergio BARONI ,  Elena PINI ,  Raffaella GANDOLFI

IPC分类号： C07J9/00 ,  A61K8/37 ,  A61Q17/04 ,  C07C57/03 ,  A61Q19/00 ,  A61Q1/14 ,  A61K8/63 ,  C07C279/14 ,  C07C69/587 ,  A61Q7/00

CPC分类号： C07J9/00 ,  A61K8/361 ,  A61K8/37 ,  A61K8/375 ,  A61K8/44 ,  A61K8/63 ,  A61K45/06 ,  A61K2800/10 ,  A61Q1/14 ,  A61Q5/00 ,  A61Q7/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/004 ,  A61Q19/007 ,  C07C57/03 ,  C07C69/587 ,  C07C279/14

摘要： The invention relates to 2,4,6-octatrienoic acid derivative compounds having general formula (I) (CH3—CH═CH—CH═CH—CH═CH—CO—O—)n—R (I) consisting of esters wherein n=1, 2, 3 and wherein R is selected from alkyl, aryl or cycloalkyl of a polyol, phenol or phenolic acid; or consisting of a salt wherein n=1 and R=arginine, as active ingredients in a pharmaceutical or cosmetic composition having a combined antioxidant activity against free radicals together with an anti-inflammatory action.

摘要翻译： 本发明涉及具有通式（I）（CH 3 -CH = CH-CH = CH-CH = CH-CO-O-）n -R（I）的2,4,6-辛二烯酸衍生物化合物， n = 1,2,3，其中R选自多元醇，苯酚或酚酸的烷基，芳基或环烷基; 或由其中n = 1和R =精氨酸的盐组成，作为具有抗自由基的组合抗氧化活性以及抗炎作用的药物或化妆品组合物中的活性成分。

公开(公告)号：US20190358148A1

公开(公告)日：2019-11-28

申请号：US16477694

申请日：2018-01-11

申请人： GIULIANI S.P.A.

发明人： Giammaria GIULIANI ,  Anna BENEDUSI ,  Barbara MARZANI

IPC分类号： A61K8/9789 ,  A61Q7/00

摘要： The present invention relates to the use of a plant extract from the genus Galeopsis species tetrahit or a composition that contains it to stimulate hair growth or improve the appearance or hair fullness. The composition containing the plant extract is applied in both cosmetic and medical-trichological fields and can be applied topically on the scalp or administered orally.

公开(公告)号：US20180072698A1

公开(公告)日：2018-03-15

申请号：US15561611

申请日：2016-03-23

申请人： GIULIANI S.P.A.

发明人： Giammaria GIULIANI ,  Anna BENEDUSI ,  Barbara MARZANI ,  Sergio BARONI

IPC分类号： C07D319/06 ,  C07D407/04 ,  A61K8/49 ,  A61Q17/00

CPC分类号： C07D319/06 ,  A61K8/498 ,  A61Q17/00 ,  C07D407/04

摘要： The invention relates to compounds having general formula (I): where R═H, CH2—OH, CH2—O—CO—CH3, CH2—O—CO—Ph (Ph=phenyl) R′═H, CH2—O—CO—CH3, CH2—O—CO-Ph (Ph=phenyl) Ar=phenyl, 3-methoxy-4-hydroxy phenyl, 2-furyl. These are compounds having antioxidant activity against free radicals together with anti-inflammatory activity, the compounds being useful as active ingredients for the preparation of pharmaceutical dermatological or cosmetic compositions for skin care.

公开(公告)号：US20170135928A1

公开(公告)日：2017-05-18

申请号：US15321121

申请日：2015-06-25

申请人： GIULIANI S.P.A.

发明人： Giammaria GIULIANI ,  Anna BENEDUSI ,  Barbara MARZANI ,  Antonio MASCOLO ,  Antonio LIMITONE

IPC分类号： A61K8/49 ,  A61Q7/00 ,  A61Q19/00 ,  A61K8/02 ,  A23L33/105 ,  A61Q5/00 ,  A61Q19/08 ,  A23L33/175 ,  A23L33/16 ,  A23L33/15 ,  A61K8/44 ,  A61Q5/02

CPC分类号： A61K8/4953 ,  A23L33/105 ,  A23L33/15 ,  A23L33/16 ,  A23L33/175 ,  A23V2002/00 ,  A61K8/0204 ,  A61K8/44 ,  A61K31/198 ,  A61K31/205 ,  A61K31/522 ,  A61K2800/5922 ,  A61K2800/92 ,  A61Q5/006 ,  A61Q5/02 ,  A61Q7/00 ,  A61Q19/00 ,  A61Q19/08 ,  E06B9/52 ,  E06B2009/527 ,  A23V2200/318 ,  A23V2250/0606 ,  A23V2250/0612 ,  A23V2250/2108 ,  A61K2300/00

摘要： The present invention relates to a composition for pharmaceutical, nutritional or cosmetic use, suitable to preserve the physiological condition and health of skin and hair and to reestablish their regenerative functions, characterized in that it comprises a mixture of carnitine, caffeine and arginine as active principle, as such or as derivatives, such as pharmacologically acceptable salts. The effect of preserving the physiologic condition and health of skin and hair, and of reestablishing their regenerative functions is mainly achieved through an increase in ATP production by skin and hair cells.

公开(公告)号：US20150366770A1

公开(公告)日：2015-12-24

申请号：US14764914

申请日：2014-02-17

申请人： GIULIANI S.P.A.

发明人： Giammaria GIULIANI ,  Ralf PAUS ,  Anna BENEDUSI ,  Barbara MARZANI ,  Sergio BARONI

IPC分类号： A61K8/41 ,  A61Q5/10

CPC分类号： A61K8/41 ,  A61K8/411 ,  A61K8/69 ,  A61K2800/42 ,  A61K2800/74 ,  A61K2800/78 ,  A61Q5/00 ,  A61Q5/10

摘要： The invention concerns the use of compounds with formula (I) R—N1-spermidine, or 1,4-butandiamin,N-(3-amino propyl)-N1-R, (I) H2N—(CH2)3—N1(R)—(CH2)4—NH2 either as such or in the form of a pharmaceutically acceptable derivative, such as an active ingredient in a cosmetic composition designed to promote hair pigmentation, particularly the pigmentation of the shaft, and a composition suitable to achieve said pigmentation effect and containing said active ingredient, either as such or in the form of a pharmaceutically acceptable derivative such as a salt, for topical administration.

摘要翻译： 本发明涉及式（I）R-N1-亚精胺或1,4-丁二胺，N-（3-氨基丙基）-N1-R，（I）H2N-（CH2）3-N1（ R） - （CH 2）4 -NH 2，或者以药学上可接受的衍生物的形式，例如设计用于促进头发色素沉着的化妆品组合物中的活性成分，特别是轴的色素沉着，以及适于实现 所述色素沉着效应并含有所述活性成分，或者以药学上可接受的衍生物例如盐的形式，用于局部给药。