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公开(公告)号：US6096519A
公开(公告)日：2000-08-01
申请号：US969644
申请日：1997-11-13
IPC分类号： A61K38/00 , A61K39/00 , C07K14/295 , C07K16/12 , C12N15/30 , C12N15/74 , C12P21/02 , C07K1/00 , G01N33/543 , G01N33/554
CPC分类号： C07K14/295 , C07K16/125 , C12N15/74 , A61K38/00 , A61K39/00 , C07K2319/00 , C07K2319/75
摘要： A plasmid isolated from Clamydia trachomatis is described, which comprises 8 genes encoding proteins useful in the formulation of vaccines or diagnostic test for determining the bacterium or specific antibodies generated during C. trachomatis infections; in particular the recombinant fusion MS2-pgp3D protein is described comprising polypeptidic sequences encoded by pCT and immunogenic in the course of infections in man. A method for preparing said protein in E. coli further described.
摘要翻译： 描述了从沙眼衣原体分离的质粒，其包含编码用于疫苗制剂的蛋白质的8种基因或用于确定沙眼衣原体感染期间产生的细菌或特异性抗体的诊断试验; 特别地描述了重组融合物MS2-pgp3D蛋白质，其包括由pCT编码的多肽序列和在人类感染过程中具有免疫原性。 进一步描述在大肠杆菌中制备所述蛋白质的方法。
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公开(公告)号：US6110705A
公开(公告)日：2000-08-29
申请号：US444189
申请日：1995-05-18
IPC分类号： A61K38/00 , A61K39/00 , C07K14/295 , C07K16/12 , C12N15/30 , C12N15/74 , C12P21/06 , C12P21/04
CPC分类号： C07K14/295 , C07K16/125 , C12N15/74 , A61K38/00 , A61K39/00 , C07K2319/00 , C07K2319/75
摘要： A plasmid isolated from Chlamydia trachomatis is described, which comprises 8 genes encoding proteins useful in the formation of vaccines or diagnostic test for determining the bacterium or specific antibodies generated during C. trachomatis infections. In particular, the recombinant fusion protein MS2-pgp3D is described, which comprises polypeptide sequences encoded by pCT and is immunogenic in the course of infections in man. A method for preparing the recombinant fusion protein MS2-pgp3D in E. coli is also described.
摘要翻译： 描述了从沙眼衣原体分离的质粒，其包含编码用于疫苗形成的蛋白质的8种基因或用于确定在沙眼衣原体感染期间产生的细菌或特异性抗体的诊断试验。 特别地，描述了重组融合蛋白MS2-pgp3D，其包含由pCT编码的多肽序列，并且在人的感染过程中是免疫原性的。 还描述了在大肠杆菌中制备重组融合蛋白MS2-pgp3D的方法。
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公开(公告)号：US06248563B1
公开(公告)日：2001-06-19
申请号：US08468544
申请日：1995-06-06
IPC分类号： C12P2106
CPC分类号： C07K14/295 , A61K38/00 , A61K39/00 , C07K16/125 , C07K2319/00 , C08G73/1042 , C08G73/1053 , C08G73/1071 , C12N15/74
摘要： A plasmid isolated from Clamydia trachomatis is described, which comprises 8 genes encoding proteins useful in the formulation of vaccines or diagnostic test for determining the bacterium or specific antibodies generated during C. trachomatis infections; in particular the recombinant fusion MS2-pgp3D protein is described comprising polypeptidic sequences encoded by pCT and immunogenic in the course of infections in man. A method for preparing said protein in E. coli further described.
摘要翻译： 描述了从沙眼衣原体分离的质粒，其包含编码用于疫苗制剂的蛋白质的8种基因或用于确定沙眼衣原体感染期间产生的细菌或特异性抗体的诊断试验; 特别地描述了重组融合物MS2-pgp3D蛋白质，其包括由pCT编码的多肽序列和在人类感染过程中具有免疫原性。 进一步描述在大肠杆菌中制备所述蛋白质的方法。
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公开(公告)号：US20130005667A1
公开(公告)日：2013-01-03
申请号：US13340549
申请日：2011-12-29
申请人： Maria Beatrice Arico , Maurizio Comanducci , Cesira Galeotti , Vega Masignani , Marizia Monica Guiliani , Mariagrazia Pizza
发明人： Maria Beatrice Arico , Maurizio Comanducci , Cesira Galeotti , Vega Masignani , Marizia Monica Guiliani , Mariagrazia Pizza
IPC分类号： A61K38/16
CPC分类号： A61K39/095 , A61K38/00 , A61K2039/545 , A61K2039/55505 , A61K2039/572 , A61K2039/575 , C07K14/22 , C07K2319/00 , C12P21/00 , C12P21/02 , C12Q1/689 , C12Q2600/156
摘要： Alternative and improved approaches to the heterologous expression of the proteins of Neisseria meningitidis and Neisseria gonorrhoeae. These approaches typically affect the level of expression, the ease of purification, the cellular localisation, and/or the immunological properties of the expressed protein.
摘要翻译： 脑膜炎奈瑟氏球菌和淋病奈瑟氏球菌的异源表达的替代和改进的方法。 这些方法通常影响表达水平，纯化的便利性，细胞定位和/或表达的蛋白质的免疫学性质。
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公开(公告)号：US20100267931A1
公开(公告)日：2010-10-21
申请号：US12825210
申请日：2010-06-28
申请人： Maria Beatrice ARICO , Maurizio Comanducci , Cesira Galeotti , Vega Masignani , Marizia Monica Guiliani , Mariagrazia Pizza
发明人： Maria Beatrice ARICO , Maurizio Comanducci , Cesira Galeotti , Vega Masignani , Marizia Monica Guiliani , Mariagrazia Pizza
CPC分类号： A61K39/095 , A61K38/00 , A61K2039/545 , A61K2039/55505 , A61K2039/572 , A61K2039/575 , C07K14/22 , C07K2319/00 , C12P21/00 , C12P21/02 , C12Q1/689 , C12Q2600/156
摘要： Alternative and improved approaches to the heterologous expression of the proteins of Neisseria meningitidis and Neisseria gonorrhoeae. These approaches typically affect the level of expression, the ease of purification, the cellular localisation, and/or the immunological properties of the expressed protein.
摘要翻译： 脑膜炎奈瑟氏球菌和淋病奈瑟氏球菌的异源表达的替代和改进的方法。 这些方法通常影响表达水平，纯化的便利性，细胞定位和/或表达的蛋白质的免疫学性质。
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公开(公告)号：US10478483B2
公开(公告)日：2019-11-19
申请号：US13806743
申请日：2011-06-24
申请人： Maria Aricò , Brunella Brunelli , Maurizio Comanducci , Mariagrazia Pizza , Silvana Savino , Maria Scarselli
发明人： Maria Aricò , Brunella Brunelli , Maurizio Comanducci , Mariagrazia Pizza , Silvana Savino , Maria Scarselli
IPC分类号： A61K39/095 , A61K39/385 , A61K39/39 , A61K39/00
摘要： The M01573 sequence of meningococcal fHbp offers poor coverage in a vaccine. The invention addresses this poor coverage in two ways. In a first aspect, a fHbp-based vaccine includes two family I fHbp sequences, one which is more closely related to MC58 than to M01573, and vice versa. In a second aspect, a multi-family fHbp-based vaccine uses a family I fHbp sequence which is more closely related to MC58 than to M01573, in combination with a family III fHbp sequence.
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公开(公告)号：US08703914B2
公开(公告)日：2014-04-22
申请号：US13340549
申请日：2011-12-29
申请人： Maria Beatrice Arico , Maurizio Comanducci , Cesira Galeotti , Vega Masignani , Marizia Monica Guiliani , Mariagrazia Pizza
发明人： Maria Beatrice Arico , Maurizio Comanducci , Cesira Galeotti , Vega Masignani , Marizia Monica Guiliani , Mariagrazia Pizza
IPC分类号： C07K1/00
CPC分类号： A61K39/095 , A61K38/00 , A61K2039/545 , A61K2039/55505 , A61K2039/572 , A61K2039/575 , C07K14/22 , C07K2319/00 , C12P21/00 , C12P21/02 , C12Q1/689 , C12Q2600/156
摘要： Alternative and improved approaches to the heterologous expression of the proteins of Neisseria meningitidis and Neisseria gonorrhoeae. These approaches typically affect the level of expression, the ease of purification, the cellular localization, and/or the immunological properties of the expressed protein.
摘要翻译： 脑膜炎奈瑟氏球菌和淋病奈瑟氏球菌的异源表达的替代和改进的方法。 这些方法通常影响表达水平，纯化的便利性，细胞定位和/或表达的蛋白质的免疫学性质。
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公开(公告)号：US20130189295A1
公开(公告)日：2013-07-25
申请号：US13806743
申请日：2011-06-24
申请人： Maria Aricò , Brunella Brunelli , Maurizio Comanducci , Mariagrazia Pizza , Silvana Savino , Maria Scarselli
发明人： Maria Aricò , Brunella Brunelli , Maurizio Comanducci , Mariagrazia Pizza , Silvana Savino , Maria Scarselli
IPC分类号： A61K39/095 , A61K39/385 , A61K39/39
CPC分类号： A61K39/095 , A61K39/385 , A61K39/39 , A61K2039/55505 , A61K2039/70
摘要： The M01573 sequence of meningococcal fHbp offers poor coverage in a vaccine. The invention addresses this poor coverage in two ways. In a first aspect, a fHbp-based vaccine includes two family I fHbp sequences, one which is more closely related to MC58 than to M01573, and vice versa. In a second aspect, a multi-family fHbp-based vaccine uses a family I fHbp sequence which is more closely related to MC58 than to M01573, in combination with a family III fHbp sequence.
摘要翻译： 脑膜炎球菌fHbp的M01573序列在疫苗中的覆盖范围较差。 本发明以两种方式解决了这种差的覆盖面。 在第一方面，基于fHbp的疫苗包括两个家族I fHbp序列，一个与MC58比M01573更密切相关的序列，反之亦然。 在第二方面，多家fHbp基疫苗使用与MC58比M01573更紧密相关的家族I fHbp序列，与III族fHbp序列组合。
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公开(公告)号：US08114960B2
公开(公告)日：2012-02-14
申请号：US12825210
申请日：2010-06-28
申请人： Maria Beatrice Arico , Maurizio Comanducci , Cesira Galeotti , Vega Masignani , Marzia Monica Guiliani , Mariagrazia Pizza
发明人： Maria Beatrice Arico , Maurizio Comanducci , Cesira Galeotti , Vega Masignani , Marzia Monica Guiliani , Mariagrazia Pizza
IPC分类号： A61K38/00 , A61K38/095
CPC分类号： A61K39/095 , A61K38/00 , A61K2039/545 , A61K2039/55505 , A61K2039/572 , A61K2039/575 , C07K14/22 , C07K2319/00 , C12P21/00 , C12P21/02 , C12Q1/689 , C12Q2600/156
摘要： Alternative and improved approaches to the heterologous expression of the proteins of Neisseria meningitidis and Neisseria gonorrhoeae. These approaches typically affect the level of expression, the ease of purification, the cellular localization, and/or the immunological properties of the expressed protein.
摘要翻译： 脑膜炎奈瑟氏球菌和淋病奈瑟氏球菌的异源表达的替代和改进的方法。 这些方法通常影响表达水平，纯化的便利性，细胞定位和/或表达的蛋白质的免疫学性质。
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公开(公告)号：US10596246B2
公开(公告)日：2020-03-24
申请号：US14368957
申请日：2011-12-29
申请人： Beatrice Maria Arico , Brunella Brunelli , Maurizio Comanducci , Mariagrazia Pizza , Silvana Savino , Maria Scarselli
发明人： Beatrice Maria Arico , Brunella Brunelli , Maurizio Comanducci , Mariagrazia Pizza , Silvana Savino , Maria Scarselli
IPC分类号： A61K39/095 , A61K47/64 , A61K39/09 , A61K39/00 , A61K39/39
摘要： The M01573 sequence of meningococcal fHbp offers poor coverage in a vaccine. The invention addresses this poor coverage in two ways. In a first aspect, a fHbp-based vaccine includes two family I fHbp sequences, one which is more closely related to MC58 than to M01573, and vice versa. In a second aspect, a multi-family fHbp-based vaccine uses a family I fHbp sequence which is more closely related to MC58 than to M01573, in combination with a family III fHbp sequence. The compositions are adjuvanted with an aluminium phosphate adjuvant.
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