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9 条记录 (耗时 0.022 秒)

    G-protein-conjugated receptor agonist
    2.
    发明授权
    G-protein-conjugated receptor agonist 失效
    G蛋白偶联受体激动剂

    公开(公告)号：US08318781B2

    公开(公告)日：2012-11-27

    申请号：US12597281

    申请日：2008-04-25

    申请人： Gozoh Tsujimoto ,  Akira Hirasawa ,  Naoki Miyata ,  Takayoshi Suzuki ,  Yoshiyuki Takahara ,  Masaji Ishiguro ,  Mie Hata

    发明人： Gozoh Tsujimoto ,  Akira Hirasawa ,  Naoki Miyata ,  Takayoshi Suzuki ,  Yoshiyuki Takahara ,  Masaji Ishiguro ,  Mie Hata

    IPC分类号： A01N43/40 ,  A01N43/78 ,  A01N37/12 ,  A01N37/44 ,  A01N43/00 ,  A61K31/445 ,  A61K31/425 ,  A61K31/33 ,  C07D213/72 ,  C07D213/78 ,  C07D277/82 ,  C07C63/00 ,  C07C65/00

    CPC分类号： C07C311/51 ,  C07C217/18 ,  C07D213/74 ,  C07D215/12 ,  C07D257/04

    摘要： Disclosed is a novel aralkyl carboxylic acid compound which has an agonistic activity on GPR-120 and/or GPR-40, particularly GPR-120, and is therefore useful as an appetite regulator, an anti-obesity agent, a therapeutic agent for diabetes, a pancreatic beta differentiating cell growth enhancer, a therapeutic agent for metabolic syndrome, a therapeutic agent for a gastrointestinal disease, a therapeutic agent for a neuropathy, a therapeutic agent for a mental disorder, a therapeutic agent for a pulmonary disease, a therapeutic agent for a pituitary hormone secretion disorder or a lipid flavoring/seasoning agent. The aralkyl carboxylic acid compound is represented by the general formula (I). (I) wherein the ring Q represents a pyridyl or the like; R1 represents a C1-6 alkyl group or the like; R2 represents a hydrogen atom, a C1-4 alkyl group or a C1-4 alkoxy group; m and n independently represent an integer of 1 to 5; and X represents an oxygen atom, a sulfur atom or —NR3— [wherein R3 represents a hydrogen atom or a C1-4 alkyl group].

    摘要翻译： 公开了一种对GPR-120和/或GPR-40，特别是GPR-120具有激动作用的新的芳烷基羧酸化合物，因此可用作食欲调节剂，抗肥胖剂，糖尿病治疗剂， 胰腺β分化细胞生长增强剂，代谢综合征治疗剂，胃肠道疾病治疗剂，神经病变治疗剂，精神障碍治疗剂，肺病治疗剂，治疗剂 垂体激素分泌障碍或脂质调味剂/调味剂。 芳烷基羧酸化合物由通式（I）表示。 （I）其中环Q表示吡啶基等; R1表示C1-6烷基等; R2表示氢原子，C1-4烷基或C1-4烷氧基; m和n独立地表示1〜5的整数。 X表示氧原子，硫原子或-NR 3 - [其中R 3表示氢原子或C 1-4烷基]。

    G-Protein-Conjugated Receptor Agonist
    3.
    发明申请
    G-Protein-Conjugated Receptor Agonist 失效
    G蛋白共轭受体激动剂

    公开(公告)号：US20110184031A1

    公开(公告)日：2011-07-28

    申请号：US12597281

    申请日：2008-04-25

    申请人： Gozoh Tsujimoto ,  Akira Hirasawa ,  Naoki Miyata ,  Takayoshi Suzuki ,  Yoshiyuki Takahara ,  Masaji Ishiguro ,  Yoshie Hata

    发明人： Gozoh Tsujimoto ,  Akira Hirasawa ,  Naoki Miyata ,  Takayoshi Suzuki ,  Yoshiyuki Takahara ,  Masaji Ishiguro ,  Yoshie Hata

    IPC分类号： A61K31/44 ,  C07D211/72 ,  C07D277/82 ,  C07C63/33 ,  A61K31/428 ,  A61K31/195 ,  A61P3/04 ,  A61P3/10 ,  A61P35/00 ,  A61P1/00 ,  A61P11/00 ,  A61P25/18

    CPC分类号： C07C311/51 ,  C07C217/18 ,  C07D213/74 ,  C07D215/12 ,  C07D257/04

    摘要： Disclosed is a novel aralkyl carboxylic acid compound which has an agonistic activity on GPR-120 and/or GPR-40, particularly GPR-120, and is therefore useful as an appetite regulator, an anti-obesity agent, a therapeutic agent for diabetes, a pancreatic beta differentiating cell growth enhancer, a therapeutic agent for metabolic syndrome, a therapeutic agent for a gastrointestinal disease, a therapeutic agent for a neuropathy, a therapeutic agent for a mental disorder, a therapeutic agent for a pulmonary disease, a therapeutic agent for a pituitary hormone secretion disorder or a lipid flavoring/seasoning agent. The aralkyl carboxylic acid compound is represented by the general formula (I). (I) wherein the ring Q represents a pyridyl or the like; R1 represents a C1-6 alkyl group or the like; R2 represents a hydrogen atom, a C1-4 alkyl group or a C1-4 alkoxy group; m and n independently represent an integer of 1 to 5; and X represents an oxygen atom, a sulfur atom or —NR3— [wherein R3 represents a hydrogen atom or a C1-4 alkyl group].

    摘要翻译： 公开了一种对GPR-120和/或GPR-40，特别是GPR-120具有激动作用的新的芳烷基羧酸化合物，因此可用作食欲调节剂，抗肥胖剂，糖尿病治疗剂， 胰腺β分化细胞生长增强剂，代谢综合征治疗剂，胃肠道疾病治疗剂，神经病变治疗剂，精神障碍治疗剂，肺病治疗剂，治疗剂 垂体激素分泌障碍或脂质调味剂/调味剂。 芳烷基羧酸化合物由通式（I）表示。 （I）其中环Q表示吡啶基等; R1表示C1-6烷基等; R2表示氢原子，C1-4烷基或C1-4烷氧基; m和n独立地表示1〜5的整数。 X表示氧原子，硫原子或-NR 3 - [其中R 3表示氢原子或C 1-4烷基]。

    Swiveling work machine
    8.
    发明授权
    Swiveling work machine 有权
    回转作业机

    公开(公告)号：US07500532B2

    公开(公告)日：2009-03-10

    申请号：US11225873

    申请日：2005-09-13

    申请人： Kenzo Koga ,  Shizuo Shimoie ,  Yoshihiro Kato ,  Fumiki Sato ,  Takanori Matsumoto ,  Naoki Miyata

    发明人： Kenzo Koga ,  Shizuo Shimoie ,  Yoshihiro Kato ,  Fumiki Sato ,  Takanori Matsumoto ,  Naoki Miyata

    IPC分类号： B62D33/02

    CPC分类号： E02F9/0816 ,  E02F9/121

    摘要： A swivel work machine includes a traveling unit, a swivel base plate supported on the traveling unit to be pivotable about a vertical swivel axis, the swivel base plate having a first lateral side and a second lateral side provided across said vertical axis, a pair of upper and lower support brackets disposed at a front end of the swivel base plate with an offset toward the first lateral side and adapted for supporting an implement, a pair of left and right vertical ribs extending rearward from the support brackets and fixed to the swivel base plate and a cabin mounted on the swivel base plate. The cabin is disposed with an offset toward the second lateral side relative to the support brackets, a bottom of the cabin being disposed downwardly of the upper support bracket. The vertical rib disposed on the side of the second lateral side extends, from its front portion to its intermediate portion, parallel with a side face of the cabin on the side of the first lateral side.

    摘要翻译： 旋转作业机包括行进单元，支撑在行进单元上的旋转底板，可绕垂直旋转轴线转动，旋转基板具有横跨所述垂直轴设置的第一横向侧和第二横向侧，一对 上部和下部支撑架设置在旋转基板的前端，偏移朝向第一侧面并适于支撑工具，一对左右垂直肋条从支撑托架向后延伸并固定到旋转底座 板和安装在旋转底板上的舱室。 机舱相对于支撑托架设置成朝向第二侧面的偏移，舱的底部设置在上支撑支架的下方。 设置在第二侧面侧的纵肋从其前部延伸到其中间部分，与第一侧面侧的车厢侧面平行。

    Swiveling work machine
    9.
    发明申请
    Swiveling work machine 有权

    公开(公告)号：US20060108171A1

    公开(公告)日：2006-05-25

    申请号：US11225873

    申请日：2005-09-13

    申请人： Kenzo Koga ,  Shizuo Shimoie ,  Yoshihiro Kato ,  Fumiki Sato ,  Takanori Matsumoto ,  Naoki Miyata

    发明人： Kenzo Koga ,  Shizuo Shimoie ,  Yoshihiro Kato ,  Fumiki Sato ,  Takanori Matsumoto ,  Naoki Miyata

    IPC分类号： B62D33/06 ,  B62D33/063

    CPC分类号： E02F9/0816 ,  E02F9/121

    摘要： A swivel work machine includes a traveling unit, a swivel base plate supported on the traveling unit to be pivotable about a vertical swivel axis, the swivel base plate having a first lateral side and a second lateral side provided across said vertical axis, a pair of upper and lower support brackets disposed at a front end of the swivel base plate with an offset toward the first lateral side and adapted for supporting an implement, a pair of left and right vertical ribs extending rearward from the support brackets and fixed to the swivel base plate and a cabin mounted on the swivel base plate. The cabin is disposed with an offset toward the second lateral side relative to the support brackets, a bottom of the cabin being disposed downwardly of the upper support bracket. The vertical rib disposed on the side of the second lateral side extends, from its front portion to its intermediate portion, parallel with a side face of the cabin on the side of the first lateral side.