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公开(公告)号：US08921535B2
公开(公告)日：2014-12-30
申请号：US12761568
申请日：2010-04-16
申请人： Gregory Paul Nitzel , Robert Gerard Ankenbauer , Jay Gregory Calvert , Donna Steuerwald Dunyak , Jacqueline Gayle Marx , Nancee Lois Oien , Douglas Steven Pearce , Mira Ivanova Stoeva , James Richard Thompson
发明人： Gregory Paul Nitzel , Robert Gerard Ankenbauer , Jay Gregory Calvert , Donna Steuerwald Dunyak , Jacqueline Gayle Marx , Nancee Lois Oien , Douglas Steven Pearce , Mira Ivanova Stoeva , James Richard Thompson
IPC分类号： C07H21/02 , C07H21/04 , C12N15/00 , C12N1/00 , C12N7/00 , C07K14/005 , C07K16/08 , A61K39/00
CPC分类号： C12N7/00 , A61K39/00 , A61K2039/53 , C07K14/005 , C07K16/081 , C12N2750/10021 , C12N2750/10022
摘要： The present invention is directed to novel nucleotide and amino acid sequences of Torque teno virus (“TTV”), including novel genotypes thereof, all of which are useful in the preparation of vaccines for treating and preventing diseases in swine and other animals. Vaccines provided according to the practice of the invention are effective against multiple swine TTV genotypes and isolates. Diagnostic and therapeutic polyclonal and monoclonal antibodies are also a feature of the present invention, as are infectious clones useful in the propagation of the virus and in the preparation of vaccines. Particularly important aspects of the invention include vaccines that provide TTV ORF1 protein, or peptide fragments thereof, as antigen.
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公开(公告)号：US20120321654A1
公开(公告)日：2012-12-20
申请号：US13501371
申请日：2010-04-16
申请人： Gregory Paul Nitzel , Robert Gerard Ankenbauer , Jay Gregory Calvert , Donna Steuerwald Dunyak , Jacqueline Gayle Marx , Nancee Lois Oien , Douglas Steven Pearce , Mira Ivanova Stoeva , James Richard Thompson
发明人： Gregory Paul Nitzel , Robert Gerard Ankenbauer , Jay Gregory Calvert , Donna Steuerwald Dunyak , Jacqueline Gayle Marx , Nancee Lois Oien , Douglas Steven Pearce , Mira Ivanova Stoeva , James Richard Thompson
IPC分类号： A61K39/12 , C12N15/63 , C12N1/21 , C07K16/08 , C12N5/10 , C12N7/01 , C12N7/04 , C07K14/01 , C12N15/34 , C12N1/19
CPC分类号： A61K39/12 , A61K2039/552 , C07K14/005 , C07K16/081 , C07K2317/33 , C12N7/00 , C12N2750/00021 , C12N2750/00022 , C12N2750/00034 , C12N2750/10021 , C12N2750/10034
摘要： The present invention is directed to novel nucleotide and amino acid sequences of Torque teno virus (“TTV”), including novel genotypes thereof, all of which are useful in the preparation of vaccines for treating and preventing diseases in swine and other animals. Vaccines provided according to the practice of the invention are effective against multiple swine TTV genotypes and isolates. Diagnostic and therapeutic polyclonal and monoclonal antibodies are also a feature of the present invention, as are infectious clones useful in the propagation of the virus and in the preparation of vaccines. Particularly important aspects of the invention include vaccines that provide TTV ORF1 protein, or peptide fragments thereof, as antigen.
摘要翻译： 本发明涉及扭矩腱病毒（TTV）的新型核苷酸和氨基酸序列，其包括其新型基因型，所有这些都可用于制备用于治疗和预防猪和其他动物疾病的疫苗。 根据本发明的实践提供的疫苗对多种猪TTV基因型和分离株有效。 诊断和治疗性多克隆和单克隆抗体也是本发明的特征，以及用于病毒繁殖和疫苗制备中的感染性克隆也是如此。 本发明的特别重要的方面包括提供TTV ORF1蛋白或其肽片段作为抗原的疫苗。
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公开(公告)号：US20110064758A1
公开(公告)日：2011-03-17
申请号：US12761568
申请日：2010-04-16
申请人： Gregory Paul Nitzel , Robert Gerard Ankenbauer , Jay Gregory Calvert , Donna Steuerwald Dunyak , Jacqueline Gayle Marx , Nancee Lois Oien , Douglas Steven Pearce , Mira Ivanova Stoeva , James Richard Thompson
发明人： Gregory Paul Nitzel , Robert Gerard Ankenbauer , Jay Gregory Calvert , Donna Steuerwald Dunyak , Jacqueline Gayle Marx , Nancee Lois Oien , Douglas Steven Pearce , Mira Ivanova Stoeva , James Richard Thompson
CPC分类号： C12N7/00 , A61K39/00 , A61K2039/53 , C07K14/005 , C07K16/081 , C12N2750/10021 , C12N2750/10022
摘要： The present invention is directed to novel nucleotide and amino acid sequences of Torque teno virus (“TTV”), including novel genotypes thereof, all of which are useful in the preparation of vaccines for treating and preventing diseases in swine and other animals. Vaccines provided according to the practice of the invention are effective against multiple swine TTV genotypes and isolates. Diagnostic and therapeutic polyclonal and monoclonal antibodies are also a feature of the present invention, as are infectious clones useful in the propagation of the virus and in the preparation of vaccines. Particularly important aspects of the invention include vaccines that provide TTV ORF1 protein, or peptide fragments thereof, as antigen.
摘要翻译： 本发明涉及扭矩腱病毒（“TTV”）的新型核苷酸和氨基酸序列，其包括其新型基因型，所有这些都可用于制备用于治疗和预防猪和其他动物疾病的疫苗。 根据本发明的实践提供的疫苗对多种猪TTV基因型和分离株有效。 诊断和治疗性多克隆和单克隆抗体也是本发明的特征，以及用于病毒繁殖和疫苗制备中的感染性克隆也是如此。 本发明的特别重要的方面包括提供TTV ORF1蛋白或其肽片段作为抗原的疫苗。
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公开(公告)号：US08846388B2
公开(公告)日：2014-09-30
申请号：US13501371
申请日：2010-04-16
申请人： Gregory Paul Nitzel , Robert Gerard Ankenbauer , Jay Gregory Calvert , Donna Steuerwald Dunyak , Jacqueline Gayle Marx , Nancee Lois Oien , Douglas Steven Pearce , Mira Ivanova Stoeva , James Richard Thompson
发明人： Gregory Paul Nitzel , Robert Gerard Ankenbauer , Jay Gregory Calvert , Donna Steuerwald Dunyak , Jacqueline Gayle Marx , Nancee Lois Oien , Douglas Steven Pearce , Mira Ivanova Stoeva , James Richard Thompson
CPC分类号： A61K39/12 , A61K2039/552 , C07K14/005 , C07K16/081 , C07K2317/33 , C12N7/00 , C12N2750/00021 , C12N2750/00022 , C12N2750/00034 , C12N2750/10021 , C12N2750/10034
摘要： The present invention is directed to novel nucleotide and amino acid sequences of Torque teno virus (“TTV”), including novel genotypes thereof, all of which are useful in the preparation of vaccines for treating and preventing diseases in swine and other animals. Vaccines provided according to the practice of the invention are effective against multiple swine TTV genotypes and isolates. Diagnostic and therapeutic polyclonal and monoclonal antibodies are also a feature of the present invention, as are infectious clones useful in the propagation of the virus and in the preparation of vaccines. Particularly important aspects of the invention include vaccines that provide TTV ORF1 protein, or peptide fragments thereof, as antigen.
摘要翻译： 本发明涉及扭矩腱病毒（“TTV”）的新型核苷酸和氨基酸序列，其包括其新型基因型，所有这些都可用于制备用于治疗和预防猪和其他动物疾病的疫苗。 根据本发明的实践提供的疫苗对多种猪TTV基因型和分离株有效。 诊断和治疗性多克隆和单克隆抗体也是本发明的特征，以及用于病毒繁殖和疫苗制备中的感染性克隆也是如此。 本发明的特别重要的方面包括提供TTV ORF1蛋白或其肽片段作为抗原的疫苗。
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公开(公告)号：US08969536B2
公开(公告)日：2015-03-03
申请号：US12733355
申请日：2009-10-16
申请人： Gregory Paul Nitzel , Robert Gerard Ankenbauer , Jay Gregory Calvert , Donna Steuerwald Dunyak , Jacqueline Gayle Marx , Nancee Lois Olen , Douglas Steven Pearce , Mira Ivanova Stoeva , James Richard Thompson
发明人： Gregory Paul Nitzel , Robert Gerard Ankenbauer , Jay Gregory Calvert , Donna Steuerwald Dunyak , Jacqueline Gayle Marx , Nancee Lois Olen , Douglas Steven Pearce , Mira Ivanova Stoeva , James Richard Thompson
IPC分类号： C07H21/02 , C07H21/04 , C12N15/00 , C12N1/00 , C12N7/00 , C07K14/005 , C07K16/08 , A61K39/00
CPC分类号： C12N7/00 , A61K39/00 , A61K2039/53 , C07K14/005 , C07K16/081 , C12N2750/10021 , C12N2750/10022
摘要： The present invention is directed to novel nucleotide and amino acid sequences of Torque teno virus (“TTV”), including novel genotypes thereof, all of which are useful in the preparation of vaccines for treating and preventing diseases in swine and other animals. Vaccines provided according to the practice of the invention are effective against multiple swine TTV genotypes and isolates. Diagnostic and therapeutic polyclonal and monoclonal antibodies are also a feature of the present invention, as are infectious clones useful in the propagation of the virus and in the preparation of vaccines. Particularly important aspects of the invention include vaccines that provide TTV ORF1 protein, or peptide fragments thereof, as antigen.
摘要翻译： 本发明涉及扭矩腱病毒（“TTV”）的新型核苷酸和氨基酸序列，其包括其新型基因型，所有这些都可用于制备用于治疗和预防猪和其他动物疾病的疫苗。 根据本发明的实践提供的疫苗对多种猪TTV基因型和分离株有效。 诊断和治疗性多克隆和单克隆抗体也是本发明的特征，以及用于病毒繁殖和疫苗制备中的感染性克隆也是如此。 本发明的特别重要的方面包括提供TTV ORF1蛋白或其肽片段作为抗原的疫苗。
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公开(公告)号：US20110150913A1
公开(公告)日：2011-06-23
申请号：US12733355
申请日：2009-10-16
申请人： Gregory P. Nitzel , Mira I Stoeva , James R. Thompson , Nancee L. Oien , Jay G. Calvert , Donna Steuerwald Dunyak , Jacqueline Gayle Mark , Robert Gerard Ankenbauer , Douglas Steven Pearce
发明人： Gregory P. Nitzel , Mira I Stoeva , James R. Thompson , Nancee L. Oien , Jay G. Calvert , Donna Steuerwald Dunyak , Jacqueline Gayle Mark , Robert Gerard Ankenbauer , Douglas Steven Pearce
CPC分类号： C12N7/00 , A61K39/00 , A61K2039/53 , C07K14/005 , C07K16/081 , C12N2750/10021 , C12N2750/10022
摘要： The present invention is directed to novel nucleotide and amino acid sequences of Torque teno virus (“TTV”), including novel genotypes thereof, all of which are useful in the preparation of vaccines for treating and preventing diseases in swine and other animals. Vaccines provided according to the practice of the invention are effective against multiple swine TTV genotypes and isolates. Diagnostic and therapeutic polyclonal and monoclonal antibodies are also a feature of the present invention, as are infectious clones useful in the propagation of the virus and in the preparation of vaccines. Particularly important aspects of the invention include vaccines that provide TTV ORF1 protein, or peptide fragments thereof, as antigen.
摘要翻译： 本发明涉及扭矩腱病毒（“TTV”）的新型核苷酸和氨基酸序列，其包括其新型基因型，所有这些都可用于制备用于治疗和预防猪和其他动物疾病的疫苗。 根据本发明的实践提供的疫苗对多种猪TTV基因型和分离株有效。 诊断和治疗性多克隆和单克隆抗体也是本发明的特征，以及用于病毒繁殖和疫苗制备中的感染性克隆也是如此。 本发明的特别重要的方面包括提供TTV ORF1蛋白或其肽片段作为抗原的疫苗。
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公开(公告)号：US09567375B2
公开(公告)日：2017-02-14
申请号：US12624473
申请日：2009-11-24
IPC分类号： A61K39/12 , A61K39/00 , C12N7/00 , C07K14/005
CPC分类号： A61K39/12 , A61K2039/525 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/552 , C07K14/005 , C07K16/1081 , C12N7/00 , C12N2770/24321 , C12N2770/24322 , C12N2770/24361 , G01N33/6854
摘要： The present invention relates to chimeric pestiviruses having utility as immunogenic compositions and vaccines. Also described herein are methods and kits for treating or preventing the spread of bovine viral diarrhea virus infection, as well as methods and kits for differentiating between vaccinated and wild-type infected animals.
摘要翻译： 本发明涉及具有作为免疫原性组合物和疫苗的作用的嵌合瘟病毒。 本文还描述了用于治疗或预防牛病毒性腹泻病毒感染的扩散的方法和试剂盒，以及用于区分接种疫苗和野生型感染动物的方法和试剂盒。
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公开(公告)号：US20100136055A1
公开(公告)日：2010-06-03
申请号：US12624473
申请日：2009-11-24
CPC分类号： A61K39/12 , A61K2039/525 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/552 , C07K14/005 , C07K16/1081 , C12N7/00 , C12N2770/24321 , C12N2770/24322 , C12N2770/24361 , G01N33/6854
摘要： The present invention relates to chimeric pestiviruses having utility as immunogenic compositions and vaccines. Also described herein are methods and kits for treating or preventing the spread of bovine viral diarrhea virus infection, as well as methods and kits for differentiating between vaccinated and wild-type infected animals.
摘要翻译： 本发明涉及具有作为免疫原性组合物和疫苗的作用的嵌合瘟病毒。 本文还描述了用于治疗或预防牛病毒性腹泻病毒感染的扩散的方法和试剂盒，以及用于区分接种疫苗和野生型感染动物的方法和试剂盒。
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9.发明授权Lawsonia derived gene and related hemolysin polypeptides, peptides and proteins and their uses 失效Lawsonia衍生的基因和相关的溶血素多肽，肽和蛋白质及其用途公开(公告)号：US07029683B1
公开(公告)日：2006-04-18
申请号：US10009919
申请日：2000-05-11
CPC分类号： A61K39/105 , C07K14/205
摘要： The present invention relates generally to therapeutic compositions for the treatment and/or prophylaxis of intestinal disease conditions in animals and birds caused or exacerbated by Lawsonia intracellularis or similar or otherwise related microorganism. In particular, the present invention provides a novel gene derived from Lawsonia intracellularis which encodes an immunogenic hemolysin peptide, polypeptide or protein that is particularly useful as an antigen in vaccine preparation for conferring humoral immunity against Lawsonia intracellularis and related pathogens in animal hosts. The present invention is also directed to methods for the treatment and/or prophylaxis of such intestinal disease conditions and to diagnostic agents and procedures for detecting Lawsonia intracellularis or similar or otherwise related microorganisms.
摘要翻译： 本发明一般涉及用于治疗和/或预防由劳森氏菌或类似物或其它相关微生物引起或加剧的动物和鸟类中肠道疾病状况的治疗组合物。 特别地，本发明提供了源自细胞内劳森氏菌的新基因，其编码免疫原性溶血素肽，多肽或蛋白质，其特别可用作疫苗制剂中的抗原，以赋予动物宿主中针对胞内劳森氏菌和相关病原体的体液免疫。 本发明还涉及用于治疗和/或预防这种肠道疾病状况的方法以及用于检测细胞内劳森氏菌或相似或相关微生物的诊断剂和方法。
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