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113 条记录 (耗时 0.051 秒)

    FUSION ANTIBODIES
    1.
    发明申请
    FUSION ANTIBODIES 有权
    融合抗体

    公开(公告)号：US20100227394A1

    公开(公告)日：2010-09-09

    申请号：US12720108

    申请日：2010-03-09

    申请人： Gregory T. Bleck ,  Dona York ,  Ian Collins

    发明人： Gregory T. Bleck ,  Dona York ,  Ian Collins

    IPC分类号： C12N5/071 ,  C07K16/00 ,  C07H21/00 ,  C12N15/74

    CPC分类号： G01N33/53 ,  A61K2039/505 ,  C07K16/00 ,  C07K2317/31 ,  C07K2319/00

    摘要： The present invention provides novel antibodies. In particular, the present invention provides fusion antibodies comprising antibody heavy and light chain fusions. The present invention further provides multivalent antibodies comprising multiple fusion antibody chains. The present invention further provides methods of generating splice resistant antibody genes.

    摘要翻译： 本发明提供新型抗体。 特别地，本发明提供了包含抗体重链和轻链融合物的融合抗体。 本发明还提供了包含多个融合抗体链的多价抗体。 本发明还提供了产生抗拼接抗体基因的方法。

    Fusion antibodies
    2.
    发明授权
    Fusion antibodies 有权
    融合抗体

    公开(公告)号：US07696322B2

    公开(公告)日：2010-04-13

    申请号：US10900928

    申请日：2004-07-28

    申请人： Gregory T. Bleck ,  Dona York ,  Ian Collins

    发明人： Gregory T. Bleck ,  Dona York ,  Ian Collins

    IPC分类号： C12P21/08 ,  C07K16/00 ,  A61K39/395 ,  C12P21/04 ,  C07H21/04

    CPC分类号： G01N33/53 ,  A61K2039/505 ,  C07K16/00 ,  C07K2317/31 ,  C07K2319/00

    摘要： The present invention provides novel antibodies. In particular, the present invention provides fusion antibodies comprising antibody heavy and light chain fusions. The present invention further provides multivalent antibodies comprising multiple fusion antibody chains. The present invention further provides methods of generating splice resistant antibody genes.

    摘要翻译： 本发明提供新型抗体。 特别地，本发明提供了包含抗体重链和轻链融合物的融合抗体。 本发明还提供了包含多个融合抗体链的多价抗体。 本发明还提供了产生抗拼接抗体基因的方法。

    Fusion antibodies
    3.
    发明授权
    Fusion antibodies 有权
    融合抗体

    公开(公告)号：US09541547B2

    公开(公告)日：2017-01-10

    申请号：US12720108

    申请日：2010-03-09

    申请人： Gregory T. Bleck ,  Dona York ,  Ian Collins

    发明人： Gregory T. Bleck ,  Dona York ,  Ian Collins

    IPC分类号： C07K16/00 ,  G01N33/53 ,  A61K39/00

    CPC分类号： G01N33/53 ,  A61K2039/505 ,  C07K16/00 ,  C07K2317/31 ,  C07K2319/00

    摘要： The present invention provides novel antibodies. In particular, the present invention provides fusion antibodies comprising antibody heavy and light chain fusions. The present invention further provides multivalent antibodies comprising multiple fusion antibody chains. The present invention further provides methods of generating splice resistant antibody genes.

    摘要翻译： 本发明提供新型抗体。 特别地，本发明提供了包含抗体重链和轻链融合物的融合抗体。 本发明还提供了包含多个融合抗体链的多价抗体。 本发明还提供了产生抗拼接抗体基因的方法。

    Fusion antibodies
    4.
    发明申请
    Fusion antibodies 有权
    融合抗体

    公开(公告)号：US20050069552A1

    公开(公告)日：2005-03-31

    申请号：US10900928

    申请日：2004-07-28

    申请人： Gregory Bleck ,  Dona York ,  Ian Collins

    发明人： Gregory Bleck ,  Dona York ,  Ian Collins

    IPC分类号： C07K16/00 ,  G01N33/53 ,  A61K39/395 ,  C07K16/46

    CPC分类号： G01N33/53 ,  A61K2039/505 ,  C07K16/00 ,  C07K2317/31 ,  C07K2319/00

    摘要： The present invention provides novel antibodies. In particular, the present invention provides fusion antibodies comprising antibody heavy and light chain fusions. The present invention further provides multivalent antibodies comprising multiple fusion antibody chains. The present invention further provides methods of generating splice resistant antibody genes.

    摘要翻译： 本发明提供新型抗体。 特别地，本发明提供了包含抗体重链和轻链融合物的融合抗体。 本发明还提供了包含多个融合抗体链的多价抗体。 本发明还提供了产生抗拼接抗体基因的方法。

    Purine and deazapurine derivatives as pharmaceutical compounds
    6.
    发明授权
    Purine and deazapurine derivatives as pharmaceutical compounds 有权

    公开(公告)号：US08796293B2

    公开(公告)日：2014-08-05

    申请号：US12298462

    申请日：2007-04-25

    申请人： Thomas Glanmor Davies ,  Michelle Dawn Garrett ,  Robert George Boyle ,  Ian Collins

    发明人： Thomas Glanmor Davies ,  Michelle Dawn Garrett ,  Robert George Boyle ,  Ian Collins

    IPC分类号： A61K31/519 ,  A61K31/44 ,  C07D471/04 ,  C07D473/34

    CPC分类号： C07D471/04 ,  C07D473/34 ,  C07D487/04

    摘要： The invention provides a compound of the formula (I) or salts, solvates, tautomers or N-oxides thereof, wherein T is N or CR5; J1-J2 is N═C(R6), (R7)C═N, (R8)N—C(O), (R8)2C—C(O), N═N or (R7)C═C(R6); E is a monocyclic carbocyclic or heterocyclic group of 5 or 6 ring members, the heterocyclic group containing up to 3 heteroatoms selected from O, N and S; Q1 is a bond or a saturated C1-3 hydrocarbon linker group, one of the carbon atoms in the linker group being optionally be replaced by an oxygen or nitrogen atom, or an adjacent pair of carbon atoms may be replaced by CONRq or NRqCO where Rq is hydrogen or methyl, or Rq is a C1-4alkylene chain linked to R1 or a carbon atom of Q1 to form a cyclic moiety; and wherein the carbon atoms of the linker group Q1 may optionally bear one or more substituents selected from fluorine and hydroxy; Q2 is a bond or a saturated hydrocarbon linker group containing from 1 to 3 carbon atoms, wherein one of the carbon atoms in the linker group may optionally be replaced by an oxygen or nitrogen atom; and wherein the carbon atoms of the linker group may optionally bear one or more substituents selected from fluorine and hydroxy, provided that the hydroxy group when present is not located at a carbon atom α with respect to the G group; and provided that when E is aryl or heteroaryl, then Q2 is other than a bond; G is hydrogen, NR2R3, OH or SH provided that when E is aryl or heteroaryl and Q2 is a bond, then G is hydrogen; R1 is hydrogen or an aryl or heteroaryl group, with the proviso that when R1 is hydrogen and G is NR2R3, then Q2 is a bond; and R2, R3R4, R6 and R8 are as defined in the claims, wherein the compound is for use in: (a) the treatment or prophylaxis of a disease or condition in which the modulation (e.g. inhibition) of ROCK kinase or protein kinase P70S6K is indicated; and/or (b) the treatment of a subject or patient population in which the modulation (e.g. inhibition) of ROCK kinase or protein kinase P70S6K is indicated.

    Systems and methods for automated diagnosis and repair of storage devices
    7.
    发明授权
    Systems and methods for automated diagnosis and repair of storage devices 失效
    存储设备自动诊断和修复的系统和方法

    公开(公告)号：US08195444B2

    公开(公告)日：2012-06-05

    申请号：US11699877

    申请日：2007-01-29

    申请人： Jeffrey Brunet ,  Ian Collins ,  Yousuf Chowdhary ,  Eric Li

    发明人： Jeffrey Brunet ,  Ian Collins ,  Yousuf Chowdhary ,  Eric Li

    IPC分类号： G06F9/455

    CPC分类号： G06F11/261

    摘要： A peripheral electronic device includes a health check application configured to execute automatically upon connection of the peripheral device to a data source, such as a personal computer. The health check application can diagnose problems and if necessary, repair the problems with the peripheral device, the data source, or both. Examples of problems include corrupted data and indications of software, firmware, and hardware failures or impending failures. In some instances, the health check application can provide a warning of an impending failure. The health check application, after initially executing, can be triggered in various ways to scan again for problems. In addition to finding and repairing problems, the health check application can also attend to maintenance.

    摘要翻译： 外围电子设备包括健康检查应用，其配置为在外围设备连接到数据源（例如个人计算机）时自动执行。 健康检查应用程序可以诊断问题，如有必要，可以修复外围设备，数据源或两者的问题。 问题的例子包括损坏的数据和软件，固件，硬件故障或即将发生的故障的指示。 在某些情况下，健康检查应用程序可以提供即将发生故障的警告。 健康检查应用程序在初始执行后可以通过各种方式触发，以再次扫描问题。 除了查找和修复问题外，健康检查应用程序也可以参加维护。

    Data backup system including a data protection component
    9.
    发明授权
    Data backup system including a data protection component 有权
    数据备份系统包括数据保护组件

    公开(公告)号：US07899662B2

    公开(公告)日：2011-03-01

    申请号：US11605770

    申请日：2006-11-28

    申请人： Jeffrey Brunet ,  Ian Collins ,  Yousuf Chowdhary ,  Eric Li ,  Alex Lemelev

    发明人： Jeffrey Brunet ,  Ian Collins ,  Yousuf Chowdhary ,  Eric Li ,  Alex Lemelev

    IPC分类号： G06F9/455 ,  G06F13/20

    CPC分类号： G06F3/0605 ,  G06F3/0632 ,  G06F3/065 ,  G06F3/0676 ,  G06F3/0677 ,  G06F3/0679 ,  G06F11/1451 ,  G06F11/1456 ,  G06F11/1461

    摘要： A data backup system is provided for backing up data files from a data source and for securing those data files against accidental modification or deletion. The system comprises storage and a data protection component that includes an application programming interface defining a command set. The system can also comprise a backup application that is configured to use the commands of the command set. The data protection component allows applications that use the commands of the command set, such as the backup application, to access the storage of the system. The data protection component prevents operating systems and applications that do not use the commands of the command set from accessing the storage. The data protection function of the data protection component can optionally be disabled to allow open access to the storage.

    摘要翻译： 提供数据备份系统，用于从数据源备份数据文件，并保护这些数据文件免受意外修改或删除。 该系统包括存储和数据保护组件，其包括定义命令集的应用程序编程接口。 系统还可以包括配置为使用命令集的命令的备份应用程序。 数据保护组件允许使用命令集的命令（如备份应用程序）访问系统存储的应用程序。 数据保护组件防止不使用命令集命令的操作系统和应用程序访问存储。 可以选择禁用数据保护组件的数据保护功能，以允许对存储器的打开访问。

    PHARMACEUTICAL COMBINATIONS COMPRISING PYRAZOLE DERIVATIVES AS PROTEIN KINASE MODULATORS
    10.
    发明申请
    PHARMACEUTICAL COMBINATIONS COMPRISING PYRAZOLE DERIVATIVES AS PROTEIN KINASE MODULATORS 失效
    包含作为蛋白激酶调节剂的吡唑衍生物的药物组合

    公开(公告)号：US20100166699A1

    公开(公告)日：2010-07-01

    申请号：US11993823

    申请日：2006-06-21

    申请人： Neil Thomas Thompson ,  Robert George Boyle ,  Ian Collins ,  Michelle Dawn Garrett ,  John Francis Lyons ,  Kyla Merriom Thompson

    发明人： Neil Thomas Thompson ,  Robert George Boyle ,  Ian Collins ,  Michelle Dawn Garrett ,  John Francis Lyons ,  Kyla Merriom Thompson

    IPC分类号： A61K38/20 ,  A61K31/497 ,  A61K39/395 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/4439 ,  A61K31/565 ,  A61K31/566 ,  A61K38/21 ,  A61K33/24 ,  A61K31/4375 ,  A61K31/675 ,  A61K31/551 ,  A61P35/00

    CPC分类号： A61K45/06 ,  A61K31/415 ,  A61K31/454 ,  A61K2300/00

    摘要： The invention provides a combination comprising an ancillary compound (e.g. one, two or more ancillary compounds) and a compound of the formula (I) having protein kinase B inhibiting activity: wherein A is a saturated hydrocarbon linker group containing from 1 to 7 carbon atoms, the linker group having a maximum chain length of 5 atoms extending between R1 and NR2R3 and a maximum chain length of 4 atoms extending between E and NR2R3, wherein one of the carbon atoms in the linker group may optionally be replaced by an oxygen or nitrogen atom; and wherein the carbon atoms of the linker group A may optionally bear one or more substituents selected from oxo, fluorine and hydroxy, provided that the hydroxy group when present is not located at a carbon atom a with respect to the NR2R3 group and provided that the oxo group when present is located at a carbon atom a with respect to the NR2R3 group; E is a monocyclic or bicyclic carbocyclic or heterocyclic group; R is an aryl or heteroaryl group; and R2, R3, R4 and R5 are as defined in the claims. Also provided are patient packs, pharmaceutical kits and packs and compositions containing the combinations, methods for preparing the combinations and their use in combination therapy as anticancer agents.

    摘要翻译： 本发明提供包含辅助化合物（例如一种，两种或多种辅助化合物）和具有​​蛋白激酶B抑制活性的式（I）化合物的组合的组合：其中A是含有1至7个碳原子的饱和烃连接基团 ，连接基团具有在R1和NR2R3之间延伸的5个原子的最大链长度，以及在E和NR 2 R 3之间延伸的4个原子的最大链长度，其中连接基团中的一个碳原子可以任选被氧或氮取代 原子; 并且其中连接基团A的碳原子可以任选地具有一个或多个选自氧代，氟和羟基的取代基，条件是当存在的羟基不相对于NR 2 R 3基团位于碳原子a时， 存在时的氧代基相对于NR 2 R 3基团位于碳原子a; E是单环或双环碳环或杂环基; R是芳基或杂芳基; 并且R 2，R 3，R 4和R 5如权利要求中所定义。 还提供了包含组合的患者包装，药物盒和包装和组合，用于制备组合的方法及其在联合治疗中作为抗癌剂的用途。