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    Physiogenomic Method for Predicting Statin Injury to Muscle and Muscle Side Effects
    1.
    发明申请
    Physiogenomic Method for Predicting Statin Injury to Muscle and Muscle Side Effects 审中-公开
    用于预测他汀类药物对肌肉和肌肉副作用的损伤的生理基因组学方法

    公开(公告)号：US20090233299A1

    公开(公告)日：2009-09-17

    申请号：US12400990

    申请日：2009-03-10

    申请人： Gualberto Ruano ,  Alan Wu ,  Paul D. Thompson

    发明人： Gualberto Ruano ,  Alan Wu ,  Paul D. Thompson

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156

    摘要： The present invention relates to the use of genetic variants of associated marker genes to predict an individual's susceptibility to muscular injury and muscular side effects in response to statin therapy. The present invention further relates to analytical assays and computational methods using the novel marker gene set. The present invention has utility for personalized medical treatment, drug safety, statin compliance, and prophylaxis of muscle side effect.

    摘要翻译： 本发明涉及使用相关标记基因的遗传变体来预测个体对肌肉损伤的敏感性和对他汀类药物治疗的肌肉副作用。 本发明还涉及使用新型标记基因组的分析测定和计算方法。 本发明具有个性化治疗，药物安全性，他汀类药物依从性和预防肌肉副作用的效用。

    Physiogenomic method for predicting statin injury to muscle and muscle side effects
    2.
    发明申请
    Physiogenomic method for predicting statin injury to muscle and muscle side effects 审中-公开
    用于预测他汀类药物对肌肉和肌肉副作用的损伤的生理基因组学方法

    公开(公告)号：US20070202518A1

    公开(公告)日：2007-08-30

    申请号：US11602108

    申请日：2006-11-20

    申请人： Gualberto Ruano ,  Alan Wu ,  Paul Thompson

    发明人： Gualberto Ruano ,  Alan Wu ,  Paul Thompson

    IPC分类号： C12Q1/68 ,  C12M1/34

    CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156

    摘要： The present invention relates to the use of genetic variants of associated marker genes to predict an individual's susceptibility to muscular injury and muscular side effects in response to statin therapy. The present invention further relates to analytical assays and computational methods using the novel marker gene set. The present invention has utility for personalized medical treatment, drug safety, statin compliance, and prophylaxis of muscle side effect.

    摘要翻译： 本发明涉及使用相关标记基因的遗传变体来预测个体对肌肉损伤的敏感性和对他汀类药物治疗的肌肉副作用。 本发明还涉及使用新型标记基因组的分析测定和计算方法。 本发明具有个性化治疗，药物安全性，他汀类药物依从性和预防肌肉副作用的效用。

    Alternating plate headerless heat exchangers
    3.
    发明授权
    Alternating plate headerless heat exchangers 有权
    交替盘无头换热器

    公开(公告)号：US08646516B2

    公开(公告)日：2014-02-11

    申请号：US11465207

    申请日：2006-08-17

    申请人： Kenneth Abels ,  W. Dennis Moss ,  Steven Lin ,  Alan Wu

    发明人： Kenneth Abels ,  W. Dennis Moss ,  Steven Lin ,  Alan Wu

    IPC分类号： F28F3/06

    CPC分类号： F28F9/0221 ,  F28D1/0316 ,  F28F3/025

    摘要： A plate and fin type heat exchanger has a heat exchanger core made from a plurality of stacked, alternating first and second heat exchange plates of a generally inverted, U-shaped cross-section. Each plate has a top wall, closed peripheral sidewalls and open ends, and the open ends of the first plates are oriented at 90° to the open ends of the second plates. The sidewalls of the plates have end portions, which in adjacent plates, are aligned to form corners of the heat exchanger core. Opposed U-shaped manifold bodies are provided having open ends and lateral walls joined in a fluid tight manner to the aligned plate sidewall end portions. End plates close off the open ends of the U-shaped bodies to form manifolds. The corners formed by the aligned plate sidewall end portions allow for an improved connection between the heat exchanger core and the U-shaped manifold bodies. This helps to ensure that a fluid tight seal is created between the heat exchanger core and the manifold bodies when the components are joined together.

    摘要翻译： 板翅式热交换器具有由大致倒U形横截面的多个层叠的，交替的第一和第二热交换板制成的热交换器芯。 每个板具有顶壁，封闭的外围侧壁和开口端，并且第一板的开口端与第二板的开口端成90°取向。 板的侧壁具有端部，其在相邻的板中对齐以形成热交换器芯的角部。 提供了相对的U形歧管体，其具有以流体密封的方式连接到对齐的板侧壁端部的开口端和侧壁。 端板封闭U形体的开口端形成歧管。 由对准的板侧壁端部形成的角部允许在热交换器芯和U形歧管主体之间改善连接。 这有助于确保当组件接合在一起时，在热交换器芯和歧管本体之间产生流体密封。

    Low distortion switching amplifier circuits and methods
    4.
    发明申请
    Low distortion switching amplifier circuits and methods 有权
    低失真开关放大器电路及方法

    公开(公告)号：US20080161953A1

    公开(公告)日：2008-07-03

    申请号：US11890813

    申请日：2007-08-07

    申请人： Hideto Takagishi ,  Wolf Zhang ,  Alan Wu

    发明人： Hideto Takagishi ,  Wolf Zhang ,  Alan Wu

    IPC分类号： G06F17/00

    CPC分类号： H03F3/2173 ,  H03F2200/03 ,  H03F2200/351

    摘要： Embodiments of the present invention include switching amplifier circuits and methods. In one embodiment, the present invention includes a low distortion method of driving a switching amplifier comprising modulating an audio input signal to produce a half-wave rectified pulse-width modulated signal and a complementary half-wave rectified pulse-width modulated signal. These signals may be amplified in a power amplifier and combined in a feedback circuit to generate a first feedback signal and a second feedback signal, which may be coupled the inputs of a modulator for controlling the output signal.

    摘要翻译： 本发明的实施例包括开关放大器电路和方法。 在一个实施例中，本发明包括驱动开关放大器的低失真方法，包括调制音频输入信号以产生半波整流脉宽调制信号和互补半波整流脉宽调制信号。 这些信号可以在功率放大器中被放大并组合在反馈电路中以产生第一反馈信号和第二反馈信号，其可耦合调制器的输入以控制输出信号。

    Reflex algorithm for early and cost effective diagnosis of myocardial infractions suitable for automated diagnostic platforms
    5.
    发明授权
    Reflex algorithm for early and cost effective diagnosis of myocardial infractions suitable for automated diagnostic platforms 失效
    用于早期和成本有效诊断适合于自动诊断平台的心肌梗死的反射算法

    公开(公告)号：US06099469A

    公开(公告)日：2000-08-08

    申请号：US88870

    申请日：1998-06-02

    申请人： E. Glenn Armstrong ,  Christoph Petry ,  Alan Wu ,  Gerald Wagner

    发明人： E. Glenn Armstrong ,  Christoph Petry ,  Alan Wu ,  Gerald Wagner

    IPC分类号： C12Q1/00 ,  G01N33/48 ,  G01N35/00 ,  G06F19/00 ,  G06Q50/00 ,  A61N5/00

    CPC分类号： G06F19/345 ,  G01N35/00584 ,  Y10S128/92

    摘要： A reflex algorithm for assessing cardiac patients, which does not require human decision-making in selecting assays to be performed. Performance of further biochemical marker tests on a patient is dependent upon the outcome of previously conducted tests. The reflex algorithm focuses on obtaining the most accurate test information as early as possible from several different tests run in very short intervals. The reflex algorithm may be implemented by a computer that can copy requests for the most appropriate test to the loadlists of automated clinical chemistry and immunoassay analyzers. Also provided is an integrated platform for executing clinical chemistry assays and immunoassays according to a reflex algorithm.

    摘要翻译： 一种用于评估心脏病患者的反射算法，其不需要人为决策来选择要进行的化验。 对患者的进一步生物化学标记物测试的性能取决于先前进行的测试的结果。 反射算法重点是从几个不同的测试中尽可能早地获得最准确的测试信息。 反射算法可以由计算机实现，该计算机可以将针对最适合的测试的请求复制到自动临床化学和免疫分析仪的装载列表。 还提供了一种用于根据反射算法执行临床化学测定和免疫测定的综合平台。

    Battery Cell Cooler
    7.
    发明申请
    Battery Cell Cooler 有权
    电池电池冷却器

    公开(公告)号：US20120237805A1

    公开(公告)日：2012-09-20

    申请号：US13423385

    申请日：2012-03-19

    申请人： Kenneth Abels ,  Alan Wu ,  John Burgers ,  Peter Zurawel ,  Zia Shahidi

    发明人： Kenneth Abels ,  Alan Wu ,  John Burgers ,  Peter Zurawel ,  Zia Shahidi

    IPC分类号： H01M10/50 ,  B23K31/00

    CPC分类号： H01M10/5004 ,  H01M2/1077 ,  H01M10/0525 ,  H01M10/613 ,  H01M10/625 ,  H01M10/647 ,  H01M10/6557 ,  H01M10/6567 ,  Y02E60/12 ,  Y02T10/7011

    摘要： A battery cell cooler containing a pair of complementary plates. The pair of complementary plates together forms a tubular flow passage and one or more tubular sections. The flow passage has an inlet end, an outlet end and dimples or ribs along the length of the flow passage. The one or more tubular sections have an inlet duct and an outlet duct, the inlet duct being coupled to an expanded receptacle at the inlet end and in fluid communication with the inlet end of the flow passage and the outlet duct being coupled to an expanded receptacle, at the outlet end and in fluid communication with the outlet end of the flow passage. Also, disclosed is a device containing a battery cell sandwiched between a pair of battery cell coolers, as described herein. Further disclosed is a method for forming the battery cell cooler, as described herein.

    摘要翻译： 包含一对互补板的电池单元冷却器。 一对互补板一起形成管状流动通道和一个或多个管状部分。 流动通道具有沿着流动通道长度的入口端，出口端和凹坑或肋。 一个或多个管状部分具有入口管道和出口管道，入口管道在入口端处连接到扩张的容器并与流动通道的入口端流体连通，并且出口管道联接到扩展容器 ，在出口端处并与流动通道的出口端流体连通。 此外，公开了如本文所述的包含夹在一对电池单元冷却器之间的电池单元的装置。 还公开了如本文所述的用于形成电池单元冷却器的方法。

    Low distortion switching amplifier circuits and methods
    8.
    发明授权
    Low distortion switching amplifier circuits and methods 有权
    低失真开关放大器电路及方法

    公开(公告)号：US08111846B2

    公开(公告)日：2012-02-07

    申请号：US11890813

    申请日：2007-08-07

    申请人： Hideto Takagishi ,  Wolf Zhang ,  Alan Wu

    发明人： Hideto Takagishi ,  Wolf Zhang ,  Alan Wu

    IPC分类号： H02B1/00

    CPC分类号： H03F3/2173 ,  H03F2200/03 ,  H03F2200/351

    摘要： Embodiments of the present invention include switching amplifier circuits and methods. In one embodiment, the present invention includes a low distortion method of driving a switching amplifier comprising modulating an audio input signal to produce a half-wave rectified pulse-width modulated signal and a complementary half-wave rectified pulse-width modulated signal. These signals may be amplified in a power amplifier and combined in a feedback circuit to generate a first feedback signal and a second feedback signal, which may be coupled the inputs of a modulator for controlling the output signal.

    摘要翻译： 本发明的实施例包括开关放大器电路和方法。 在一个实施例中，本发明包括驱动开关放大器的低失真方法，包括调制音频输入信号以产生半波整流脉宽调制信号和互补半波整流脉宽调制信号。 这些信号可以在功率放大器中被放大并组合在反馈电路中以产生第一反馈信号和第二反馈信号，其可耦合调制器的输入以控制输出信号。