Physiogenomic method for predicting statin injury to muscle and muscle side effects
    1.
    发明申请
    Physiogenomic method for predicting statin injury to muscle and muscle side effects 审中-公开
    用于预测他汀类药物对肌肉和肌肉副作用的损伤的生理基因组学方法

    公开(公告)号:US20070202518A1

    公开(公告)日:2007-08-30

    申请号:US11602108

    申请日:2006-11-20

    IPC分类号: C12Q1/68 C12M1/34

    摘要: The present invention relates to the use of genetic variants of associated marker genes to predict an individual's susceptibility to muscular injury and muscular side effects in response to statin therapy. The present invention further relates to analytical assays and computational methods using the novel marker gene set. The present invention has utility for personalized medical treatment, drug safety, statin compliance, and prophylaxis of muscle side effect.

    摘要翻译: 本发明涉及使用相关标记基因的遗传变体来预测个体对肌肉损伤的敏感性和对他汀类药物治疗的肌肉副作用。 本发明还涉及使用新型标记基因组的分析测定和计算方法。 本发明具有个性化治疗,药物安全性,他汀类药物依从性和预防肌肉副作用的效用。

    DISTRESS BEACON
    2.
    发明申请
    DISTRESS BEACON 审中-公开

    公开(公告)号:US20160057596A1

    公开(公告)日:2016-02-25

    申请号:US14521273

    申请日:2014-10-22

    IPC分类号: H04W4/22 H04W4/06 H04W4/02

    CPC分类号: H04W4/90 H04W4/029 H04W4/06

    摘要: A mobile device can include a distress application configured to activate a distress beacon that is broadcast as a radio frequency (RF) signal on a plurality of different protocols. Each of the plurality of different protocols can employ a different frequency band.

    摘要翻译: 移动设备可以包括遇险应用,其被配置为激活作为多个不同协议上的射频(RF)信号广播的遇险信标。 多个不同协议中的每一个可以采用不同的频带。

    SYSTEM AND METHOD FOR TERRAIN ANALYSIS
    3.
    发明申请
    SYSTEM AND METHOD FOR TERRAIN ANALYSIS 审中-公开
    TERRAIN分析系统与方法

    公开(公告)号:US20120139325A1

    公开(公告)日:2012-06-07

    申请号:US13223693

    申请日:2011-09-01

    IPC分类号: E21C41/26 G06K9/48

    摘要: Described herein is a computerised method for identifying and classifying edges in a dataset representative of an open-pit mine terrain. The method includes the step of identifying one or more surfaces of the terrain having common topological attributes (306). Then, for each surface identified, edges of the identified surface are detected (308) and each of the detected edges are classified (316) as one of a toe, crest, or other than a crest or a toe. The method also includes the step of updating the dataset (208) with the edges classified as toes or crests.

    摘要翻译: 这里描述了一种用于识别和分类表示露天矿地形的数据集中的边缘的计算机化方法。 该方法包括识别具有共同拓扑属性的地形的一个或多个表面的步骤(306)。 然后,对于识别的每个表面,检测到所识别的表面的边缘(308),并且将每个检测到的边缘分类为(316)作为趾部,顶部之一或除了顶部或趾部之外的其中之一。 该方法还包括更新数据集(208)的步骤,边缘被分类为脚趾或峰顶。

    Recessed wall-wash staggered mounting method
    4.
    发明授权
    Recessed wall-wash staggered mounting method 有权
    嵌入式洗墙交错安装方法

    公开(公告)号:US07856788B2

    公开(公告)日:2010-12-28

    申请号:US12696305

    申请日:2010-01-29

    申请人: Paul Thompson

    发明人: Paul Thompson

    IPC分类号: E04B9/00

    摘要: The invention comprises a completely recessed wall-wash lighting fixture capable of being installed within a ceiling. The lighting fixture comprises a housing, which contains a lamp. The invention may comprise a lighting fixture further comprises a reflector disposed within the housing and adjacent to the first end of the housing. The invention may also comprise a flared lamp shield attached to the housing, which is capable of protecting the lighting fixture from damage. The lamp shield extends below the ceiling when the lighting fixture is installed.

    摘要翻译: 本发明包括能够安装在天花板内的完全凹陷的洗墙灯。 照明器具包括一个包含灯的外壳。 本发明可以包括照明器具还包括设置在壳体内并邻近壳体的第一端的反射器。 本发明还可以包括附接到壳体的喇叭形灯罩,其能够保护照明器具免受损坏。 安装照明灯具时,灯罩在天花板下方延伸。

    STENTS MODIFIED WITH MATERIAL COMPRISING AMNION TISSUE AND CORRESPONDING PROCESSES
    5.
    发明申请
    STENTS MODIFIED WITH MATERIAL COMPRISING AMNION TISSUE AND CORRESPONDING PROCESSES 有权
    用包含粘结组织和相应工艺的材料修改的手套

    公开(公告)号:US20100228335A1

    公开(公告)日:2010-09-09

    申请号:US12713666

    申请日:2010-02-26

    IPC分类号: A61F2/82 B05D7/00

    摘要: A stent scaffold combined with amniotic tissue provides for a biocompatible stent that has improved biocompatibility and hemocompatibility. The amnion tissue can be variously modified or unmodified form of amnion tissue such as non-cryo amnion tissue, solubilized amnion tissue, amnion tissue fabric, chemically modified amnion tissue, amnion tissue treated with radiation, amnion tissue treated with heat, or a combination thereof. Materials such as polymer, placental tissue, pericardium tissue, small intestine submucosa can be used in combination with the amnion tissue. The amnion tissue can be attached to the inside, the outside, both inside and outside, or complete encapsulation of the stent scaffold. In some embodiments, at least part of the covering or lining comprises a plurality of layers of amnion tissue. The method of making the biocompatible stent and its delivery and deployment are also discussed.

    摘要翻译: 与羊膜组织结合的支架支架提供具有改善的生物相容性和血液相容性的生物相容性支架。 羊膜组织可以是羊膜组织的各种修饰或未修饰形式,例如非低温羊膜组织,溶解的羊膜组织,羊膜组织织物,化学修饰的羊膜组织,用辐射处理的羊膜组织,用热处理的羊膜组织或其组合 。 诸如聚合物,胎盘组织,心包组织,小肠粘膜下层的材料可以与羊膜组织结合使用。 羊膜组织可以连接到内部,外部,内部和外部,或完全包封支架支架。 在一些实施例中,覆盖物或衬里的至少一部分包括多层羊膜织物。 还讨论了制备生物相容性支架及其递送和部署的方法。

    Web assistant
    6.
    发明授权
    Web assistant 有权
    网络助手

    公开(公告)号:US07739329B2

    公开(公告)日:2010-06-15

    申请号:US10278367

    申请日:2002-10-23

    申请人: Paul Thompson

    发明人: Paul Thompson

    IPC分类号: G06F15/16 G06F3/00

    摘要: A method and apparatus for providing agent assistance to a client visiting a website of an organization. The method includes the steps of collecting contact information about the visit to the website by the client and connecting the client with an agent of the organization when the collected contact information exceeds a predetermined criterion.

    摘要翻译: 一种用于向访问组织的网站的客户机提供代理协助的方法和装置。 该方法包括以下步骤:当所收集的联系人信息超过预定标准时,收集客户访问网站的联系信息并将客户端与组织的代理连接。

    Plate spinner systems and devices
    7.
    发明申请
    Plate spinner systems and devices 审中-公开
    板式旋转器系统和装置

    公开(公告)号:US20080181823A1

    公开(公告)日:2008-07-31

    申请号:US11594516

    申请日:2006-11-08

    IPC分类号: B01L11/00 G01N37/00

    摘要: The present invention provides plate spinner systems and devices, and methods of using such systems and devices. In preferred embodiments, the systems and devices contain one or more of the following features: a manual power generating component (e.g. a hand crank power supply); a rotor assembly composed of a rotor with brackets for securing a sample holding device such as a sample processing device or a micro-titer plate; a rotor hub that supports nearly all of the weight of the rotor assembly; a manually operated brake; and a kettle cover containing a rotor tachometer.

    摘要翻译: 本发明提供板式旋转器系统和装置,以及使用这种系统和装置的方法。 在优选实施例中,系统和装置包含以下特征中的一个或多个:手动发电部件(例如手动曲柄电源); 由具有支架的转子组成的转子组件,用于固定样品处理装置或微量滴定板等样品保持装置; 转子毂,其支撑转子组件的几乎所有重量; 手动制动器; 和一个包含转子转速表的水壶盖。

    Method for selectively producing male or female sterile plants
    8.
    发明申请
    Method for selectively producing male or female sterile plants 有权
    选择性地产生雄性或雌性不育植物的方法

    公开(公告)号:US20050150013A1

    公开(公告)日:2005-07-07

    申请号:US10504784

    申请日:2003-02-14

    摘要: A method of producing male or female sterile plants comprising the steps of transforming plant material with a polynucleotide which encodes at least one enzyme which reacts with a non-phytotoxic substance to produce a phytotoxic one, and regenerating the thus transformed material into a plant, wherein the said non-phytotoxic substance is applied to the plant up to the time of male or female gamete formation and/or maturation, so that the non-phytotoxic substance provides for the production of a phytotoxic one which selectively prevents the formation of or otherwise renders the said gametes non-functional, wherein the enzyme is expressed preferentially in either male or female reproductive structures, characterised in that (i) the non-phytotoxic substance is selected from the group consisting of ester derivatives of non-phosphonate herbicides which herbicides are directly phytotoxic to non-green tissue, D-alpha amino acids, peptide derivatives of non-protein D-alpha amino acids, S-enantiomers of aryloxyphenoxypropionates and S-enantiomers of ester derivatives of aryloxyphenoxypropionates and (ii) the enzyme is selected from the group consisting of carboxylesterases, D-amino acid oxidases, D-amino acid dehydrogenases, D-amino acid racemases, 2-arylpropionyl-CoA epimerases, alpha-methylacyl-CoA racemases, thioesterases and acyl-CoA synthetases.

    摘要翻译: 一种产生雄性或雌性不育植物的方法,包括以编码与非植物毒性物质反应产生植物毒性物质的至少一种酶的多核苷酸转化植物材料并将由此转化的材料再生成植物的步骤,其中 所述非植物毒性物质直到雄性或雌性配子形成和/或成熟时被施用于植物,使得非植物毒性物质提供了用于选择性地防止形成或以其它方式形成的植物毒性物质 所述配子是非功能性的,其中所述酶优先在雄性或雌性生殖结构中表达,其特征在于(i)非植物毒性物质选自除草剂直接的非膦酸酯除草剂的酯衍生物 对非绿色组织的植物毒性,D-α氨基酸,​​非蛋白D-α氨基酸的肽衍生物,S-enant 芳氧基苯氧基丙酸酯的酯衍生物的芳氧基苯氧基丙酸酯和S-对映体的异单体和(ii)该酶选自羧酸酯酶,D-氨基酸氧化酶,D-氨基酸脱氢酶,D-氨基酸消旋酶,2-芳基丙酰辅酶A 差向异构酶,α-甲基酰基-CoA消旋酶,硫酯酶和酰基辅酶A合成酶。

    Method and apparatus for a calibrated variable phase offset timing between synchronous clock subdomains
    9.
    发明申请
    Method and apparatus for a calibrated variable phase offset timing between synchronous clock subdomains 有权
    同步时钟子域之间校准的可变相位偏移定时的方法和装置

    公开(公告)号:US20050021920A1

    公开(公告)日:2005-01-27

    申请号:US10919668

    申请日:2004-08-16

    IPC分类号: G06F1/10 G06F12/00 G06F13/16

    CPC分类号: G06F13/1689 G06F1/10

    摘要: A method and apparatus for a calibrated variable phase offset timing between synchronous clock subdomains is described. In one embodiment, the invention is an apparatus. The apparatus includes a first subsystem and a second subsystem coupled to the first subsystem. The apparatus also includes a clock signal generator coupled to the first subsystem and coupled to the second subsystem. The clock signal generator is to supply a first clock to the first subsystem and to supply a second clock to the first subsystem and to supply a third clock to the second subsystem. Each of the first clock, the second clock and the third clock are derived from a common clock, the first clock having a first predetermined phase offset relative to the third clock, and the second clock having a second predetermined phase offset relative to the third clock. The first predetermined phase offset and the second predetermined phase offset are adjustable based on performance characteristics of the first subsystem and performance characteristics of the second subsystem.

    摘要翻译: 描述了用于同步时钟子域之间校准的可变相位偏移定时的方法和装置。 在一个实施例中,本发明是一种装置。 该装置包括耦合到第一子系统的第一子系统和第二子系统。 该装置还包括耦合到第一子系统并耦合到第二子系统的时钟信号发生器。 时钟信号发生器将第一时钟提供给第一子系统,并向第一子系统提供第二时钟并向第二子系统提供第三时钟。 第一时钟,第二时钟和第三时钟中的每一个从公共时钟导出,第一时钟具有相对于第三时钟的第一预定相位偏移,并且第二时钟具有相对于第三时钟的第二预定相位偏移 。 第一预定相位偏移和第二预定相位偏移可基于第一子系统的性能特征和第二子系统的性能特性来调节。

    Device for securing electrical cords
    10.
    发明授权
    Device for securing electrical cords 失效
    用于固定电线的装置

    公开(公告)号:US5135409A

    公开(公告)日:1992-08-04

    申请号:US591278

    申请日:1990-10-01

    申请人: Paul Thompson

    发明人: Paul Thompson

    IPC分类号: H01R13/639

    CPC分类号: H01R13/6392

    摘要: A device for maintaining cooperating plugs on a pair of electrical cords connected comprising a generally elongate body adapted to enclose the plugs of a pair of electrical cords; said body comprising at least two cooperating members which, when engaged, form an enclosure for the plugs; at least two pairs of appendages affixed to the inside of the cooperating members; said appendages adapted to grip both electical cords so as to maintain the plugs in a connected relationship; and means to selectively engage and disengage the members comprising the body.

    摘要翻译: 一种用于在连接的一对电线上保持配合的插头的装置,包括适于包围一对电线的插头的大致细长的主体; 所述主体包括至少两个配合构件,所述至少两个配合构件当被接合时形成所述塞子的外壳; 至少两对附属物贴在合作成员的内部; 所述附件适于抓住两条电线,以便将插头保持在连接的关系中; 以及用于选择性地接合和脱离包括所述主体的构件的装置。