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    IMMUNOGENIC COMPOSITIONS FOR CHLAMYDIA TRACHOMATIS
    1.
    发明申请
    IMMUNOGENIC COMPOSITIONS FOR CHLAMYDIA TRACHOMATIS 审中-公开
    木质素培养基的免疫组化

    公开(公告)号：US20110070266A1

    公开(公告)日：2011-03-24

    申请号：US12896353

    申请日：2010-10-01

    申请人： Guido Grandi ,  Giulio Ratti ,  Alessandra Bonci ,  Oretta Finco

    发明人： Guido Grandi ,  Giulio Ratti ,  Alessandra Bonci ,  Oretta Finco

    IPC分类号： A61K39/118 ,  A61P31/04

    CPC分类号： A61K39/118 ,  A61K39/00 ,  A61K39/02 ,  A61K2039/505 ,  A61K2039/55505 ,  A61K2039/55561 ,  C07K14/195

    摘要： The invention relates to immunogenic compositions comprising combinations of Chlamydia trachomatis antigens and their use in vaccines. The composition may comprise at least two components, one component of which comprises Chlamydia trachomatis antigens for eliciting a Chlamydia trachomatis specific TH1 immune response and another component of which comprises antigens for eliciting a Chlamydia trachomatis specific TH2 immune response. The invention further relates to an immunogenic composition comprising a Chlamydia trachomatis Type III secretion system (TTSS) regulatory protein and a Chlamydia trachomatis Type III secretion system (TTSS) secreted protein or a fragment thereof. The invention further relates to the use of combinations of adjuvants for use with antigens associated with a sexually transmissible disease, such as Chlamydia trachomatis antigens. Preferred adjuvant combinations include mineral salts, such as aluminium salts and oligonucleotides comprising a CpG motif. The invention further provides a combination of Chlamydia trachomatis antigens comprising a Chlamydia trachomatis antigen that is conserved over at least two serovars.

    摘要翻译： 本发明涉及包含沙眼衣原体抗原及其在疫苗中的应用的组合的免疫原性组合物。 组合物可以包含至少两种组分，其一种组分包含沙眼衣原体抗原，其用于引发沙眼衣原体特异性TH1免疫应答，其另一种成分包含用于引发沙眼衣原体特异性TH2免疫应答的抗原。 本发明还涉及包含沙眼衣原体III型分泌系统（TTSS）调节蛋白和沙眼衣原体III型分泌系统（TTSS）分泌蛋白或其片段的免疫原性组合物。 本发明还涉及佐剂组合用于与性传播疾病如沙眼衣原体抗原相关的抗原的用途。 优选的佐剂组合包括无机盐，例如铝盐和包含CpG基序的寡核苷酸。 本发明还提供沙眼衣原体抗原的组合，其包含在至少两种血清型中保守的沙眼衣原体抗原。

    Immunogenic compositions for Chlamydia trachomatis
    2.
    发明申请
    Immunogenic compositions for Chlamydia trachomatis 审中-公开
    沙眼衣原体的免疫原性组合物

    公开(公告)号：US20060034871A1

    公开(公告)日：2006-02-16

    申请号：US11018868

    申请日：2004-12-22

    申请人： Guido Grandi ,  Guilio Ratti ,  Alessandra Bonci ,  Oretta Finco

    发明人： Guido Grandi ,  Guilio Ratti ,  Alessandra Bonci ,  Oretta Finco

    IPC分类号： A61K39/118 ,  C12N1/20

    CPC分类号： A61K39/118 ,  A61K39/00 ,  A61K39/02 ,  A61K2039/505 ,  A61K2039/55505 ,  A61K2039/55561 ,  C07K14/195

    摘要： The invention relates to immunogenic compositions comprising combinations of Chlamydia trachomatis antigens and their use in vaccines. The composition may comprise at least two components, one component of which comprises Chlamydia trachomatis antigens for eliciting a Chlamydia trachomatis specific TH1 immune response and another component of which comprises antigens for eliciting a Chlamydia trachomatis specific TH2 immune response. The invention further relates to an immunogenic composition comprising a Chlamydia trachomatis Type III secretion system (TTSS) regulatory protein and a Chlamydia trachomatis Type III secretion system (TTSS) secreted protein or a fragment thereof. The invention further relates to the use of combinations of adjuvants for use with antigens associated with a sexually transmissible disease, such as Chlamydia trachomatis antigens. Preferred adjuvant combinations include mineral salts, such as aluminium salts and oligonucleotides comprising a CpG motif. The invention further provides a combination of Chlamydia trachomatis antigens comprising a Chlamydia trachomatis antigen that is conserved over at least two serovars.

    摘要翻译： 本发明涉及包含沙眼衣原体抗原及其在疫苗中的应用的组合的免疫原性组合物。 组合物可以包含至少两种组分，其一种组分包含沙眼衣原体抗原，其用于引发沙眼衣原体特异性TH1免疫应答，其另一种成分包含用于引发沙眼衣原体特异性TH2免疫应答的抗原。 本发明还涉及包含沙眼衣原体III型分泌系统（TTSS）调节蛋白和沙眼衣原体III型分泌系统（TTSS）分泌蛋白或其片段的免疫原性组合物。 本发明还涉及佐剂组合用于与性传播疾病如沙眼衣原体抗原相关的抗原的用途。 优选的佐剂组合包括无机盐，例如铝盐和包含CpG基序的寡核苷酸。 本发明还提供沙眼衣原体抗原的组合，其包含在至少两种血清型中保守的沙眼衣原体抗原。

    Immunogenic compositions for chlamydia trachomatis
    3.
    发明申请
    Immunogenic compositions for chlamydia trachomatis 审中-公开
    沙眼衣原体的免疫原性组合物

    公开(公告)号：US20100255002A1

    公开(公告)日：2010-10-07

    申请号：US10561236

    申请日：2004-06-25

    申请人： Guido Grandi ,  Oretta Finco ,  Giulio Ratti ,  Alessandro Bonci

    发明人： Guido Grandi ,  Oretta Finco ,  Giulio Ratti ,  Alessandro Bonci

    IPC分类号： A61K39/40 ,  A61K39/118 ,  A61K39/39 ,  A61P31/04

    CPC分类号： A61K39/118 ,  A61K39/00 ,  A61K39/02 ,  A61K2039/505 ,  A61K2039/55505 ,  A61K2039/55561 ,  C07K14/195

    摘要： The invention relates to compositions comprising combinations of Chlamydia trachomatis antigens and their use in vaccines. Specific combinations may be selected from a first antigen group of PepA, LcrE, ArtJ, DnaK, and CT398, and a second antigen group of PepA, LcrE, ArtJ, DnaK, CT398, OmpH-like, L7/L12, OmcA, AtoS, CT547, Eno, HtrA and MurG. The invention further relates to the use of combinations of adjuvants for use with antigens associated with a sexually transmissible disease, such as Chlamydia trachomatis antigens. Preferred adjuvant combinations include mineral salts, such as aluminium salts and oligonucleotides comprising a CpG motif.

    摘要翻译： 本发明涉及包含沙眼衣原体抗原的组合的组合物及其在疫苗中的用途。 具体的组合可以选自PepA，LcrE，ArtJ，DnaK和CT398的第一抗原组，PepA，LcrE，ArtJ，DnaK，CT398，OmpH-样，L7 / L12，OmcA，AtoS， CT547，Eno，HtrA和MurG。 本发明还涉及佐剂组合用于与性传播疾病如沙眼衣原体抗原相关的抗原的用途。 优选的佐剂组合包括无机盐，例如铝盐和包含CpG基序的寡核苷酸。

    IMMUNOGENIC COMPOSITIONS
    5.
    发明申请
    IMMUNOGENIC COMPOSITIONS 审中-公开
    免疫组化

    公开(公告)号：US20130273091A1

    公开(公告)日：2013-10-17

    申请号：US13824041

    申请日：2011-09-16

    申请人： Francesco Berti ,  Mario Contorni ,  Paolo Costantino ,  Oretta Finco ,  Guido Grandi ,  Domenico Maione ,  John Telford

    发明人： Francesco Berti ,  Mario Contorni ,  Paolo Costantino ,  Oretta Finco ,  Guido Grandi ,  Domenico Maione ,  John Telford

    IPC分类号： A61K39/385

    CPC分类号： A61K39/385 ,  A61K39/092 ,  A61K47/6415 ,  A61K47/646 ,  A61K2039/6037 ,  A61K2039/627

    摘要： The invention provides an immunogenic composition comprising: a) a conjugate that is a capsular saccharide from GBS serotype 1a conjugated to a carrier protein; b) a conjugate that is a capsular saccharide from GBS serotype 1b conjugated to a carrier protein; and c) a conjugate that is a capsular saccharide from GBS serotype III conjugated to a carrier protein. The invention also provides a method for immunising a patient against infection by GBS comprising the step of administering to the patient a conjugate that is a capsular saccharide from GBS conjugated to a diphtheria toxoid or derivative thereof, wherein the patient has been pre-immunised with a diphtheria toxoid or derivative thereof.

    摘要翻译： 本发明提供免疫原性组合物，其包含：a）缀合物，其是与载体蛋白缀合的GBS血清型1a的荚膜糖; b）缀合物，其是与载体蛋白质缀合的GBS血清型1b的荚膜糖; 和c）缀合物，其是与载体蛋白质缀合的GBS血清型III的荚膜糖。 本发明还提供了一种用于免疫患者免受GBS感染的方法，包括向患者施用作为与白喉类毒素或其衍生物缀合的GBS的荚膜糖的缀合物的步骤，其中所述患者已经用 白喉类毒素或其衍生物。