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1.发明申请Method For Extracting At Least One Compound From A Liquid Phase Comprising A Functionalized Ionic Liquid, And Microfluidic System For Implementing Said Method 有权从包含官能化离子液体的液相中提取至少一种化合物的方法和用于实施所述方法的微流体系统公开(公告)号：US20080185339A1
公开(公告)日：2008-08-07
申请号：US11912077
申请日：2006-04-06
CPC分类号： B01D11/04 , B01D11/0496
摘要： (EN) The invention concerns a method for extracting at least one chemical or biological compound from a liquid phase comprising at least one functionalized ionic liquid, via a liquid extracting fluid (F) which is miscible with said ionic liquid(s), and a microfluidic system (10) for implementing said method. The inventive extraction method includes moving, on one surface (12) of a microfluidic system (19), at least one microdrop (14) of said liquid phase into an extraction solution (20) which comprises said extracting fluid and which is localized on said surface to obtain in output of said solution, under the effect of an electric field, an extract (E) moving away from said surface which is rich in extracting fluid and enriched in said or at least one of said compound(s), and a raffinate (R) moving on said surface which is rich in ionic liquid(s) and deleted in said or one of said compound(s).
摘要翻译： （EN）本发明涉及通过与所述离子液体混溶的液体提取液（F）从包含至少一种官能化离子液体的液相中提取至少一种化学或生物化合物的方法，以及 用于实现所述方法的微流体系统（10）。 本发明的提取方法包括在微流体系统（19）的一个表面（12）上移动所述液相的至少一个微滴（14）至包含所述提取流体并且位于所述液相 在所述溶液的作用下获得所述溶液的输出，所述提取物（E）在电场的作用下离开所述表面移动，所述提取物（E）富含提取流体并富集所述化合物或所述化合物中的至少一种，并且所述提取物 所述残液在所述表面上移动，所述表面富含离子液体并在所述化合物或所述化合物之一中缺失。
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2.发明授权Method for extracting at least one compound from a liquid phase comprising a functionalized ionic liquid, and microfluidic system for implementing said method 失效从包含官能化离子液体的液相中提取至少一种化合物的方法，以及用于实施所述方法的微流体系统公开(公告)号：US08333888B2
公开(公告)日：2012-12-18
申请号：US13024035
申请日：2011-02-09
CPC分类号： B01D11/04 , B01D11/0496
摘要： A microfluidic system including: a substrate, one surface of which is covered with electrodes configured to move, under effect of an electric field, microdrops of a liquid phase including at least one functionalized ionic liquid; and capillaries for introducing a liquid extraction fluid onto the surface and for extracting the liquid extraction fluid from an orifice by forced convection, to obtain an extraction bath located on the surface for extraction of at least one chemical or biological compound from the liquid phase, and the bath is open to a surrounding space on at least two of its opposite sides, for moving, in contact with the surface, the microdrop upstream and downstream of the bath.
摘要翻译： 一种微流体系统，包括：衬底，其一个表面被电极覆盖，电极被配置为在电场的作用下移动包含至少一种官能化离子液体的液相的微滴; 以及用于将液体提取液引入到表面上并通过强制对流从孔中提取液体提取流体的毛细管，以获得位于表面上的用于从液相中萃取至少一种化学或生物化合物的提取液，以及 浴在至少两个相对侧面上的周围空间开口，用于与表面接触，在浴的上游和下游移动微滴。
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3.发明授权Method for extracting at least one compound from a liquid phase comprising a functionalized ionic liquid, and microfluidic system for implementing said method 有权从包含官能化离子液体的液相中提取至少一种化合物的方法，以及用于实施所述方法的微流体系统公开(公告)号：US07914679B2
公开(公告)日：2011-03-29
申请号：US11912077
申请日：2006-04-06
IPC分类号： B01D11/04
CPC分类号： B01D11/04 , B01D11/0496
摘要： A method for extracting at least one chemical or biological compound from a liquid phase including at least one functionalized ionic liquid, via a liquid extracting fluid that is miscible with the ionic liquid, and a microfluidic system implementing the method. The extraction method includes moving, on one surface of a microfluidic system, at least one microdrop of the liquid phase into an extraction solution that includes the extracting fluid and that is localized on the surface to obtain in output of the solution, under effect of an electric field, an extract moving away from the surface that is rich in extracting fluid and enriched in the at least one compound, and a raffinate moving on the surface that is rich in ionic liquid and deleted in the at least one compound.
摘要翻译： 一种从包含至少一种功能化的离子液体的液相中提取至少一种化学或生物化合物的方法，通过可与离子液体混溶的液体提取液，以及实施该方法的微流体系统。 提取方法包括在微流体系统的一个表面上将液相的至少一个微滴移动到包括萃取流体并且定位在表面上以在溶液的输出中获得的提取溶液中，在 电场，从表面富含萃取液并富集至少一种化合物的提取物，以及在富含离子液体的表面上移动并在至少一种化合物中缺失的萃余液。
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公开(公告)号：US20080124252A1
公开(公告)日：2008-05-29
申请号：US11631554
申请日：2005-07-05
申请人： Gilles Marchand , Francoise Vinet , Guillaume Delapierre , Fatima Hassine , Said Gmouh , Michel Vaultier
发明人： Gilles Marchand , Francoise Vinet , Guillaume Delapierre , Fatima Hassine , Said Gmouh , Michel Vaultier
CPC分类号： C07D221/18 , B01F13/0071 , B01F13/0076 , B01J14/00 , B01J19/0093 , B01L3/502792 , B01L2300/0816 , B01L2300/089 , B01L2400/0406 , B01L2400/0415 , B01L2400/0427 , B01L2400/0433 , B01L2400/0442 , B01L2400/0487 , C07C41/14 , C07C227/16 , C12P17/12 , G01N2035/1046
摘要： The present invention relates to a droplet microreactor, i.e. a microreactor consisting of a droplet of a specific liquid, the microreactor being wall-less, wherein the interface of the specific liquid with the ambient environment and with the support on which the droplet is deposited defines the limits of the microreactor. The microreactor is characterized in that it consists of a droplet comprising at least one ionic liquid. The present invention also relates to methods for carrying out chemical or biochemical reactions and/or mixes using said droplet microreactor, and also to a lab-on-chip comprising a microreactor according to the invention.
摘要翻译： 液滴微反应器本发明涉及液滴微反应器，即由特定液体的液滴组成的微反应器，微反应器是无壁的，其中特定液体与周围环境的界面和其上沉积有液滴的载体界定 微反应器的极限。 微反应器的特征在于其由包含至少一种离子液体的液滴组成。 本发明还涉及使用所述液滴微反应器进行化学或生化反应和/或混合的方法，还涉及包括根据本发明的微反应器的片上实验室。
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5.发明申请Microdevice for the In Situ Detection of Particles of Interest in a Fluid Medium and Operating Method 失效用于在流体介质中感兴趣的颗粒的原位检测的微型设备和操作方法公开(公告)号：US20100244855A1
公开(公告)日：2010-09-30
申请号：US12731963
申请日：2010-03-25
IPC分类号： G01R27/04
CPC分类号： G01N27/127 , B82Y15/00 , G01N27/122
摘要： The invention relates to a detection device of small size, allowing direct in situ detection of particles with no labelling, enabling the particles to be rapidly analysed, and having both a specificity and a sensitivity that are at least equivalent to the existing devices. In one embodiment, the invention provides a device having a nanowire, intended for interacting with the particles of interest, which is suspended between two anchors that define a source and a drain, the source and the drain are configured to be connected to an AC voltage generator and to a DC voltage generator, respectively, in order to generate a first input signal; an excitation electrode, placed laterally facing the nanowire and configured to be connected to an AC voltage generator, in order to generate a second input signal; and a measurement electrode placed opposite the excitation electrode relative to the nanowire and generating a single output signal representative of the particles of interest.
摘要翻译： 本发明涉及一种小尺寸的检测装置，允许直接原位检测没有标记的颗粒，使得能够快速分析颗粒，同时具有至少等同于现有装置的特异性和灵敏度。 在一个实施例中，本发明提供了一种具有纳米线的装置，其旨在与感兴趣的颗粒相互作用，所述颗粒悬挂在限定源极和漏极的两个锚点之间，源极和漏极被配置为连接到AC电压 发电机和DC电压发生器，以便产生第一输入信号; 激励电极，横向面对纳米线并且被配置为连接到AC电压发生器，以便产生第二输入信号; 以及与激发电极相对于纳米线放置的测量电极，并产生表示感兴趣的颗粒的单个输出信号。
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6.发明申请METHOD FOR SUCCESSIVELY FUNCTIONALIZING A SUBSTRATE AND MICROSTRUCTURE IS OBTAINABLE BY SAID METHOD 审中-公开方法功能化基底和微结构的方法可以通过方法获得公开(公告)号：US20090053481A1
公开(公告)日：2009-02-26
申请号：US11997477
申请日：2006-08-02
CPC分类号： B01J19/0046 , B01J2219/00387 , B01J2219/00529 , B01J2219/00608 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00722 , Y10T428/24802
摘要： A method for successively functionalizing a substrate whose surface is provided with at least two areas (1, 2) made up of different materials, with at least one chemical substrate, characterized in that the functionalization is carried out without masking and consists (a) in functionalizing a first area (1) without masking the second area (2) or possible successive areas by transforming the substrate with the aid of a chemical substance X1, wherein the first area material reactivity is greater with respect to the reactivity of the substance X1 than the reactivity of the other possible successive areas with respect thereto, and (b1) in treating the second area (2) or the other possible successive areas with a chemical substance Y1 for removing reaction products deposited on said areas during the functionalization from the areas of the substance X1 and/or the possible successive areas without damaging the functionalized surface of the first area.
摘要翻译： 一种用于使表面设置有由不同材料构成的至少两个区域（1,2）的衬底与至少一个化学衬底相连地功能化的方法，其特征在于，所述功能化在不掩蔽下进行，并且包括（a） 通过借助于化学物质X1转化所述衬底而不掩蔽所述第二区域（2）或可能的连续区域来功能化第一区域（1），其中所述第一区域材料反应性相对于所述物质X1的反应性更大 相对于其它可能的连续区域的反应性，和（b1）在用于除去在功能化过程中沉积在所述区域上的反应产物的化学物质Y1处理第二区域（2）或其它可能的连续区域时 物质X1和/或可能的连续区域，而不损害第一区域的官能化表面。
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7.发明授权公开(公告)号：US09588084B2
公开(公告)日：2017-03-07
申请号：US13497962
申请日：2010-09-24
IPC分类号： G01N27/30 , G01N29/036 , G01N29/02
CPC分类号： G01N29/036 , G01N29/022 , G01N2291/0255 , G01N2291/0256 , G01N2291/0426
摘要： The present invention concerns a device for detecting gases or volatile organic compounds (VOC) comprising an electrically conducting or semiconducting zone functionalized with an organic film resulting from the polymerization of aromatic diazonium salt derived monomer.
摘要翻译： 本发明涉及一种用于检测气体或挥发性有机化合物（VOC）的装置，其包括由芳族重氮盐衍生的单体的聚合产生的由有机膜官能化的导电或半导电区域。
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8.发明授权Bifunctional molecules comprising a cycloalkyne or heterocycloalkyne group and a redox group 有权包含环炔或杂环炔基和氧化还原基团的双功能分子公开(公告)号：US08592619B2
公开(公告)日：2013-11-26
申请号：US13257365
申请日：2010-03-16
IPC分类号： C07F17/02 , H01L45/00 , H01L21/312
CPC分类号： C07F17/02
摘要： The invention relates to compounds comprising a cycloalkyne or heterocycloalkyne group and a redox group. Said compounds are of general formula (I) wherein Z is a cycloalkyne or heterocycloalkyne with at least 8 links, optionally substituted by a halogen atom or a linear or branched C1 to C5 alkyl, A is an organic structure having oxidation-reduction properties, and B is an organic link between the cycloalkyne or heterocycloalkyne cycle and the organic structure A. The invention is especially applicable to the field of molecular electronics.
摘要翻译： 本发明涉及包含环炔或杂环炔基和氧化还原基团的化合物。 所述化合物具有通式（I），其中Z是具有至少8个连接的环烯烃或杂环炔基，任选被卤素原子或直链或支链C 1至C 5烷基取代，A是具有氧化还原性质的有机结构，和 B是环炔或杂环炔环与有机结构A之间的有机连接。本发明特别适用于分子电子领域。
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9.发明授权Silane compounds having a cyclic carbon chain including an alkyne function for functionalizing solid substrates and immobilizing biological molecules on said substrates 失效具有环状碳链的硅烷化合物，其包括用于官能化固体底物并将生物分子固定在所述基材上的炔官能团公开(公告)号：US08546598B2
公开(公告)日：2013-10-01
申请号：US13257326
申请日：2010-03-16
CPC分类号： C07F7/1804
摘要： The invention relates to a silane compound including a cycloalkyne functionality, to a method for functionalising a solid substrate, and to the solid substrate thus produced. The silane compound of the invention corresponds to the formula X-E-A-Z where X is a silyl group, E is an organic spacer group, A is a single bond or a —CONH—, —NHCO—, —OCH2CONH—, —NHCOCH2O—, —O— or —S— group, and Z is a cycloalkyne or heterocycloalkyne with at least 8 members. The invention is particularly suitable for use in the field of medicine.
摘要翻译： 本发明涉及包括环炔官能团的硅烷化合物，固体基质的功能化方法以及如此制备的固体基质。 本发明的硅烷化合物对应于式XEAZ，其中X是甲硅烷基，E是有机间隔基团，A是单键或-CONH-，-NHCO-，-OCH 2 CONH-，-NHCOCH 2 O-，-O - 或-S-基团，Z是具有至少8个成员的环炔或杂环炔。 本发明特别适用于医药领域。
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10.发明授权Microdevice for the in situ detection of particles of interest in a fluid medium and operating method 失效用于在流体介质中原位检测感兴趣的颗粒的微型装置和操作方法公开(公告)号：US08334702B2
公开(公告)日：2012-12-18
申请号：US12731963
申请日：2010-03-25
CPC分类号： G01N27/127 , B82Y15/00 , G01N27/122
摘要： The invention relates to a detection device of small size, allowing direct in situ detection of particles with no labelling, enabling the particles to be rapidly analysed, and having both a specificity and a sensitivity that are at least equivalent to the existing devices. In one embodiment, the invention provides a device havinga nanowire, intended for interacting with the particles of interest, which is suspended between two anchors that define a source and a drain, the source and the drain are configured to be connected to an AC voltage generator and to a DC voltage generator, respectively, in order to generate a first input signal;an excitation electrode, placed laterally facing the nanowire and configured to be connected to an AC voltage generator, in order to generate a second input signal; anda measurement electrode placed opposite the excitation electrode relative to the nanowire and generating a single output signal representative of the particles of interest.
摘要翻译： 本发明涉及一种小尺寸的检测装置，允许直接原位检测没有标记的颗粒，使得能够快速分析颗粒，同时具有至少等同于现有装置的特异性和灵敏度。 在一个实施例中，本发明提供了一种具有纳米线的装置，其旨在与感兴趣的颗粒相互作用，所述颗粒悬挂在限定源极和漏极的两个锚点之间，源极和漏极被配置为连接到AC电压 发电机和DC电压发生器，以便产生第一输入信号; 激励电极，横向面对纳米线并且被配置为连接到AC电压发生器，以便产生第二输入信号; 以及与激发电极相对于纳米线放置的测量电极，并产生表示感兴趣的颗粒的单个输出信号。
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